International Journal of Advances in Pharmaceutics
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Advances and development in transdermal drug delivery system-A review
Get PDFIt is one of the best pharmaceutical dosage forms for those patients, they cannot take medicaments orally. Transdermal drug delivery system (TDDS) established itself as an integral part of novel drug delivery systems (NDDS). On the application of Transdermal patches, the delivery of the drug across dermis gives the systemic effect. TDDS is costly alternative to conventional formulation. It is also important due to its unique advantage. Controlled absorption, more uniform plasma levels, improved bioavailability, reduced side effects, painless and simple application and flexibility of terminating drug administration by simply removing the patch from the skin are some of the potential advantages of transdermal drug delivery. Development of controlled release transdermal dosage form is a complex process involving extensive efforts. This review article describes the methods of preparation of different types of transdermal patches. In addition, the various methods of evaluation of transdermal dosage form and Advance Development in TDDS have also been reviewed
An insight to ocular in situ gelling systems
Get PDFEye is delicate organ of body whose defence mechanism restricts entry of exogenous substances. Conventional drug delivery systems get washed off within a short period of time and results in poor ocular bioavailability. Development of in situ gel having protracted ocular residence time is one of the mile stone triumphs by pharmaceutical researcher for treatment of eye aliments. This polymeric system showed sol-to-gel phase transition by change in physiological parameters in pre-corneal area which includes pH, temperature or ionic interactions etc. Three types of in situ gels are well known based on mechanism involved in phase transition viz. temperature dependent, pH sensitive, ion activated systems. Gel formed after phase transitions have high viscosity along with bio-adhesive property, which increases resistance for instantaneous rinse off due to defence contrivance. Plus it prevents nasal-lachrymal drainage and avoids the systemic side effects. Recently, in situ gels have been vexed in amalgamation with another drug delivery system. It may include use of two or more stimuli systems together or added advantages of nano-technology. Combination of in situ gel with nano-particles is utmost remedy for ocular treatment with water insoluble drugs
Liquisolid Compacts: A Review
Get PDFSolubility is a major problem for nearly one third drugs in their development phase. Liquisolid technique is a most promising technique for promoting dissolution by increase in solubility. Liquisolid compact technology is a novel concept for oral drug delivery. Liquisolid compact technology was first described by spireas et.al. (1998). According to the new formulation method of liqui-solid compacts, liquid medications such as solutions or suspensions of water insoluble drugs in suitable nonvolatile liquid vehicles can be converted into acceptably flowing and compressible powders by blending with selected powder excipients
Niosomes: An aproach to current drug delivery-A review
Get PDFNiosomes are a novel drug delivery system (NDDS), in which the medication is encapsulated in a vesicle. The vesicle is composed of a bilayer of non-ionic surface active agents and hence the name niosomes. The niosomes are very small, and microscopic in size. Their size lies in the nanometric scale. Although structurally similar to liposomes, they offer several advantages over them. It has been a study interest in the development of a NDDS. NDDS has an object to deliver the drug at a rate directed by the needs of the body during the period of treatment of a disease, and reach the active ingredient to the site of action. A number of NDDS have been reported through various routes of administration, to achieve controlled and targeted drug delivery. Encapsulation of the drug in vesicular structures is one of the most important systems, which can be predicted to prolong the existence of the drug in systemic circulation and reduce the toxicity, if prescribed uptake can be achieved. Consequently a number of vesicular drug delivery systems such as liposomes, niosomes, transfersomes, and pharmacosomes were developed. Advances have since been made in the area of vesicular drug delivery, leading to the development of systems that allow drug targeting and the sustained or controlled release of conventional medicines. The focus of this review is to the various method of preparations, characterization of niosomes, advantages and brings out the application vesicular systems
Review on microspheres as a drug delivery carrier
Get PDFA well designed controlled drug delivery system can overcome some of the problems of conventional therapy and enhance the therapeutic efficacy of a given drug .To obtain maximum therapeutic efficacy, it becomes necessary to deliver the agent to the target tissue in the optimal amount in the right period of time there by causing little toxicity and minimal side effects. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release fashion. One such approach is using microspheres as carriers for drugs. In this article importance of microsphere as a novel drug delivery carrier to attain site specific drug delivery was discussed
Controlling Dengue- A review of battery of targets
Get PDFDengue fever occurs by Infection of mosquito-borne dengue virus and sometimes fatal dengue hemorrhagic fever. Every year cases of dengue infections are increasing.This suggests that the virus is becoming more virulent and its transmission is expanding. Nevertheless, no effective treatment for dengue infection currently exists. This paper has focused several potential targets for antiviral drug development against flavivirus. We discuss the flavivirus genome, NS1, NS2, NS3, Envelope protein and NS5 MTase domain and NS5 RdRp domain as a potential drug targets
Formulation and evaluation of herbal tablets containing Agaricus bisporus powder
Get PDFAgaricus bisporus is an edible mushroom known for its nutritional and bio-medicinal properties. The methanolic extract of Agaricus bisporus for phytochemical screening performed and Alkaloids, Carbohydrate, Glycosides, Protein, Flavonoids, Saponins, Phenolic, Steroids. Some of them are responsible for anti-diabetic activities. In the present study oral administrable dosage form of herbal tablet and evaluated. The result of all test were found to be satisfactory
Technology transfer in pharmaceutical industry- A Review
Get PDFThe objective of this review article is to study how technology is transferred in pharmaceutical industry. The article attempts to discuss about the technology transfer process, importance of technology transfer, reasons for using technology transfer, policy approaches of technology transfer, effective factors in technology transfer, Facets of technology transfer, goals of technology transfer, steps involved in technology transfer, barriers of technology transfer and the issues involved in the technology transfer in the pharmaceutical industry. The transfer may be said to be successful if the receiving unit and the transferee can effectively utilize the technology for business gain. The transfer involves cost and expenditure that should be agreed by the transferee and transferor. The success of any particular technology transfer depends upon process understanding or the ability to predict accurately the future performance of a process
Development & evaluation of herbal fast dissolving tablet of Capparis divaricata Lam
Get PDFFast dissolving tablets can be disintegrated, dissolved or suspended by saliva in the mouth. Herbal medicines are effective in all types of diseases. Standardization assures a consistently stronger product with guaranteed constituents. The aim of this study was to formulate fast dissolving tablets of Capparis Divaricata Lam leaves extract to achieve faster disintegration in the oral cavity without water. Fast dissolving tablets of Capparis Divaricata Lam leaves extract were prepared by using different super disintegrants like cross povidone, cross carmellose sodium and sodium starch glycolate by direct compression method. FDTs were evaluated for physicochemical properties and in-vitro dissolution. The drug release from FDTs increased with increasing concentration of superdisintegrants at certain extent and was found to be highest with formulations containing cross povidone. The tablets were subjected to weight variation, drug content uniformity, hardness, friability, in-vitro disintegration time and in- vitro drug release studies
Recent advancements and applications of multiple emulsions
Get PDFMultiple emulsions are complex polydispersed systems where both oil-in-water and water-in-oil emulsions exists simultaneously, stabilized by lipophilic and hydrophilic surfactants respectively. These emulsions are also known as emulsions of emulsions, liquid membrane system or double emulsions. Multiple emulsions can be classified into two types, namely water-in-oil-in-water (W/O/W) and oil-in-water-in-oil (O/W/O) emulsions. These emulsions find wide range of applications in controlled and sustained drug delivery, targeting of bioactives, vaccine adjuvants, delivery of proteins and peptides, enzyme immobilization, taste masking and treatment of drug overdose. The aim of this article was to provide a detailed review of types, preparation methods, formulation approaches, evaluation parameters, release mechanisms and applications of multiple emulsions