International Journal of Advances in Pharmaceutics
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A Review: Radioactive Microspheres as a Theranostics
Get PDFMicrospheres as a drug delivery system hold great promise in reaching the goal of controlled drug delivery as well as site specific delivery. In the last few decades, scientific and technological advancements have been made in the research and development of radio labeled microspheres. These are used successfully for the treatment of various cancers and tumors. Since response to chemotherapy and external radiotherapy is not so effective and hazardous too, so an alternative to this is internal radiation therapy. These radio labeled microspheres are very stable and have a proven efficacy in the field of primary as well as metastatic cancers. Radioactive microspheres can be selectively targeted to various tumors without undue radiation to the nontumorous tissues. The radioactive microspheres are injected to halt tumor growth via the blood supply, thereby enabling surgical removal once the tumor size decreases. This review provides an outlook to various aspects of radioactive microspheres and their role in treatment of various tumors and cancers
A review- Recent research on microsponge a novel new drug delivery system
Get PDFMicrosponge is recent novel technique for control release and target specific drug delivery system. Therefore many scientist or researcher attracted towards the microsponge drug delivery system. Also Microsponge technology has been introduced in topical drug products to facilitate the controlled release of active drug into the skin in order to reduce systemic exposure and minimize local cutaneous reactions to active drugs. More and more developments in delivery systems are being integrated to optimize the efficacy and cost-effectiveness of the therapy. Microsponge technology offers entrapment of ingredients and is believed to contribute towards reduced side effects, improved stability, increased elegance, and enhanced formulation flexibility. In addition, numerous studies have confirmed that microsponge systems are non-irritating, non-mutagenic, non-allergenic, and non-toxic. Microsponge drug delivery system technology is being used currently in cosmetics, over-the-counter (OTC) skin care, sunscreens and prescription products
A General Review on Vitamin world
Get PDFVitamins, are any of the normal blends required by the body in little wholes for absorption, to guarantee prosperity, and for honest to goodness advancement in kids. Vitamins also help the course of action of hormones, platelets, tactile framework chemicals, and innate material. The distinctive vitamins are not artificially related, and most fluctuate in their physiological exercises. They generally go about as stimuli, joining with proteins to make metabolically powerful intensifies that in this way convey numerous essential mixture reactions all through the body. Without vitamins, an expansive number of these reactions would back off or stop. The multifaceted behaviour by which vitamins follow up on the body, however, are as yet far from clear
A hydrogels: Methods of preparation and applications
Get PDFHydrogels are three-dimensional, hydrophilic, polymeric networks capable of absorbing large amounts of water or biological fluids. Due to their high water content, porosity and soft consistency, they closely simulate natural living tissue, more so than any other class of synthetic biomaterials. Skin is the largest organ of human body and drug delivery through this route is called transdermal drug delivery system. This route of drug administration is used for local as well assystemic delivery of drug. In this review article an attempt has been made to explain the advantages, disadvantages, classification of hydrogels, methods of preparation and applications and future challenges in hydrogel based drug delivery syste
Identification of novel inhibitor against dengue NS5
Get PDFDengue fever, a neglected emerging disease for which no vaccine or antiviral agents exist at present, is caused by dengue virus, a member of the Flavivirus genus, which includes several important human pathogens, such as yellow fever and West Nile viruses. The NS5 protein from dengue virus is bifunctional and contains 900 amino acids. The S -adenosyl methionine transferase activity resides within its N-terminal domain, and residues 270 to 900 form the RNA-dependent RNA polymerase (RdRp) catalytic domain. Viral replication begins with the synthesis of minus-strand RNA from the dengue virus positive-strand RNA genome, which is subsequently used as a template for synthesizing additional plus-strand RNA genomes. This essential function for the production of new viral particles is catalyzed by the NS5 RdRp. In this scenario, the present study aims to identify new molecules which could block or suppress the activity of RNA dependent RNA polymerase enzyme by molecular docking studies using Autodock Vina. In this study we used in silico approach by modeling NS5 protein, Optimization of the structure was done by adding polar hydrogens and Kollman charges using Pyrx .We further carried out docking studies by means of Autodock Vina, with various phytochemicals. Based on binding energy, phytochemicals were screeened and their interaction with NS5 was identified. Thus, we report Rohitukine alkaloid that has successfully satisfied all in silico parameters, necessitating further in vitro and in vivo studies. The improved conditions and new structural information should accelerate structure-based design of antiviral compounds against Dengue virus
Formulation and in vitro study of Ibuprofen loaded crosslinked sodium alginate and gellan gum microspheres
Get PDFIbuprofen loaded microspheres were prepared using sodium alginate and gellan gum and were cross-linked by maleic anhydride, aluminium chloride. The resulting microspheres were evaluated by in-vitro release study, swelling index, microscopic analysis and entrapment efficiency. DSC study shows there was no interaction between drug and excipients. Entrapment was found good in all the formulations while the maximum entrapment (97.6%) was recorded in formulation cross-linked by aluminium chloride and their average particle size were 150 to 160 m. Approximately 50% of drug was released by the formulation cross-linked by aluminium chloride (F2) over a period of 6 hours. From this experiment, it is observed that the formulation with cross-linked by aluminium chloride is the better formulation among others due to good release profile and entrapment efficiency
An overview of technology transfer in industry
Get PDFThe objective of this review article is to study how technology is transferred in the pharmaceutical industry. This review article is to discuss the procedure for technology transfer process in pharmaceutical industry, importance of technology transfer, reasons for using technology transfer, methods of technology transfer, facets of technology transfer, list of institutes in Indian assisting in technology transfer, organization of technology transfer, function of technology transfer, steps involved in technology transfer, few case of involved in the technology transfer in the pharmaceutical industry and understand the aspects related with technology transfer
Recent Advancement in Emulgel: A Novel Approach for Topical Drug Delivery
Get PDFGels are the preferable dosage forms for topical delivery of drugs in present days, but their use is not suitable for drugs with hydrophobic nature. In order to overcome the limitation of gels as a dosageform forhydrophobic drugs, an emulsion based approach is being used. When gels and emulsions are used in combined form the dosage form are referredas emulgel. The combination of hydrophilic cornified cells in hydrophobic intercellular material provides abarrier to both hydrophilic and hydrophobic substances. Polymer canfunction as emulsifiers and thickeners because the gelling capacity of these compounds allows the formulationof stable emulsions by decreasing surface as well as interfacial tension and increasing theviscosity of the aqueous phase. Various permeation enhancers can potentiate the effect, so emulgelscan be used as better topical drug delivery systems over the conventional systems. The use of emulgels can be used as formulationsystem for analgesics and antifungal drugs
A brief review on bilayer floating tablet
Get PDFBilayer tablet is innovative period for the successful improvement of controlled release formulation along with a variety of features to provide a technique of successful drug delivery system. Controlled release dosage forms have been comprehensively used to improve therapy with several important drugs. Inclusion of drug in controlled release gastro-retentive dosage forms which can remain in the gastric region for several hours would considerably extend the gastric residence time of drugs and improve bioavailability, reduce drug waste and enhance the solubility of drugs that are less soluble in high pH environment. Numerous approaches are presently utilized in the prolongation of Gastric Retention Time, including floating drug delivery system, swelling and expanding systems, polymeric bio adhesive systems, high-density systems, modified shape systems and other deferred gastric emptying strategy
Advance development and current challenges in nails drug delivery-A review
Get PDFNails drug delivery system (NDDS) is an important delivery system in mammals, in which their nails are highly affected by the fungal diseases. Disorders of the nail unit range from relatively innocuous conditions such as pigmentation in heavy smokers, to painful and debilitating states where the nail unit can be dystrophied, hypertrophied, inflamed, infected etc. The human nail forms a resistant barrier to the topical penetration of drugs. Thus, treatment of nail disorders, such as fungal infections, remains a challenge because of the difficulty encountered in achieving therapeutic concentrations of drugs at the site of infection, which is often under the nail. Ungual and trans-ungual drug delivery continues to receive significant attention due to the need for efficacious topical therapies for onychomycosis given the potential risk of systemic adverse effects associated with the conventional oral therapy. To successfully treat nail disorders, applied drugs must permeate through the dense keratinized nail plate and reach the deeper layers of the nail plate, nail bed and the nail matrix. Physical, chemical and mechanical methods have been used to decrease the nail barrier. This current review include anatomy of human nail, nails disorders, factors affecting tans-ungual delivery of drugs and methods used for enhancement of drugs penetration into/across the nail