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La loi no 2023-175 du 10 mars 2023 relative à l'accélération de la production d'énergies renouvelables
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Severe allergic contact connubial dermatitis to Nigella Sativa Seed Oil due to repeated contacts to beard cosmetics
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Apparent diffusion coefficients of 31P metabolites in the human calf muscle at 7 T
No full textInternational audienceAbstract Purpose In this study, we aimed to measure the apparent diffusion coefficients (ADCs) of major phosphorous metabolites in the human calf muscle at 7 T with a diffusion-weighted (DW)-STEAM sequence. Methods A DW-STEAM sequence with bipolar gradients was implemented at 7 T, and DW MR spectra were acquired in three orthogonal directions in the human calf muscle of six healthy volunteers (TE/TM/TR = 15 ms/750 ms/5 s) at three b -values (0, 800, and 1200 s/mm 2 ). Frequency and phase alignments were applied prior to spectral averaging. Averaged DW MR spectra were analyzed with LCModel, and ADCs of 31 P metabolites were estimated. Results Four metabolites ( phosphocreatine (PCr), adenosine triphosphate (ATP), inorganic phosphate (Pi) and glycerol phosphorylcholine (GPC) ) were quantified at all b -values with mean CRLBs below 10%. The ADC values of PCr, ATP, Pi, and GPC were (0.24 ± 0.02, 0.15 ± 0.04, 0.43 ± 0.14, 0.40 ± 0.09) × 10 –3 mm 2 /s, respectively. Conclusion The ADCs of four 31 P metabolites were successfully measured in the human calf muscle at 7 T, among which those of ATP, Pi and GPC were reported for the first time in humans. This study paves the way to investigate 31 P metabolite diffusion properties in health and disease on the clinical MR scanner
Decomposing grass leaf elongation rate: hydraulics, visco-elasticity and ontogeny
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How subjective well-being, patient-reported clinical improvement (PROMs) and experience of care (PREMs) relate in an acute psychiatric care setting?
No full textInternational audienceBackground Patient-reported outcome measures (PROMs) and patient-reported experience measures (PREMs) are increasingly acknowledged as critical tools for enhancing patient-centred, value-based care. However, research is lacking on the impact of using standardized patient-reported indicators in acute psychiatric care. The aim of this study was to explore whether subjective well-being indicators (generic PROMs) are relevant for evaluating the quality of hospital care, distinct from measures of symptom improvement (disease-specific PROMs) and from PREMs. Methods Two hundred and forty-eight inpatients admitted to a psychiatric university hospital were included in the study between January and June 2021. Subjective well-being was assessed using standardized generic PROMs on well-being, symptom improvement was assessed using standardized disease-specific PROMs, and experience of care using PREMs. PROMs were completed at admission and discharge, PREMs were completed at discharge. Clinicians rated their experience of providing treatment using adapted PREMs items. Results Change in subjective well-being (PROMs) at discharge was significantly ( p < 0.001), but moderately ( r 2 = 28.5%), correlated to improvement in symptom outcomes, and weakly correlated to experience of care (PREMs) ( r 2 = 11.0%), the latter being weakly explained by symptom changes ( r 2 = 6.9%). Patients and clinicians assessed the experience of care differently. Conclusions This study supports the case for routinely measuring patients’ subjective well-being to better capture the unmet needs of patients undergoing psychiatric hospital treatment, and the use of standardized patient-reported measures as key indicators of high quality of care across mental health services
