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THE EFFECT OF RED LIGHT THERAPY (PHOTOBIOMODULATION) ON MUSCLE RECOVERY AND PHYSICAL PERFORMANCE IN ATHLETES
Get PDFIntroduction: Physical activity plays a key role in maintaining physical and mental health, influencing the quality of life and prevention of many diseases. Modern sports, due to increasing training requirements, carry an increased risk of injuries and muscle strains. Therefore, non-invasive methods supporting regeneration, such as red light therapy, also known as photobiomodulation (PBM), are of increasing interest.
Purpose of the Study: The aim of this review is to analyze the effect of photobiomodulation on muscle regeneration and physical performance in athletes. The paper presents the current state of knowledge, potential mechanisms of action and results of studies involving physically active people.
Materials and Methods: A review of the scientific literature on the use of red light therapy in sports medicine was conducted. Publications from recent years were included, including clinical trials, systematic reviews and experimental articles, focusing on the effect of PBM on muscle function and physical performance.
Conclusions: Photobiomodulation can support regenerative processes by stimulating mitochondria, increasing ATP production and reducing inflammation. Observed effects include accelerated regeneration, improved muscle strength and endurance and reduced risk of injury. Despite promising results, further studies are needed to standardize procedures and determine the long-term effectiveness of the therapy in different sports disciplines
TARGETING MULTIPLE PATHWAYS WITH ONE MOLECULE: THE THERAPEUTIC VERSATILITY OF TIRZEPATIDE
Get PDFTirzepatide is a novel dual agonist of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors that offers promising therapeutic potential beyond glycemic control. Originally developed for the treatment of type 2 diabetes mellitus, tirzepatide has demonstrated a wide array of pleiotropic effects in clinical studies. These include significant reductions in body weight, improvements in lipid profiles, decreased blood pressure, and attenuation of hepatic steatosis. Emerging data also support its cardioprotective and nephroprotective roles, as well as efficacy in patients with heart failure with preserved ejection fraction (HFpEF). Furthermore, tirzepatide is currently under investigation for the treatment of obstructive sleep apnea and shows early promise in neuroprotection. This review summarizes the current evidence on the diverse biological actions of tirzepatide and discusses their potential clinical implications in the context of metabolic syndrome and associated comorbidities.
Materials and methods: A review of the literature available in the PubMed database was performed, using the key words: “tirzepatide”, “obesity treatment”, “GIP”, “GLP-1”, “glucose-dependent insulinotropic polypeptide”, “glucagon-like peptide-1”.
Conclusion: The clinical benefits of tirzepatide extend well beyond glucose lowering, encompassing a broad spectrum of metabolic, cardiovascular and renal effects. These pleiotropic actions position tirzepatide as a valuable pharmacological agent in the multifactorial management of type 2 diabetes, obesity and related conditions. Continued investigation into its mechanisms of action and therapeutic scope may further redefine its role in the treatment of complex metabolic disorders. Given the growing body of evidence, tirzepatide represents a paradigm shift toward integrated care for patients with metabolic syndrome and its systemic manifestations
ACROMEGALY – ETIOLOGY, SYMPTOMS, TREATMENT. LITERATURE REVIEW
Get PDFAcromegaly is a rare endocrine disorder, typically resulting from a growth hormone (GH)-secreting pituitary adenoma. While these tumors are generally benign, they can sometimes exhibit local invasiveness or resistance to standard treatments. Clinically, the condition manifests through both distinctive physical changes and a range of systemic symptoms that may affect the cardiovascular, respiratory, metabolic, and neurological systems, and may also be associated with an increased risk of neoplastic diseases. Without timely treatment, these complications can significantly raise mortality risk, highlighting the importance of early detection. Initial screening usually includes measuring the levels of insulin-like growth factor 1 (IGF-1). Despite medical advancements, diagnosing acromegaly remains challenging, and delays in diagnosis are common, often resulting in advanced disease and severe complications. The preferred initial treatment is surgical resection of the tumor. For individuals who are ineligible for surgery or do not achieve remission postoperatively, medical therapy using somatostatin analogues is recommended. The primary therapeutic aims include normalization of IGF-1 and GH levels, reduction of tumor size, and management of associated complications
NEW DIRECTIONS IN THE TREATMENT OF PEMPHIGUS VULGARIS? SAFETY AND EFFICACY OF RITUXIMAB AND DUPILUMAB – REVIEW OF LITERATURE
Get PDFBackground. Recent years have demonstrated a considerable development of biological treatment of various autoimmune diseases. Lack of response and adverse effects of standard treatment have been pushing research to find new therapeutic agents with good efficacy and safety profile.
Aim. This study reviews the current knowledge about the potential use of rituximab and dupilumab, two biological drugs, in the treatment of pemphigus vulgaris (PV), a debilitating skin disease.
Material and methods. The article is based on research of clinical trials and case studies published on the PubMed and Cochrane databases using the following keywords: pemphigus vulgaris, rituximab, dupilumab.
Results. The existing trials show that rituximab offers faster achievement of complete remission when compared to standard prednisone or mycophenolate mofetil treatment. It also reduces the cumulative prednisone dose followed by alleviation of steroid-related adverse events. Its effect is even visible on the molecular level, being the depletion of T-helper cells that play a crucial role in activation of anti-desmoglein antibody producing B-memory cells. The use of dupilumab in PV has only been documented in a few case studies, which still show that most patients with refractory PV benefited from dupilumab treatment by finally achieving and maintaining remission.
Conclusions. Despite limited randomized studies and small patient groups, the results of the existing research suggest a promising role of biological agents in the future treatment of patients with pemphigus vulgaris
ENSURING CONSISTENT TRAFFIC MANAGEMENT THROUGH INFORMATION SUPPORT ON ROAD APPROACH SECTIONS TO MAJOR CITIES
Get PDFAn increase in the number of vehicles results in higher traffic flow intensity and density, which affects the emergence of an inefficient, congested and potentially dangerous traffic regime. Under such conditions, the management of individual vehicles does not provide effective control over the functioning of the transport system as a whole. In addition, the modern needs to adapt to growing demand through the implementation of intelligent control subsystems capable of monitoring, analyzing, and performing real-time traffic control.The growth in the intensity and density of traffic flows affects the likelihood of traffic accidents and congestion and, as a result, increases travel time. Therefore, there is a need to create a specialized control subsystem capable of managing traffic flows, analyzing them, assessing the current state of the transport system, and predicting further developments. To create such a subsystem, it is necessary to analyze and study traffic flows in more detail, create a simulation model to understand the problem and the algorithm of actions to solve it.The article substantiates the necessity of creating such a subsystem for the sections of highway approaches to large and major cities. The stages of building a traffic simulation model are presented, the principles of the control process of algorithmization are considered, as well as the use of PTV VISSIM software for real-time simulation
EFFECTIVENESS OF CONSERVATIVE MYOMECTOMY FOR PRESERVATION OF WOMEN'S REPRODUCTIVE CAPACITY
Get PDFOver the past few years, the population of Ukraine has faced a number of traumatic events. These events have a negative impact on the life of all Ukrainians and cause an increase in the frequency and severity of stress disorders. However, the biggest shock was the beginning of the active phase of the war in February 2022 in Ukraine. Women develop post-traumatic stress disorder (PTSD) under the influence of super-extreme situations. Amidst stress and PTSD, women experience changes in hormonal levels, immune status, and reproductive health issues.
According to current data, about 30% of people exposed to traumatic events will have PTSD and need help. As for the female population, about 10% of adult women and 7% of girls are diagnosed with PTSD in their lifetime. It is also known that women experience PTSD almost 1.5 times more often than men. The prevalence of mental disorders is particularly high among internally displaced persons. In particular, in this cohort, 22% of men and 36% of women develop and are diagnosed with PTSD.
According to WHO, the problem of uterine tumour processes is one of the most important areas of modern medicine. According to the International Classification of Diseases, 10th Revision (ICD-10: D25.0-D25.9), uterine leiomyoma (UGC), as one of the most common tumours of the female reproductive system, ranks among the top gynaecological diseases (GD) and is combined with extragenital (EGD) and genital (GC) pathologies. Studies conducted in recent years have shown that the incidence of LM has shown an upward trend in recent decades and is 35-45% in women over the age of 30. According to scientists, the true incidence of breast cancer is as high as 77%. The incidence of recurrent LM after reconstructive surgery ranges from 2.6 to 50 % of cases. Studies have shown that in 18.0% of patients of early reproductive age, after myomectomy, newly emerging myomatous nodes were detected. The analysis of the results allowed us to conclude that myoma recurrence is 1.2 times more likely to occur in a subgroup of patients with PTSD. It was also found that myoma recurrence occurs mainly in the first two years after surgery.
 
DETERMINATION OF SURFACE ENERGY AT THE INTERFACE BETWEEN POLYMER AND AGGRESSIVE AREA
Get PDFThere are discussed the methodology and results of the study of surface energy at the interface between a polymer and an aggressive area.There are presented the methods and results of x-ray diffraction studies of intermediate grain sires and apps on polymer surface
FISH FARMING PROJECTS AROUND THE WORLD: A PRESENTATION OF SELECTED STATISTICS FROM THE FOOD AND AGRICULTURE ORGANISATION (FAO), 2022 REPORT
Get PDFThis paper aims to shed light on one of the most significant food-related projects: fish farming. Its importance is evident both at the individual level, by providing high nutritional value, and at the national level, through its contribution to economic and social development (food security, self-sufficiency, etc.). It also offers profitability for institutions operating within a market that is flourishing daily. The Food and Agriculture Organisation (FAO) has emphasised the importance of investing in this sector. Accordingly, this paper presents key statistics from the FAO's 2022 report. The findings indicate that fish farming production reached an estimated 120 million tonnes in 2020, a remarkable increase considering that the activity was once marginal and only began to develop from 1985 onwards. China leads in global production, accounting for more than 50%. Regionally, Asia ranks first in terms of global output, followed by Africa and Europe. Egypt is Africa's largest fish farming producer, contributing approximately 3% of global production. It is hoped that Algeria will increase its investment in this sector to achieve food security, particularly given its vast potential and capacity to take a leading position
ISSUES OF USING FINANCIAL RESOURCES TO ENSURE SUSTAINABLE DEVELOPMENT OF THE AGRICULTURAL SECTOR
Get PDFThe agricultural sector is characterized by a number of specific features. First of all, reforms in this area are accompanied by instability of production. Many circumstances, such as climatic fluctuations, inflation rate, credit-price growth, decrease in purchasing power, significant reduction in state support for agriculture and the entire agro-industrial complex, increase in debts of agricultural producers and industrial enterprises producing means of production necessary for agriculture and agricultural producers, etc., affect the financial security of agricultural enterprises to one degree or another. In conditions of market relations, financial security, financial stability, financial security act as an important component for economically independent enterprises. Taking all this into account, the article approaches financing as the main condition for sustainable development of the agricultural sector. The author studies the experiences of Latvia, China, and Britain and makes proposals on financing directions to ensure sustainable development of the agricultural sector. The article analyzes the interaction of sustainable development and the agricultural sector, the needs arising from the goals of sustainable development, and argues that access to financial resources is a necessary condition for sustainable development. According to the author, sustainable development requires adequate financial support, and financing should be organized in accordance with the specialization of the agricultural sector, the characteristics of the region and the soil. In this case, it can be more efficient
PROFILING IN BORDER CONTROL SERVICES: A MONGOLIAN PERSPECTIVE
Get PDFProfiling at border control services involves using a set of criteria based on observable factors like travel patterns, behavior, and document details to identify individuals who may pose potential security risks.
This approach allows border officials to focus their scrutiny on those considered more likely to be involved in illegal activities such as smuggling, human trafficking, or terrorism while facilitating smooth passage for low-risk travelers. Implementation occurs through a combination of data analysis, observation, and questioning techniques by trained border officers, often utilizing specialized software to flag potential concerns based on collected information.
This article explores the use of profiling techniques in border control services, focusing on Mongolia's border security context. It discusses the historical evolution of profiling from criminal psychology to its current role in identifying security threats.
The research highlights the importance of profiling as a complement to technological solutions in addressing human factors in border security.
It compares traditional Mongolian identification methods with modern profiling techniques and identifies challenges faced by Mongolian Border Security Checkpoint officers.
The study suggests the need for formal profiling training programs, specialized curricula, and dedicated profiling teams with diverse expertise to improve border security operations