RS Global Journals
Not a member yet
3430 research outputs found
Sort by
DIGITAL HEALTH SOLUTIONS IN ATRIAL FIBRILLATION MANAGEMENT: ENHANCING DETECTION, MONITORING, AND PATIENT OUTCOMES
Get PDFIntroduction and Objective: Atrial fibrillation (AF) is a prevalent cardiac arrhythmia associated with significant morbidity and mortality. Rapid advances in artificial intelligence (AI), wearable devices, and mobile health (mHealth) technologies hold promise to improve AF risk prediction, diagnosis, and patient management. This narrative review aims to synthesize current evidence on the integration of these innovative tools in AF care, with a focus on technological capabilities, patient engagement, and public health implications.
Review Methods: A narrative review was conducted, analyzing peer-reviewed articles, clinical trials, and authoritative reports published between 2014 and 2023. Sources were identified through comprehensive database searches using keywords related to AF, AI, digital health, and health equity. The review integrates interdisciplinary insights from cardiology, digital technology, and public health literature.
State of Knowledge: Recent studies demonstrate that AI algorithms applied to electrocardiograms (ECGs) and wearable sensor data can enhance early detection and risk stratification of AF. Mobile health tools foster patient engagement and improve self-management through real-time monitoring and education. However, challenges remain related to data privacy, algorithmic bias, and equitable access to these technologies. Public health strategies must consider social determinants of health to maximize benefits and reduce disparities in AF outcomes.
Conclusion: Innovative digital technologies offer transformative potential in AF management and public health. Future research should address existing gaps, focusing on validation in diverse populations, ethical implementation, and strategies to ensure health equity. Multidisciplinary collaboration is essential to harness these tools effectively and improve cardiovascular health outcomes globally
THE ROLE OF BACTERIAL BIOFILM IN REFRACTORY CHRONIC RHINOSINUSITIS: A NARRATIVE REVIEW
Get PDFObjectives: Chronic Rhinosinusitis (CRS) is a common inflammatory disease impacting 5-12% of the population, leading to substantial morbidity and healthcare expenses. Bacterial biofilms on the sinonasal mucosa are a key factor in CRS's development, persistence, and resistance to treatment. This review explores their role in refractory CRS, focusing on structure, formation, impact on severity, and diagnostic/therapeutic approaches.
Methods: We conducted a comprehensive literature review using PubMed, Scopus, and Web of Science, searching for keywords related to CRS, bacterial biofilms, antibiotic resistance, and therapies. We prioritized studies from the last decade examining biofilms' impact on CRS pathogenesis, resistance, and novel treatments.
Key findings: Biofilms, organized microbial communities within an extracellular polymeric matrix, are significantly more resistant to antibiotics and host immune responses than free-floating bacteria. They form through stages: initial attachment, proliferation, and complex 3D structure development, with quorum sensing vital for maturation. Common CRS biofilm pathogens include Staphylococcus aureus, Pseudomonas aeruginosa, and Haemophilus influenzae. Biofilms correlate with more severe disease, poorer surgical outcomes, and higher recurrence. Diagnostics include electron microscopy, confocal laser scanning microscopy (CLSM), and molecular methods. Treatment involves surgical removal, topical antibiotics, and novel strategies like phage therapy, quorum sensing inhibitors, and micro-biome-based interventions.
Conclusions: Biofilms are critical in refractory CRS, causing persistence, treatment resistance, and worse outcomes. A deep understanding of biofilm mechanisms is crucial for effective diagnostics and therapies. Future research should standardize diagnostics, clarify biofilm-host interactions, and conduct trials on new, personalized biofilm-targeting treatments
THE COUNTER-NARRATIVE AND THE DECONSTRUCTION OF COLONIAL DISCOURSE: REPRESENTATIONS OF RESISTANCE IN ABDELRAZAK BOUKEBBA’S FAST-INFLAMING BLOOD
Get PDFThis study analyzes Algerian writer Abdelrazak Boukebba's short story collection Fast-Inflaming Blood as a subtle counter-narrative that subverts and deconstructs colonial narrative, particularly in its representations of the Palestinian cause. Drawing on the Edward Said's theoretical model and broader currents within postcolonial thought—namely, the notion of "counter-narrative"—the article examines the way the book transforms structural violence in the form of siege, bombardment, and forced migration into a literary process that reframes the notions of embodiment, space, and temporality. Through advanced aesthetic and intellectual strategies, Boukebba's book rewrites the colonial period as a dynamic arena of cultural resistance rather than as a passive victimization narrative and cultural recovery. The methodological approach employed combines critical cultural analysis with interpretive literary inquiry, allowing for a nuanced reading of how memory, identity, and resistance are configured within the text. Particular attention is given to stories such as Special Courage, in which the burial of a child becomes a ritual of resilience, and A Special Sea, where the fragmentation of space under occupation is rearticulated as a collective archive of memory. Everyday symbols—like an olive unearthed from a rocket crater or a sea narrated through oral tradition—serve not merely as metaphors but as acts of cultural survival. Ultimately, the study contends that Fast-Inflaming Blood stands as a paradigmatic example of literature’s power to dismantle colonial paradigms and to reimagine resistance as an enduring, embodied, and spatially grounded force
THE IMPACT OF THE DASH AND MEDITERRANEAN DIETS ON BLOOD PRESSURE AND CARDIOVASCULAR RISK FACTORS: A REVIEW OF SCIENTIFIC EVIDENCE AND PRACTICAL IMPLICATIONS
Get PDFIntroduction: Hypertension is one of the major risk factors for premature mortality and cardiovascular diseases. Lifestyle modifications, including diet, play a crucial role in its prevention and treatment. The aim of this review was to assess the impact of the DASH diet and the Mediterranean diet (MedDiet) on blood pressure values.
Materials and methods: Data from randomized controlled trials (RCTs) and meta-analyses examining the effects of the DASH and MedDiet on systolic (SBP) and diastolic blood pressure (DBP) were analyzed. The review included key studies such as PREMIER, DASH-Sodium, ENCORE, PREDIMED, as well as meta-analyses published up to 2021.
Results: The DASH diet was associated with significant reductions in SBP and DBP, particularly when combined with sodium reduction, weight loss, and increased physical activity. The MedDiet also contributed to blood pressure lowering, although the effect was smaller (average reduction in SBP by 1.5 mmHg and in DBP by 0.9 mmHg compared to other diets) and depended on the study population and control group.
Conclusions: Both the DASH and Mediterranean diets are effective non-pharmacological strategies for managing hypertension. Their implementation should be supported through counseling, mobile technology, and systemic actions. Further RCTs with sodium intake monitoring are needed to more fully assess the impact of the MedDiet on blood pressure
BUPROPION FOR ADHD: MECHANISMS OF ACTION AND ITS POTENTIAL AS AN ALTERNATIVE TREATMENT — A REVIEW
Get PDFIntroduction: Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common psychiatric disorders in childhood. Its core symptoms are related to executive dysfunction and include inattention, hyperactivity, and impulsivity. As a neurodevelopmental disorder, ADHD requires chronic, long-term treatment. Therefore, it is essential to identify the most effective and safest therapeutic options that minimize the side effects of prolonged pharmacological intervention.
Aim of the Study: This article examines the potential role of bupropion in ADHD treatment, focusing on its mechanism of action, efficacy in symptom alleviation, and possible side effects.
Materials and Methods: This review was conducted using multiple databases, including PubMed, Scopus, and Google Scholar. The search terms used were: “ADHD”, “bupropion”, “methylphenidate”, “comorbidity”, “side effects”, and “non-stimulants”.
Summary of Current Knowledge: ADHD should be managed with both pharmacological and non-pharmacological methods. While methylphenidate is considered first-line pharmacological treatment, it is associated with a relatively high discontinuation rate. Bupropion, as an alternative, may offer effective symptom relief and better tolerability in patients who experience severe side effects from stimulant medications.
Conclusions: Bupropion appears to be effective in treating ADHD compared to placebo and is generally well tolerated, especially in contrast to first-line stimulant treatments. It may be a viable alternative for patients who do not tolerate stimulants. However, further research using objective comparative methods is necessary to evaluate the effectiveness and side effect profiles of bupropion versus methylphenidate
CURRENT CHALLENGES AND TREATMENT STRATEGIES FOR VULVAR CANCER: DIAGNOSIS, THERAPY, AND PREVENTION
Get PDFIntroduction and purpose: Vulvar cancer is a rare malignancy of the female genital tract. However, due to the increasing incidence of Human Papillomavirus (HPV) infections, there's a growing trend of this cancer affecting younger women. Often, misdiagnosis leads to delayed detection, resulting in a poor prognosis.
The aim of this study is to review the current literature concerning the epidemiology, incidence, trends, risk factors, diagnosis, and treatment of vulvar cancer, in accordance with the latest ESGO 2021 guidelines.
Description: This review provides a comprehensive overview of available treatment modalities, including surgical cytoreduction, chemotherapy, and emerging therapies such as immunotherapy and cancer vaccines. The importance of interdisciplinary care is highlighted, alongside the critical role of prevention and patient education in mitigating cancer risk.
Summary: Despite diagnostic and therapeutic challenges, the overall prognosis for patients with vulvar cancer remains generally favorable. Nevertheless, disease recurrence—though associated with relatively low mortality—requires increased clinical vigilance. Therefore, patient education on the importance of regular monitoring during remission is essential
FROM CHRONIC SINUSITIS TO SINONASAL TUMORS: THE EXPANDING ROLE OF FESS IN MODERN SURGERY
Get PDFObjective: The objective of this study was to explore the evolving role of Functional Endoscopic Sinus Surgery (FESS) - the gold standard in the treatment of chronic rhinosinusitis and other sinus diseases. Advances in diagnostic imaging, surgical instruments, and navigation systems have significantly improved the safety and efficacy of this technique. This study provides an overview of the FESS technique, and its expanding indications - application in the treatment of selected sinus tumors, such as inverted papilloma, juvenile nasopharyngeal angiofibroma (JNA), and osteomas.
Methods: A narrative review of the literature was conducted, focusing on the development of FESS, its surgical technique, safety profile, and clinical outcomes. Special attention was given to its comparison with traditional open approaches in both inflammatory and neoplastic conditions of the sinonasal tract.
Key Findings: The analysis revealed that technological progress - particularly in diagnostic imaging, surgical instruments, and intraoperative navigation - has significantly improved the precision and safety of FESS. Clinical evidence demonstrates that endoscopic resection of sinonasal tumors often achieves recurrence rates equal to or lower than those associated with open surgery, while minimizing morbidity, hospitalization time, and facial disfigurement. Successful outcomes depend on appropriate patient selection, meticulous preoperative planning, and the surgeon’s expertise.
Conclusions: Functional Endoscopic Sinus Surgery is a safe and effective modality for treating a wide range of sinonasal diseases, including chronic rhinosinusitis and selected benign tumors. With proper patient selection, preoperative planning, and surgical expertise, FESS offers substantial benefits over traditional open approaches, including reduced morbidity and improved recovery. Continued technological advancements and long-term outcome studies will further refine its role in comprehensive sinonasal care
PHARMACOLOGICAL TREATMENT STRATEGIES FOR ADHD: A SYSTEMATIC REVIEW
Get PDFIntroduction: Attention deficit hyperactivity disorder (ADHD) is one of the most commonly diagnosed neurodevelopmental disorders in children and adolescents. Various treatment methods are available for this condition, including pharmacological and non-pharmacological strategies. Pharmacotherapy is currently the most effective method of reducing the core symptoms of ADHD. The most commonly used medications include psychostimulants such as methylphenidate and amphetamines. Comparing the efficacy and safety of available medications is particularly important in order to select the appropriate treatment for individual.
Aim of the study: The aim of our study is to review the available literature on the pharmacological treatment of attention deficit hyperactivity disorder and to summarize current knowledge. We presented the mechanisms of action, clinical efficacy, and safety profile of individual drugs used in the pharmacotherapy of ADHD.
Methods and materials: We reviewed the literature available in the PubMed database using the following keywords: “ADHD treatment”; “Attention Deficit Hyperactivity Disorder treatment”; “Stimulants”; “Non-stimulants”; “Methylphenidate”; “Atomoxetine”; “ADHD”; “Bupropion”; ‘Modafinil’; “α-agonists”; “Lisdexamphetamine (LDX)”; “Mixed Amphetamine Salts”, “Clonidine”; “Viloxazine”; “Centanafadine”
Conclusion: Pharmacotherapy is the most effective method of reducing the core symptoms of ADHD. Psychostimulants are currently considered the most effective and most commonly used drugs for the treatment of attention deficit hyperactivity disorder. In cases of intolerance or contraindications to their use, non-stimulant medications are an alternative. New medications such as viloxazine and centanafadine also offer promising alternatives. Individualization of pharmacological treatment is crucial to achieve optimal results
NON-PHARMACOLOGICAL INTERVENTIONS IN SCHIZOPHRENIA - SYSTEMATIC REVIEW
Get PDFSchizophrenia is a severe and chronic mental disorder that affects up to 1% of the general population. Research suggests that the most effective therapeutic approach combines medication with non-pharmacological strategies. This review explores the impact of non-pharmacological treatment on the course of schizophrenia, including its effects on key symptoms, as well as patients' quality of life and overall life satisfaction. This article is a comprehensive review based on articles obtained from scientific databases such as PubMed and Google Scholar, with sources selected based on their relevance and significance to the subject matter. The findings indicate that non-pharmacological treatments, including lifestyle modifications, psychosocial interventions, and neuromodulation training play a crucial role in improving the quality of life for individuals with schizophrenia. There is evidence supporting the reduction of both negative and positive symptoms, as well as an increased likelihood of returning to everyday activities. Non-pharmacological strategies are integral to the comprehensive management of schizophrenia. While the effectiveness of pharmacological interventions is well-established, current clinical guidelines also highlight the complementary role of non-pharmacological treatments, which contribute meaningfully to therapeutic outcomes and overall patient well-being. 
WEARABLE TECHNOLOGIES AND AI-DRIVEN ANALYTICS FOR CIRCADIAN RHYTHM MONITORING: OPPORTUNITIES AND CHALLENGES IN HEALTHCARE
Get PDFBackground: Circadian rhythm is a central regulator of human physiology, governing metabolic, endocrine, and neurobehavioral processes. Disruption of circadian alignment has been associated with obesity, insulin resistance, dyslipidemia, depression, and anxiety. Maintaining circadian health is therefore essential for both metabolic and mental well-being. In parallel, the rapid expansion of wearable technologies and digital health applications has enabled continuous, non-invasive monitoring of sleep–wake cycles and physiological parameters. When combined with artificial intelligence (AI), these tools offer new opportunities to assess and optimize circadian health in real-world settings.
Objective: This review aims to summarize recent evidence on the use of wearable devices and AI-driven applications in monitoring circadian rhythm, with particular focus on their implications for metabolic and mental health.
Methods: A literature review was conducted, focusing on publications between 2020 and 2025. Databases including PubMed, Scopus, and Web of Science were searched using keywords such as “circadian rhythm,” “wearables,” “digital health,” “artificial intelligence,” “metabolic disorders,” and “mental health.” Studies evaluating digital biomarkers, predictive algorithms, and clinical or public health applications of wearable-based monitoring were included.
Results: Current evidence indicates that wearables reliably measure sleep duration, activity levels, heart rate variability, and proxies of circadian alignment. AI-driven analytics enhance the precision of these measurements, enabling early detection of circadian misalignment and prediction of health outcomes such as metabolic syndrome or depressive episodes. Applications include continuous monitoring in high-risk populations, integration with telemedicine platforms, and development of personalized lifestyle interventions. However, challenges persist, including limited validation against gold-standard clinical tools, data privacy concerns, lack of standardized protocols, and unequal access to digital health technologies.
Conclusion: Wearable devices combined with AI-based analytics represent a promising approach to promoting circadian health and preventing related disorders. Future research should prioritize rigorous clinical validation, ethical frameworks for data management, and integration into healthcare systems to maximize their potential impact on both individual and population health