Institutional Repository in Medical Sciences of Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova
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Particularități individuale ale indicilor morfometrici ai arterei axilare
Full text linkBackground
Lately, the radial artery has been increasingly used in coronary angiography and in cases when its diameter is
too small, or there occurs a spasm after the introduction of the contrast medium, the axillary artery is used. In order
to avoid injury to the brachial plexus during catheterization of the axillary artery, it is necessary to know both the
anatomo-topographic peculiarities and its morphometric parameters.
The aim of the study was to evaluate the morphometric parameters of the axillary artery and of its branches
depending on gender and constitutional type.
Material and methods
The upper limb arteries were studied on 210 angiographies of both genders, taken from the database of the
Euromed Diagnostic Medical Center, Chisinau, Republic of Moldova.
By determining the proportionality index of the humerus thickness/length, three constitutional types were
established. Using the RadiAnt DICOM Viewer 3.42 software, the length of the axillary artery, its proximal/distal
internal diameter, as well as the proximal internal diameter of all its branches were determined.
Results
The mean length of the axillary artery was 8.69±0.15 cm; in males – 8.98±0.18 cm, in females – 8.25±0.25
cm. The proximal internal diameter of the axillary artery was 7.82±0.16 mm, and the distal one – 6.38±0.14 mm;
depending on gender, its proximal diameter was 8.08±0.20 mm in males and 7.40±0.24 mm in females, and the distal
one – 6.6±0.19 mm in males and 6.03±0.20 mm in females.
Conclusions
Advanced imaging methods have the capacity for precise description of the individual peculiarities of the axillary
artery morphometric parameters
The role of endothelins in cancer progression: recent insights and therapeutic opportunities
Full text linkBackground. Endothelins (ETs) and their receptors (ETAR and ETBR) play a significant role in
cancer progression, influencing processes such as proliferation, invasion, and metastasis. The
endothelin axis contributes to modulating the tumour microenvironment (TME), affecting
angiogenesis, immune evasion, and therapeutic resistance.
Objective of the study. To elucidate the role of endothelins in cancer progression, metastasis and
treatment resistance, as well as the need for therapeutic targeting of the endothelin axis.
Materials and methods. A comprehensive review of scientific literature was conducted using peerreviewed sources from databases such as PubMed, ScienceDirect, MDPI, Biomed Central, and Wiley
Online Library, focusing on the studies published between 2019 and 2024.
Results. Endothelin-1 (ET-1) stimulates tumorigenesis via β-arrestin-mediated signaling, activating
mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase/protein kinase B (PI3K/Akt),
and Wnt/β-catenin pathways to induce pro-survival mechanisms and proliferation. It facilitates
epithelial-mesenchymal transition (EMT) by upregulating matrix metalloproteinases (MMP-2, MMP9) and suppressing tissue inhibitors of metalloproteinases (TIMPs), enhancing metastatic potential.
Hypoxia amplifies ET-1 production, fostering angiogenesis through vascular endothelial growth factor
(VEGF) upregulating and stabilizing hypoxia-inducible factor-1α (HIF-1α). ETBR expression
correlates with immune evasion by recruiting M2-polarized macrophages and suppressing cytotoxic
T-cell activity, observed in melanoma and gastric cancer. Despite promising preclinical results with
ET receptor antagonists (bosentan, macitentan) in reducing tumor growth and metastasis, clinical trials
have shown limited efficacy as monotherapies. Integrated strategies such as pairing ETAR inhibitors
with paclitaxel or immune checkpoint blockers demonstrate enhanced antitumor effects by disrupting
stromal-tumor crosstalk and vascular normalization. Emerging approaches, including polyphenols
(quercetin, resveratrol) and extracellular vesicle-mediated gene silencing, offer novel routes to target
ET-axis dysregulation. The endothelin axis is pivotal regulator of TME remodelling, influencing
stromal interactions, immune suppression, and therapeutic resistance. Repurposing FDA-approved ET
antagonists, represents a viable strategy to improve cancer outcomes. Further research should prioritize
biomarker-driven patient stratification and dual-target therapies to address the complexity of ET
signalling in malignancy.
Conclusions. The endothelin axis is central to cancer pathogenesis, influencing tumour processes and
interactions within the tumour microenvironment. Targeting ET receptors offers promising therapeutic
directions, particularly through repurposing approved ET receptor antagonists
Managementul riscului în sarcina și nașterea la femei de vârstă reproductivă avansată. Rezumatul tezei de doctor în științe medicale. 331.03 – Medicină socială și management
No full textStructura tezei: introducere, 4 capitole, concluzii generale şi recomandări, bibliografie
din 429 de titluri, 135 pagini de text de bază, 50 figuri, 43 tabele, 13 anexe. Rezultatele
obţinute sunt publicate în 9 lucrări ştiinţifice și trei certificate de inovator.
Cuvinte-cheie: vârstă reproductivă avansată, sarcină, naștere, managementul riscului,
factori de risc, modele predictive, caracteristici biosociale
Scopul lucrării: Evaluarea asocierii caracteristicilor biosociale, clinico-anamnestice și
sistemice ale sarcinii șinașterii la femei de vârstă reproductivă avansată, în vederea dezvoltării
unor modele probabilistice predictive destinate optimizării managementului obstetrical și
îmbunătățirii rezultatelor materno-fetale.
Obiectivele cercetării: Evaluarea particularităților biosociale, clinico-anamnestice și
sistemice ale sarcinii și nașterii la femei de vârstă reproductivă avansată (FVRA). Determinarea
relațiilor și asocierii caracteristicilor biosociale, clinico-anamnestice și sistemice ale sarcinii și
nașterii la FVRA. Evaluarea rolului îngrijirii antenatale și informării femeilor gravide de vârstă
reproductivă avansată cu privire la riscurile sarcinii și nașterii, precum și identificarea barierelor
în obținerea rezultatelor materno-fetale optime. Elaborarea modelelor probabilistice predictive
pentru evenimente clinice asociate sarcinii și nașterii la FVRA. Elaborarea unui set de
recomandări pentru îmbunătățirea rezultatelor materno-fetale la FVRA.
Noutatea şi originalitatea ştiinţifică: În cadrul lucrării, pentru prima dată în Republica
Moldova, se aplică o evaluare multivariată a asocierii caracteristicilor biosociale, clinicoanamnestice, și sistemice asociate sarcinii și nașterii la femeile de vârstă reproductivă avansată. De
asemenea, sunt elaborate modele probabilistice predictive pentru diverse evenimente clinice, bazate
pe riscurile evaluate. Această abordare oferă o perspectivă aprofundată asupra impactului acestor
caracteristici asupra rezultatelor obstetricale, contribuind la îmbunătățirea siguranței și prognosticului materno-fetal prin abordarea individualizată a riscurilor și optimizarea gestionării riscurilor.
Problema ştiinţifică importantă soluționată: Lucrarea a contribuit la fundamentarea
științifică a evaluării multivariate a asocierii caracteristicilor biosociale, clinico-anamnestice
și sistemice care influențează evoluția și rezultatele sarcinii și nașterii la femeile de vârstă
reproductivă avansată. În urma evaluării riscurilor, au fost dezvoltate modele probabilistice
predictive pentru diverse evenimente clinice, demonstrând importanța implementării
managementului riscurilor ca instrument esențial pentru individualizarea prevenirii și
gestionării riscurilor asociate sarcinii și nașterii în această categorie de femei.
Semnificaţia teoretică și valoarea aplicativă a lucrării: Semnificaţia teoretică și
valoarea aplicativă a lucrării: Cercetarea a contribuit la aprofundarea înțelegerii complexității
caracteristicilor biosociale, clinico- anamnestice și sistemice care influențează sarcina și
nașterea la femeile de vârstă reproductivă avansată, rezultând în elaborarea a șapte modele
probabilistice predictive pentru diverse evenimente clinice. Studiul subliniază importanța
unei abordări multidimensionale și propune un cadru conceptual nou, care integrează aceste
caracteristici într-o manieră coerentă și adaptată specificității acestei categorii de paciente.
Abordarea reprezintă o nouă paradigmă în cercetarea și practica medicală, facilitând
individualizarea managementului sarcinilor și îmbunătățind siguranța materno-fetală prin
integrarea unui spectru mai larg de variabile în modelele probabilistice predictive.
Implementarea rezultatelor ştiinţifice: Rezultatele studiului dat au fost implementate în activitatea didactică și ştiinţifică a Catedrei de medicină socială și management ”Nicolae Testemițanu”
şi activitatea practică managerială a Spitalului Clinic Municipal nr.1 „Gheorghe Paladi”.Структура диссертации: введение, 4 главы, общие выводы и рекомендации,
библиография из 429 источников, 135 страниц основного текста, 50 рисунков, 43 таблиц,
13 приложений. Полученные результаты опубликованы в 9 научных работах и трех
свидетельствах изобретателя.
Ключевые слова: поздний репродуктивный возраст, беременность, роды, управление рисками, факторы риска, предсказательные модели, биосоциальные характеристики.
Цель работы: оценка связи биосоциальных, клинико-анамнестических и системных
характеристик беременности и родов у женщин позднего репродуктивного возраста
(ЖПРВ) с целью разработки вероятностных предсказательных моделей для оптимизации
акушерского управления и улучшения материнско-фетальных исходов.
Задачи исследования: Оценка биосоциальных, клинико-анамнестических и системных особенностей беременности и родов у ЖПРВ. Определение связей и ассоциаций
биосоциальных, клинико-анамнестических и системных характеристик беременности и
родов у ЖПРВ. Оценка роли антенатального ухода и информирования беременных ЖПРВ
о рисках беременности и родов, а также выявление барьеров в достижении оптимальных
материнско-фетальных исходов. Разработка вероятностных предсказательных моделей
для клинических событий, связанных с беременностью и родами у ЖПРВ. Разработка
набора рекомендаций для улучшения материнско-фетальных исходов у ЖПРВ.
Новизна и научная оригинальность: Впервые в Республике Молдова проведена
многомерная оценка связи биосоциальных, клинико-анамнестических и системных
характеристик при беременности и родах у ЖПРВ. Разработаны вероятностные
предиктивные модели клинических событий на основе оцененных рисков. Такой подход
способствует повышению безопасности и прогнозирования материнско-фетальных
исходов через индивидуализированное управление рисками.
Решаемая важная научная проблема: Исследование обосновало многомерную
оценку влияния биосоциальных, клинико-анамнестических и системных характеристик на
течение и исход беременности и родов у ЖПРВ. Оцененные риски легли в основу
вероятностных предиктивных моделей, подтвердив значимость риск-менеджмента для
индивидуализированной профилактики и управления рисками.
Теоретическое значение и прикладная ценность работы: Исследование углубило
понимание влияния биосоциальных, клинико-анамнестических и системных характеристикна беременность и роды у ЖПРВ, что позволило разработать семь вероятностных предиктивных моделей. Работа подчеркивает важность многомерного подхода и предлагает
новую концептуальную основу, способствующую индивидуализации ведения беременности и повышению безопасности матери и плода.
Внедрение научных результатов: Результаты данного исследования были внедрены в учебную и научную деятельность афедры социальной медицины и менеджмента
«Николае Тестемицану» и в практическую управленческую деятельность Клинической
муниципальной больницы №1 «Георге Палади».Thesis structure: Introduction, 4 chapters, general conclusions and recommendations,
bibliography with 429 references, 135 pages of core text, 50 figures, 43 tables, 13 annexes. The
results obtained have been published in 9 scientific papers and three innovation certificates.
Keywords: advanced reproductive age, pregnancy, childbirth, risk management, risk
factors, predictive models, biosocial characteristics
Purpose of the research: Evaluation of the association between biosocial, clinicalanamnestic, and systemic characteristics of pregnancy and childbirth in women of advanced
reproductive age (WARA), with the aim of developing probabilistic predictive models for
optimizing obstetrical management and improving maternal-fetal outcomes.
Research objectives: Assessment of the biosocial, clinical-anamnestic, and systemic
characteristics of pregnancy and childbirth in WARA. Determining the relationships and
associations between biosocial, clinical-anamnestic, and systemic characteristics of pregnancy
and childbirth in WARA.
Assessing the role of antenatal care and informing pregnant women of advanced
reproductive age about the risks of pregnancy and childbirth, as well as identifying barriers to
achieving optimal maternal-fetal outcomes. Developing probabilistic predictive models for
clinical events associated with pregnancy and childbirth in WARA. Developing a set of
recommendations for improving maternal-fetal outcomes in WARA.
Scientific novelty and originality: For the first time in the Republic of Moldova, this study
applies a multivariate assessment of the associations between biosocial, clinical-anamnestic, and
systemic characteristics related to pregnancy and childbirth in WARA. Additionally, predictive
probabilistic models have been developed for various clinical events based on the evaluated risks.
This approach provides an in-depth perspective on the impact of these characteristics on obstetric
outcomes, contributing to improved maternal-fetal safety and prognosis through individualized
risk management and optimization of risk governance.
Important scientific problem solved: The study has contributed to the scientific
foundation of multivariate assessments of the associations between biosocial, clinicalanamnestic, and systemic characteristics influencing the course and outcomes of pregnancy and
childbirth in WARA. By evaluating risks, predictive probabilistic models for various clinical
events have been developed, highlighting the importance of implementing risk management as a
crucial tool for individualizing the prevention and management of pregnancy and childbirthrelated risks in this category of women.
Theoretical significance and practical value of the work: The research has deepened the
understanding of the complexity of biosocial, clinical-anamnestic, and systemic characteristics
influencing pregnancy and childbirth in WARA. This has resulted in the development of seven
predictive probabilistic models for various clinical events. The study underscores the importance
of a multidimensional approach and proposes a new conceptual framework that integrates these
characteristics coherently, tailored to the specificity of this patient category. This approach
represents a new paradigm in medical research and practice, facilitating individualized pregnancy
management and improving maternal-fetal safety by incorporating a broader range of variables
into predictive probabilistic models.
Implementation of scientific results: The results of this study have been implemented in
the teaching and scientific activity of the Department of Social Medicine and Management
"Nicolae Testemițanu" and in the managerial practice of the Clinical Municipal Hospital No. 1
"Gheorghe Paladi.
Exploring trabecular meshwork stem cells: potential roles, therapeutic implications and challenges in glaucoma
Full text linkIntroduction: Recent investigations surrounding trabecular mesh (TM) stem cells have generated
significant interest due to their possible role in glaucoma treatment. Trabecular mesh cells are crucial
in maintaining IOP (intraocular pressure), and their dysfunction is involved in glaucoma pathogenesis.
Several studies highlight innovative models for studying glaucomatous function and the regeneration
of TM. For example, Buffault et al. provide an overview of current TM glaucomatous models,
emphasizing their importance in the mechanism of open-angle glaucoma and testing the possible
therapies (Buffault J., 2023).
The purpose of this review is to provide an overview of TMSCs, their capacity for regeneration, and
their therapeutic uses in glaucoma.
Material and methods: A literature review was conducted using the PubMed, Scopus, and Web of
Science databases. Keywords used:”trabecular meshwork stem cells”, “glaucoma”, “regenerative
therapy” and “stem cell-based treatment”. Of 102 abstracts selected for the 2015-2025 period, just 64
were selected based on preclinical data.
Results: Research suggests that TM stem cells are found in the juxtacanalicular area of the TM and
are capable of multipotent differentiation and self-renewal. Studies conducted in vivo show that the
stem cells can develop into functional TM-like cells, which restore outflow capability, lower the IOP
in glaucomatous patients, and preserves retinal ganglion cells. Furthermore, TM stem cell
transplantation has demonstrated potential in decreasing fibrotic alterations and encouraging TM
repair. Clinical applicability is still hampered by issues like immune response mitigation, long-term
survival, and cell delivery method optimization.
In conclusion, the investigation of TM stem cells offers a critical path forward for the study and
treatment of glaucoma. Even if preclinical research indicates that cell-based therapies are effective,
further investigation is needed to improve them, evaluate their long-term safety, and provide
standardized procedures for clinical use. Developments in tissue engineering and stem cell biology
could open the door to successful TMSC-based treatments for the treatment of irreversible vision loss
brought on by this life-threatening condition
Review: the role of color Doppler ultrasound in the evaluation of thyroid nodules
Full text linkBackground: Thyroid nodules are commonly detected in clinical practice, with a significant portion
being benign, but a small percentage harbor malignancy. Accurate evaluation of these nodules is
crucial for guiding management decisions, such as the need for biopsy or surgery. Color Doppler
ultrasound, an advanced imaging technique, is increasingly used to assess thyroid nodules by
evaluating blood flow within the nodule. The aim of this review is to examine the role of color Doppler
ultrasound in the diagnostic workup of thyroid nodules and its effectiveness in differentiating benign
from malignant nodules.
Material and Methods: A review of studies published in medical databases, including PubMed and
Cochrane Library, was conducted to evaluate the utility of color Doppler ultrasound in assessing
thyroid nodules. Key studies focused on the use of Doppler imaging to analyze vascularity patterns in
thyroid nodules and its correlation with malignancy. The review included articles that assessed the
sensitivity, specificity, and overall diagnostic performance of color Doppler in the context of thyroid
nodule evaluation.
Results: Color Doppler ultrasound assesses blood flow within a thyroid nodule, with malignant
nodules often exhibiting abnormal vascular patterns, such as increased peripheral or internal blood
flow. Studies have shown that color Doppler ultrasound can provide additional information beyond
conventional ultrasound, particularly in nodules with ambiguous characteristics. Malignant thyroid
nodules are frequently associated with increased vascularity, irregular blood vessels, or a higher
resistance index in blood flow. Sensitivity and specificity for identifying malignancy using color
Doppler ultrasound vary across studies but generally range from 60% to 90%. However, the technique
is not definitive on its own and is often used in combination with conventional ultrasound features such
as size, shape, and margins of the nodule.
Conclusion: Color Doppler ultrasound is a valuable adjunct in the evaluation of thyroid nodules,
helping to differentiate benign from malignant lesions based on vascular patterns. While it enhances
diagnostic accuracy, especially for nodules with uncertain characteristics, it is not a standalone
diagnostic tool. Color Doppler should be used in conjunction with other imaging modalities like
conventional ultrasound and fine needle aspiration biopsy (FNAB) to improve the overall diagnostic
approach for thyroid nodule evaluation
Preeclampsia şi rolul factorilor de predicție în trimestrul trei de sarcină: 321.15 - Obstetrică și ginecologie: Rezumatul tezei de doctor în științe medicale
Full text linkStructura tezei. Lucrarea este expusă pe 103 de pagini, cu următoarea structură:
cuprins, adnotare, lista abrevierilor, introducere, analiza bibliografică la tema tezei din
literatura de specialitate, materiale şi metode de cercetare, rezultate proprii expuse în 3
capitole, sinteza rezultatelor obţinute, concluzii generale, recomandări practice,
bibliografie ce include 120 de surse naţionale şi internaționale, 44 de figuri, 6 tabele,
90 de anexe. Rezultatele obţinute sunt publicate în 9 lucrări ştiinţifice.
Cuvinte cheie: preeclampsie, markeri de predicție, al treilea trimestru, ecografie Doppler.
Scopul studiului. Evaluarea rolului factorilor de predicție a preeclampsiei în trimestrul
trei de sarcină, pentru optimizarea managementului și îmbunătățirea prognosticului
materno-fetal.
Obiectivele studiului. Stabilirea particularităților anamnestice și evolutive ale sarcinii
la gravidele cu preeclampsie în trimestrul trei de sarcină. Evaluarea factorilor de risc
ce contribuie la apariția preeclampsiei în trimestrul trei de sarcină. Aprecierea nivelului
indicilor HIF-1a, IL-6, indicilor Doppler a arterelor uterine, și stabilirea interrelației
acestora în prezicerea preeclampsiei. Stabilirea algoritmului de conduită pentru
gravidele cu risc de a dezvolta preeclampsie.
Noutatea științifică a rezultatelor obținute. Prin analizarea detaliată a factorilor de risc
personali și medicali asociați preeclampsiei, precum și a evoluției sarcinii, cercetarea a
contribuit la înțelegerea complexității acestei afecțiuni. Această abordare ne-a permis
identificarea factorilor de risc, și a demonstrat rolul biomarkerilor HIF-1a, IL-6 și
interrelația acestora cu indicii Doppler a arterelor uterine în prezicerea preeclampsiei.
Realizarea algoritmului de conduită pentru prezicerea PE reprezintă o contribuție în
practica medicală, pentru a preveni apariția complicațiilor severe materno-fetale.
Problema științifică rezolvată în teză constă în determinarea rolului biomarkerilor
HIF-1a, IL-6 și indicilor Doppler a arterelor uterine în dezvoltarea preeclampsiei, iar
rezultatele acestei cercetări confirmă relevanța studiului.
Semnificația teoretică a lucrării. Rezultatele studiului extind baza teoretică pentru
utilizarea biomarkerilor în prezicerea preeclampsiei. Au fost stabilite nivelurile prag
pentru HIF-1a (>320,65 pg/ml) și IL-6 (>15,08 pg/ml) care împreună cu parametrii
Doppler (PI) a arterelor uterine modificați, sunt asociate cu un risc crescut de apariție
a preeclampsie. În baza rezultatelor primite a fost realizat algoritmul de conduită pentru
prezicerea preeclampsiei în al treilea trimestru de sarcină.
Valoarea aplicativă a lucrării. Aplicarea algoritmului propus, ce constă în
identificarea factorilor de risc materni, nivelul seric crescut a HIF-1a (>320,65 pg/ml)
și IL-6 (>15,08 pg/ml), indicele velocimetriei Doppler (PI) a arterelor uterine
patologic, ne permit identificarea gravidelor cu risc de a dezvolta preeclampsie. Astfel,
performanța acestor biomarkeri este necesară pentru predicția PE în trimestrul trei de
sarcină. Rezultatele obținute ne oferă informații teoretice extinse care pot fi folosite în
practică pentru optimizarea managementului gravidelor cu preeclampsie.
Implementarea rezultatelor științifice. Rezultatele cercetării au fost implementate în
activitatea curativă curentă a IMSP Spitalul Clinic Municipal Gheorghe Paladi
Material design in hard tissue engineering
Full text linkAcknowledgement: This research was funded by UEFISCDI and ANCD through the project
“Nanostructured Bone Grafts with Predetermined Properties- CollNanoBone” project number
29ROMD/20.05.2024. The support of the Romanian Government for providing access to the research
infrastructure of the National Center for Micro and Nanomaterials through the National Program titled
“Installations and Strategic Objectives of National Interest” is also highly acknowledged.Introduction: Considering the high incidence and the relatively large amount needed, the overall
market share of the bone grafting materials is ~49% of the total field of biomaterials and thus many
researchers focused their efforts in developing new and improved materials for hard tissue engineering.
Considering the evolution of these materials, from morpho-compositional point of view there are 4
major generations: 1st Generation: Metals and Alloys; 2nd generation: Ceramics and Polymers; 3rd
generation: Composite and Nanocomposites and 4th generation: Tissue Engineered NanoComposites.
Even not yet totally agreed, the 5th generation seems to be the materials obtained by Materials Design
and 3D printing is one of the most popular processing technique.
Materials and Methods: the presentation will be focused on the materials design, synthesis,
processing and characterization of the composite materials.
Results: This presentation will be mainly focused on the evolution of the materials in the field, from
compositional to morphological design including coatings and 3D printed grafts and loading these
materials with specific active agents and drugs to use them in specific diseases such as osteoporosis,
bone infection and cancer, etc. A special attention will be paid to the composite materials based on
collagen and hydroxyapatite highlighting the influence of specific conditions that can alter their
properties and certainly, the role of the loading agents. Considering the current trends at EU level,
green and sustainability, circularity or blue approach are also exploited in developing bone grafting
materials and to improve the properties and performances of the medical products.
Conclusions: the overall performances of the materials used in hard tissue engineering are related to
the composition and morphology while the presence of specific biological active agents can be
essential in the treatment of specific bone-related diseases
The role of glycation on transplantology methods in cancer treatment
Full text linkBackground. Advanced glication end products (AGEs) are formed in result of Millard reaction in
hiperglycemic conditions caused by Warburg`s effect. Many studies have shown the presence of AGEs
in neoplastic tissues through which are: pyrraline, imidazolone A and B, argpyrimidine, fructosyllysine, methylglyoxal-lysine dimer, Nε(carboxyethyl)-lysine (CEL), Nε(carboxymethyl)-lysine
(CML), N2-(1-carboxyethyl)-2′-dezoxyguanosine) (CEdG). It proves corellation between AGEs and
cancer. Actually chimeric antigen receptor (CAR)-T cell therapy has been revolutionary in cancer
treatment and therefore AGEs may be potential target for it.
Objective of the study. To elucidate the mechanisms through which AGEs influence cancer
development in order to find different approaches in diagnostic, treatment and preventing of cancer.
Materials and methods. A review of the literature from 2014-2024 was performed, using 11 articles,
including data from ScienceDirect, PubMed Central, Biomed Central, MedScape, and others.
Results. Can be noticed some mechanisms how AGEs influence cancer. Firstly, direct glycation of
proteins as histones and nucleic acids as DNA causes epigenetic changes, mutations genomic
instability and formation of neoantigens, that complicates targeted treatment with (CAR)-T, producing
tumor antigen heterogeneity. Secondly, AGEs cause a significant decrease in proliferation and an
increase in apoptosis of primary stem cells. It may be explained by interaction of AGEs - the receptor
for advanced glycation end products (RAGE). Therefore, direct blocking of proteins involved in the
apoptotic or RAGE pathway can improve viability of stem cells and efficiency of regenerative
therapies with stem cells. Finally, accumulation of AGEs leads to irreversible bond of AGEs with
proteins, especially with conjunctive tissue proteins. Obviously glycation of extracellular matrix
increases tumor invasion and metastasis. Moreover it alters migration of immune cells and efficiency
of (CAR)-T cell therapy.
Conclusions. In conclusion, glycation is pathognomonic process in cancer and therefore its studying
is a key to the pathogenetic therapy with actual methods in tissue and cell transplantology, like (CAR)-
T cell therapy. On the one side AGEs, as markers of cancer, may be used in targeting of therapy. On
the other side antiglycation agents may potentiate transplantology methods of cancer treatment
Treatment of voluminous odontogenic maxillary cysts by decompression and aspiration method
No full textIntroducere: Chisturile maxilare sunt formațiuni cavitare endoosoase, de obicei epiteliale, care conțin lichid, semisolid
sau gaz. Ele apar din celule epiteliale odontogene sau neodontogene și sunt favorizate de infecțiile pulpare și
parodontale. Chisturile radiculare reprezintă peste 95% din chisturile maxilare. Tratamentul variază în funcție de dimensiune,
localizare și relația cu structurile anatomice, incluzând opțiuni conservatoare (decompresie, marsupializare) sau
chirurgicale (chistectomie). Decompresia este indicată pentru chisturile mari, pacienții cu contraindicații la anestezie
generală și cazurile care necesită conservarea dinților adiacenți.
Scopul lucrării: Determinarea eficacității tratamentului minim invaziv al chisturilor maxilare voluminoase prin
metoda de decompresie și aspirație cu tub.
Material și metode: Studiul a inclus 32 de pacienți (21 bărbați, 11 femei, vârsta medie 40,1 ani) tratați prin decompresie
și aspirație între 2014-2020. Chisturile au fost localizate preponderent la maxilar (59,4%). Decompresia s-a
realizat cu tub de celuloid (84,4%) sau microproteză acrilică (15,6%). Pacienții au fost evaluați clinic și imagistic (OPG,
CBCT). Tehnica operatorie: După anestezie locală, s-a creat un orificiu în corticală pentru inserarea unui tub de drenaj,
fixat cu suturi. Pacienții au efectuat lavaj zilnic cu soluție salină. Evaluarea postoperatorie s-a realizat la 3, 6, 9, 12 luni și
până la 6 ani. Reducerea volumului chistic s-a cuantificat prin măsurători radiologice și formule matematice.
Rezultate: Dimensiunea chisturilor s-a redus semnificativ la 6-18 luni postoperator. Lungimea medie preoperatorie
a fost de 3,5 cm (mediana 3,1 cm), iar postoperator de 2,3 cm (mediana 2,1 cm). Decompresia a demonstrat eficacitate
în reducerea dimensiunii chisturilor, cu regenerare osoasă progresivă.
Concluzii: Decompresia și aspirația sunt metode eficiente, minim invazive, ce reduc morbiditatea postoperatorie
și conservă structurile anatomice. Tratamentul contribuie la reabilitarea precoce a pacienților, însă necesită o monitorizare
atentă pentru prevenirea recurențelor.Background. Maxillary cysts are intraosseous cavitary formations, usually epithelial, containing liquid, semisolid,
or gas. They arise from odontogenic or non-odontogenic epithelial cells and are favored by pulpal and periodontal
infections. Radicular cysts account for over 95% of maxillary cysts. Treatment varies depending on size, location, and
relationship with anatomical structures, including conservative options (decompression, marsupialization) or surgical
(cystectomy). Decompression is indicated for large cysts, patients with contraindications to general anesthesia, and cases
requiring preservation of adjacent teeth.
Objective of the study. Determining the effectiveness of minimally invasive treatment for large maxillary cysts
using the decompression and tube aspiration method.
Material and Methods. The study included 32 patients (21 men, 11 women, mean age 40.1 years) treated by decompression
and aspiration between 2014-2020. The cysts were predominantly located in the maxilla (59.4%). Decompression
was performed using a celluloid tube (84.4%) or acrylic microprosthesis (15.6%). Patients were evaluated clinically
and imaging-wise (OPG, CBCT). Operative Technique: After local anesthesia, an opening was created in the cortex
for the insertion of a drainage tube, fixed with sutures. Patients performed daily lavage with saline solution. Postoperative
evaluation was performed at 3, 6, 9, 12 months, and up to 6 years. Cyst volume reduction was quantified by radiological
measurements and mathematical formulas.
Results. The cyst size was significantly reduced at 6-18 months postoperatively. The mean preoperative length
was 3.5 cm (median 3.1 cm), and postoperative 2.3 cm (median 2.1 cm). Decompression demonstrated efficacy in reducing
cyst size, with progressive bone regeneration.
Conclusions: Decompression and aspiration are effective, minimally invasive methods that reduce postoperative
morbidity and preserve anatomical structures. The treatment contributes to early rehabilitation of patients but requires
careful monitoring to prevent recurrences