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A Bent Ga(III)/Ln(III) 12-MC-4 Featuring Interchangeable Guest Ligands
No full textInternational audienc
Zones Ateliers: Un réseau de recherches collaboratives, situées et engagées
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Clinical Phenotypes of Critically Ill Patients with COVID-19 Infected with Omicron: A Nationwide Prospective Cohort Study
No full textInternational audienceINTRODUCTION: The clinical presentation of critically ill patients with coronavirus disease 2019 (COVID-19) has evolved significantly with the emergence of the Omicron variant. Current intensive care unit (ICU) admissions involve patients with diverse comorbidities and immune statuses, highlighting the need to redefine homogeneous phenotypic subgroups within this population. This study aimed to characterize distinct clinical phenotypes among critically ill patients with COVID-19 and acute respiratory failure. METHODS: This multicenter prospective substudy of the SEVARVIR cohort included adult patients from 39 French ICUs between December 2021 and October 2024 with acute respiratory failure and infected with the Omicron variant. Clustering analysis was conducted using Kohonen’s self-organizing maps (SOMs) and validated with ClinTrajan, two unsupervised clustering methods, to identify homogeneous patient phenotypes. RESULTS: During the study period, 777 patients with Omicron infection were included, and 7 distinct clinical clusters were identified. Clusters 1 and 2 included patients with metabolic and cardiovascular comorbidities. Cluster 3 featured younger, mildly ill patients with isolated chronic respiratory failure, while cluster 4 comprised older male patients with isolated respiratory failure. Cluster 5 included patients with isolated hematologic malignancies, cluster 6 patients with multiorgan failure, and cluster 7 organ transplant recipients, with high severity scores and impaired renal function. ICU management varied substantially across clusters. Patients in clusters 5 and 7 had the highest requirements for organ support, with frequent use of invasive mechanical ventilation, vasopressors (cluster 6), and renal replacement therapy (cluster 7). Dexamethasone and tocilizumab were most commonly prescribed in cluster 4 (91.3% and 30.2%, respectively). Mortality at day 28 varied significantly across clusters, ranging from 13.1% in cluster 3 to 41.1% in cluster 6. CONCLUSIONS: This clustering analysis highlights, for the first time, the clinical heterogeneity of critically ill patients infected with Omicron, identifying seven distinct clusters with varying clinical presentations, management strategies and outcomes. These findings underscore the relevance of a phenotype-driven approach to support personalized treatment strategies and guide future clinical trials. TRIAL REGISTRATION: Clinicaltrials.gov, NCT05162508. A Graphical Abstract is available for this article
Systematic Review and Meta-Analysis of Psychological and Behavioral Symptoms in Alzheimer’s Disease and Their Impact on Professional Caregiver Burden
No full textAbstract Background Alzheimer's disease is a progressive neurodegenerative disorder associated with cognitive decline and psychological and behavioral symptoms (PBSA), which significantly impact both patients and professional caregivers. Despite their central role in managing PBSA, limited research has evaluated caregivers’ knowledge of these symptoms and the burden they experience. Understanding caregivers’ perceptions and the intensity of PBSA is essential to improving care quality and caregiver well-being. Methods A systematic review and meta-analysis were conducted following PRISMA guidelines. Databases searched included PubMed, PsycINFO, and Google Scholar up to December 2024. Of 918 identified records, 56 studies met inclusion criteria. Data extraction was conducted using CADIMA, and statistical analyses were performed with the “METAFOR” package in R. Pooled effect sizes of mean Neuropsychiatric Inventory (NPI) subdomain scores were calculated to assess symptom intensity. A mixed-effects meta-regression examined whether sample size influenced caregiver burden variability. Results Agitation (pooled mean = 2.90; 95% CI [0.64, 5.17]), depression (15.92; 95% CI [8.89, 22.96]), apathy (9.40; 95% CI [3.48, 22.28]), anosognosia (15.92; 95% CI [8.89, 22.96]), and anxiety (1.72; 95% CI [0.98, 2.46]) were the most intense symptoms. Formal caregivers’ knowledge varied across studies, with pooled means of 2.67 (95% CI [2.02, 3.31]) for symptom knowledge and 6.24 (95% CI [5.02, 7.31]) for treatment knowledge. Substantial heterogeneity was present (I² > 90%). Meta-regression revealed that sample size was not a significant moderator of caregiver burden (estimate = -0.017, p = 0.804), with residual heterogeneity remaining high (I² = 99.85%). Conclusion This review highlights the high prevalence and intensity of PBSA in Alzheimer’s care and underscores the variability in caregiver knowledge and burden. Sample size does not account for differences in reported burden, suggesting the influence of other contextual or organizational factors. These findings emphasize the urgent need for structured education and support programs tailored to formal caregivers to enhance symptom management and reduce burden
Proteomic analysis of differential biological responses and fatty acid metabolism in slow-growing chickens fed dietary tuna oil directly or via glucose transporter-targeted nanoparticles
No full textInternational audienceThis study investigated the effects of tuna oil (PC) and tuna oil encapsulated in lipid nanoparticles (TNP) on metabolic pathways in thigh muscle of slow-growing chickens using proteomic analysis. Compared with the negative control (NC) diet containing 6% rice bran oil, the PC and TNP diets replaced half of the rice bran oil with tuna oil, thereby increasing dietary n-3 PUFAs and altering the n-6/n-3 ratio. Iliotibialis muscle samples were collected from slow-growing Korat chickens (n = 6 for each PC and TNP; n = 5 for NC). Fatty acid profiles were analyzed by gas chromatography-mass spectrometry following lipid extraction and methylation. Proteomics analysis was performed using polyacrylamide gel-based protein separation and nanoLC-MS/MS to identify and quantify differentially expressed proteins. Distinct biological responses were observed between dietary treatments. In the TNP group, energy metabolism shifted toward aerobic pathways, with increased β-oxidation and reduced reliance on alternative pathways, such as the creatine-phosphate system, to support the tricarboxylic acid cycle. In contrast, the PC group exhibited high lipid peroxidation and by-products, triggering robust antioxidant and detoxification responses, as well as membrane repair mechanisms. Although the TNP group also activated antioxidant defenses, the response was less pronounced and was accompanied by increased expression of proteins involved in vesicle trafficking. Lipid peroxidation in the PC group was associated with calcium influx to maintain calcium homeostasis and stabilize muscle contraction under oxidative stress. This was evidenced by the upregulation of proteins related to sarcoplasmic reticulum calcium pumps and muscle contraction stabilization. Conversely, the TNP group demonstrated adaptive responses to increased contractile activity with lower oxidative burden. Regarding immune function, the PC group showed stronger MHC-based immunosurveillance, reflecting heightened oxidative stress. Although immune responses were less pronounced in the TNP group, immune surveillance was maintained through selective protein expression. Overall, these findings demonstrate distinct cellular strategies in response to oxidative stress and immune challenges between PC and TNP treatments, highlighting the potential of lipid nanoparticle systems to optimize dietary lipid delivery in poultry
Asile : Dies a quo du délai de transfert; CJUE, 18 déc. 2025, aff. C-560/23, Tang
No full textInternational audienceUn jugement annulant une décision de transfert à raison de circonstances nouvelles déterminantes et renvoyant l’affaire à l’autorité administrative pour réexamen est une décision intermédiaire et non une décision définitive sur le recoursCette procédure doit être conçue de manière à l’impératif de célérité pour la détermination de l’État membre responsable
EEG theta dynamics for error processing during online movement control
No full textInternational audienceTo ensure optimal visuomotor feedback control during manual tracking, the brain must continuously monitor the error between the hand and the target. Modulations in the theta band (3-8 Hz) are related to error processing, but this has been mainly shown in cognitive control contexts. Hence, their relationship with hand-target errors during online control remains unclear. Here we assessed the impact of motor error processing on EEG theta-band activity in 29 healthy participants while they performed continuous tracking of a moving target with their dominant (right) hand. Two conditions were used to manipulate error processing demands: 1) in the Repeated condition, the same target trajectory was presented 80 times, allowing participants to implicitly learn the pattern and reduce tracking errors; 2) in the Random condition, 80 different trajectories were used, inducing persistent high tracking errors. Behavioral analyses confirmed that tracking errors were significantly higher in the Random than in the Repeated condition. Importantly, EEG theta power was also significantly higher in the Random condition, with a peak difference occurring at electrodes overlaying the left sensorimotor regions. This effect was selective to theta activity, as there was no modulation in alpha-(8-12 Hz) and beta-band (15-30 Hz) activity. Overall, this study extends the role of theta oscillations to online error processing in the context of motor control. It is possible that theta modulations reflected cortical activity mediating the communication and integration of information within sensorimotor circuits including the motor, premotor and parietal cortex, which are known to mediate online movement control. Highlights • Theta power increased with tracking error demands over contralateral sensorimotor regions• No differences in parieto-occipital alpha or sensorimotor beta across conditions• Suggests parieto-frontal sensorimotor integration for online motor error correction</div
Evaluating the applicability of ESGO quality indicators in the surgical management of endometrial cancer: Insights from a Francogyn cohort
No full textInternational audienceBackground: Endometrial cancer (EC) is a significant health concern in France, necessitating high-quality surgical care to improve patient outcomes. The European Society of Gynaecological Oncology (ESGO) established quality indicators (QIs) to standardize and improve management.Objective: This study evaluates the applicability of ESGO QIs in a real-world setting across 13 centers in France.Methods: This retrospective multicenter cohort study included 2789 patients surgically treated for EC from 2001 to 2020. Demographic data, surgical techniques, adherence to ESGO QIs and trends over time were analyzed. Key indicators analyzed included multidisciplinary team discussions, pre-operative imaging adequacy, surgical techniques employed, and molecular classifications.Results: All patients were discussed in multidisciplinary meetings. Adequate preoperative imaging was achieved in 80.63 % of cases. Minimally invasive surgery was performed in 66.12 % of early-stage patients, showing a significant year-on-year increase from 12 % in 2001 to 85 % in 2020. Among obese patients, 60.78 % underwent laparoscopic procedures, with a conversion rate to open surgery of 3.57 %. Molecular classification results highlighted 35 % of patients as low risk and 32 % as high risk.Conclusion: Our findings indicate that adherence to actual ESGO QIs has substantially improved the quality of surgical management for endometrial cancer in France, despite some areas requiring further enhancement. A coordinated political approach is essential to address existing barriers and ensure consistent implementation of these quality standards across all centers, ultimately aiming to elevate patient care and outcomes in the French healthcare system
