HAL Université de Tours
Not a member yet
55851 research outputs found
Sort by
Caractérisation de l’attachement à la mère chez les chèvres de race Alpine
No full textNational audienc
Lanthanide(III)-based metallacrowns functionalized with ruthenium(II) complexes for multiplex imaging and oxygen sensing in the NIR-II
No full textInternational audienceOxygen is one of the key metabolites in aerobic organisms. Oxygen deprivation (hypoxia) is connected to various diseases, including cancers, cardiovascular diseases and strokes.[1] Therefore, it is essential to quantify oxygen levels in biological systems in real-time to ensure an early diagnosis of dysfunction. Multiplex imaging in the second near-infrared window (NIR-II, 1000–1700 nm) opens new perspectives for the comprehensive understanding of complex biological processes and for more accurate diagnosis of diseases by enabling real-time acquisition of images with improved contrast and spatial resolution in deeper tissues.[2] However, today, the number of suitable NIR-II imaging agents remains highly limited. Lanthanide(III)-based metallacrowns (MCs) belong to a class of metal complexes that have demonstrated unique luminescence properties and perspectives to be used as NIR-II imaging agents.[3-6] In this work, we present synthetic pathways to generate two families of Ln(III)/Ga(III) MCs functionalized with Ru(II) complexes. Detailed photophysical studies have been performed in air- and N2-saturated solutions. We have shown that the characteristic emissions of Yb(III), Nd(III) and Er(III) in the NIR-II range can be sensitized upon excitation in the visible range, through Ru(II)-centered metal-to-ligand charge transfer states. In contrast to many fluorescent oxygen sensors for which the presence of the analyte induces a decrease of the emission signal, the presence of oxygen leads to the enhancement of Ln(III)-centered emission in studied Ln(III)/Ga(III) MCs. NIR-II imaging experiments using capillaries and biological tissue-mimicking phantoms have shown that signals arising from different Ln(III) can be detected and discriminated unambiguously
Vécu de la crise sanitaire par les parents dont l'enfant est pris en charge en oncopédiatrie
No full textLa crise sanitaire et le confinement ont entraîné un certain nombre de bouleversements, y compris dans les prises en charge des enfants et adolescents atteints de cancer et de leur famille. L’accompagnement psychosocial, impulsé par les politiques publiques (Plans Cancer) – « école à l’hôpital », activités physiques, ludiques et créatives, présence des deux parents au chevet de l’enfant – a été en grande partie suspendu. Comment cela modifie-t-il l’expérience sociale du cancer ? Comment les parents composent-ils et s’adaptent-ils à cette modification de la prise en charge ? Quels sont leurs besoins ?A partir d’hypothèses qui émergent d’une étude qualitative exploratoire (19 entretiens réalisés en juin et juillet 2020), cette recherche prendra appui sur un échantillon plus important (30 entretiens supplémentaires) pour analyser le vécu par les parents de cette crise sanitaire et de ses conséquences en fonction des lieux de prise en charge. Il s’agira notamment de décrire le processus paradoxal imposé par la crise sanitaire et la réorganisation des services : d’un côté, l’écart à la norme entre enfants, parents, et leurs pairs se serait réduit grâce à la généralisation du confinement - une situation à la fois singulière et commune - à l’ensemble de la population et de l’autre, le maintien de repères du monde extérieur dans les murs de l’hôpital afin de conserver la vie la plus « normale » possible a été rompu. Nous étudierons ce paradoxe et ses conséquences, à partir des transactions sociales opérées par les parents en fonction de leurs déterminants socioculturels et des identités de genre
Impact of Adaptation Strategies to Power Outages on Business in Sub‐Saharan Africa: Does Energy Management Measure Make a Difference?
No full textInternational audienceABSTRACT Power outages hinder economic development. Although their effects are less pronounced in developed countries, they are more severe in developing nations. Recent literature suggests, in addition to traditional strategies, the adoption of energy management measures as an adaptation strategy to power outages. This study evaluates, in the context of Sub‐Saharan Africa, the impact of adopting energy management measures while also considering traditional strategies such as backup generators. The analysis is based, on the one hand, on the 2023 World Bank Enterprise Survey dataset and, on the other hand, on the implementation of a Probit model to identify the determinants of adoption, as well as a 2SLS model to address endogeneity in impact measurement. The findings reveal that, although implementing energy management measures incurs costs, their adoption significantly increases business turnover and net income, particularly in the industrial sector. Conversely, although adopting a generator backup has a positive impact on turnover, it reduces net income in the service sector. Its impact on net income in the industrial sector is not even statistically significant. It is generally recognized in the ISO 50001 standard that, aside from optimizing energy consumption within businesses, the adoption of energy management measures also contributes to reducing the ecological footprint. By adopting this approach, businesses can enhance their resilience to power outages while simultaneously reducing their environmental impact
Opéra-comique in Copenhagen and Christiania in the Enlightenment: between center and periphery
No full textInternational audienc
Best microbiological practice recommendations for the diagnosis of peri-prosthetic joint infections: the CRIOGO bacteriology reference center network
No full textInternational audienceDiagnosis of prosthetic Joint Infections (PJI) remains challenging at the microbiological level. Despite the implementation and adoption of new methods, an heterogeniety of microbiological practices is still observed. These CRIOGO recommendations (Centre de Référence des Infections Ostéo-articulaires du Grand Ouest) aim to set out some basic principles for the diagnosis of PJI in microbiology laboratories. The CRIOGO microbiologists' team who have been working together for 15 years were invited to provide regional recommendations for microbiology diagnosis based on their practical expertise. These recommendations were developed through a systematic review of the literature and discussion amongst experts. The proposed CRIOGO recommendations were voted on upon by a 10 local panelists via the Delphi process. Total consensus was reached on all 27 recommendations that received 100% agreement. The CRIOGO microbiologists' team proposed practical guidelines in response to the most frequently asked questions received at our laboratory reference centres. A short, comprehensive answer supported by literature backs up the argument. Out of the 27 detailed CRIOGO recommendations, 22 achieved 100% consensus. This work was initiated to harmonise our daily practices for managing PJI diagnosis within the CRIOGO network in line with the literature
A New Similarity Measure for Temporal Semantic Sequences
No full textNational audienceFuzzy index that reflects the comparability of two sequences in terms of their time length.• Meaningful and consistent comparison.• Similarity value based on the difference in their time lengths.</div
Design and synthesis of new Pentacene derivatives containing Dimethoxydiphenylamine arms and theoretical study
No full textInternational audienceIn a quest of exploitation of soluble and stable pentacene derivatives for organic electronics devices or for interface layers in perovskite solar cells, a novel series of arylamine-capped pentacene derivatives namely DMPA (Ph)Pent, DMPA(Ph) 2 Pent, DMPA(Ph) 3 Pent, and Cz(Ph)Pent were synthesized, characterized, and studied. Two key parameters were investigated in this work: i) the length of the aryl spacer and ii) the substitution of dimethoxyphenylamine (DMPA) arms with carbazole-DMPA arms, to study their effects on the structure-property relationship. These unprecedented compounds, synthesized via a two-step, showed excellent solubility and stability as a result of the introduction of DMPA and carbazole-DMPA arms. The HOMO-LUMO energy gaps were calculated through experimentally and theoretically. These new pentacene derivatives exhibited high thermal stability, with decomposition temperatures around 470 • C and high rigidity with glass transition temperatures ranging from 125 • C to 231 • C. These promising thermal and electrochemical properties highlight these new soluble and stable materials as potential strong candidates for a range of applications, including organic thin-film transistors and interface layers in perovskite solar cells
Juvenile hormone and maternal egg care in the European earwig (part I): Manipulation of JH, agonist, and precocene fails to induce the onset of egg care
No full textInternational audienceParental care is a crucial behaviour in animals. Yet the mechanisms regulating its initiation remain poorly understood, particularly in insects. Juvenile hormone (JH) is widely recognised as a key hormonal regulator in insects that influences a broad diversity of physiological and behavioural traits, including parental care after oviposition. However, its role in triggering the onset of egg care remains unexplored. To address this, we experimentally manipulated JH levels in 194 pre-ovipositing European earwig females and tested whether they initiated care towards foreign eggs. Contrary to our predictions, topical application or injection of JH, methoprene (a JH analogue), precocene (a JH production inhibitor) or acetone (control) at varying doses failed to induce egg care or to prevent egg cannibalism. This rejection of foreign eggs was not due to experimental stress, as positive control females that had previously laid eggs cared for new foreign eggs, even after acetone exposure. These results demonstrate that neither the presence or absence of JH nor the mere presence of eggs is sufficient to induce maternal care in preovipositing females. Instead, our findings suggest that additional signals beyond JH modulation and/or alternative hormonal pathways may be critical for initiating care behaviours in earwigs. Overall, this study advances our understanding of the complex regulatory mechanisms underlying parental care and the multifaceted role of JH in insect behaviour