HAL Université de Tours
Not a member yet
55851 research outputs found
Sort by
The Eye of the Graffitologist: Authentication and Falsification of Medieval and Early Modern Graffiti
No full textInternational audienc
Recension de Y. Sordet, Histoire du livre et de l'édition, Paris, Albin Michel, 2022
No full textInternational audienc
Allies and Enemies: On the Political Determinants of Trade in Critical Minerals
No full textThis paper examines the effect of political dissimilarity on the bilateral trade of critical minerals, which are essential for renewable energy and high-technology applications. Using UN voting similarity as a measure of political dissimilarity, we empirically examine how international relations impact trade flows. Moreover, we distinguish between processed and semi-processed goods, between commodities used in energy and digital applications and those not used in these sectors, and between products traded in concentrated versus diversified markets. Employing a gravity model over the period 1995-2022 and the Poisson Pseudo Maximum Likelihood (PPML) estimator, we account for zero trade flows and heteroskedasticity. Our analysis reveals that political dissimilarity with China and the United States is an important determinant of trade in critical minerals, particularly for semi-processed products, those used in energy and digital transitions, and products with more geographically concentrated markets. At the product level, minerals such as nickel, cobalt, vanadium, molybdenum, copper, and aluminum appear especially sensitive to strategic considerations. Finally, our findings are robust across different model specifications, particularly with respect to concerns about endogeneity between political dissimilarity and trade in critical minerals.</div
Effects of bisphenols on the assisted reproductive technology outcomes considering the patient clinical parameters
No full textInternational audienceContext Bisphenol A (BPA) and its analogues disrupt endocrine functions, adversely impacting oocyte meiosis, maturation, and granulosa cell (GC) steroidogenesis. Objective To identify clinical factors, particularly adiposity and age, influencing ovarian cell sensitivity to bisphenol (BP) exposure. Methods This study analyzed a cohort of 368 women undergoing assisted reproductive technology (ART) from 2019 to 2023. Four BPs (BPA, BPS, BPF, and BPAF) were quantified, and ART outcomes (eg, oocyte count, embryo quality, and pregnancy rates) were assessed using regression models. GCs from 156 patients were cultured and exposed to BPS for 48 hours to evaluate progesterone and estradiol secretion based on clinical parameters. Results BPS and BPA were the most prevalent BPs in follicular fluid. BP exposure was associated with reduced fertilization rates (P = .05). Obesity tended to lower live birth rates (P = .08) but did not affect embryo development or implantation. Age significantly impacted embryo quantity (P < .001) and quality (P = .03). GC progesterone secretion was correlated with donor age after exposure to 1 µM and 10 µM BPS (P = .03 for both). GCs from younger women appeared more sensitive to BPS. Conclusion Although obesity did not affect embryonic development, its association with reduced live birth rates suggests a suboptimal environment for implantation and/or fetal development. Age was linked to lower antral follicle count, pregnancy rates, and live birth rates. Younger women's GCs may exhibit heightened sensitivity to BPS exposure, warranting further investigation
Development and validation of a highly sensitive method for the analysis of succinate dehydrogenase inhibitors (SDHIs) in plant-based food and beverages
No full textInternational audienceRecently, concerns have been raised over succinate dehydrogenase inhibitor (SDHI) fungicides and their potential adverse effects on the environment and nontarget organisms including humans. Appropriate analysis methods are thus necessary for their proper risk assessment. Here, a highly sensitive method based on QuEChERS and UHPLC-MS/MS was developed and validated for the simultaneous quantification of 12 SDHIs and seven of their metabolites in beverages, fruits and vegetables. The method displayed linearity over more than three orders of magnitude, precision with RSD <20 % and recoveries between 70 and 120 % for all compounds, ensuring robustness across a wide concentration range. Limits of quantification as low as 0.003-0.3 ng/g depending on the matrix and analytes were reached. The method was applied to 28 representative samples of fruits, vegetable, fruit juices, wine and water samples. The results illustrate the reliability of this method for the quantification of SDHI fungicides in a variety of foodstuff matrices
Music and Language in Williams Syndrome: An Integrative and Systematic Mini-Review
No full textInternational audienceIndividuals with Williams syndrome (WS) are known for their interest in language and music. As producing and comprehending music and language usually involve a set of similar or comparable cognitive abilities, the music–language relationship might be of interest to better understand WS. We identified, analyzed, and synthesized research articles on music and language among individuals with WS. Three different databases were searched (SCOPUS, PubMed, PsycInfo). Eight research articles were identified after screening, based on title, abstract and full text. In this integrative–systematic review, we assess methodologies, report findings and examine the current understanding of several subdimensions of the relationship between music and language. The findings suggest that basic musical abilities such as tone, rhythm and pitch discrimination are correlated with several verbal skills, particularly the understanding of prosody. Musical practice seems to benefit individuals with WS, in particular for prosody understanding and verbal memory. A correlation was also observed between emotional responsiveness to music and verbal ability. Further studies are needed to better characterize the relationship between music and language in WS. The clinical use of musical practice could be of interest in improving prosodic skills and verbal memory, which deserves extended experimental investigation
Influence de la dynamique des paramètres de contrôle et phénomène de basculement dans un modèle simple d’instrument à anche
No full textInternational audienceLes instruments de musique à anche simple comme les clarinettes sont des systèmes dynamiques non linéaires liant des paramètres de contrôle, utilisés par le musicien pour contrôler l’instrument, à des variables de sortie caractérisant le son musical perçu par l’auditeur. Les études théoriques précédentes sur la production sonore ont été réalisées en considérant les paramètres de contrôle constants dans le temps. Ces études ont montré que la propriété de multistabilité - c.-à-d la coexistence de plusieurs solutions stables pour un jeu donné de paramètres - est souvent observée dans les modèles. Cependant, pendant les transitoires, le musicien fait varier les paramètres de contrôle dans le temps. Par exemple, pendant l'attaque d'une note, il augmente la pression dans sa bouche (le paramètre de contrôle principal) pour atteindre la note désirée. Il a également été montré, principalement en science du climat, qu’un système dynamique multistable dont les paramètres de contrôle évoluent dans le temps peut subir un basculement (ou tipping) qui désigne une transition brusque entre deux solutions stables, provoquée uniquement par la variation d’un paramètre. Les concepts traditionnels de diagramme de bifurcation et de bassins d’attraction sont essentiels pour l’étude de ce phénomène mais ne permettent pas de l’expliquer pleinement. Ce travail étudie théoriquement le basculement pendant le transitoire d’attaque d'un modèle simplifié de clarinette représentant une note spécifique et possédant une bistabilité entre sa solution d’équilibre (le silence) et sa solution périodique (la note). L’étude détermine, en fonction des conditions initiales et du taux de variation de la pression buccale, si un son est produit lors du transitoire d’attaque. Elle contribue également à mieux comprendre l'impact de la dynamique des paramètres de contrôle sur le comportement transitoire des instruments à anche. Une présentation complémentaire réalisée par les auteurs examine cet impact sur le comportement en régime établi de ces instruments
Recevabilité de l'appel contre une ordonnance du JLD statuant sur une mesure de sûreté : ce qui n'est pas interdit est autorisé
No full textInternational audienc
VOC-ADO: A lexical database for French-speaking adolescents
No full textInternational audienceWe present VOC-ADO, a database of the written vocabulary of French adolescents between the ages of 11 and 15 (French secondary school students). VOC-ADO provides a wealth of lexical information for 110,338 words listed in school textbooks of all disciplines (i.e., academic vocabulary), as well as novels, comics, and magazines (i.e., non-academic vocabulary). For each word, several indexes of frequency and lexical dispersion are reported, as well as word length, syntactic categories, orthographic neighborhood size, and lemma frequency. Each analysis is presented separately for the Academic and Non-academic subcorpora, as well as for the overall Global corpus. Analyses of the corpora indicate that the Academic subcorpus contains a smaller variety of unique words than the Non-academic subcorpus and exhibits higher lexical sophistication. By contrast, there is a larger proportion of content words in non-academic media than in school textbooks. Finally, VOC-ADO shows a strong frequency correlation with Manulex, a French database of elementary school vocabulary, and Lexique, a lexical database of adult vocabulary. However, many words present in VOC-ADO are not found in elementary school vocabulary. These results underscore the need to examine lexical development beyond elementary school, considering the unique characteristics of the written vocabulary encountered by French-speaking adolescents. In this regard, VOC-ADO provides researchers, educators, and clinicians interested in adolescent literacy with a valuable tool to select and analyze words based on specific characteristics. The database is freely available and can be downloaded by clicking on the following link: VOC-ADO Database link