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Piezoelectric Properties Enhancement by Continuous multi-Doping in lead-Free (Ba,Ca)(Ti,Zr)O3 Thin Films Libraries
No full textInternational audienc
Study of the Dielectric non-Linearities in 0.5(Ba0.7Ca0.3TiO3)-0.5(BaZr0.2Ti0.8O3) Thin Film
No full textInternational audienc
Is there a specificity to oral spelling and what does it tell us about central and peripheral processing levels in written production?
No full textInternational audienceIt is generally assumed that the central cognitive processing involved in written pro-duction is similar, whatever the modality of production: handwriting, typing or oral spelling. Studies on predictors of response times in picture naming provide support for this hypothesis in the case of handwriting and typing. The aim of the current study was to report data in support of this similarity hypothesis for oral spelling. Seventy-five undergraduate students spelled two hundred and thirty-four picture names aloud. Mixed-effects models were run with nine predictors on responses times and oral spelling durations. Oral spelling durations enabled us to investi-gate the interaction between central and peripheral processing levels. Although the results for response times suggest common central processing levels for all produc-tion modalities, the interaction between central and peripheral cognitive processing levels was different from what has been reported, in particular in the case of typing
Acetaminophen, a new tool for the refinement of the experimental infection of toxoplasmosis in mice
No full textInternational audienceIn recent years, animal welfare gained increasing importance in society and especially in scientific research. It has become necessary to refine the experimental procedures as much as possible in infectiology as in our reference model, toxoplasmosis, in accordance with the 3Rs rule and various ethical concerns. Thus, the establishment of a treatment using analgesics would provide relief to animals acutely infected with Toxoplasma gondii . However, the use of analgesics should in no way alter the pathophysiology of the disease and the host immune response, so as not to interfere with the initial scientific study. Little is currently known about the use of acetaminophen (APAP) in an infectious model. In the present work, we studied the impact of APAP at a reference dose of 30 mg/kg/day in a mouse model of acute toxoplasmosis. Zoonotic, telemetric, behavioral, histological and immune parameters were analyzed to better characterize the consequences of treatment with APAP either by gavage or by self-medication in Gel Water. APAP administered by gavage did not induce cellular or tissue toxicity or alter the physiological development of the mice. In addition, the nature of Gel Water itself, independent of APAP, had an effect on the immune response. APAP improved overall well-being and slowed the onset of clinical signs without altering the physiopathology or the immune responses induced by T. gondii . These first results in mice confirmed our initial hypothesis that APAP appears to be a pharmacological tool to refine and improve animal welfare during the acute phase of toxoplasmosis. Therefore, our project has highlighted the combination of specific markers to contribute to animal welfare in mice. In the long term, the use of APAP could be extended to other infectious models with other target animal species
In-host evolution of Yersinia enterocolitica during a chronic human infection
No full textInternational audienceBacteria exhibit remarkable adaptability in response to selective pressures encountered during infection and antibiotic treatment. We characterize four Yersinia enterocolitica clonal isolates from successive bacteremia episodes that evolved within an elderly patient over 14 years. Their common evolution is characterized by a genome size reduction resulting in the loss of about a hundred genes and a so far undescribed deletion in the DNA gyrase gene gyrA conferring quinolone resistance. Third-generation cephalosporin resistance of the last isolate correlates with a truncation of OmpF in synergy with an increased production of BlaA and AmpC β-lactamases. A strong proteome remodeling of the isolates reveals a perturbed stringent response, as well as impaired metabolism which substantiate their severe growth defects in vitro, accounting for antibiotics tolerance and possibly therapeutic failure. This study documents previously unreported genetic and phenotypic changes associated with in-host adaptation of a pathogenic Yersinia species under antibiotic pressure
Baie de Cayola, Les Sables d’Olonne (Vendée), Fouille archéologique programmée (03-06 mai 2023), Rapport final d’opération archéologique
No full textEtude archéologique de la charpente de la cathédrale Saint-Etienne de Sens. Rapport d'étude
No full textÉtudes en histoire de la pensée politique autour de Jean Bodin: Hommage au professeur Mario Turchetti
No full textDans le présent dossier, des historiens, des philosophes, des anglicistes, tous spécialistes de la pensée politique des xvie et xviie siècles, éclairent les différentes facettes du parcours du chercheur hors-norme que fut Mario Turchetti (1944-2021), tout à la fois philologue et linguiste, historiographe et historien de la pensée politique
Les influenceurs virtuels à l’épreuve de la génération Z : entre fascination technologique et rejet éthique
No full textInternational audienceCette communication explore la perception des influenceurs virtuels par lagénération Z. Ces figures numériques remettent en question les repères traditionnels del’influence humaine. Une approche qualitative a été privilégiée, à travers l’analyse de 160verbatim recueillis via un questionnaire diffusé en ligne. Le codage thématique met enévidence une polarisation des discours : fascination technologique, sécurité pour lesmarques, mais aussi rejet éthique, malaise existentiel et critique de l’inauthenticité. Lesinfluenceurs virtuels apparaissent à la fois comme des leviers d’innovation et des objetsde défiance. Les résultats soulignent une tension entre attraction pour la nouveauté etattachement à l’authenticité, invitant à une utilisation prudente de ces figures par lesmarques
Le son des errata dans les Essais de Montaigne : réflexions sur une note de Jean-François Gilmont
No full textInternational audienceLa recherche sur un erratum de Montaigne dans les Essais de 1580 et 1582 a été l’occasion de commenter une note de Jean-François Gilmont à l’Orthotypographia de Hornschuch : « La correction des épreuves se faisait habituellement avec l’aide d’un jeune lecteur. Bien souvent celui-ci lisait à haute voix le texte original et le correcteur le suivait sur l’épreuve et notait les erreurs. Mais d’autres correcteurs préféraient lire à voix haute et demander à l’apprenti de suivre l’original des yeux » (édition française de 1997, p. 74, note 35). Que sait-on de la correction par la lecture à haute voix ? Dans le cas des Essais, quels pouvaient être le rôle et la responsabilité de ce lecteur anagnostes chez Simon Millanges (à Bordeaux) puis chez Abel l’Angelier ou Michel Sonnius à Paris, ou plutôt chez leurs imprimeurs