550909 research outputs found
Sort by
Booster Obsolescence and Life Extension (BOLE) for Space Launch System (SLS)
Get PDFA human mission to the moon and Mars is the stated space exploration goal of the United States and the international community. To achieve these goals, NASA is developing the Space Launch System (SLS) and the Orion crew capsule as key elements in the architecture for missions to the moon and Mars. As part of the SLS Booster Obsolescence and Life Extension (BOLE) program, Northrop Grumman Space Systems is working to address booster obsolescence issues in design and manufacturing. The upgraded boosters will also provide increased performance that will benefit future lunar campaigns, science missions, and the eventual Mars campaign
Electromagnetic Compatibility Considerations for International Space Station Payload Developers
Get PDFThe International Space Station (ISS) is a laboratory for scientific research, innovative technology development, and global education. The ISS provides a number of facilities and platforms for payload developers and investigators to conduct biological, microgravity, and Earth and space observation science, as well as for performing technology development. Due to the unique nature of the ISS vehicle and its electrical power and data systems, achieving electromagnetic compatibility (EMC) with the vehicle requires special considerations by the payload developer. The ISS electromagnetic interference (EMI) requirements and test methods are based on MIL-STD-461, Electromagnetic Emissions and Susceptibility Requirements for the Control of Electromagnetic Interference, Revision C, and MIL-STD-462, Electromagnetic Interference Characteristics, Measurement of, respectively. The low source impedance of the test setup requires special considerations when designing or selecting EMI power filters and switched mode power supplies. Many filters, suited for later revisions of MIL-STD-461, will result in non-compliant designs. ISS electrical power system power quality requirements, imposed to protect the stability of the system, can also affect EMI filter design. The selection and use of commercial-off-the-shelf (COTS) equipment for ISS applications requires special considerations to meet both EMC and crew safety requirements. Furthermore, the ISS environment can provide unique immunity challenges; if the payload developer ignores these challenges, the result is a possible loss of science or impact to technology demonstration. The ISS provides a unique opportunity for the science and technology development community. However, in order to be successful, the payload developer must incorporate special EMC considerations, many of which will be presented
Air Traffic Management TestBed Traffic Viewer: Developer's Guide
Get PDFThe Air Traffic Management (ATM) TestBed is a Platform as a Service that is being developed by the National Aeronautics and Space Administration (NASA) to help design, configure, integrate, run, and monitor air traffic simulations. The platform is designed to provide cloud services including back-end, big-data analytics tools, on-demand computing resource management, data storage, and communication middleware. The ATM TestBed reduces the time to test concepts and technologies, supports interactions among various methods such as human-in-the-loop and automation-in-the-loop simulations, and enables collaborative simulations by sharing technologies and tools in the ATM community. The Traffic Viewer application provides a graphical user interface tool for visualizing real and simulated air traffic as well as airspace definition in two-dimensional space. This guide describes a high-level design and implementation of Traffic Viewer and provides information for a new developer or a user to add new capabilities by following the software design and leveraging existing capabilities
Hydrostatic and Physiologic Contributions to Intraocular Pressure Change During Postural Change
Get PDFMany studies have observed that intraocular pressure (IOP) is dependent on tilt angle () during postural change. In this work, we aggregated 36 independent datasets from 30 published articles, representing 821 subjects, which reported data on IOP during postural change. From this data, we developed a generalized quantitative relationship between IOP and . We then compared the experimentally derived results to simulated predictions generated by our lumped parameter model of the eye, LPEye, considering only hydrostatic effects. The difference between the analytical and simulated values of IOP can be used to quantify the physiologic regulatory contribution
Ion Channels From Structure to Electrophysiology and Back
Get PDFA reliable way to establish whether our understanding of a channel is satisfactory is to reproduce its measured ionic conductance over a broad range of applied voltages in computer simulations. In molecular dynamics (MD), this can be done by way of applying an external electric field to the system and counting the number of ions that traverse the channel per unit time. Since this approach is computationally very expensive, we have developed a markedly more efficient alternative in which MD is combined with the electrodiffusion (ED) equation. In this approach, the assumptions of the ED equation can be rigorously tested, and the precision and consistency of the calculated conductance can be determined. We have demonstrated that the full current/voltage dependence and the underlying free energy profile for a simple channel can be reliably calculated from equilibrium or non-equilibrium MD simulations at a single voltage. Free energy profiles can be obtained from non-equilibrium simulations without a loss of accuracy even without the knowledge of diffusion coefficient. To carry out MD simulations, a structural model of a channel has to be assumed, which is an important constraint, considering that high-resolution structures are available for only very few simple channels. If the comparison of calculated ionic conductance with electrophysiological data is satisfactory, it greatly increases our confidence that the structure and the function are described sufficiently accurately. We examined the validity of the ED for several channels embedded in phospholipid membranes - four naturally occurring channels: trichotoxin, alamethicin, p7 from hepatitis C virus (HCV) and Vpu from the HIV-1 virus, a synthetic, hexameric channel, formed by a 21-residue peptide that contains only leucine and serine and a bacterial pentameric ligand-gated ion channel, GLIC. All these channels mediate transport of potassium and chloride ions. It was found that the ED equation is satisfactory for these systems. In some of them, experimental and calculated electrophysiological properties are in good agreement, whereas in others there are strong indications that the structural models are incorrect
Condensation, Partial Melting and Evaporation Processes Influence the Bulk Compositions of Spinel-Cored Spherules in the CO3.1 Chondrite Miller Range 90019
Get PDFHere we focus on spinel-cored spherule calcium-aluminum rich inclusions (CAI), dominantly ~75-80 microns in diameter in the CO3.1 chondrite Miller Range 90019, which make up ~ 12 % of the fine-grained CAIs in one thin section. Their mineralogical content ranges from rare grossite- and hibonite-bearing varieties, through perovskite-melilitebearing, to fassaite-bearing and finally anorthitebearing. Non-spherical CAIs have been divided into 4 other groups, defined based on mineralogical abundances. We also characterized a group of AOAs from this sample. No glass has been recognized in any inclusions. Some relatively evolved members (anorthite-, spinel- + fassaite-bearing) among the spherules are found engulfed in AOAs. We characterized the bulk compositions of ~145 CAIs and AOAs in this meteorite, derived from EDS-x-ray mapping of the inclusions. We determined bulk compositions both with and without Wark-Lovering rims (when present), which are largely composed of diopside forsterite. The balance of the inclusions appear to have not been melted or partially melted, but rather they have textures that indicate they are condensates, often modified by extensive reaction with nebular gases. This presents the opportunity to examine effects on the bulk compositions of spherules resulting potentially from melting plus evaporation. Other aspects of this suite of refractory inclusions have been discussed in these abstracts. Oxygen isotope variations in one spherule were presented in [4]. The latter study showed a complex history of reaction with nebular gases possessing a variety of Oisotope compositions. Additional O isotopic studies of inclusions in this work are included in Mane et al
