HAL Clermont Université
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Observation of the and decays
No full textInternational audienceThe first observation of the decay and the most precise measurement of the branching fraction of the decay are reported, using proton-proton collision data from the LHCb experiment collected in 2016--2018 at a centre-of-mass energy of 13~TeV, corresponding to an integrated luminosity of 5.4~fb. Using the and decays as normalisation channels, the ratios of branching fractions are measured to be: where the first uncertainty is statistical and the second systematic
A Degree Centrality-Enhanced Computational Approach for Local Network Alignment Leveraging Knowledge Graph Embeddings
No full textInternational audienceBiological network alignment serves various goals, including identifying similar regions between networks of different species, transferring biological knowledge, and predicting protein complexes and functions. This paper presents KOGAL (KnOwledge Graph ALignment), a scalable multiprocessing algorithm for local protein-protein interaction (PPI) network alignment. KOGAL aims to predict conserved protein complexes across species’ PPI networks. It employs two strategies for seed discovery and initial alignment: the first computes the cosine similarity between embedding vectors derived from knowledge graph models like TransE or DistMult to generate an alignment matrix. The second strategy begins the alignment process by calculating the centrality degree of nodes within each network, highlighting the importance of each protein in the network structure. Protein similarities are quantified by combining protein sequence similarities with knowledge graph embeddings, ensuring biologically meaningful structural alignments. KOGAL depicts strong results compared to other state-of-the-art approaches. When evaluated on real PPI networks, KOGAL demonstrates high accuracy across multiple metrics, including coverage, sensitivity, the number of matched reference conserved complexes (Frac), complex-wise sensitivity (Sn), positive predictive value (PPV), geometric accuracy (ACC), and maximum matching ratio (MMR)
Modular affine Hecke category and regular centralizer
No full textIn this paper we provide a "combinatorial" description of the category of tilting perverse sheaves on the affine flag variety of a reductive algebraic group, and its free-monodromic variant, with coefficients in a field of positive characteristic. This provides a replacement for the familiar "Soergel theory" for characteristic-0 coefficients. As an application we deduce character formulas for indecomposable tilting perverse sheaves on the affine flag variety in terms of l-Kazhdan-Lusztig polynomials
Le fevre de Creeil - Édition, traduction et notes d'après le manuscrit BnF fr. 837
No full textÉdition, traduction et notes du Fevre de Creeil d'après le ms. BnF fr. 83
Le clerc qui fu repus derriere l'escrin - Jean de Condé - Édition, traduction et notes d'après le ms. BnF fr. 1446
No full textÉdition, traduction et notes du fabliau Le clerc qui fu repus derriere l'escrin d'après le ms. BnF fr. 83
A 2-year exploratory study to elaborate a methodological protocol for evaluating volcanic terroir influence in Gamay wines in the French PDO Côtes d′Auvergne
No full textInternational audienceThe objective of our study is to report a methodology used to determine chemical and sensory attributes of wines that were elaborated from vineyards growing on volcanic-derived soils in the French PDO Côtes d’Auvergne. For that purpose, vineyard soils were sampled in eight different geographical locations and analyzed by their granulometry, hydric stress and multi-elemental composition. Red wines were elaborated during vintages 2020 and 2021 and chemically characterized by classical oenological parameters, anthocyanins and multi-elemental analysis by ICP-MS, and sensorially described by a panel of nineteen experienced tasters. The results show that vineyards could be differentiated into two typologies of soils: four clay-limestone soils (A) and four basaltic soils (B). B soils presented a more heterogeneous granulometry, a higher water retention and a more concentrated mineral content compared to A soils. Volcanic Gamay wines, originating from these B soils, differed by their red yellowish color, lower total acidity, lower anthocyanin contents, higher contents of sodium, lithium and strontium and stronger peppery/smoky flavors compared to non-volcanic wines originating from A soils. The sensory descriptors were discussed as a function of the chemical composition of wines and could reveal the importance of volcanic terroirs in the sensory and chemical composition of wines
Reduced ATP turnover during hibernation in relaxed skeletal muscle
No full textInternational audienceAbstract Hibernating brown bears, due to a drastic reduction in metabolic rate, show only moderate muscle wasting. Here, we evaluate if ATPase activity of resting skeletal muscle myosin can contribute to this energy sparing. By analyzing single muscle fibers taken from the same bears, either during hibernation or in summer, we find that fibers from hibernating bears have a mild decline in force production and a significant reduction in ATPase activity. Single fiber proteomics, western blotting, and immunohistochemical analyses reveal major remodeling of the mitochondrial proteome during hibernation. Furthermore, using bioinformatical approaches and western blotting we find that phosphorylated myosin light chain, a known stimulator of basal myosin ATPase activity, is decreased in hibernating and disused muscles. These results suggest that skeletal muscle limits energy loss by reducing myosin ATPase activity, indicating a possible role for myosin ATPase activity modulation in multiple muscle wasting conditions