İstanbul Üniversitesi Açık Erişim Sistemi
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PERSISTENCE OF ANTIBODIES AFTER SARS-COV-2 VACCINES IN HAEMODIALYSIS PATIENTS: A 6 MONTHS FOLLOW-UP
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Hsp27, Hsp60, Hsp70, or Hsp90 depletion enhances the antitumor effects of resveratrol via oxidative and ER stress response in human glioblastoma cells
No full textThe Pathophysiology of Left Ventricular Hypertrophy, beyond Hypertension, in Autosomal Dominant Polycystic Kidney Disease
No full textHeart disease is one of the leading causes of death in autosomal dominant polycystic kidney disease (ADPKD) patients. Left ventricular hypertrophy (LVH) is an early and severe complication in ADPKD patients. Two decades ago, the prevalence of LVH on echocardiography in hypertensive ADPKD patients was shown to be as high as 46%. Recent studies using cardiac magnetic resonance imaging have shown that the prevalence of LVH in ADPKD patients may be lower. The true prevalence of LVH in ADPKD patients is controversial. There is evidence that factors other than hypertension contribute to LVH in ADPKD patients. Studies have shown that young normotensive ADPKD adults and children have a higher left ventricular mass index compared to controls and that the prevalence of LVH is high in patients with ADPKD whose blood pressure is well controlled. Polycystin-1 (PC-1) and polycystin-2 (PC-2) control intracellular signaling pathways that can influence cardiac function. Perturbations of PC-1 or PC-2 in the heart can lead to profound changes in cardiac structure and function independently of kidney function or blood pressure. PC-1 can influence mammalian target of rapamycin and mitophagy and PC-2 can influence autophagy, processes that play a role in LVH. Polymorphisms in the angiotensin-converting enzyme gene may play a role in LVH in ADPKD. This review will detail the pathophysiology of LVH, beyond hypertension, in ADPKD
Stock assessment of red mullet, Mullus barbatus Linnaeus, 1758 by length-based and catch-based models in the Northeastern Mediterranean
No full textNormal 0 false false false EN-US X-NONE X-NONE Stock assessment for Mullus barbatus using one catch-based and three different length-based data limited models was performed based on the official catch statistics and commercial length-frequency data from northeastern Mediterranean. The catch-based CMSY model results showed that the catch amount did not exceed the maximum sustainable yield (MSY), and the fisheries reference points (B/BMSY and F/FMSY) indicated a healthy stock status in 2020. The length-based Bayesian (LBB) estimator indicated that the biomass ratio was above safe biological limits (B < 0.5 BMSY), but fishing mortality was slightly higher than natural mortality. Likewise, length-based spawning potential ratio (LBSPR) results showed that SL50 for red mullet was higher than its Lm50, while the estimated median spawning potential ratio (SPR) was above the limit of 20% set as the biological reference point. The length-based integrated mixed effect (LIME) results were more optimistic than those from the LBB and LBSPR. The estimated SPR was found above 40% which is the target reference point for a sustainable stock. According to the results of different assessment models, the red mullet stock was deemed sustainable in terms of biomass, but monitoring of fishing pressure is recommended
A Structure that Needs to Be Saved in Eyup: Balchik Tekke
No full textBalchik Tekke was established on the site of the Darulhadis building, which was built as an educational structure in the Fatih era in the Eyup district of Istanbul. The structure, which was established towards the end of the 16th century, has been renovated several times over time and has been in existence since the 20th century. Abandoned in 1925, the structure was destroyed by a fire in 1939 and has largely disappeared. Since its foundation, it has been used as a Halveti/Sunbuli, Halveti/Ushshaki and Sa'di Tekke, respectively. In the tomb that has reached today, there are four simple graves, one of which has three stone chests, which are considered sarcophagi. The inscriptions of the witnesses identified in these graves are in Arabic. These belong to Dervish Muhammad, Aisha Sultan (1584), Mustafa Bey, the son of Hasan (1606), Mehmed Bey, the son of Ahmed (1609), and Mehemmed Bey (1623). In addition, sources state that there are also the graves of Historian Semdanizade Suleyman Efendi and the first eight sheikhs of the tekke in this tomb and cemetery. The mosque-tawhidhane and tomb spaces in the tekke, which consist of masonry and wooden structures, have masonry walls. A row of cut mould stones and two rows of bricks were used on the alternating braided walls. It is understood that the structure is covered with a wooden roof covered with tiles from the outside. The windows with cut stone cornices, round-arched openings and iron railings located near the corner in the east and north directions belong to the tomb. The Qibla wall of the masjid-tawhidhane site, which was covered in a square plan on the western side of the tomb and adjacent to the tomb, has been demolished today. This study focuses on the changes of the Balchik Tekke throughout the history and its current situation