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Network topology and the behavior of socially-embedded financial markets
No full textInternational audienceWe study the impact of the network topology on various market parameters (volatility, liquidity and efficiency) when three populations or artificial trades interact (Noise, Informed and Social Traders). We show, using an agent-based set of simulations that choosing a Regular, a Erdos-Renyi or a scale free network and locating on each vertex one Noise, Informed or Social Trader, substantially modifies the dynamics of the market. The overall level of volatility, the liquidity and the resulting efficiency are impacted by this initial choice in various ways which also depends upon the proportion of Informed vs. Noise Traders
A decentralized cooperative control scheme for a distributed space transportation system
No full textInternational audienc
Optimal control of a continuous-time W-configuration assemble-to-order system
No full textInternational audienceWe analyze a W-configuration assemble-to-order system with random lead times, random arrival of demand , and lost sales, in continuous time. Specifically, we assume exponentially distributed production and demand inter-arrival times. We formulate the problem as an infinite-horizon Markov decision process. We deviate from the standard approach by first characterizing a region (the recurrent region) of the state space where all properties of the cost function hold. We then characterize the optimal policy within this region. In particular, we show that within the recurrent region components are always produced. We also characterize the optimal component allocation policy which specifies whether an arriving product demand should be fulfilled. Our analysis reveals that the optimal allocation policy is counter-intuitive. For instance, even when one product dominates the other, in terms of lost sale cost and lost sale cost rate (i. e ., demand rate times the lost sale cost), its demand may not have absolute priority over the other product's demand. We also show that the structure of the optimal policy remains the same for systems with batch production, Erlang distributed production times, and non-unitary product demand. Finally, we propose efficient heuristics that can be either used as an approximation to the optimal policy or can be used as a starting policy for the common algorithms that are used to obtain the optimal policy in an effort to reduce their computational time
Les jeux de mots des fictionnaires colliens ou la transgression de la clôture gestaltique du "mot". (Variations chronosignifiantes)
No full textInternational audienc
COMETS AVIS 2018-36 - Le harcèlement sexuel dans les laboratoires : quelques considérations éthiques
No full textCOMETS Comité d'éthique du CNRS Avis n°2018-36Avis n°2018-36, approuvé en séance plénière du COMETS le 5 mars 2018
Exercise programmes for ankylosing spondylitis
No full textInternational audienceObjective To describe the criteria used to guide clinical decision-making regarding when a patient is ready to return to running (RTR) after ACL reconstruction. Design Scoping review. Data sources The MEDLINE (PubMed), EMBASE, Web of Science, PEDro, SPORTDiscus and Cochrane Library electronic databases. We also screened the reference lists of included studies and conducted forward citation tracking. Eligibility criteria for selecting studies Reported at least one criterion for permitting adult patients with primary ACL reconstruction to commence running postoperatively. Results 201 studies fulfilled the inclusion criteria and reported 205 time-based criteria for RTR. The median time from when RTR was permitted was 12 postoperative weeks (IQR=3.3, range 5–39 weeks). Fewer than one in five studies used additional clinical, strength or performance-based criteria for decision-making regarding RTR. Aside from time, the most frequently reported criteria for RTR were: full knee range of motion or >95% of the non-injured knee plus no pain or pain 70% plus extensor and flexor LSI>70%; and hop test LSI>70%. Conclusions Fewer than one in five studies reported clinical, strength or performance-based criteria for RTR even though best evidence recommends performance-based criteria combined with time-based criteria to commence running activities following ACL reconstruction
ORAI3 silencing alters cell proliferation and promotes mitotic catastrophe and apoptosis in pancreatic adenocarcinoma.
No full textInternational audienceCalcium (Ca2+) release from the endoplasmic reticulum plays an important role in many cell-fate defining cellular processes. Traditionally, this Ca2+ release was associated with the ER Ca2+ release channels, inositol 1,4,5‑triphosphate receptor (IP3R) and ryanodine receptor (RyR). Lately, however, other calcium conductances have been found to be intracellularly localized and to participate in cell fate regulation. Nonetheless, molecular identity and functional properties of the ER Ca2+ release mechanisms associated with multiple diseases, e.g. prostate cancer, remain unknown. Here we identify a new family of transient receptor potential melastatine 8 (TRPM8) channel isoforms as functional ER Ca2+ release channels expressed in mitochondria-associated ER membranes (MAMs). These TRPM8 isoforms exhibit an unconventional structure with 4 transmembrane domains (TMs) instead of 6 TMs characteristic of the TRP channel archetype. We show that these 4TM-TRPM8 isoforms form functional channels in the ER and participate in regulation of the steady-state Ca2+ concentration ([Ca2+]) in mitochondria and the ER. Thus, our study identifies 4TM-TRPM8 isoforms as ER Ca2+ release mechanism distinct from classical Ca2+ release channels
Salvage Surgery for Esophageal Cancer: How to Improve Outcomes?
No full textInternational audienceBACKGROUND:Locoregional recurrence rates after definitive chemoradiotherapy (dCRT) for locally advanced esophageal cancer (EC) are high. Salvage surgery (SALV) is considered the best treatment option in case of persistent or recurrent disease for operable patients, but SALV has been associated with increased morbidity and mortality. The aim of this study is to identify factors linked to outcomes after SALV to better select candidates and to optimize perioperative care.STUDY DESIGN:We retrospectively analyzed data from 308 consecutive SALV patients from a large multicenter European cohort. Univariate and multivariate analyses were performed to identify factors associated with in-hospital postoperative morbidity, anastomotic leakage (AL), and overall survival (OS).RESULTS:The in-hospital postoperative mortality and morbidity rates were 8.4 and 34.7%, respectively. Squamous cell histology (p = 0.040) and radiation dose ≥ 55 Gy (p = 0.047) were independently associated with major morbidity. The AL rate was 12.7%, and cervical anastomosis was independently associated with AL (p = 0.002). OS at 5 years was 34.0%. Radiation dose ≥ 55 Gy (p = 0.003), occurrence of postoperative complications (p = 0.006), ypTNM stage 3 (p = 0.019), and positive surgical margins (p < 0.001) were linked to poor prognosis.CONCLUSIONS:SALV is a valuable option for patients with persistent or recurrent disease after dCRT and offers long-term survival. Factors such as radiation dose and anastomosis location identified here will help to optimize outcomes after SALV, which may be considered a standard treatment in the EC therapeutic armamentarium
