Kütahya Health Sciences University Research Information System
Not a member yet
19078 research outputs found
Sort by
Prognostic Significance of C-PLAN Index in Patients Treated with Immunotherapy for Non-Small-Cell Lung Cancer
No full textBackground/Objectives: Non-small-cell lung cancer (NSCLC) is a common disease with a high mortality rate and is often treated with immunotherapies; however, prognostic markers are required to identify patients who are most likely to benefit from these treatments. Therefore, we designed this study to assess the prognostic significance of the C-PLAN index, which includes performance status (PS) and C-reactive protein (CRP). Methods: A total of 560 patients were included in this multicenter study. Patients had been diagnosed with NSCLC and had received nivolumab therapy. The C-PLAN index, defined in 2022, is a score derived from the combination of PS, CRP, lactate dehydrogenase (LDH), albumin, and neutrophil–lymphocyte ratio (NLR). Patients were classified into good-, moderate-, and poor-prognosis groups according to the C-PLAN score. Results: The median metastatic overall survival was 25 months in the group with a C-PLAN score < 2 and 6 months in the group with a C-PLAN score ≥ 2 (p < 0.001). The median metastatic progression-free survival was 11 months in the group with a C-PLAN score < 2 and 3 months in the group with a C-PLAN score ≥ 2. Conclusion: This is the first comprehensive study demonstrating that the C-PLAN index can be used for prognostic purposes in immunotherapy. This score, which can be easily, economically, and practically calculated in outpatient clinics, can predict patient prognosis and determine who should receive longer durations of immunotherapy.</jats:p
Effects of the WNT signaling pathway on inflammation and fibrosis in idiopathic pulmonary fibrosis: Clinical, radiological and molecular evaluation
No full text
Üniversite Öğrencilerinde FoMO, Netlessfobi ve Aile Bütünlük Duygusu Arasındaki İlişkinin İncelenmesi
No full textEffect of different feeding approaches on growth, neonatal morbidities, mortality and neurodevelopmental outcome in preterm infants: a systematic review and network meta-analysis
No full textObjective To compare feeding strategies on preterm infants’ growth during hospitalisation, neonatal morbidities, mortality and neurodevelopmental outcome (NDO) at 18–26 months corrected age. Methods We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension statement for network meta-analysis. We searched five medical databases for randomised controlled trials comparing different feeding approaches in preterm infants and their effects on growth, neonatal morbidities, mortality and NDO. The Cochrane Collaboration’s tool was used to assess the risk of bias. We used a random-effects model. Pooled mean differences (MD) or risk ratios with 95% CIs were calculated. Results Ninety-five studies (9663 infants) were included. Human milk (HM) with bovine milk fortifier (BMF) (adjusted according to blood urea nitrogen) achieved the best length increment (MD=0.56cm/week; 95% CI 0.19 to 0.93). Notably, HM+BMF (3.5gm/kg/d protein) showed the best head circumference growth (MD 0.46cm/week; 95% CI 0.10 to 0.81) but no significant difference in weight gain. There were no significant differences in neonatal morbidities/mortality. While MOM|+PTF (supp) displayed significantly lower NDO delay in the domain of mild cognitive delay. Conclusion Overall, there is a lack of strong evidence to support a specific enteral feeding strategy and further high-quality research is required. Targeted HM fortification appears to improve head growth, while adjusted fortification enhances length. Given the significant inconsistency detected, which may compromise the reliability of the network estimates, these results must be interpreted carefully
Bilateral daimi kanin ve daimi lateral transpozisyonu: Olgu raporu
No full textGİRİŞ: Transpozisyon, arktaki iki komşu dişin normal anatomik konumlarının dışında, birbirlerinin yerini alacak şekilde geliştiği ve sürdüğü dental anomalidir. Sadece köklerin veya kronların yer değiştirdiği kısmi transpozisyon olarak gelişebildiği gibi, hem kronların hem de köklerin tamamen yer değiştirdiği tam transpozisyon olarak da görülebilmektedir. Kadınlarda erkeklere kıyasla daha fazla izlenmekle beraber, çoğunlukla maksillada gözlenmektedir ve unilateraldir. Maksiller kanin diş transpozisyonu en sık gözlenen tiptir ve genellikle birinci premolar veya lateral diş ile ilişkilidir. Transpozisyon anomalisi izole olarak görülebilmekle birlikte, persiste süt dişleri, hipodonti, kama lateral ve dilaserasyon gibi konjenital dental anomaliler de duruma eşlik edebilmektedir. Bu olgu raporunda, mandibular daimi kanin ve daimi lateral dişlerin bilateral transpozisyonunun sunulması amaçlanmaktadır.OLGU RAPORU: Sistemik olarak sağlıklı 10 yaşındaki erkek hasta diş çürüğü ve ağrı şikayetiyle kliniğimize başvurmuştur. Alınan anamnez ve yapılan klinik muayene sonucunda hastanın karışık dişlenme döneminde olduğu belirlenmiştir. Yapılan değerlendirmede 32-33 ve 42-43 numaralı dişlerde transpozisyon anomalisi gözlenmiştir. Ek olarak, sağ tarafta 83 ve 42 numaralı dişlerin de transpoze olduğu saptanmış, ayrıca maksillada şiddetli yer darlığı, maksiler lateral dişlerde dişsel cross-bite ve çift taraflı posterior cross-bite varlığı tespit edilmiştir. Çürük lezyonları tedavi edilerek, hastaya rutin aralıklarla oral hijyen eğitimi verilmiş ve ortodonti bölümüne yönlendirilmiştir. Hastanın bölümümüzde takipleri devam etmektedir.SONUÇLAR: Transpozisyon nadir görülen bir dental anomali olup, estetik ve fonksiyonel açıdan olumsuz etkilere sebep olabilmektedir. Detaylı bir klinik ve radyografik muayene sayesinde anomalinin erken teşhisi sağlanmakta, böylece maloklüzyonun şiddetlenmesinin önüne geçilebilmektedir.Anahtar Kelimeler: dental anomali, maloklüzyon, transpozisyonINTRODUCTION: Transposition is a dental anomaly characterized by the development and eruption of two adjacent teeth in the arch, which exchange their physiological positions. It can be partial (involving crowns or roots) or complete (involving both). It is more prevalent in females and predominantly affects the maxilla, usually presenting unilaterally. Maxillary canine transposition is the most common form and is typically associated with the first premolar or lateral incisor. Although transposition may occur as an isolated anomaly, it is often accompanied by other congenital dental anomalies such as retained deciduous teeth, hypodontia, peg-shaped lateral incisors, and dilacerations. This case report aims to present bilateral transposition of mandibular permanent canine and permanent lateral teeth.CASE REPORT: A systemically healthy 10-year-old male patient was admitted to our clinic with complaints of dental caries and pain. Anamnesis and clinical examination revealed that the patient, who was in the mixed dentition period, presented with a transposition anomaly involving teeth 32-33 and 42-43. Additionally, transposition between teeth 83 and 42 on the right side was identified. Severe crowding in the maxilla, dental crossbite involving the maxillary lateral incisors, and bilateral posterior crossbite were also noted. The carious lesions were treated, the patient was given oral hygiene training at routine intervals and referred to the orthodontic department. Follow-up continues in our department.CONCLUSIONS: Transposition is a rare dental anomaly that can have negative aesthetic and functional effects. A detailed clinical and radiographic examination enables early diagnosis of the dental anomaly, thus preventing aggravation of the malocclusion.Keywords: dental anomaly, malocclusion, transposition</p
Gender-Specific Trends In Tracheal, Bronchus, And Lung Cancer Burden Attributable To Air Pollution Across Turkiye And Globally: A Descriptive Study For The Years 1990-2023
No full textTracheal, bronchial, and lung (TBL) cancer remains one of the leading causes of cancer related mortality worldwide. The aim of this study was to examine gender-specific temporal trends and the disease burden of TBL cancer attributable to air pollution across country income groups from 1990 to 2023, and to compare these patterns with Türkiye to support targeted prevention efforts and public health policymaking. Using GBD study data 1990-2023, this study examined trends in mortality and DALYs associated with TBL cancer attributable to air pollution in Türkiye and worldwide. Joinpoint regression analysis was used to detect significant temporal changes, and the APC was calculated to quantify overall trends. Results are reported with 95% uncertainty intervals, and fold changes were calculated. Results indicate between 1990 and 2023, the global burden of TBL cancer attributable to air pollution generally declined, with male mortality rates decreasing by 16% and female rates remaining stable. The death rate for males in Türkiye rose by 30% (from 9.13 to 11.88 per 100,000), while the female death rate increased by 87% (from 1.32 to 2.47 per 100,000 population) over the period. High-income countries achieved significant reductions in mortality, with rates dropping by 60% for males and 30% for females. Conversely, Türkiye’s trends align more closely with the negative trends observed in Upper-middle income countries, where male death rates rose by 13% and female rates by 12%. Despite a global decline in TBL cancer burden attributable to air pollution, Türkiye experienced a notable rise. Gender-specific joinpoint patterns reveal sustained increases in male mortality since the early 2000s and two periods of accelerated growth among females. Compared with high-income countries, which achieved substantial reductions, These results underscore the need for intensified, gender-responsive air-quality policies and cancer-prevention strategies to curb the rising burden in Türkiye.</p
Expression and Characterization of Clostridium histolyticum collagenase (ColH) in Escherichia coli
No full textElucidation of the Cranial Arterial Anatomy Using the Transorbital Endoscopic Approach
No full textNew surgical techniques that access the orbit and intracranial cavity have been developed in recent years called transorbital neuroendoscopic surgery. The superior eyelid route, as a transorbital corridor, is a clinically feasible route to access selected anterior and middle skull base pathologies. However, studies regarding the suitability of this approach in vascular surgery are lacking. In this study, transorbital endoscopic dissections were performed bilaterally in 4 cadavers through the superior eyelid approach. The authors aimed to define the arterial vascular structures that can be accessed through this approach. In this study, the M1 and M2 segments of the middle cerebral artery and the branches originating from it were accessible with a 0 degree endoscope after an appropriate dissection. Thus, the endoscopic superior eyelid approach may be a novel alternative approach for some cranial pathologies