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Investigating the Relationship Between the Body Roundness Index and Presbylarynx
No full textAbstractObjective: The aim of this study was to determine whether the body roundness index (BRI) differs between older adults with endoscopically defined presbylarynx and age-matched subjects and to examine its relationship with patient-reported outcomes and acoustic measures.Methods: This prospective, cross-sectional study included adults aged ≥ 60 who were classified into a presbylarynx group and control group using videolaryngostroboscopy. Anthropometric measurements of height, weight, body mass index (BMI), and BRI were recorded. Patient-reported scales (T-VHI-10, T-RSI, and T-EAT-10) were applied and acoustic analyses were performed using standardized protocols. Group comparisons were performed using the Mann-Whitney U-test and χ2 Fisher's exact test.Results: No significant difference was determined between the two groups of a total of 167 study participants (presbylarynx group n = 87; control group n = 80), in respect of the anthropometric indices (all p ≥ 0.113). Among symptomatic participants (T-VHI-10 > 7), a lower waist circumference (p = 0.016) and a significantly lower BRI (median 5.06 vs. 6.80; p = 0.003) were recorded for the presbylarynx group. The acoustic analysis results of the whole sample revealed higher shimmer (%), lower HNR, lower CPPS, and higher AVQI-3.0 in the case group (all p < 0.05).Conclusion: Although conventional anthropometric measures were similar in the whole population, a lower BRI was a notable finding among symptomatic individuals with presbylarynx, who also presented with a noise-dominant acoustic profile. Integrating body composition markers, such as BRI, with acoustic biomarkers may help to refine phenotyping and inform targeted rehabilitation strategies for the aging voice.</p
Boron and hBN nanoparticle-supplemented fecal microbiota transplantation as a potential therapy for testicular injury
No full textIs There a Relationship Between Children's Overweight and Obesity Status and Mothers' Nutritional Knowledge Level?
No full textFizyoterapi ve Rehabilitasyon Öğrencilerinin Fizyoterapi ve Rehabilitasyon Mesleğine İlişkinBilgi Kaynaklarının Belirlenmesi
No full textLUTETIUM-177 DOTATATE THERAPY AFTER LANREOTIDE FAILURE IN NEUROENDOCRINE TUMOR PATIENTS WITH LIVER METASTASES: A THREE-CASE EXPERIENCE
No full textLUTETIUM-177 DOTATATE THERAPY AFTERLANREOTIDE FAILURE IN NEUROENDOCRINETUMOR PATIENTS WITH LIVER METASTASES: ATHREE-CASE EXPERIENCEMustafa ErsoyKütahya Sağlık Bilimleri Üniversitesi Tıp Fakültesi, İç Hastalıkları AnaBilim Dalı, KütahyaBackground: Neuroendocrine tumors (NETs) frequently metastasize to the liver and may initially respond to somatostatin analogs such as lanreotide or octreotide. However, many patientseventually experience progression despite biochemical control.Peptide receptor radionuclide therapy (PRRT) with Lutetium-177DOTATATE (Lu-177) has emerged as an effective therapeuticoption for somatostatin receptor–positive, progressive NETs. Wereport three patients with liver-dominant metastatic NETs whoexperienced disease progression under lanreotide and subsequently received Lu-177 DOTATATE.Case Presentations: Case 1: A 58-year-old male with awell-differentiated ileal NET (Ki-67: 8%) presented with multiplebilobar liver metastases. Despite 18 months of lanreotide therapy, radiologic progression was detected. The patient receivedfour cycles of Lu-177 DOTATATE (7.4 GBq per cycle, every 8weeks). After the third cycle, partial radiologic response and significant improvement in diarrhea and flushing were observed.No grade >=3 toxicity occurred.Case 2: A 64-year-old female with a pancreatic NET (Ki67: 12%) and diffuse liver metastases showed progression after 14 months of lanreotide treatment. Four cycles of Lu-177DOTATATE were administered. Stable disease was achieved,and the patient remained progression-free for 15 months aftercompletion of therapy. Mild, transient thrombocytopenia (grade1) was the only toxicity observed Case 3: A 61-year-old male with a rectal NET (Ki-67: 10%)and multiple unresectable liver metastases progressed after oneyear of lanreotide therapy. The patient underwent four cycles ofLu-177 DOTATATE (total activity 29.6 GBq). Partial metabolic response was seen after the second cycle, accompanied byimprovement in carcinoid symptoms. Treatment was completedwithout severe hematologic or renal adverse events. Disease progression occurred 12 months after the final cycle.Discussion: All three patients had well-differentiated, somatostatin receptor–positive NETs that progressed after lanreotide.PRRT with Lu-177 DOTATATE resulted in either partial responseor durable disease stabilization, with favorable tolerability. Theobserved median progression-free period (12–15 months) alignswith previously published real-world and NETTER-1 trial data.PRRT provides meaningful clinical benefit after somatostatin analog failure, particularly in liver-dominant disease.Conclusion: Lutetium-177 DOTATATE represents an effective and well-tolerated treatment option for patients with metastatic NETs progressing after lanreotide. In our small case series,all patients achieved disease control and symptomatic improvement with acceptable safety. These findings support the use ofPRRT as a standard second-line approach following somatostatin analog failure in receptor-positive NETs.Keywords: Neuroendocrine tumor, Lanreotide, Lutetium-177DOTATATE</p
Evaluation of beliefs, practices and importance among Health Sciences University students regarding hand hygiene
No full textDevital immatür daimi dişlerde rejeneratif endodontik tedavi: Olgu sunumu Regenerative endodontic treatment of a devital immature permanent tooth: A case report
No full textGİRİŞ: Rejeneratif endodontik tedavi (RET), devital immatür daimi dişlerde, kök gelişiminin sürdürülmesini ve vitalitenin yeniden kazanılmasını amaç- layan tedavi yaklaşımıdır. Bu tedavinin temeli kök hücreler, doku iskeleti ve büyüme faktörlerinden oluşan doku mühendisliği bileşenlerine dayanmak- tadır. Bu olgu raporunun amacı, dental travma sonucunda devitalize olan immatür daimi dişlere RET uygulamasının tedavi sonuçlarının sunulmasıdır.OLGU RAPORU: Sistemik olarak sağlıklı 12 yaşındaki hasta, estetik şikayet ile kliniğimize başvurmuştur. Alınan anamnezde, iki yıl önce 11 ve 21 numaralı dişlerde kron kırıkları geliştiği, ancak sonrasında herhangi bir tedavi yapılmadığı öğrenilmiştir. Klinik muayenede, perküsyon testinin pozitif, vitalite testlerinin negatif olduğu tespit edilmiş ayrıca 11 numaralı dişin bukkal mukozasında fistülizasyon saptanmıştır. Radyografik muayenede, her iki dişte de kronik apikal periodontitis saptanmıştır. Dişlerin kök gelişimlerinin Cvek’e göre evre 4’te olduğu belirlenmiş ve RET uygulamasına karar verilmiştir. İlk seansta dişlere yandan perfore irrigasyon iğnesi ile 20 ml %2.5’luk NaOCl, 5 ml salin ve 20 ml %17’lik EDTA ile irrigasyon uygulanmış ve medikament olarak kalsiyum hidroksit kullanılmıştır. Üç hafta sonra herhangi bir semptom olmadığı belirlenip, 20 ml %17’lik EDTA ve 5 ml salin ile irrigasyonunun ardından apikalden #30 H-file eğe ile 3mm taşılmıştır, yeterli kanama sağlanamadığı için, otolog kandan PRF (Trombositten Zengin Fibrin) elde edilmiş ve plugger yardımıyla kanala yerleştirilmiştir. Koronal üçlüye 4 mm MTA yerleştirilmiş ve daimi restorasyon yapılmıştır. Dokuzuncu ayda dişlerin asemptomatik olduğu, apikal dokularda iyileşme ve dentin duvarlarında kalınlaşma saptanmıştır.SONUÇLAR: Devital immatür daimi dişlerde RET klinik uygulama ve başarı hedefleri açısından avantajlara sahiptir. Doku iskeleti seçiminin başarı üzerindeki etkisini değerlendiren uzun dönem takipli çalışmalara ihtiyaç duyulmaktadır.Anahtar Kelimeler: rejeneratif endodontik tedavi, MTA, immatür diş, PRFINTRODUCTION: Regenerative endodontic treatment (RET) is therapeutic approach for devital immature permanent teeth, aiming to maintain root development and restoring pulp vitality. This treatment is based on the components of tissue engineering; stem cells, scaffold, and growth factors. This case report presents RET outcomes in immature teeth with trauma-related pulp necrosis.CASE REPORT: A healthy 12-year-old patient presented with aesthetic complaints. Anamnesis, revealed crown fractures in teeth 11-21 two years ago. On clinical examination, the teeth were sensitive to percussion but non-responsive to vitality tests. Additionally, a fistula was observed on the buccal mucosa of tooth #11. Radiographic evaluation showed chronic apical periodontitis in both teeth. According to Cvek, root development was stage 4, and RET was planned. In the first session, irrigation was applied using 20 ml of 2.5% NaOCl, 5 ml of saline, and 20 ml of 17% EDTA, calcium hydroxide was applied as intracanal medicament. After three weeks, with the absence of symptoms, irrigation with 17% EDTA and saline was applied. Apical bleeding induced using a #30H-file. Inability to provide adequate bleeding, PRF (Platelet-Rich Fibrin) was placed into the canal. A 4 mm MTA was placed over the coronal third, and permanent restoration was completed. At nine months, the teeth were asymptomatic, with evidence of apical healing and continued root development.CONCLUSIONS: RET offers advantages in the clinical management and success outcomes of devital immature permanent teeth. Long-term follow-up studies are needed to evaluate the effect of scaffold type on success.Keywords: regenerative endodontic therapy, MTA, immature tooth, PRF</div