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PSYCHOSOCIAL INTERVENTIONS TO SUPPORT POST-TRAUMATIC GROWTH IN WOMEN VICTIMS OF VIOLENCE
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Planlı Gebeliği Olan Kadınların Prekonsepsiyonel Dönemdeki Yaşam Tarzı Değişikliklerinin Gebelik Sonuçlarına Etkisi: Retrospektif Bir Çalışma
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Effectiveness of a Dysphagia Management Education Program for Caregivers of Stroke Patients Receiving Home Care: Randomized Controlled Study
No full textBackground and purpose: Stroke is one of the leading causes of long-term disability worldwide, and dysphagia is a frequent complication that negatively affects both patients and their caregivers. Caregivers often lack sufficient knowledge and skills in managing dysphagia, which may increase caregiving burden and adversely affect patients’ recovery. This randomized controlled experimental study was conducted to evaluate the effects of dysphagia management training provided to caregivers of stroke patients receiving home care. Materials and methods: The sample size was determined through power analysis. Eligible participants were randomly assigned to the intervention group (n = 42) and the control group (n = 42) using a simple randomization method. Questionnaires were administered to both groups at baseline, the first month, and the third month. Results: The study revealed significant differences between the intervention and control groups in all primary outcomes, including the Mini Nutritional Assessment–short form (effect size = 0.875), Zarit caregiver burden scale (effect size = 0.895), SF-36 quality of life questionnaire (effect size = 0.950), and dysphagia management information form (effect size = 0.921; all P < .001). Caregivers in the intervention group reported a significantly lower caregiving burden, higher quality of life, and greater knowledge of dysphagia management, while patients demonstrated better nutritional status compared to those in the control group. Conclusion: Routine assessment of caregivers’ knowledge of dysphagia management and providing training to those caring for stroke patients before discharge is recommended. Such interventions are anticipated to yield positive outcomes for both patients and caregivers and contribute to reducing healthcare expenditures
N-metil-N-nitro-N-nitrosoguanidin (MNNG) ile Uyarılan Sıçan Mide Kanseri Modelinde Sevofluranın Etki Mekanizmasının Değerlendirilmesi
No full textBiocontrol potential of Vibrio maritimus chitinase: Heterologous expression and insecticidal activity against Acanthoscelides obtectus
No full textIn this study, the chitinase gene from the marine bacterium Vibrio maritimus was heterologously expressed in Escherichia coli, purified via affinity chromatography and tested for its insecticidal activity against the storage pest Acanthoscelides obtectus. The recombinant VmChiA protein exhibited a molecular mass of ∼60 kDa, with optimum activity observed at pH 6.0 and 40 °C. Enzyme kinetic analysis revealed a Km value of 0.042 mM, Vmax of 17.48 μmol min−1, kcat of 1.75 min−1 and catalytic efficiency of 41.61 mM−1 min−1, respectively. Furthermore, a dose of 40 U mL−1 of recombinant VmChiA showed similar efficacy to malathion insecticide against A. obtectus, with 100 % mortality in both treatments. LC50 and LC90 values of VmChiA were 13.95 U mL−1 and 27.66 U mL−1, respectively. Furthermore, the three-dimensional structure of the catalytic site of VmChiA was modeled. Molecular dynamics simulation technique was used to explore and analyze the dynamics and interactions. A salt bridge (GLU274-ARG296) in the α + β domain was observed as a critical feature facilitating substrate (GlcNAc)2 binding and enzymatic activity. These findings demonstrate that recombinant VmChiA possesses potent insecticidal properties, highlighting its potential as a bio-based, eco-friendly alternative for managing significant agricultural pests
