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SİGARA KULLANMAYAN GENÇ KADINDA GÖRÜLEN YAYGIN EVRE KÜÇÜK HÜCRELİ AKCİĞER KANSERİ OLGUSU: FARKLI BİR HASTALIK PROFİLİ VE KİŞİSELLEŞTİRİLMİŞ TEDAVİ FIRSATI?
No full textA comment on oral vs. nasal intubation and post-extubation laryngeal injury
No full textA comment on oral vs. nasal intubation and post-extubation laryngeal injuryNurullah TÜRE1To the editor,I read with great interest the report by Meena & Gill [1], which prospectively and commendably under clinician blind- ing assessed early laryngoscopic findings after extubation. The pragmatic design and timely endoscopic verification make a useful contribution to the perioperative airway litera- ture. However, two clarifications would strengthen reproduc- ibility and align the conclusions with the study’s design.The analysis records “intubation duration,” which appears to reflect time to achieve intubation rather than the total time patients remained intubated during surgery the latter being the physiologically relevant dose for pressure and friction- mediated injury. Crucially, cuff pressure (and its time course) was not measured. Because both total intubation time and cuff pressure-time exposure are primary determinants of mucosal ischemia and contact trauma, their omission likely induces nondifferential exposure misclassification, biasing route comparisons toward no difference. Even if the two routes truly differ under longer anesthesia or higher cuff pres- sures, the current specification would dilute that signal. Mini- mal remediation is possible by reporting anesthesia/airway time from records, stratifying by case length, and conducting sensitivity analyses that model plausible cuff-pressure ranges.Airway route was chosen by surgical indication and anes- thesiologist preference a classic confounding by indication setting. With a modest sample and few moderate-to-severe events, a standard multivariable model cannot reliably con- trol imbalances in case mix (operative field, positioning, instrumentation such as Magill forceps, operator effects In this context, a non-significant p-value is not evidence of equivalence; it only indicates insufficient power to detect a difference. An appropriate inference framework would pre- specify a clinically meaningful non-inferiority margin (e.g., absolute risk difference ≤ 10%), estimate effect sizes with 95% CIs, and use balancing methods (propensity scores/ IPTW) to address allocation bias. Absent these elements, concluding that routes “demonstrated comparable rates and severity” overstates what the design can support.Re-analyzing the cohort with total intubation time and a cuff-pressure proxy, balanced route comparison, and effect-size/CIs within a non-inferiority framework would align statistical claims with physiologic plausibility and strengthen the paper’s clinical takeaway without altering its prospective spirit.</div
In vitro evaluation of microleakage for different cementation materials used in prefabricated zirconia crowns
No full textBackground: Microleakage is a significant factor that leads to the failure of full-coronal restorations. Moreover, the choice of cementation material may affect microleakage. This study aimed to evaluate microleakage in prefabricated zirconia crowns (PZCs) when cemented with different luting cements. Methods: Thirty-six freshly extracted primary maxillary incisors were prepared for PZCs. The teeth were randomly divided into three groups (n = 12) to be lutation with one of two different resin-modified glass ionomer cements (Ketac Cem Plus and FujiCEM Evolve) or a self-adhesive resin cement (RelyX U200). After the cementation process, the teeth were thermocycled 6000 times at temperatures ranging from 5◦C to 55◦C with a dwell time of 15 seconds and a transfer time of 10 seconds, immersed in basic fuchsin solution and then sectioned buccolingually. Subsequently, the sections were scored based on observations made using a stereomicroscope at 30× magnification. Statistical analysis was conducted using one-way analysis of variance and the independent two-sample t-test. The significance level was set at p < 0.05. Results: The lowest microleakage score was attained by the self-adhesive resin cement group (mean 1.00). No statistically significant differences were found among the groups (p = 0.467). Moreover, no statistically significant difference was observed between the microleakage scores for the primary central and lateral teeth, regardless of the cementation material used (p = 0.314). Conclusions: According to the outcomes of this study, self-adhesive resin cements may be a promising alternative to resin-modified glass ionomer cements
Symptoms of Fibromyalgia Syndrome have Effects on Pain Grade
No full textObjective To define different pain grades in individuals with fibromyalgia syndrome (FMS) and investigate the effects of pain degree on disease impact, kinesiophobia, pain-related concerns and quality of life. Materials and methods This cross-sectional and descriptive study was conducted with a total of 93 female individuals with FMS. The individuals with FMS were grouped according to different pain grades using the Graded Chronic Pain Scale. Clinical impact was assessed among these groups in terms of the following outcome measures: disease impact, kinesiophobia, pain-related concerns and quality of life. Results Of the individuals with FMS, 30 were included in the mild pain group, 13 in the bothersome pain group, and 50 in the high-impact pain group. There were significant differences between these three groups in terms of disease impact (p<0.001), kinesiophobia (p<0.001), pain-related concerns (p=0.017), the physical component of quality of life (p=0.007)and the mental component of quality of life (p<0.001). Disease impact, kinesiophobia and pain-related concern levels were higher in the high-impact pain group than in the mild and bothersome pain groups. The physical and mental component score of quality of life was lower in the high-impact pain group than in the mild group. Conclusions Individuals with FMS with different pain grades differ in terms of disease impact, kinesiophobia levels, pain-related concerns and quality of life levels. The differentiation of pain grades may be important for the evaluation process and specific treatment planning
Betaine induces apoptosis via ROS-independent mechanisms in U87 glioblastoma cells: a potential metabolic anticancer strategy
No full textMetastatik Nazofarenks Kanserinde Setuksimab Monoterapisi İle Uzun Süreli Remisyon Sağlanan Olgu
No full textThe Effect of Sex on the Turkish Voice Spectrum
No full textObjective: The Long-Term Average Spectrum (LTAS) of voice is a functional method used to discriminate various voice qualities. In this study, the voice quality characteristics of Turkish female and male speakers were examined and compared through voice spectra created with LTAS. Material and Methods: 30 male and 30 female speakers with typical voices, aged 18 to 50, were required to read a text at a habitual pitch and loudness. The recorded speech samples were used to create voice spectra containing 75 bands with a bandwidth of 160 Hz and covering the range from 0 to 12 kHz. The spectral tilt (ST) of the voice spectra was also compared between the sexes. Results: Multiple comparisons revealed that there were significant intensity differences between sexes at the band regions of 0–160 Hz, 160–320 Hz, 640–960 Hz, 2880–3040, 4000–5120 Hz where females had higher intensities than males except for the band of 0–160 Hz. STs of females were found to be significantly lower than those of males. Conclusion: All significant band differences between the sexes were below 6 kHz, and both sexes had a rather flat-spectrum above 6 kHz. Females had significantly higher intensities around the region of 2880–3040 Hz, because of aspiration noise caused by the possible posterior glottal gap during phonation. Females had shallower STs than males, indicating that females had greater hyperfunctional voice quality. The voice spectrum characteristics of Turkish speakers were compared with those of other studies and found more similarities with Spanish than Persian
