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Harmonic trigonometrically convexity
No full textIn this study, we introduce and study the concept of harmonic trigonometrically convex functions and their some algebric properties. We prove two Hermite-Hadamard type inequalities for the newly introduced class of functions. We also obtain some refinements of the Hermite-Hadamard inequality for functions whose first derivative in absolute value, raised to a certain power which is greater than one, respectively at least one, is harmonic trigonometrically convex
Design, synthesis, antioxidant and anticholinesterase activities of novel isonicotinic hydrazide-hydrazone derivatives
No full textThe design and synthesis of hydrazone derivatives are increasing in popularity day by day due to the significant biological activities of this scaffold. In the present study, twelve novel isonicotinic hydrazide-hydrazone analogues were synthesized by the condensation reaction of isonicotinic hydrazide with ben-zaldehyde possessing sulfonate moiety. The structures of the novel compounds have been characterized in detail using spectroscopic techniques. All compounds have shown inhibitory effects against the AChE en-zyme at rates ranging from 21.00 to 59.48%. Among them, compound 5 has exhibited the best inhibitory effect of 59.48% against AChE at a concentration of 0.1 mM. Furthermore, to determine how effective the novel compounds are as antioxidants, FRAP and DPPH studies were also carried out. FRAP values in compounds 1-12 were found to range from 26.989-3415.556 mu mol FeSO4.7H2O/mg. They also displayed moderate antioxidant potential in the range of SC50= 0.03-87.32 mg/mL compared with the control Trolox (SC50 = 0.004) in DPPH radical scavenging activities. It was seen that the AChE inhibition percentages of the compounds were in the range of 23.04-58.10% at 0.1 mM concentration. This is the first research on the synthesis, antioxidant and enzyme inhibition properties of these compounds. (c) 2023 Elsevier B.V. All rights reserved
Investigation of the effects of changes in formulation and cooking times on the quality parameters in the production of goji berry leather
No full textGoji berry (Lycium barbarum L.) is described as a food with several health benefits. This valuable fruit has been processed into fruit leather, which is one of the important traditional products. This study allowed us to determine the effect of changing formulations (starch and flour) and cooking times (10, 15, and 20 min) on quality criteria during goji berry leather production. The goji berry leather samples exhibited the following characteristics: pH values ranging from 4.96 to 4.99, titration acidity values spanning from 2.97% to 3.23%, dry matter content within the range of 84.78% to 87.69%, ash content between 3.12%, and 4.27%, water activity (a(w)) values ranging from 0.37 to 0.38, protein content between 14.71%, and 15.66%, HMF content varying from 17.33 mg/kg to 34.51 mg/kg, total phenolic content ranging from 7.14 mg GAE/g to 7.89 mg GAE/g, total sugar content falling between 61.18%, and 63.89%, reducing sugar content within the range of 60.13% to 61.89%, sucrose content ranging from 0.91% to 2.25%, thickness values ranging from 0.74 mm to 0.89 mm, hardness values varying between 17.09, and 33.27, stickiness values within the range of 4.10 to 23.34, cohesiveness values from 0.85 to 1.00, elasticity values ranging from 0.88 to 0.97, chewability values spanning from 12.85 to 30.85, L(* )values ranging from 27.27 to 32.66, a* values between 8.62, and 10.32, b*values varying from 7.06 to 8.59, C* values within the range of 11.15 to 12.81, and H degrees values falling between 39.31, and 41.13. Following the sensory evaluation of leather samples, it was determined that the color score ranged from 3.80 to 4.27, the smell score fell between 3.53 and 4.00, the taste score varied from 2.93 to 4.00, the mouthfeel score ranged from 2.93 to 3.93, and the general acceptability score was found to be within the range of 3.27 to 4.20. It was determined that cooking time and additional additives affect some quality values of the goji berry leather.Scientific Research Project (BAP) of Bayburt University [2018/01-69001-26]This study was supported by Scientific Research Project (BAP) of Bayburt University with the project number 2018/01-69001-26
How Does Cynicism Mediate Spiritual Leadership and Organizational Commitment? The Case of Turkish and Indonesian Universities
No full textThis study seeks to determine the role of cynicism in the relationship between the perceived spiritual leadership of university employees and their organizational commitment. Because of the international nature of the problem at hand-university staff in Turkey and Indonesia who are engaged in ongoing educational activities-a comparison strategy predicated on cultural differences was favored. The study utilized correlation analysis and normal distribution determination in SPSS, and structural equation modeling in AMOS to reveal regression relations. Findings suggest that academics in Turkey and Indonesia are more committed to their institutions when they have a positive perception of the organization's spiritual leadership. Likewise, when university employees perceive cynicism in the organization, their commitment to spiritual leadership and the organization reduces. In other words, cynicism appears to partially mediate the relationship between spiritual leadership perception and organizational commitment in both countries
Türkiye’deki Profesyonel ve Amatör Lig Futbolcularının Organik Gıda Tercihlerinin Belirlenmesi
No full textBu çalışmanın amacı amatör ve profesyonel liglerde futbol oynayan sporcuların organik gıda tercihlerini, medeni durum, oynadığı lig, yaş, spor yaşı, eğitim durumu, kronik sakatlık durumu, oynadığı mevki, gelir düzeyi gibi değişkenler açısından incelenmiştir. Çalışma, amatör liglerde oynayan 838, profesyonel liglerde oynayan 233, toplamda 1071 futbol oyuncusu üzerinde gerçekleştirilmiştir. Çalışmada veri toplama aracı olarak Kişisel Bilgi Formu, “Organik ürün tüketimini etkileyen faktörler ve tutumlar üzerine bir saha çalışması” (Sarıkaya, 2007), “Erciyes Üniversitesi İİBF akademik ve idari personeli ile İİBF işletme gündüz ve ikinci öğretim öğrencilerinin organik ürünleri algılamaları” (Kacur, 2009) ölçekleri kullanılmıştır. Verilerin analizinde iki bağımsız değişken arasındaki anlamlı farkın olup olmadığını belirlemek amacı ile t-Test kullanılmıştır. Birden fazla bağımsız değişkenin kendi aralarındaki ilişkiyi belirlemek amacı ile Anova, hangi grupların arasında anlamlı fark olduğu ise Tukey Post Hoc testi uygulanmıştır. Sonuçta katılımcılarım medeni durum, kronik hastalık durumu, yaş, eğitim durumu, oynadığı lig ve gelir durumu değişkenlerinde anlamlı fark tespit edilmiştir. Bununla birlikte katılımcıların organik gıdalar hakkında bilgi sahibi oldukları ve organik gıdaları sağlıklı buldukları sonucuna da ulaşılmıştır
Modified distance optimization method for the asymmetric bioreduction conditions of phenyl(thiophen-2-yl)methanone by Weissella paramesenteroides N7
No full textChirality plays a significant part in life since it is closely linked to carrying out the many metabolic processes that make up a living being. Chiral secondary alcohols such as diaryl-, aryl heteroaryl-, and diheteroaryl are employed in pharmaceuticals as drug intermediates. Although biocatalytic asymmetric reduction of prochiral ketones containing aromatic and heteroaromatic groups is widely known, biocatalytic reduction of heteroaromatic prochiral ketones containing sulfur heteroatoms is rarely known. Very few studies exist in the literature, including the biocatalytic reduction of phenyl(thiophen-2-yl) methanone (1). Moreover, the biocatalytic reduction of 1 with a mathematical modelling and optimization technique is unknown until now. In this study, Weissella paramesenteroides N7 biocatalyst for the asymmetric bioreduction of 1 using a novel modified distance optimization method. Optimization conditions were found as pH = 6.46, temperature = 26 degrees C, incubation period = 71 h, agitation speed = 200 rpm by the modified distance optimization method, and it was determined that the conversion and enantiomeric excess (ee) under these conditions could be 98.7% and 98%, respectively. Under these proposed optimization conditions, (S)-phenyl(thiophen-2-yl)methanol ((S)-2) was obtained with >99% ee, >99% conversion, and 97% yield. In addition, 11.29 g of 1 was completely converted into (S)-2 (11.07 g, 97% isolated yield) under optimized conditions. This is the first report about the fabrication of enantiopure (S)-2 in high gram scale using a biocatalyst and a novel modified distance optimization technique. In this study, the successful applicability of the new modified distance optimization method in biocatalytic asymmetric reduction reactions has been successfully demonstrated. (c) 2023 Elsevier Ltd. All rights reserved
Exome-Wide Association Study of Competitive Performance in Elite Athletes
No full textThe aim of the study was to identify genetic variants associated with personal best scores in Turkish track and field athletes and to compare allelic frequencies between sprint/power and endurance athletes and controls using a whole-exome sequencing (WES) approach, followed by replication studies in independent cohorts. The discovery phase involved 60 elite Turkish athletes (31 sprint/power and 29 endurance) and 20 ethnically matched controls. The replication phase involved 1132 individuals (115 elite Russian sprinters, 373 elite Russian endurance athletes (of which 75 athletes were with VO2max measurements), 209 controls, 148 Russian and 287 Finnish individuals with muscle fiber composition and cross-sectional area (CSA) data). None of the single nucleotide polymorphisms (SNPs) reached an exome-wide significance level (p < 2.3 x 10(-7)) in genotype-phenotype and case-control studies of Turkish athletes. However, of the 53 nominally (p < 0.05) associated SNPs, four functional variants were replicated. The SIRT1 rs41299232 G allele was significantly over-represented in Turkish (p = 0.047) and Russian (p = 0.018) endurance athletes compared to sprint/power athletes and was associated with increased VO2max (p = 0.037) and a greater proportion of slow-twitch muscle fibers (p = 0.035). The NUP210 rs2280084 A allele was significantly over-represented in Turkish (p = 0.044) and Russian (p = 0.012) endurance athletes compared to sprint/power athletes. The TRPM2 rs1785440 G allele was significantly over-represented in Turkish endurance athletes compared to sprint/power athletes (p = 0.034) and was associated with increased VO2max (p = 0.008). The AGRN rs4074992 C allele was significantly over-represented in Turkish sprint/power athletes compared to endurance athletes (p = 0.037) and was associated with a greater CSA of fast-twitch muscle fibers (p = 0.024). In conclusion, we present the first WES study of athletes showing that this approach can be used to identify novel genetic markers associated with exercise- and sport-related phenotypes.Gazi University Rectorate (Scientific Research Projects Coordination's Unit) [TCD-2021-7116]This research received no external funding
Evaluation of Noise Levels in Flour Factories in Terms of Occupational Health and Safety
No full textThis study aims to determine the daily noise exposure levels in flour mills and evaluate the effects on the health and safety of workers. The study measured the equivalent sound pressure levels of workers exposed in two flour mills operating in Konya province in dBA. The factories include machines with high noise levels, such as sifters, sieves, and rollers. A Type-2 class sound pressure level meter was used in the measurements taken in accordance with ISO 9612: 2009 standard. Based on the measured values, the A-weighted equivalent sound pressure levels were determined, and the daily personal noise exposure levels were calculated taking into account the working hours. It was determined that the equivalent sound pressure levels and the daily individual noise exposure levels of the workers were in the range of 88.2-97.7 dBA and 87.9-97.4 dBA, respectively, and above the minimum daily personal exposure limit (80 dBA) specified in the legislation. As a result of the study, it was evaluated that the noise in flour mills can negatively affect the health and safety of workers as well as their job performance
KİLİKYA ERMENİLERİNİN ÇUKUROVA’DAKİ İKTİSADÎ FAALİYETLERİ
No full textKilikya olarak da isimlendirilen Çukurova, stratejik konumundan dolayı tarih boyunca önemli bir bölge oldu. Bu coğrafyaya hâkim olmak isteyen birçok devlet ve topluluğun içinde Ermeniler de vardı. Ermeniler, 1071 Malazgirt Savaşı’ndan sonra Anadolu’daki yer değişimi neticesinde Çukurova’ya geldiler ve bölgede kendi hakimiyetlerini sağlamaya çalıştılar. Siyasî ilişkilerin yanında varlıklarını gösterebilme adına iktisadî kalkınmaya önem verdiler. İktisadî başarıyla da bölgedeki siyasî varlıklarını daha sağlam zemine oturtmaya çaba sarf ettiler. Bu kapsamda verimli ve zengin Çukurova topraklarını amaçlarına uygun olarak kullandılar. Bu zenginlikten en üst düzeyde fayda sağlamaya çalışan Ermeni hânedân liderleri, tarım ve hayvancılıktan madenciliğe kadar birçok iktisadî girişimde bulundular. Bu şekilde hem bölgeye dikkat çekmeyi hem de söz konusu zenginlikten siyasî noktada bir sonuç almayı hedeflediler. Ermeniler, bu kapsamda bölgenin her türlü ürününü ticarileştirdiler. Ayrıca başta Ceneviz ve Venedik olmak üzere çeşitli tüccar gruplarına yönelik iskân ve vergi muafiyeti tanıdılar. Böylece Çukurova’nın ticarî potansiyelini artırmaya yönelirken bölge ticareti ve ticaret yollarını da kendi kontrollerine almak için uğraş verdiler. Bu girişimlerini kanunlarla da destekleyen Ermeniler, kanunnâmeler ilan etiler. Böylece ticarî alanda düzen sağlayıp daha fazla gelir elde etmeyi amaçladılar. Bu çalışma, Kilikya Ermenilerinin XI. yüzyılın sonunda bölgeye gelip yerleşmelerinin akabinde söz konusu iktisadî kalkınma konusunda neler yaptığını ve hangi faaliyetlerde bulunduğunu ele almaktadır
Characterization of Bee Bread Produced with Defined Starter Cultures Mimicking the Natural Fermentation Process
No full textBee bread is a product with unique properties for humans and bees that is produced through the fermentation of pollen in the honeycomb, mainly caused by lactic acid bacteria (LAB) and yeast strains present in the environment. It is a rich source of nutrients such as proteins, polyphenols and vitamins. Despite the potential nutritional value of bee bread, it is consumed at low levels, as harvesting bee bread from the hives is costly and difficult. This study aimed to produce a standard bee bread by using different strains of the fructophilic lactic acid bacteria (FLAB) Lactobacillus kunkeei and the yeasts Starmeralla magnolia MP-2 and Zygosaccharomyces siamensis MP-14, previously isolated from bee products. In this context, bee bread was produced from pollen by solid-state fermentation using selected FLAB and yeast species, which were then compared with spontaneously developed and commercially available bee bread in terms of microbial stability, physicochemical properties, total phenolic component amounts, in vitro digestibility and amino acid profiles. As a result, it was determined that bee bread made from bee pollen fermented with starter cultures showed improved characteristics than commercial bee bread and was more advantageous in terms of absorption as well as production processes.Yildiz Technical University Scientific Research Projects (BAP) [FYL-2021-4330]This research was funded by Yildiz Technical University Scientific Research Projects (BAP) with the project number FYL-2021-4330