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Assessment of glass
No full textEspecially for new-generation buildings, since esthetic appearance as well as thermal comfort is essential, glass materials have been widely used as building materials in buildings. Due to its superior optical properties, it is preferred in buildings, especially in window areas. On the other hand, the heat losses and gains and light transmission rates from the glass used in the building envelopes and especially in the window areas are very effective on the energy efficiency of the buildings. Therefore, innovative glass technologies are developed and used in new smart buildings. In this context, the most preferred glass technologies are laminated glass and tempered glass for the building envelope. For window areas, it can be listed as low emissivity glasses, high-technology glasses, vacuum glasses, glasses with phase change materials and insulated glasses.The use of new-generation glass technologies instead of traditional glass technologies provides significant benefits to users regarding economic, environmental, and social effects. © 2024 Elsevier Ltd. All rights reserved
Durability of slag-based alkali-activated materials: A critical review
No full textAs the world becomes increasingly aware of the devastating effects of climate change, the need for sustainable building materials that are both durable and environmentally friendly increases. Geopolymer and alkali-activated materials formed by a chemical reaction between an alkaline activator solution and an aluminosilicate source have gained popularity in recent years. The alkaline activator solution dissolves the aluminosilicate source, which then undergoes a polycondensation reaction to form a three-dimensional geopolymeric gel network. The development of this network ensures the strength and durability of the material. Today, this phenomenon of durability has been studied in detail to enable the development of superior construction materials, taking into account degradation mechanisms such as carbonation, leaching, shrinkage, fire, freezing and thawing, and exposure to aggressive environments (chlorides, acids, and sulphates). Although there are many unsolved problems in their engineering applications, slag-based alkali-activated materials appear to be more advantageous and are promising as alternative materials to ordinary Portland cement. First of all, it should not be ignored that the cure sensitivity is high in these systems due to compressive strength losses of up to 69%. Loss of strength of alkali-activated materials is considered an important indicator of degradation. In binary precursors, the presence of fly ash in slag can result in an improvement of over 10% in compressive strength of the binary-based alkali-activated materials after undergoing carbonation. The binary systems can provide superior resistance to many degradation mechanisms, especially exposure to high-temperature. The partial presence of class F fly ash in the slag-based precursor can overcome the poor ability of alkali-activated materials to withstand high temperatures. Due to the desired pore structure, alkali-activated materials may not be damaged even after 300 freeze-thaw cycles. Their superior permeability compared to cementitious counterparts can extend service life against chloride corrosion by more than 20 times. While traditional (ordinary Portland cement-based) concrete remains the most widely used material in construction, geopolymer concrete's superior performance makes it an increasingly emerging option for sustainable and long-lasting infrastructure.Izmir Democracy UniversityNo Statement Availabl
Exploring the Potential of Isoindole-1,3-Dione Derivatives as Novel Inhibitors of Aldose Reductase: An In Silico and In Vitro Insight into Therapeutic Strategies for Diabetic Complications
No full textThis study explores the potential of isoindole-1,3-dione derivatives as novel inhibitors of aldose reductase (AR), focusing on their in silico and in vitro effects for therapeutic strategies against diabetic complications. Aldose reductase, a critical enzyme in the polyol pathway, plays a significant role in glucose metabolism and has been linked to diabetic complications. In this comprehensive study, isoindole-1,3-dione derivatives were synthesized and evaluated for their inhibitory effects on the recombinant human AR enzyme. The compounds’ inhibitory activities were measured both in vitro and through in silico techniques, employing molecular docking and free binding energy calculations and ADME studies. The newly synthesized compounds demonstrated varied inhibitory effects, with ethyl and phenyl substituents at specific positions enhancing inhibitory activity. Notably, compounds with carboxylic acid derivatives exhibited potent inhibitory effects, especially compound 6 with an IC50 value of 1.649 ?M. In conclusion, this study provides valuable insights into the inhibitory potential of isoindole-1,3-dione derivatives against AR, suggesting their potential therapeutic application in mitigating diabetic complications. The combination of experimental and computational approaches offers a comprehensive understanding of the compounds’ interaction mechanisms and pharmacokinetic profiles, supporting their further exploration as antidiabetic agents. © 2024 Wiley-VCH GmbH
Evaluation of miR-130b-3p and miR-375 levels and telomere length with telomerase activity in prostate cancer
No full textProstate cancer (PC) is the most frequent cancer in males, as well as the second highest cause of cancer-related deaths in men. Differences in expression levels of miRNAs were linked with prostat cancer pathogenesis. qPCR was used to evaluate the expression of miR-130b-3p and miR-375 in Benign Prostate Hyperplasia (BPH (n = 20) and PC (n = 22, pre- and post-operative) patients plasma. Relative telomere lengths (RLTs) in genomic DNA isolated from plasma were measured with qPCR, and telomerase activity analyzed by the ELISA method. PSA levels of PC patients were greater than of BPH patients (p = 0.0473). miR-130b-3p and miR-375 levels were significantly lower in pre-operative specimens of PC patients according to BPH (p = 0,0362, p = 0.0168, respectively). Similarly, post-operative miR-375 levels were lower in PC patients than in BPH patients (p = 0.1866). BPH patients had shorter RTLs than PC patients in both pre- (p=0.0438) and post-operative (p=0.0297) specimens. Telomerase activity was higher in PC patients than BPH(p = 0.0129). Interestingly, telomerase activity was further increased after surgery (p = 0.0003). We aim to identify the levels of miR-130b-3p and miR-375 expression and their relationship with telomerase activity in PC patients. Our data suggest that miRNAs and telomere length (TL) with telomerase activity may play a role in regulating prostate tumorgenesis and may be used as biomarkers for PC diagnosis
Examination of aerobic and anaerobic capacities and football-specific technical skills of young football players
No full textLisansüstü Eğitim Enstitüsü, Beden Eğitimi ve Spor Ana Bilim Dalı, Beden Eğitimi ve Spor Bilim DalıBu aras?tırmanın amacı genç futbolcuların aerobik ve anaerobik kapasiteleri ve futbola özgü teknik becerilerinin incelenmesidir. Bu araştırmada nicel araştırma yöntemlerinden tarama modeli kullanıldı. Araştırmanın örneklem grubu Bayburt Özel İdare Spor Kulübü U-19 kategorisinde futbol oynayan 38 futbolcudan oluşturuldu. Futbolculardan antropometrik ölçümler (boy, kilo), anaerobik testler (dikey sıçrama testi, esneklik testi, illinois çeviklik testi, bacak kuvvet testi, yıldız denge testi), aerobik test (cooper testi) ve Mor-christian genel futbol yetenek testi (top sürme, şut ve pas isabeti) ölçümleri alındı. Araştırma sonucunda elde edilen ölçüm sonuçları SPSS 22 paket programına aktarılarak öncelikle normallik testi uygulandı. Yapılan ölçümlerde elde edilen verilerin ortalama ve standart sapma değerleri hesaplandı. Elde edilen sonuçlara göre veri dağılımının çarpıklık ve basıklık değerleri, Tabachnick ve Fidell (2013)'in bir verinin normal dağılıp dağılmadığının göstergesi olarak bildirdiği -1,5 ile + 1,5 arasında olduğu görüldü ve verilerin normal dağılım gösterdiği anlaşıldı. Normal dağılım gösteren bu veri setlerinin analizlerinde parametrik testlerden One Away Anova (Tek Yönlü Varyans Analizi) ve descriptives testleri yapıldı. Sporculara uygulanan testler sonucunda futbolcuların anaerobik testleri (çeviklik, esneklik, bacak kuvvet, dikey sıçrama ve yıldız denge) aerobik testi(dayanıklılık) futbola özgü becerilerin ve yeteneklerin (top sürme, şut ve pas isabeti) uygulanması üzerinde sırasıyla (p<,000-, p<,000-, p<,000) anlamlı farklılık olduğu bulgularına ulaşıldı. Çalışmanın sonucu olarak motor becerlerilerin (çeviklik, esneklik, kuvvet, dayanıklılık ve güç) futbola özgü teknik becerileri (top sürme, şut ve pas isabeti) olumlu yönde etkilediği düşünülmektedir.The purpose of this research is to examine "the aerobic and anaerobic capacities of young football players and football-specific technical skills". In this research, survey model, one of the quantitative research methods, was used. The sample group of the research consisted of 38 athletes playing football in the U-19 category of Bayburt Special Administration Sports Club. Football players were asked to take anthropometric measurements (height, weight), anaerobic tests (vertical jump test, flexibility test, Illinois agility test, leg strength test, star balance test), aerobic test (cooper test) and Mor-christian general football ability test (dribbling, shooting and passing accuracy) measurements were taken. The measurement results obtained as a result of the research were transferred to the SPSS 22 package program and the normality test was first applied. The mean and standard deviation values of the data obtained from the measurements were calculated. According to the results obtained, the skewness and kurtosis values of the data distribution were found to be between -1.5 and + 1.5, which Tabachnick and Fidell (2013) reported as an indicator of whether a data was normally distributed or not, and it was understood that the data showed a normal distribution. In the analysis of these normally distributed data sets, parametric tests such as one away anova and descriptives tests were performed. As a result of the tests applied to the athletes, the football players' anaerobic tests (agility, flexibility, leg strength, vertical jump and star balance), aerobic test (endurance) and football-specific skills and abilities (dribbling, shooting and passing accuracy) were respectively (p<,000-, p<,000-, p<,000) It was found that there was a significant difference. As a result of the study, it is thought that motor skills (agility, flexibility, strength, endurance and power) positively affect football-specific technical skills (dribbling, shooting and passing accuracy)
Examination of the relationship between exercise addiction levels of sports science students, happiness and life satisfaction (Bayburt province sample)
No full textLisansüstü Eğitim Enstitüsü, Beden Eğitimi ve Spor Ana Bilim Dalı, Beden Eğitimi ve Spor Bilim DalıBu çalışmanın amacı spor bilimleri fakültesinde öğrenim gören öğrencilerin egzersiz bağımlılık düzeylerinin, mutluluk ve yaşam doyumu düzeyleri arasındaki ilişkinin incelenmesi ve bu verilerin demografik değişkenler açısından incelenmesi oluşturmaktadır. Araştırma grubunu 213 katılımcı oluşturmaktadır. Araştırmada veri toplama aracı olarak; "Kişisel Bilgi Formu", "Egzersiz Bağımlılık Ölçeği", "Oxford Mutluluk Ölçeği Kısa Formu" ve "Yaşam Doyumu Ölçeği" kullanılmıştır. Verilerin analizinde yüzde frekans dağılımları, ikili bağımsız grupların karşılaştırması için t-testi, ikiden fazla bağımsız gruplar için One-Way ANOVA ve ölçekler arasındaki ilişkiyi tespit edebilmek için Pearson korelasyon analizi kullanılmıştır. Araştırma sonuçlarına göre katılımcıların yaş ve spor yaşı değişkenleri ile egzersiz bağımlılık ölçeği alt boyutları ve toplam puanları arasında istatistiki ilişkiye rastlanmıştır. Haftalık egzersiz yapma sıklığı ile egzersiz bağımlılık ölçeği toplam puanları arasında ilişkiye, egzersiz bağımlılığı bireysel-sosyal ihtiyaçların ertelenmesi ve çatışma alt boyutu arasında istatistiki açıdan ilişkiye rastlanmamıştır. Öğrenim görülen bölüm ve egzersize başlama nedeni ile egzersiz bağımlılık düzeylerine ilişkin yalnızca bireysel-sosyal ihtiyaçların ertelenmesi ve çatışma alt boyutunda istatistiki açıdan anlamlı farklılık olduğu bulunmuştur. Cinsiyet ve spor türü ile egzersiz bağımlılığı tüm alt boyutları ve toplam puanları arasında istatistiki açıdan anlamlı farklılığa rastlanmamıştır. Yaş, haftalık egzersiz yapma sıklığı, algılanan gelir düzeyi ve egzersize başlama nedeni ile mutluluk ölçeği arasında anlamlı farklılığa rastlanmıştır. Cinsiyet, öğrenim görülen bölüm, spor yaşı, spor türü ile mutluluk ölçeği arasında anlamlı farklılığa rastlanmamıştır. Cinsiyet, haftalık egzersiz yapma sıklığı ve algılanan gelir düzeyi ile yaşam doyumu arsında anlamlı farklılık olduğu, yaş, spor yaşı, öğrenim görülen bölüm, egzersize başlama nedeni ve spor türü arasında anlamlı fark tespit edilmemiştir. Egzersiz bağımlılık ölçeği toplam puanı ile mutluluk ölçeği arasında negatif yönlü düşük düzeyde ilişkiye, mutluluk ölçeği ile yaşam doyumu arasında pozitif yönlü orta düzeyde ilişkiye rastlanmıştır.This study was conducted to examine the relationships between attitudes towards sport, social-emotional competence and social appearance anxiety levels of sport sciences faculty students. In this context, the relational survey model was used consistent with the purpose of the quantitative study. The sample group of the study consisted of a total of 302 sports sciences faculty students, 112 womans and 190 mans. Convenience sampling method was used in the selection of the research group. A questionnaire form was used as a data collection tool and this form consists of four parts. The first part of this questionnaire consists of "Personal Information Form", the second part consists of "Attitude Towards Sports Scale", the third part consists of "Social-Emotional Competence Scale" and the fourth part consists of "Social Appearance Anxiety Scale". First, descriptive statistics of the raw data obtained through this form were calculated considering the type of data. Difference and correlation analyzes were conducted for the data obtained in the study. In this context, significant differences were found in the participants' attitudes towards sports according to the department variable and social appearance anxiety according to the class variable. In addition, it was determined that there were significant relationships between the participants' ages and social appearance anxiety at a low level in a positive direction and between the average monthly personal income levels and physical development attitudes, On the other hand, no significant difference was found within the scope of gender and active sports variables and no significant relationship was found within the scope of monthly average family income level variable. In addition, no significant relationship was observed between the participants' social appearance concerns and their attitudes towards sports and social-emotional competence levels. However, it was determined that there were positive, moderately significant relationships between the participants' attitudes towards sports and their social-emotional competencies. Accordingly, it can be concluded that as the participants' attitudes towards sports increase, their social-emotional competencies also increase
Önlisans Öğrencilerinin Risk İçeren Dijital Oyun Bağımlılığına İlişkin Farkındalıklarının Saptanması ve Eğitilmesi
No full textRiskli davranışlar, bireylerin yaşamlarını olumsuz yönde etkileyen ve birey-çevre ilişkisi için risk içeren durumlardır. Riskli durumlara maruz kalma zamanla bireylerde bağımlılığa neden olabilmektedir. Günümüzde gençler arasında en yaygın görülen riskli davranışlardan biri de dijital oyun bağımlılığıdır. Bu çalışmada öğrencilerin dijital oyun bağımlılığı ile ilgili farkındalıklarının geliştirilmesi amaçlanmıştır. Çalışma grubu, 2023-2024 eğitim öğretim yılında Aydıntepe Meslek Yüksekokulunda öğrenim gören önlisans öğrencilerinden oluşmaktadır. Bu çalışma kapsamında öncelikle üniversite öğrencilerinin dijital oyun bağımlılığı farkındalıkları tespit edilmiş daha sonra bu konuda eğitim verilerek bağımlılığa ilişkin farkındalık kazandırmak amaçlanmıştır. Çalışmada nicel araştırma yöntemlerinden tek grup ön test-son test deneysel desen kullanılmıştır. Dijital oyun bağımlılığı farkındalığı düşük olan öğrencilere yapılan eğitim sonrasında farkındalıklarının orta düzeye yükseldiği ve bunun istatistiksel açıdan anlamlı olduğu tespit edilmiştir
Turkish validity and reliability of the Haptotherapeutic Well-Being Scale
No full textObjectives Haptotherapy fosters a sense of unity between the body, mind, and emotions. In addition, it contributes to expanding the woman's perception of her pregnancy and developing a more positive attitude towards pregnancy and childbirth. The study aims to examine the Turkish validity and reliability of the Haptotherapeutic Well-Being Scale, which will be used to evaluate the well-being levels of haptonomy and haptotherapy practices in women. Design The study was methodological type. Methods The study conducted between October 20 and December 20, 2023, with 242 women who volunteered to participate by sharing forum pages on social media (Facebook, Instagram) via the web. Data were collected using a personal information form, including sociodemographic and obstetric characteristics and the Haptotherapeutic Well-Being Scale. Results The Haptotherapeutic Well-Being Scale consists of 14 items and five sub-dimensions. In confirmatory factor analysis, all path coefficients were statistically significant (p < 0.001). The overall Cronbach's Alpha and sub-dimension values of the scale are above 0.90. There is a positive and very strong correlation between all sub-dimensions of the scale (p < 0.001). Conclusion The Haptotherapeutic Well-Being Scale was found to be valid and reliable for the Turkish sample. Trials registrationhttps://clinicaltrials.gov identifier NCT06467188; registered June 14, 2024
THE EFFECT OF DIFFERENT DOSES OF LIQUID VERMICOMPOST APPLICATION ON YIELD AND YIELD COMPONENTS OF SOME POTATO (SOLANUM TUBEROSUM L.) VARIETIES
No full textThis is one of the early studies to produce healthy, yielding, and high -quality tubers from the potatoes grown in Bayburt, an organic agriculture basin, using liquid vermicompost that can supplement organic fertilizers. The purpose of this study was to examine the effect of liquid vermicompost applications (0, 3, 6, 9, and 12 L ha(-1)), which can supplement the stable manure used as bottom fertilizer, on yield and yield components of potato (Solanum tuberosum L.) varieties (Agria and Lady Olympia). The research was designed in random blocks with three replications. As a result of the study, it was found that the tuber yield was within the range of 20.24-30.40 tons' ha(-1), the protein ratio was within the range of 1.53-2.51%, and the starch ratio was within the range of 11.98%-15.99%. The liquid vermicompost doses applied to the potato varieties created significant differences in all three parameters. Due to the positive effect of the Agria (3.40 tons/da) variety on the yield and vegetative development of potatoes, It was concluded that 9 L liquid vermicompost application per decare would be beneficial.Scientific Research Projects Unit, Bayburt University, Bayburt, Turkey [2020/01-69001-01]This study was funded and supported by the Scientific Research Projects Unit, Bayburt University, Bayburt, Turkey (Project No: 2020/01-69001-01)
Diltiazem and Verapamil: Combined experimental and computational approaches to structural and spectroscopic characterization
No full textDiltiazem and Verapamil are two important drug molecules in a separate group of Calcium Channel Blockers. The purpose of this work is to determine and compare the structural and spectroscopic properties of these two molecules using a number of experimental techniques and quantum chemical calculations. Compounds were characterized spectroscopically using FT-IR, Raman, NMR (1H, 13C, and DEPT), and UV-vis methods. Further-more, the Density Functional Theory (DFT) method, Becke's three-parameter hybrid functional (B3LYP), and the 6-311++G(d,p) basis set were used to determine the ground state geometric structures of molecules, and the spectroscopic properties of the obtained optimum structures were investigated computationally. The optimization studies performed under vacuum circumstances and for the isolated molecules were found to be very close to the experimental results. In fact, r.m.s. values were discovered for Diltiazem and Verapamil with bond lengths of 0.013 and 0.024, and bond angles of 1 degrees and 2 degrees, respectively. The vibration characteristics of the compounds were discovered using the collected FT-IR and Raman spectra, and significant vibrational modes were assigned. After scaling, it was revealed that the quantum chemical data was congruent with the experimental ones, and that the characteristic vibrational modes were appropriately predicted. DFT calculations effectively determine molecules' structures due to internal consistency, despite being slightly distant from experimental data. Theoretical values for carbon and hydrogen atoms are better in agreement with observed values when scaling with 0.92 and 0.90. From the UV-vis spectra, Diltiazem HCl absorbance peaks were found at 207 and 237 nm, whereas Verapamil HCl absorbance peaks were identified at 203, 229, and 278 nm. When the theoretical calculations and experimental findings were compared, the anticipated absorption peaks were found to have shifted nearer the visible area. Furthermore, Hirshfeld surfaces and Molecular Electrostatic Potential surfaces were obtained and analyzed in order to better understand the electronic characteristics. The TDOS and PDOS (total and partial density of state) spectra were also studied. Finally, using the HOMO and LUMO energy values, the critical chemical parameters were evaluated, and it was discovered that both molecules had positive electron affinity and electro-negativity values, indicating that they will accept electrons when the electron-nucleus attraction exceeds the electron-electron repulsion.Atatrk University Research fund [FDK-2022-11079]This work was supported by Atatuerk University Research fund through research Grant No.: FDK-2022-11079