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Enzyme Mimic Behavior of Platinum(II) Complex with Tridentate Ligand—Fe3O4—MWCNT Nanocomposite for the Electrochemical Detection of H2O2 and NADH
No full textCilvēksituācija konfliktu un krīžu kontekstā: aktuālie pētījumi socioloģijā un mutvārdu vēsturē/ The Human Situation in the Context of Conflict and Crisis: Current Research in Sociology and Oral History
No full textSummaries of Papers of the Section “Human Situation in the Context of Conflicts and Crises: Current Research in Sociology and Oral History” at the 82nd International Scientific Conference of the University of Latvia.
Aşırı Kilolu Genç Yetişkinlerde Dairesel Aerobik Eğitimin Vücut Kompozisyonu, Kas Kuvveti ve Fiziksel Uygunluk Parametreleri Üzerine Etkisi
No full textÇalışmanın amacı dairesel aerobik eğitimin vücut kompozisyonu, kas kuvveti ve fiziksel uygunluk parametreleri üzerine etkisini incelemektir. 18-25 yaş arasındaki aşırı kilolu bireylerin dahil edildiği çalışmada vücut kompozisyonu, kas kuvveti ve fiziksel uygunluk değerlendirmeleri yapılmıştır. Fiziksel uygunluk seviyesi değerlendirmesi için 6 dk. yürüme testi, flamingo denge testi, disklere dokunma testi ve mekik testi kullanılmıştır. Çalışma grubundaki bireylere 4 hafta boyunca haftada 3 gün 35 dk. dairesel aerobik eğitim verilirken kontrol grubuna ise aynı sürede aerobik eğitim verilmiştir. Araştırma, çalışma grubunda 10, kontrol grubunda 12 kişi ile tamamlanmıştır. Egzersiz sonrasında her iki grubun da VKİ değerleri istatiksel olarak anlamlı şekilde azalmıştır. Çalışma grubunda bel çevresi ölçümü (p=0,011); yağ ölçümlerinden aksiller (p=0,042), abdominal (p=0,016), uyluk (p=0,026) ve bacak ölçümü (p=0,011); kas kuvveti ölçümlerinden omuz ekstansörleri (p=0,011), omuz abduktörleri (p=0,031), kalça ekstansörleri (p=0,035) ve diz ekstansörleri değeri (p=0,003); fiziksel uygunluk parametrelerinden ise mekik testi (p=0,028), 6 dk yürüme testi (p=0,001), dominant tarafta disklere dokunma testi (p=0,05) ve flamingo testi (p=0,028) egzersiz öncesine göre istatiksel olarak anlamlı ölçüde iyileşmiştir. Çalışmamızın sonucunda, aşırı kilolu genç yetişkinlerde dairesel aerobik eğitiminin vücut kompozisyonu, kas kuvveti ve fiziksel uygunluk test parametreleri üzerinde olumlu etkisi olduğu ortaya konmuştur.</jats:p
Death in Qur’an courses for 4–6 year-olds: a critical analysis of teaching programmes and teacher’s books
No full textImprovement of voltage stability and loading capacity using FACTS devices and distributed generation resources in power systems
No full textEXTRACTION CONDITIONS FOR DIFFERENT PARTS OF MELOCAN (SMILAX EXCELSA L.) USING SUPERCRITICAL CARBON DIOXIDE
No full textMelocan, which is very important in both traditional Turkish cuisine and traditional medicine, especially in the Black Sea region of Türkiye, is a climbing, thorny and perennial plant that grows naturally in the bushy woodlands. In the study, different melocan parts (sprout, fruit and leaf) have been extracted under two different pressure levels (250 and 350 bar), temperatures (30 and 50 °C), durations (60 and 90 minutes), and two different levels of ethanol concentration (10% and 20%) through supercritical carbon dioxide (Sc-CO2) extraction method, which is an environmentally-friendly method. It has been observed that the melocan leaf which has been extracted through Sc-CO2 at 350 bar pressure and 50 °C which has been modified with 20% ethanol for 90 mins has the richest total phenolic substance content (TPC) as 2265.1 mg gallic acid equivalent (GAE)/kg dry weight and total antioxidant capacity (TAC) as 2876.7 mg trolox equivalent (TE)/kg dry weight.</jats:p
Gastronomik Bir Değer Olarak Coğrafi İşaretli Ürünlerin Değerlendirilmesi: Yozgat İli Örneği
No full textCoğrafi işaretler 'yerellik dünya ile buluşuyor' sloganıyla otantik ve yerel ürünleri korumak ve gelecek nesillere aktarmak için alınan yasal önlemlerdir. Coğrafi işaretli ürünler bulundukları bölgenin tanıtımında anahtar role sahip ürünlerdir. Gastronomi turizm ise genellikle belirli bir destinasyona seyahat eden ziyaretçilere sunulan yerel kökenli yiyecek ve içeceklerin kültürel ve turistik değerini ifade etmektedir Coğrafi işaret ve gastronomi turizmi kavramlarının günümüzde daha popüler hale gelmesiyle bireyler seyahat ettikleri bölgelerde sadece tarihi ve kültürel değerlere değil aynı zamanda yerel yiyecek ve içeceklere de ilgi duymaya başlamıştır. Bu durum bir destinasyon için belirli bir coğrafi işaretle tescil edilmiş ürünlerin o destinasyonun tanıtımında ve imajının güçlendirilmesinde önemli bir rol oynamasını sağlamaktadır. Ayrıca bu ürünler destinasyondaki turist hareketliliğini artırmakta ve ekonomik kazanımlar sağlamaktadır. Bu çalışmanın amacı Yozgat'ın coğrafi işaretli ürünlerini gastronomi turizmi açısından değerlendirmek ve mevcut turist arzına entegre edilmesi için önerilerde bulunmaktır. Bu kapsamda literatür taraması yapılmış ve coğrafi işaretli ürünlerin gastronomi turizmi açısından önemi ortaya konmaya çalışılmıştır. Çalışma sonucunda Yozgat'ta gastronomi turizmi alanında hareketlilik kazanılması veya başlatılması için Yozgat'ta turizm alanında çalışan ilgili kurum, kuruluş ve karar vericilere bazı öneriler sunulmuştur</jats:p
Can Toll-Lıke Receptor 4 Gene Polymorphism Play a Role ın Pathogenesis of Breast Cancer?
No full textAbstract Introduction: Breast cancer is one of the most common cause of death from cancer in women worldwide. Dynamic interaction between tumors and the immune system is essential for tumor survival, growth, and metastasis. The immune system is known to play a major role in preventing tumor progression by recognizing tumor antigens, and dysregulation of immune system activity could contribute to tumorigenesis. Recent studies have shown that dysregulation of innate immunity receptors such as Toll-like receptors (TLRs) play an important role in the activation of natural and adaptive immunity in response to endogenous hazard signals from pathogens and damaged or dead cells. These receptors are expressed in the immune system cells and some epithelial cells. Recent studies have shown that these receptors are also exaggerated in malignant breast cancer cells. Many studies have shown that the TLR4 gene expression is increased in breast cancer cells, but also associated with metastasis. However, there is no study that could correlate TLR4 gene polymorphisms with breast cancer. Materials and methods: We conducted a case study with 100 patients and 100 healthy subjects and planned to investigate whether there is a relationship between TLR4 gene polymorphisms [rs4986790 (Asp299Gly) ve rs4986791 (Thr399Ile)] and breast cancer. In this study, polymerase chain reaction (PCR) based restriction fragment length polymorphism (RFLP) method was used for gene polymorphisms. Results: It was observed that there was relationship between breast cancer and TLR4 gene polymorphisms. Because TLR-4 plays an active role in the innate immune system, the loss of function of this protein may lead to a depressed immune response, thus promoting cancer development.</p
Nodal Burden and Oncologic Outcomes in Patients With Residual Isolated Tumor Cells After Neoadjuvant Chemotherapy (ypN0i+): The OPBC-05/ICARO Study
No full text PURPOSE The nodal burden of patients with residual isolated tumor cells (ITCs) in the sentinel lymph nodes (SLNs) after neoadjuvant chemotherapy (NAC) (ypN0i+) is unknown, and axillary management is not standardized. We investigated rates of additional positive lymph nodes (LNs) at axillary lymph node dissection (ALND) and oncologic outcomes in patients with ypN0i+ treated with and without ALND. METHODS The Oncoplastic Breast Consortium-05/ICARO cohort study (ClinicalTrials.gov identifier: NCT06464341 ) retrospectively analyzed data from patients with stage I to III breast cancer with ITCs in SLNs after NAC from 62 centers in 18 countries. The primary end point was the 3-year rate of any axillary recurrence. The rate of any invasive recurrence was the secondary end point. RESULTS In total, 583 patients were included, of whom 182 (31%) had completion ALND and 401 (69%) did not. The median age was 48 years. Most patients (74%) were clinically node-positive at diagnosis and 41% had hormone receptor–positive/human epidermal growth factor receptor 2–negative tumors. The mean number of SLNs with ITCs was 1.2. Patients treated with ALND were more likely to present with cN2/3 disease (17% v 7%, P < .001), have ITCs detected on frozen section (62% v 8%, P < .001), have lymphovascular invasion (38% v 24%, P < .001), and receive adjuvant chest wall (89% v 78%, P = .024) and nodal radiation (82% v 75%, P = .038). Additional positive nodes were found at ALND in 30% of patients, but only 5% had macrometastases. The 3-year rates of any axillary and any invasive recurrence were 2% (95% CI, 0.95 to 3.6) and 11% (95% CI, 8 to 14), respectively, with no statistical difference by type of axillary surgery. CONCLUSION The nodal burden in patients with ypN0(i+) was low, and axillary recurrence after ALND omission was rare in patients selected for this approach. These results do not support routine ALND in all patients with ypN0(i+). </jats:sec
Fractal Dimension Analysis of Mandibular Trabecular Architecture in Gingival Recession During Orthodontic Retention: A Cross-Sectional Study
No full textObjectives: This study used fractal dimension (FD) analysis to evaluate alveolar trabecular changes associated with gingival recessions in the mandibular incisor-canine and premolar regions in the post-orthodontic retention period, compare them to non-recession regions, and assess their correlation with plaque (PI) and gingival indices (GIs). Methods: This cross-sectional case–control study included 60 patients with mandibular gingival recession (35 females, 25 males; mean age: 21.91 ± 2.59 years), with apical trabecular bone regions of interest (ROIs) identified in the incisor-canine and premolar regions. Patients were divided into four groups based on the regions of recession, with non-recessional regions in the contralateral quadrant considered as control regions. FD analysis was performed on the specified ROIs using panoramic radiographs taken before treatment (T0), after treatment (T1), and in the retention period (T2). Patients’ PI and GI scores and incisor-mandibular plane angles (IMPAs) were recorded. Results: The FD values significantly decreased in Groups 1 and 2 (left and right incisor-canine regions) (p < 0.05), but no significant changes were found in Groups 3 and 4 (left and right premolar regions) and the control group. The FD values showed a significant correlation with the PI and GI scores (p < 0.05), but no correlation was found with IMPAs (p > 0.05). Conclusions: Alterations in alveolar trabeculation in gingival recession can be assessed by FD analysis. Decreased FD values correlate with worsening oral hygiene and higher PI and GI scores. Changes in the IMPA do not correlate with changes in FD, highlighting the importance of regular periodontal check-ups after orthodontic treatment.</jats:p