Zonguldak Bülent Ecevit University Institutional Repository
Not a member yet
9495 research outputs found
Sort by
İlahiyat Fakültesi Erkek Akademisyenlerinin Kadına Yönelik Şiddet Algısı ve Çözüm Önerileri
No full textIn recent years, a significant increase in violence against women has emerged as a severe issue negatively impacting both women and society. This violence encompasses various forms, including physical, sexual, economic, psychological, and, increasingly, cyberbullying due to the widespread use of the internet. Research on violence against women and news reports commonly identify men as the perpetrators of such acts. The desire for control and interpretations based on religion can justify these acts of violence. Consequently, this study aims to discern the perspectives of male scholars in theology faculties regarding violence against women (VAW), its underlying causes, and potential solutions. To achieve this objective, a qualitative research method known as the multiple case study design was employed. The study group consisted of 25 male scholars selected through convenient sampling. Data were collected through interviews with the participants and subsequently analyzed using thematic content analysis. To effectively resolve and eliminate a problem, it is essential first to identify and accurately understand its root causes. In this context, the definitions of VAW provided by male scholars reflect subjective processes and perceptions. Their statements regarding the causes of VAW and recommendations for solutions generally revolve around the disruption of family order and values, leading to the breakdown of societal structures, particularly regarding their physical and psychological dimensions. Participants who emphasize the necessity of societal change to prevent VAW have highlighted the importance of incorporating practices into daily life that promote social awareness, equality, and justice. From this perspective, it can be argued that there is a pressing need to integrate educational policies and practices into daily life that can critically examine cultural and societal norms, transform perceptions and practices that trigger violence, and actively contribute to solving this problem. * This article is the revised and developed version of conference presentation entitled “Perceptions and Solutions of male Academicians in the theologhy Faculty Regarding Violence Against Women”, orally delivered at the 4th Turkish Symposium of Social Sciences.</jats:p
Effects of different fresh gas flows on carboxyhemoglobin levels: non-invasive carbon monoxide monitoring
No full textImmunonutritional Markers and the Protective Role of Sternal Irrigation and Antibiotic-Impregnated Membranes in Sternal Wound Infection: A Retrospective Cohort Study
No full textBackground: Sternal wound infections (SWIs) remain a significant complication following cardiac surgery. Inflammatory and nutritional status are increasingly recognized as key contributors to their development. This study aimed to investigate the predictive utility of immunonutritional biomarkers and to evaluate the protective effect of combining sternal irrigation with an antibiotic-impregnated membrane. Methods: This retrospective cohort study included 480 patients undergoing off-pump coronary artery bypass grafting. Patients were categorized based on sternal management strategy (standard closure or local prophylaxis using gentamicin-enriched irrigation combined with an antibiotic-impregnated fascia lata membrane) and according to the severity of SWIs, classified as superficial or deep. Inflammatory and nutritional markers—including C-reactive protein (CRP), neutrophils, lymphocytes, albumin, neutrophil-to-lymphocyte ratio (NLR), C-reactive protein-to-albumin ratio (CAR), and prognostic nutritional index (PNI)—were assessed at three time points: preoperatively, on postoperative day 3, and after week 1. Results: SWIs were observed in 93 patients, including 75 superficial and 18 deep infections. The combined prophylactic approach was associated with a nearly 1.8-fold reduction in deep SWIs (OR: 0.55; 95% CI: 0.15–0.87) and a modest reduction in superficial infections (OR: 0.89; 95% CI: 0.5–1.3; p = 0.061). Threshold values of 3.75 for preoperative NLR, 9.8 for ΔNLR, and 16.7 for ΔCAR demonstrated strong predictive capacity for identifying patients at increased risk of developing deep SWIs. Patients receiving local prophylaxis exhibited significantly lower CRP, NLR, and CAR values and higher PNI levels at all time points. Conclusions: The combination of sternal irrigation and local antibiotic prophylaxis appears to confer protection against SWIs, potentially by mitigating postoperative inflammation. Immunonutritional biomarkers offer a promising means for early risk stratification. To confirm their clinical utility and broader applicability, these results should be validated in prospective, multicenter studies encompassing a wider range of cardiac surgical procedures
Coğrafi İşaretlerin Yerel Gıdaları Turizm Ürününe Dönüştürmedeki Önemi: Akçakoca Örneği
No full textBu araştırmanın amacı Akçakoca’nın coğrafi işaretli yerel gıdalarının ilçenin ziyaret edilmesinde ne derece etkili olduğunu tespit etmektir. Araştırma verileri Haziran 2023-Ağustos 2023 tarihleri arasında Akçakoca’yı ziyaret eden yerli turistlerden kolayda örneklem yöntemi kullanılarak anket formu aracılığıyla elde edilmiştir. 500 katılımcıdan elde edilen veriler, SPSS programı kullanılarak nicel analiz tekniği ile analiz edilerek yorumlanmıştır. Araştırma bulguları, katılımcıların Akçakoca’ya yönelik algılarının genel olarak olumlu olduğunu göstermektedir. Katılımcıların büyük bir kısmı daha önce Akçakoca’yı ziyaret etmiş olup (%71,4), bölgeyi eğlenmek amacıyla tercih ettiklerini ve doğal güzellikleriyle öne çıktığını belirtmişlerdir. Katılımcılar Akçakoca’yı atmosferi dinlendirici, doğal çekiciliklere sahip, park ve mesire alanları bulunan bir destinasyon olarak değerlendirmiştir. Ancak altyapı ve trafik düzeni gibi alanlarda daha düşük memnuniyet oranları tespit edilmiştir. Coğrafi İşaretli ürünler hakkında katılımcıların ifadeleri genel olarak olumludur ve bu ürünlerin yerelliği ifade ettiğini, tanıtıma katkı sağladığını belirtmişlerdir. Katılımcılar arasında yaş, eğitim durumu ve ikamet edilen şehre göre ifadelerde farklılıklar görülmüştür. Araştırma bulguları, Akçakoca’nın turistik çekiciliğinin artırılmasında coğrafi işaretli ürünlerin etkili bir araç olabileceği ortaya koymaktadır.</jats:p
An Investigation of TRIM36 Expression in Breast Cancer
No full textBreast cancer is the most frequently diagnosed cancer type worldwide and ranks 2nd among cancers that cause death. While the role of TRIM36 has been investigated in certain human cancers, such as prostate and lung cancer, its functions remain largely unexplored. In this study, the expression level of TRIM36, whose role in breast cancer has not been previously examined, and its potential association with breast cancer pathogenesis were analyzed. RNA was isolated from normal and tumor tissues of 45 breast cancer patients. Complementary DNA (cDNA) was synthesized from the RNA, and mRNA expression levels of GAPDH and TRIM36 were quantified using qRT-PCR. TRIM36 expression was observed in breast tissues; however, no statistically significant difference was found in TRIM36 mRNA expression levels, normalized to GAPDH, between normal and tumor tissues (p=0.731). Although this study suggests that TRIM36 gene expression levels in breast cancer tissues do not differ from normal tissues, the limited sample size highlights the need for more comprehensive studies to elucidate the relationship between the TRIM36 gene and breast cancer.</jats:p
Evaluation of Simulation Results of HEC-RAS Coupled 1D/2D and 2D Modeling Approaches Through Scenario-Based Analysis
No full textWhile 1D, 2D, and coupled 1D/2D models are widely used in flood extent mapping, a significant research gap remains in comparative analyses of 2D and coupled 1D/2D approaches. Study of the Dinsiz Stream Basin is of critical importance due to its proximity to industrial zones and residential areas, as well as its susceptibility to flood risk. Due to the lack and insufficiency of flow data in the basin, only long-term rainfall data were used in the analysis. Rainfall return periods of 50, 100, 200, and 500 years were estimated using statistical methods, and these values were utilized to generate flood hydrographs for this study. These values were then transferred to HEC-HMS, and the resulting hydrographs were input into HEC-RAS to establish coupled 1D/2D and 2D models for comparison. Flood mapping was performed for different return periods to evaluate the flood impact. This study revealed that maximum water levels in the 1D/2D models were higher than in the 2D models. The results showed that Dinsiz Stream could cause major losses for the second organized industrial zone located nearby when it overflows. The accuracy of the model was ensured with photographs of the flood event that occurred in 2021, ensuring the reliability of the findings.</jats:p
Malignant adenomyoepithelioma of the breast with axillary lymph node metastasis: a case report and review of the literature
No full textBackgroundAdenomyoepithelioma (AME) is a relatively rare type of tumor formed by the coordinated proliferation of glandular epithelial cells and myoepithelial cells. Clinically, most of them are benign, while malignant ones are extremely rare. Malignant breast adenomyoepithelioma is somewhat invasive and may recur locally or metastasize distantly through the vascular pathway. However, reports on axillary lymph node metastasis are scarce. In this case, we present an extremely rare instance of malignant breast adenomyoepithelioma with axillary lymph node metastasis. By combining previous studies, we conduct an in-depth analysis of the clinicopathological features, treatment methods, and prognosis of this disease, and propose targeted diagnostic and treatment suggestions.Case presentationA 64-year-old woman initially presented with no abnormalities in the axillary lymph nodes upon clinical examination or imaging. Following the diagnosis of malignant adenomyoepithelioma, the patient underwent unilateral mastectomy. Six months after surgery, the patient developed ipsilateral axillary lymph node enlargement, which was confirmed by pathological examination as metastasis of malignant adenomyoepithelioma of the breast to the axillary lymph nodes. The patient underwent axillary lymph node dissection, followed by four cycles of epirubicin and cyclophosphamide (AC) chemotherapy. Nine months after the operation, the patient returned to our outpatient clinic for follow-up, and the examination results showed no signs of recurrence or distant metastasis.ConclusionWe meticulously described the clinical symptoms, signs, and imaging characteristics of both the primary lesion of malignant adenomyoepithelioma of the breast and its axillary metastasis in the patient. Through a comparison of the pathologic features between the primary breast lesion and the axillary metastatic lymph nodes, we found a certain degree of consistency in terms of microscopic pathologic features and immunohistochemical molecular expression. Furthermore, we conducted an extensive review of the literature on breast malignant adenomyoepithelioma over the past decade. By summarizing the clinicopathological characteristics, treatment modalities, and prognosis of the patients, we found that patients with breast malignant adenomyoepithelioma have a certain risk of recurrence and metastasis. Notably, even when the clinical examination of axillary lymph nodes yields negative results and imaging shows no enlargement, a more assertive surgical approach may still be necessary. Specifically, a sentinel lymph node biopsy, despite the potential for false-negative outcomes, could be advantageous for the patient’s prognosis by enabling early determination of the need for axillary lymph node dissection.</jats:sec
<i>Bartonella</i> Species in Small Mammals in Turkey: <i>Bartonella bilalgolemii</i> sp. nov. Isolated from a Ural Field Mouse (<i>Apodemus uralensis</i>)
No full textBackground: The genus Bartonella is composed of Gram-negative, fastidious, facultative intracellular bacteria that can cause bacteremia in mammals and various disorders in humans. Rodents have been reported as reservoirs of more than 30 Bartonella species, seven of which cause zoonotic infections. Materials and Methods: In the present study, the isolation of Bartonella sp. was attempted from 150 spleen samples from 13 rodent species (mostly Apodemus species) from three geographically different regions in Turkey. Results: Bartonella sp. was successfully isolated from 65 of these 150 samples (43%). The prevalences of Bartonella sp. in tested rodents in the regions of Giresun, Yozgat, and Burdur were 68%, 44%, and 16%, respectively. Using polymerase chain reaction/sequence analysis of the citrate synthase-coding gene (gltA), Bartonellaisolates were classified seven species including B. taylorii, B. grahamii, B. birtlesii, B. mastomydis, and three putatively new Bartonella species. We performed further identification techniques for one of the three Bartonella species that were different from the validated Bartonella species according to the gltA sequence analysis. Conclusion: Here, we report the genomic and phenotypic characterization of Bartonella sp. strain G70 that was isolated from the splenic tissue of an Apodemus uralensis (Pallas 1881), the Ural field mouse, captured in the Giresun region of northeastern Turkey. Bartonella sp. strainG70 (RSKK 22001) was characterized by whole genome and partial gene (gltA, 16S ribosomal RNA) sequencing and comparison, scanning electron microscopy, biochemical tests, and matrix-assisted laser desorption ionization time-of-flight mass spectrometry. This novel Bartonella is a Gram-negative, rod-shaped bacterium and has neither flagella nor pili. The genome from strain G70 was 1,606,969-bp-long with a G + C content of 35.7%. Bartonella rochalimae was found to be the closest phylogenetic relative of strain G70 (OrthoANI = 90.5%, digital DNA-DNA hybridization = 41.4%). We therefore propose that this new species be named Bartonella bilalgolemii sp. nov. with strain G70T as the type strain
Modulation of Brain-derived Neurotrophic Factor and Nerve Growth Factor Gene Expression in the Hippocampus and Cortex Regions of Rats with Penicillin-induced Experimental Epilepsy: The Effect of Adenosine Triphosphate-sensitive Potassium Channels
No full textABSTRACT Objective: The objective is to investigate the effect of adenosine triphosphate (ATP)-sensitive potassium (KATP) channels on brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) gene expression in the hippocampus and cortex regions using a penicillin-induced epilepsy model. Materials and Methods: The study included four groups, control (C), epilepsy (E), epilepsy-opener (E-O), and epilepsy-blocker (E-B), and three subgroups, 1st day, 4th day, and 8th day after the seizure. The hippocampus and cortex were dissected from all animals and BDNF and NGF messenger ribonucleic acid (mRNA) expression levels were quantified using quantitative polymerase chain reaction (qPCR). Results: The relative gene expression of the NGF gene evaluated in hippocampal tissues was found to be significantly higher in the epilepsy 1st-day group compared with the C group (P < 0.05). The relative gene expression of the NGF gene in cortex tissues was found to be significantly higher in the epilepsy 8th-day group compared with the C group (P < 0.05). The relative gene expression of the BDNF gene in hippocampal tissues was also significantly higher in the epilepsy 1st-day group compared with the C group (P < 0.05). BDNF gene expression levels in the cortex region were significantly higher in the E group on the 8th day, in the E-O group on the 1st, 4th, and 8th days, and in the E-B group on the 1st day; BDNF gene expression level was also significantly higher in the E-B group on the 8th day compared with the C group (P < 0.05). Conclusion: KATP channels play a modulatory role in the expression levels of BDNF and NGF genes in the cortex over an extended period of 8 days, parallel to their efficacy observed in the hippocampus on day 1. These mechanisms need to be thoroughly investigated and emphasized due to their importance. </jats:sec
Sustainability of beach tourism in Türkiye in the era of climate change
No full textTourism is vulnerable to climate change. Türkiye is one of the leading tourism destinations. Beach tourism, based on the trio of sea, sun, and sand, is the main type of tourism in Türkiye. Climatic comfort in a destination is important for tourism attractiveness. Knowing how climate change will affect tourism is very important for the sustainability of the tourism sector. Therefore, applying climate indices to beach tourism in order to accurately evaluate climate conditions today and in the future is very important for the sustainability of tourism. In this study, to determine the impact of climate change on beach tourism the Climate Index for Tourism (CIT) is applied. CIT is specifically designed for beach tourism. Data is gathered from the Copernicus Climate Change Service (C3S). Both historical observations and future climate projections are used. Considering the net zero targets of greenhouse gas emitter countries, only Representative Concentration Pathways (RCP) 4.5 scenario is implemented. Panoply software is used to visualize CIT maps. The future of beach tourism in Türkiye is evaluated for near (2021-2040), mid (2041-2060) and late-century (2081-2100). As a result, it has been shown that the Mediterranean and Aegean coasts will continue to be suitable for beach tourism in the summer. In the late century, due to warming temperatures, ideal conditions may shift to acceptable on the Mediterranean coasts. On the other hand, the CIT scores of the Black Sea shores will be lower and only part of this region will have acceptable climatic conditions under the RCP 4.5 scenario. The coastlines around the Marmara Region will represent a transition between the Aegean and Black Sea coasts.</jats:p