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Low frequency of human cytomegalovirus in cancerous and precancerous cervical samples of Iranian women
No full textBackground: HPV-16 has a significant role in cervical cancers; co-infection with human cytomegalovirus (HCMV) as an oncomodulatory pathogen may increase the risk of carcinogenesis. This study aimed to investigate the frequencies of HCMV and HPV-16 in cervical samples. Materials & methods: A total of 102 cancerous and precancerous cervical samples were examined by real-time PCR targeting the HPV-16 E6 gene, and HCMV immediate-early gene. Results: In total, 65 samples (63.7) were positive for HPV-16. HCMV was found in seven samples (6.9). Both HPV-16 and HCMV were present in four samples (cervical intraepithelial neoplasia-3 and squamous cell carcinoma groups with two samples each). Conclusion: HCMV can infect cervical tissues at a low frequency, suggesting that HCMV is unlikely to play a role in the cervical carcinogenesis. © 2021 All rights reserved
The Pandora's box of novel technologies that may revolutionize lung cancer
No full textNon-small cell lung cancer (NSCLC) is one of the most common cancers globally and has a 5-year survival rate ~20. Immunotherapies have demonstrated long-term and durable responses in NSCLC patients, although they appear to be effective in only a subset of patients. A more comprehensive understanding of the underlying tumour biology may contribute to identifying those patients likely to achieve optimal outcomes. Profiling the tumour microenvironment (TME) has shown to be beneficial in addressing fundamental tumour-immune cell interactions. Advances in multiplexing immunohistochemistry and molecular barcoding has led to recent advances in profiling genes and proteins in NSCLC. Here, we review the recent advancements in spatial profiling technologies for the analysis of NSCLC tissue samples to gain new insights and therapeutic options for NSCLC. The combination of spatial transcriptomics combined with advanced imaging is likely to lead to deep insights into NSCLC tissue biology, which can be a powerful tool to predict likelihood of response to therapy. © 2021 The Author(s
Task allocation approach for minimizing make-span in wireless sensor actor networks
No full textWireless Sensor Actor Networks (WSANs) have contributed to the development of pervasive computing wherein time consideration to perform the tasks of pervasive applications is necessary. Hence, time constraint is one of the major challenges of WSANs. In this paper, we propose an analytical approach based on queuing theory to minimize the total time taken for completion of tasks, i.e., make-span, in WSANs with hybrid architecture. The best allocation rates of tasks to actor nodes are figured out through solving inequities and qualities resulting from a steady state analysis of the proposed model. Applying the calculated tasks arrival rates at each of the actors, the make-span could be minimized. To assess the accuracy of the tasks assignment rates to each of the actors attained from the suggested analytical approach and to provide a graphical representation of the WSAN a formal model in terms of the generalized stochastic Petri net (GSPN) is presented. The proposed GSPN model is analyzed, tasks distribution weights to the actors are determined, and then tasks allocation rates can be computed. Comparing the results achieved from the analytical approach and the GSPN model demonstrates that allocation rates and hence, the make-span figured out from proposed approach and the formal model are the same. Experimental results in typical scenarios show shorter make-span and longer network lifetime compared to when one of the two popular traditional task allocation algorithms, namely, opportunistic load balancing (OLB), and stochastic allocation (SA) algorithms, is used. © 2021 CRL Publishing. All rights reserved
Microbiological detoxification of mycotoxins: Focus on mechanisms and advances
No full textSome fungal species of the genera Aspergillus, Penicillium, and Fusarium secretes toxic metabolites known as mycotoxins, have become a global concern that is toxic to different species of animals and humans. Biological mycotoxins detoxification has been studied by researchers around the world as a new strategy for mycotoxin removal. Bacteria, fungi, yeast, molds, and protozoa are the main living organisms appropriate for the mycotoxin detoxification. Enzymatic and degradation sorptions are the main mechanisms involved in microbiological detoxification of mycotoxins. Regardless of the method used, proper management tools that consist of before-harvest prevention and after-harvest detoxification are required. Here, in this review, we focus on the microbiological detoxification and mechanisms involved in the decontamination of mycotoxins. © 2021 Bentham Science Publishers
Carcinogenic and Non-carcinogenic Risk Assessment of Heavy Metals in Water Resources of North East of Iran in 2018
No full textIntroduction: Contamination of water with heavy metals has turned into a health concern, particularly in the developing countries. In this study, concentration of heavy metals and associated carcinogenic and non-carcinogenic risk was investigated in water samples collected from Gonbad-e Kavus, a high-risk area for cancer. Materials and Methods: Samples were collected from Gorgan River, Golestan reservoir and wells around villages with high prevalence in 2018.Samples were analysed through inductively coupled plasma mass spectrometry. After determining the concentration of heavy metals in water samples from different sources, health risk assessment was carried out according to the Environmental Protection Agency. Results: Arsenic in samples 6-9 was higher than 10 pg/L, calcium and magnesium in sample 5 was higher than 200 mg/L and 150 mg/L respectively, and sodium in all samples was higher than 50 mg/L. According to the findings, these concentrations were higher than the maximum allowed limit in most water samples. Hazard quotient (HQ) in samples 8 and 9 were associated with arsenic and health risk in sample 1 was related to antimony. Furthermore, since all samples contained high amounts of lithium, water from this area better should not be consumed by children older than one year. Conclusion: Given the high rate of arsenic contamination, consumption of water in the study area could be health threatening for all individuals and is not recommended for children. This highlights the need for taking immediate actions to review the water treatment process and ensure safety of the drinking water in this area. © 2021. All Rights Reserved
miRNAs; a novel strategy for the treatment of COVID-19
No full textCoronavirus disease 2019 (COVID-19) is the seventh member of the bat severe acute respiratory syndrome family. COVID-19 can fuse their envelopes with the host cell membranes and deliver their genetic material. COVID-19 attacks the respiratory system and stimulates the host inflammatory responses, enhances the recruitment of immune cells, and promotes angiotensin-converting enzyme 2 activities. Patients with confirmed COVID-19 may have experienced fever, dry cough, headache, dyspnea, acute kidney injury, acute respiratory distress syndrome, and acute heart injury. Several strategies such as oxygen therapy, ventilation, antibiotic or antiviral therapy, and renal replacement therapy are commonly used to decrease COVID-19-associated mortality. However, these approaches may not be good treatment options. Therefore, the search for an alternative-novel therapy is urgently important to prevent the disease progression. Recently, microRNAs (miRNAs) have emerged as a promising strategy for COVID-19. The design of oligonucleotide against the genetic material of COVID-19 might suppress virus RNA translation. Several previous studies have shown that host miRNAs play an antiviral role and improve the treatment of patients with COVID-19. miRNAs by binding to the 3�-untranslated region (UTR) or 5�-UTR of viral RNA play an important role in COVID-19-host interplay and viral replication. miRNAs interact with multiple pathways and reduce inflammatory biomarkers, thrombi formation, and tissue damage to accelerate the patient outcome. The information in this review provides a summary of the current clinical application of miRNAs for the treatments of patients with COVID-19. © 2021 International Federation for Cell Biology
Lymphocytes subsets in correlation with clinical profile in CVID patients without monogenic defects
No full textObjectives: Common variable immunodeficiency (CVID) patients experience clinical manifestations rather than recurrent respiratory infections including autoimmunity, enteropathy, and lymphoproliferation. We evaluated the correlation of lymphocyte subpopulations with such manifestations. Methods: Twenty-six genetically unsolved CVID patients were subdivided into four phenotypes: infection only (IO), autoimmunity (AI), chronic enteropathy (CE), and lymphoproliferative disorders (LP) and examined for lymphocyte subsets by flow cytometry and TCD4+ proliferation by Carboxyfluorescein succinimidyl ester (CFSE) test. Results: We detected reduced memory B and increased total, effector memory (EM), cytotoxic, and activated TCD8+ in IO, AI and CE, decreased plasmablasts, total and naive TCD4+, Regulatory TCD4+ (Treg) and naive TCD8+ in IO and CE, elevated CD21low B and terminally differentiated effector memory (TEMRA) TCD8+ in IO and AI, increased helper T (Th2) and Th17 in IO, decreased Th1 in AI and defective total and naive B and central memory (CM) TCD4+ in CE. IO showed reduced TCD4+ proliferation response. Conclusions: In genetically unsolved CVID patients, increased Th2 and Th17 and reduced Treg is associated with IO, increased CD21low B and TEMRA TCD8+ and reduced Th1 is contributed to AI and reduced total and naive B, CM TCD4+ and naive TCD8+ and expanded total TCD8+ is correlated with CE. © 2021 Informa UK Limited, trading as Taylor & Francis Group
A case report of ROHHAD syndrome in an 8-year-old Iranian Boy
No full textIntroduction: Rapid-onset obesity concurrently with hypoventilation, hypothalamic, autonomic dysregulation (ROHHAD) is an uncommon disease that presents with multiorgan disorders during early childhood, with fewer than 100 cases reported around the world. We aim to present a case of ROHHAD syndrome admitting with rare neurologic symptoms. We also present our treatment regimen. Case Presentation: An 8-year-old boy was admitted to our department with ataxia and gait disturbance that led us to the final diagnosis after a thorough investigation. He had multiple admissions and was treated for other diagnoses. His first symptoms started from age 5 with obstructive apnea. He underwent an adenectomy surgery at that time, but the symptoms continued. A year after the surgery, he was admitted again due to his somnolence but was diagnosed only with hypothyroidism and anemia. At the age of 7 years and 8 months, he was admitted to our department with ataxia and abnormal gait from the past year with instability and numerous falls. He also had shown hyperphagia that had been resulted in 10 kilograms of weight gain in six months. He was experiencing gradual behavioral symptoms, including episodes of self and hetero aggression and impulsivity. His other symptoms included fatigue, somnolence, gastrointestinal dysmotility, hyperhidrosis, central hypothyroidism, polyuria, precocious puberty, and rapid obesity. His laboratory investigation revealed hyperprolactinemia. Conclusions: Our case indicates that ROHHAD is a complex disease with divergent signs and symptoms that needs to be kept in mind for diagnosis and should be treated with a high level of collaboration of various medical specialties. Since late diagnosis of this syndrome leads to a magnificent increase in morbidity and mortality rates, it is vital to pay extreme attention to this syndrome. The diagnosis should be considered even more in children over two years old with rapid-onset obesity, which is accompanied by other symptoms. Here, our patient�s complaint was ataxia that revealed the underlying cause after investigation. Copyright © 2021, International Journal of Endocrinology and Metabolism. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
A rebuttal letter to the letter ID number CLRH-D-21�00,836 entitled �On the efficacy and safety of rituximab therapy in patients with systemic sclerosis disease: missing points, bottlenecks, over-exaggeration and discrepancies�
No full textGastric Kaposi sarcoma presenting as an upper gastrointestinal bleeding in a non-AIDS patient
No full textBackground: Majority of the patients affected by Kaposi sarcoma (KS) have human immunodeficiency virus (HIV). Highly active antiretroviral therapy (HAART) lessened the incidence of AIDS (acquired immunodeficiency syndrome)- related KS. Cutaneous signs are the most common, but involving the gastrointestinal (GI) tract is very important and dangerous because of serious complications including perforation and bleeding. Case Presentation: This report is a rare case of gastric-KS presenting as melena in a non-AIDS 67-year-old woman. We describe the diagnosis and management of this rare complication. Conclusion: GI-KS is often asymptomatic with different endoscopic appearances, and maybe present without cutaneous lesions. Thus, a high diagnostic suspicion is needed and we should attend these GI complications. © The Author(s