Golestan University of Medical Sciences
Golestan University of Medical Sciences RepositoryNot a member yet
3346 research outputs found
Sort by
Acinetobacter baumannii: An overview of emerging multidrug-resistant pathogen
No full textThe emergence of infections caused by Acinetobacter baumannii, a multidrug-resistant bacterium, has been a concern worldwide. This bacterium is an important hospitalacquired pathogen that causes several diseases including ventilator-associated pneumonia, bloodstream infections, and meningitis. This study aimed to determine antibioticresistant mechanisms in the pathogenesis of A. baumannii and the alternative treatment strategies against it. The combined actions of outer membrane protein A, formation of a biofilm on biotic and abiotic surfaces, phospholipases C and D, metal homeostatic system, lipopolysaccharides, and verotoxins are relevant for virulence and pathogenesis. A. baumannii resists the broad-spectrum antibiotics by its mechanisms of resistance, such as β-lactamases, efflux pump, aminoglycoside modifying enzymes, permeability changes, and alternation of targets. In an attempt to overcome the resistance mechanisms, plant-derived compounds and a combination of the antibiotics and the plant phytocompounds have been focused. Nanoparticles synthesised with the plant extract have been studied extensively. Furthermore, we projected modern methods, including multi-omics analysis, to study insight into mechanisms of actions of antibiotics. The information suggested that the potential antibiotic mechanisms of A. baumannii could lead to an alternative treatment against A. baumannii infections
In vivo and In vitro Anti-hydatidosis Effect of Garlic: A Systematic Review
No full textBackground: Hydatidosis is a parasitic disease caused by the larval stage of Echinococcus granulosus sensu lato. The aim of the current systematic review study was to clarify the effect of garlic on hydatid cyst in vivo and in vitro. Methods: We performed our analyses up to Feb 20, 2021, in accordance with the PRISMA guideline. We systematically searched five English databases (Science Direct, PubMed, Scopus, Ovid and Cochrane) and four Persian databases (Scientific Information Database SID, Iran Medex, Iran Doc, and Magiran) with appropriate syntax. The data was extracted from the relevant articles and analyzed. Results: From 160 studies obtained by initial search, nine studies were selected for further analysis. Among 6 in vitro studies, 3 (50%) used methanolic extract, 2 (34%) hydroalcoholic and chloroformic extract, and 1 (16%) chloroformic extract. Two (67%) studies used BALB/c mice, and one study (33%) used Swiss albino mice. The method of treatment of mice in all studies was oral. The results showed that garlic has a mild to potent effect on hydatidosis, and this effect was more considerable in vitro than in vivo. Conclusion: Based on the results of various studies, it can be concluded that Allium sativum extract can be used as a suitable alternative to drugs such as albendazole or can be used as a complementary treatment to reduce the dose of the current drugs. © 2022 Bentham Science Publishers
Corrigendum to �Non-ionic surfactant vesicles as novel delivery systems for sulfasalazine: Evaluation of the physicochemical and cytotoxic properties� Journal of Molecular Structure 1230 (2021) 129874 (Journal of Molecular Structure (2021) 1230, (S0022286021000053), (10.1016/j.molstruc.2021.129874))
No full textThe authors regret that the affiliation of all the authors in the article with the title (Non-ionic surfactant vesicles as novel delivery systems for sulfasalazine: Evaluation of the physicochemical and cytotoxic properties) that is incorrect. Please correct the affiliation of Mehrdad Aghaeia,1, Vahid Erfani-Moghadamb,c,1, Leila Daneshmandid, Alireza Soltanie,a*, Nafiseh Abdolahia,**, Marco Cordanif, Asieh Yahyazadehe, Sahar Moazen Rada, Samaneh Tavassolia, Hanzaleh Balakheylia aGolestan Rheumatology Research Center, Golestan University of Medical Science, Gorgan, Iran bCancer Research Center, Golestan University of Medical Sciences, Gorgan, Iran cDepartment of Medical Nanotechnology, School of Advanced Technologies in Medicine, Golestan University of Medical Sciences, Gorgan, Iran dDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA eDepartment of Chemistry, Faculty of Science, University of Guilan, P.O. Box 41335-1914, Rasht, Iran fInstitute for Advanced Studies in Nanoscience (IMDEA Nanociencia), Madrid, Spain The authors would like to apologize for any inconvenience caused. © 2022 Elsevier B.V
Urinary nitrate and sodium in a high-risk area for upper gastrointestinal cancers: Golestan Cohort Study�
No full textBackground: The epidemiological evidence regarding the carcinogenicity of nitrate and sodium in drinking water is limited, partly because measuring the exposure at the individual level is complex. Most studies have used nitrate in water supplies as a proxy for individual exposure, but dietary intakes and other factors may contribute to the exposure. The present study investigates the factors associated with urinary nitrate and sodium in a high-risk area for esophageal and gastric cancers. Methods: For this cross-sectional study, we used data and samples collected in 2004�2008 during the enrollment phase of the Golestan Cohort Study from a random sample of 349 participants (300 individuals from 24 rural villages and 49 from the city of Gonbad), stratified by average water nitrate in their district, the source of drinking water, and the usual dietary intake of nitrate and sodium. Nitrate, sodium, and creatinine were measured in a spot urine sample collected at the time of interview. We used the provincial cancer registry data to calculate the cumulative incidence rates of esophageal and gastric cancers for each location through June 1, 2020, and used weighted partial Pearson correlation to compare the incidence rates with median urinary nitrate and sodium in each village or the city. Results: Among 349 participants (mean age±SD: 50.7 ± 8.6 years), about half (n = 170) used groundwater for drinking, and the use of groundwater was significantly more common in high-elevation locations (75.8). The geometric mean of the creatinine-corrected urinary nitrate concentration was 68.3 mg/g cr (95CI: 64.6,72.3), and the corresponding geometric mean for urinary sodium was 150.0 mmoL/g cr (95CI: 139.6,161.1). After adjusting for confounders, urinary nitrate was associated with being a woman, drinking groundwater, and living in high-elevation locations, but not with estimated dietary intake. Urinary sodium concentration was significantly associated with monthly precipitation at the time of sampling but not with elevation or drinking water source. There were significant positive correlations between both median urinary nitrate and sodium in each location and esophageal cancer incidence rates adjusted for sex and age (r = 0.65 and r = 0.58, respectively, p < 0.01), but not with gastric cancer incidence. Conclusion: In a rural population at high risk for esophageal and gastric cancers, nitrate excretion was associated with living at a higher elevation and using groundwater for drinking. The associations between nitrate and sodium excretion with esophageal cancer incidence warrant future investigation. © 202
Corrigendum to data on nitrate�nitrite pollution in the groundwater resources a Sonqor plain in Iran Data in Brief Volume 20 (2018) Pages 394�401, (S2352340918308734), (10.1016/j.dib.2018.08.023)
No full textThe authors regret to say that they have forgotten to cite a key reference for the Table 4 and Fig. 7 during the preparation of draft manuscript. In this regard, the following citation should be considered as the reference for the mentioned sections: Setareh Parasto, Rezaei Mansour, Hassani Amir Hossam, Zeinatizadeh Ali Akbar. Distribution of groundwater pollution to nitrate in GIS environment: A case study of Songhar plain. Journal of Kermanshah University of Medical Sciences (improvement) (journal of Kermanshah University of Medical Sciences). 1393 cited 2021October28; 18 (3 (76)): 157�164. Available from: https://www.sid.ir/fa/journal/ViewPaper.aspx?id=224048.The authors would like to apologize for the authors of the above-detailed article any inconvenience caused. © 2022 The Author
The roles and therapeutic applications of cytokines in endometrial cancer
No full textEndometrial cancer (EC) is a common gynecological cancer globally and the most frequent gynecologic malignancy in industrialized countries. Patients are typically diagnosed when the disease is still restricted to the uterus. 5-year overall survival ranges from 70 to 90 in patients without metastatic disease; however, the metastatic form of the disease affects 16 of EC patients, with a 5-year survival rate of 16.8 . The immune system can detect abnormal cells as non-self in the early stages of carcinogenesis, producing the appropriate pro-inflammatory environment to eliminate cancer cells. In a second phase, cancer cells use various immune-editing systems to alter the profile of the immune response from pro to anti-inflammatory, resulting in immune escape. The directors of this immune switching mechanism are cytokines. Studies have reported the increased expression of several pro-and anti-inflammatory cytokines in EC tissues and cell lines, including Interleukin (IL)� 6, IL-8, IL-31, IL-33, IL-10, TGF-β, VEGF, and IL-1Ra. Immune cells producing these cytokines have also been reported to be present in EC tissues. Therefore, in this study, we aimed to show the possible mechanisms of the mentioned cytokines on EC progression, as well as the most current and prospective advancements in cytokine-based therapeutic applications. © 2022 Elsevier B.V
Features of Pathobiology and Clinical Translation of Approved Treatments for Coronavirus Disease 2019
No full textBackground: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is currently the most important etiological agent of acute respiratory distress syndrome (ARDS) with millions of infections and deaths in the last 2 years worldwide. Several reasons and parameters are responsible for the difficult management of coronavirus disease-2019 (COVID-19) patients; the first is virus behavioral factors such as high transmission rate, and the different molecular and cellular mechanisms of pathogenesis remain a matter of controversy, which is another factor. Summary: In the present review, we attempted to explain about features of SARS-COV-2, particularly focusing on the various aspects of pathogenesis and treatment strategies. Key Messages: We note evidence for the understanding of the precise molecular and cellular mechanisms of SARS-CoV-2 pathogenesis, which can help design the appropriate drug or vaccine. Additionally, and importantly, we reported the updated issues associated with the history and development of treatment strategies such as, drugs, vaccines, and other medications that have been approved or under consideration in clinics and markets worldwide. © 202
Comparing the Effect of Extended PLISSIT Model and Group Counseling on Sexual Function and Satisfaction of Pregnant Women: A Randomized Clinical Trial
No full textIntroduction: Changes in the performance and sexual satisfaction of women during pregnancy can be one of the important factors involved in the emergence of sexual problems in women. This study aimed to compare the effect of Extended Permission, Limited Information, Specific Suggestion, Intensive Therapy (Ex-PLISSIT) and group counseling on sexual function and satisfaction of pregnant women. Methods: A randomized clinical trial was conducted on 111 pregnant women from 2016 to 2018 in Zanjan, Iran. Eligible participants were selected through convenience sampling method and allocated into three groups Ex-PLISSIT model, group counseling and control group, using block randomization method. Sexual function and sexual satisfaction were evaluated via the Female Sexual Function Index (FSFI) and Hudson's sexual satisfaction questionnaire at baseline and four weeks after the last counseling session. Data were analyzed using SPSS ver. 13 and ANCOVA, ANOVA, Wilcoxon, chi-square, Mann-Whitney U, and Kruskal Wallis tests. Results: Median (interquartile range) of the participants' sexual function in the Ex-PLISSIT group was 25.9 (4) in the counseling group, 26 (5.5), in the control group, and 25.8 (4.8) at the baseline. These scores changed to 28.9 (5.4), 27.9 (5.1), and 25.2 (4.3) at the 4-week follow-up, respectively. These differences were statistically significant. Moreover, there was a statistically significant difference in the mean sexual satisfaction scores between the three groups, at the follow up period. Conclusion: Providing sexual counseling by any approach during routine prenatal care by community midwives may improve couples' sexual health. © 2022 The Author(s)
Comparison of the effects of two different doses of Filgrastim in febrile neutropenia management in childhood malignancy: A randomized clinical trial
No full textBackground: Febrile neutropenia (FN) is most often caused due to chemotherapy. Solid or certain lymphoproliferative malignancies can increase the duration of hospitalization and other complications in cancer patients. Filgrastim is used in childhood FN management. This study aimed to compare the effect of two different doses of Filgrastim on hematological and paraclinical factors in hospitalized febrile neutropenic patients with cancer. Materials and methods: In this randomized clinical trial, 60 febrile neutropenic patients with cancer complying with the inclusion criteria were assigned to both groups A and B. Thirty patients in group A received Filgrastim 5µg/kg/day whereas 30 others in group B received Filgrastim 15µg/kg/day. Hematological factors, physical examination findings, antibiotic administration period, and type of malignancy were then recorded. Complete blood count with differential (CBC diff) was also tested. Lung infiltration was examined by chest X-ray (CXR), and the spleen and abdomen were monitored by ultrasound. Results: The mean age of patients was 6 ± 3 years old. The most prevalent malignancies included acute lymphoblastic leukemia (ALL) (35.0), neuroblastoma (18.3), osteosarcoma (11.7), acute myeloid leukemia (AML) (8.3), and Rhabdomyosarcoma (8.3). The frequency distribution of malignancies significantly differed between the two groups (P=.01). Changes in hematological factors, including white blood cells (WBC), mature neutrophil cells, and absolute neutrophil count (ANC) in group A, appeared lower than those in the other group. However, none of the studied factors, including hematological factors, physical examination findings, and antibiotic administration period, were found to differ significantly between the two groups (P> 0.05). Conclusion: Much as a higher dose of Filgrastim seems to bear a better effect on ANC, no significant difference was identified between the two groups. Further studies should be designed with a larger population to address the issue. © 2022. Iranian Journal of Pediatric Hematology and Oncology. All Rights Reserved
Comparison of antithyroid effects and hepatic complications of methimazole with catechin and its nanoencapsulation form in adult male rats
No full textMethimazole is an antithyroid drug and is used clinically in hyperthyroidism. Liver dysfunction is one of the side effects of methimazole. Catechins are natural flavonoids and have antioxidant, antithyroid, and liver protection effects. Despite the wide range of biological properties of catechins, their effective use is limited due to poor water solubility, low stability, and low bioavailability. Catechin niosomal nanoencapsulation improves the properties of catechin and increases its antioxidant activities. Niosomal vesicles were synthesized by the Thin Film Hydration method and their physicochemical characteristics, morphology, and percentage of trapped catechin in them were determined by dynamic light scattering (DLS), transmission electron microscopy (TEM), and spectrophotometry, respectively. In this study, 32 adult male rats were divided into 4 groups: Control, 50 mg/kg methimazole, 100 mg/kg catechin, and 100 mg/kg nanocapsule niosomal form of catechin. The drugs were administered orally and the duration of treatment was 8 weeks. Then, the serum concentration of thyroid hormones and thyroid stimulating hormone (TSH) by enzyme-linked immunosorbent assay (ELISA) method, and serum liver function tests were performed using an autoanalyzer. The activities of hepatic oxidative enzymes were measured spectrophotometrically. Our study showed that the percentage of catechin encapsulation in the niosome was calculated to be 51. A significant difference was observed in the catechin and encapsulated catechin treatment groups compared to the methimazole group (p <0.0001). In all three treatment groups of methimazole, catechin, and niosomal nanocapsule catechin, serum levels of TT3, TT4, FT3, FT4, body weight and daily consumption of water and food were significantly reduced compared to the control group (p <0.0001). The antithyroid effects of catechin and its encapsulated form were comparable to methimazole. Also, the encapsulation improved the hepatoprotective effects of catechin. © 2022 Walter de Gruyter GmbH, Berlin/Boston