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    Almonds (Prunus Dulcis Mill. D. A. Webb): A Source of Nutrients and Health-Promoting Compounds

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    Almonds (Prunus dulcis Miller D. A. Webb (the almond or sweet almond)), from the Rosaceae family, have long been known as a source of essential nutrients; nowadays, they are in demand as a healthy food with increasing popularity for the general population and producers. Studies on the composition and characterization of almond macro- and micronutrients have shown that the nut has many nutritious ingredients such as fatty acids, lipids, amino acids, proteins, carbohydrates, vitamins and minerals, as well as secondary metabolites. However, several factors affect the nutritional quality of almonds, including genetic and environmental factors. Therefore, investigations evaluating the effects of different factors on the quality of almonds were also included. In epidemiological studies, the consumption of almonds has been associated with several therapeutically and protective health benefits. Clinical studies have verified the modulatory effects on serum glucose, lipid and uric acid levels, the regulatory role on body weight, and protective effects against diabetes, obesity, metabolic syndrome and cardiovascular diseases. Moreover, recent researchers have also confirmed the prebiotic potential of almonds. The present review was carried out to emphasize the importance of almonds as a healthy food and source of beneficial constituents for human health, and to assess the factors affecting the quality of the almond kernel. Electronic databases including PubMed, Scopus, Web of Science and SciFinder were used to investigate previously published articles on almonds in terms of components and bioactivity potentials with a particular focus on clinical trials

    Multi-assay investigation of viral etiology in pediatric central nervous system infections

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    Introduction: In an attempt to identify a wide spectrum of viral infections, cerebrospinal fluid (CSF) specimens were collected from pediatric cases with the preliminary diagnosis of viral encephalitis/meningoencephalitis in two reference hospitals, from October 2011 to December 2015. Methodology: A combination of nucleic acid-based assays, including in house generic polymerase chain reaction (PCR) assays for enteroviruses, flaviviruses and phleboviruses, a commercial real-time PCR assay for herpesviruses and a commercial real time multiplex PCR, enabling detection of frequently-observed viral, bacterial and fungal agents were employed for screening. Results: The microbial agent could be characterized in 10 (10\%) of the 100 specimens. Viral etiology could be demonstrated in 7 (70\%) specimens, which comprises Human Herpesvirus 6 (4/7), Herpes Simplex virus type1 (2/7) and Enteroviruses (1/7). In 3 specimens (30\%), Streptococcus pneumoniae, Listeria monocytogenes and Staphylococcus aureus were detected via the multiplex PCR, which were also isolated in bacteriological media. All specimens with detectable viral nucleic acids, as well as unreactive specimens via nucleic acid testing remained negative in bacteriological cultures. Conclusions: Herpes and enteroviruses were identified as the primary causative agents of central nervous system infections in children. Enterovirus testing must be included in the diagnostic work-up of relevant cases

    Network And Modernıty Of “Hıgh Socıety” In Urban Spaces Of Istanbul, 1856-1896

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    19. yüzyıl İstanbul’unda gerçekleşen değişim ve dönüşümler, ağırlıkla merkezi otoritenin tepeden dayattığı reformist hareketler olarak algılanmıştır. Bu tez ise yaşanan dönüşümü kentli tarafından talep edilen bir modernleşme isteği olarak görmektedir. Bu bağlamda da değişim ve dönüşümler tez çalışmasında modernlik halleri olarak tanımlanmış ve izleri İstanbul kent mekânlarında araştırılmıştır. Edilgen olmayan kentli, yaşadığı çevreyi –ya da kenti- modern hayatın yeni eylemlerinden doğan yeni hayat tarzına uygun hale getirmeye çabalarken kentin modernleşmesinde söz sahibi olmuştur. Kent toplumunda spekülatör ya da sermayedar olarak bilinen banker, sarraf ya da benzeri mesleklerle uğraşan, piyasada güç sahibi oldukları gibi tabii oldukları cemaatlerde öncü / lider olarak görülen, yönetimsel güçleri sayesinde merkezi otorite dışında / yanında olan edilgen olmayan aktör-bireylerden oluşan kentli topluluğu, tez çalışmasında yüksek sosyete olarak adlandırılmıştır. Tanımlı aktörler olarak yüksek sosyetenin modernlik halleri Giddens’a atıfla, tanımlı bir zaman-mekânda -1856-1896 yılları arasında İstanbul kent mekânlarındagerçekleştirdikleri tanımlı eylemler –temel gündelik hayat etkinlikleri barınma ve çalışma ile rutinlerin bozulduğu sosyal etkinlikler- üzerinden araştırılmıştır. İstanbul’un bir yılında yüksek sosyetenin gerçekleştirmiş olduğu etkinliklerin çeşitliliği, mevsimlerdeki sezonları buna bağlı olarak da aktör-bireylerin gündelik hayatlarını farklılaştırmıştır. Mevsimlerin devingenliğindeki bu özgün durumun varlığına göre biçimlenmiş olan tez çalışmasında gündelik hayattaki farklılaşmalar muhtelif yöntemler kullanılarak araştırılmıştır. Yüksek sosyetenin belirlenmesinde, topluluğun biyografisini oluşturmak olarak tanımlanabilecek maddi bir araştırma yöntemi olan prosopografi kullanılmıştır. Daha sonra, prosopografinin çıktıları olan biyografik sözlük ve iletişim ağından yararlanılarak, gündelik güzergâhlar ya da zaman-mekân izleri haritaları üretilmiştir. Haritalama yönteminin kullanıldığı bu aşamadan sonra da süreli yayınlardan elde edilen enstantanelerden eylemler aracılığıyla eylemin gerçekleştiği yerlerin ya da başka bir deyişle kentsel mekânların biyografileri oluşturulmuştur. Merkezi otorite açısından bakan genel değerlendirmeler yerine gerçek zaman-mekânda, aktörlerin eylemleri üzerinden araştırılan modernlik halleri için birincil kaynaklar olan dönemin ticaret yıllıklarından, süreli yayınlardan ve haritalardan faydalanılmıştırThe changes and transformations that took place in 19th century Istanbul were seen as a desire for modernization rather than reformist movements imposed by the central authority. In this context, changes and transformations have been defined as the states of modernity in the thesis and their traces have been investigated in urban spaces of İstanbul. The non-passive urban citizen has had a say in the modernization of the city while trying to adapt the environment in which he/she lives for the new life style arising from the new activities of modern life. The urban community of nonpassive actor-individuals, known as speculators or capitalists in urban society, engaged in banker, sarraf or similar professions, are seen as pioneers / leaders in their communities who are related or not related to the central authority through their administrative powers, was called high society. The state of modernity of the high society as defined actors, with reference to Giddens, was investigated in a defined time-space (urban spaces of Istanbul between the years 1856-1896) through defined activities they took (such as basic daily activities like dwelling, working and also social activities where routines were broken). The diversity of the high society's activities in one year of Istanbul differentiated the seasons and the daily lives of actor-individuals -accordingly to the seasons. In this thesis, which is shaped according to the existence of this unique situation on the seasons, the differences in daily life were investigated by using various methods. In the determination of high society, prosopography, a material research method that can be defined as forming the biography of the community, was used. Then, maps of daily routes or time-space traces were produced by using the biographical lexicon and communication network which are the outputs of prosopography. After this stage in which mapping method was used, biographies of the places or in other words urban spaces where the activities took place were created through the snapshots obtained from periodicals published in the second half of the 19th century. In order to avoid general evaluations primary sources like annuals, periodicals and maps of the period, were researched

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