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Prognostic significance of early complete response in patients with locally advanced rectal cancer undergoing preoperative chemoradiotherapy: Multicentric study of Turkish Society for Radiation Oncology Group (TROD)
No full textBackground/Aims: To assess the effect of various parameters on the
oncologic outcomes, including the time interval between therapy and
surgery (S) in locally advanced rectal cancer (LARC) patients receiving
preoperative chemoradiotherapy (CRT).
Materials and Methods: The data of 914 LARC patients who received
preoperative CRT between 1994 and 2015 were collected retrospectively.
Patients received 45-50.4 Gy RT with 5FU based chemotherapy (CT). They
all underwent radical resection followed by maintenance CT. Clinical and
pathologic variables were compared between the pCR and no-pCR groups.
Survival was estimated by the Kaplan-Meier method and Cox proportional
hazard model was used in multivariate analysis.
Results: After median follow-up of 60.5 (range=12-297.6) months, median
overall survival (OS) was 58.75 months and disease-free survival (DFS)
53.32 months. pCR was observed in 18.9\% of all cases. pCR,
lymphovascular invasion and metastatic lymph node ratio (mLNR) were
significantly associated with OS and DFS on multivariate analysis. The
5-year OS and DFS rates were better in pCR group (95.3\% vs 80.7\% for
OS, p<0.0001 and 87.4\% vs 71\% for DFS, p<0.0001). pCR patients with
4-8 weeks interval had lower rates of distant metastasis (9\% vs 20\%,
p=0.01) and any recurrences (13.6\% vs 29.6\%, p=0.001) than the
remaining. Both OS and DFS were better in favor of pCR achieved at 4-8
week interval time (p<0.0001 for each).
Conclusion: pCR after preoperative CRT in LARC correlated with better
oncologic outcome. The best OS and DFS durations were achieved in
patients who experienced pCR after 4-8-weeks interval before surgery
Review on Vehicle-to-Grid Systems: The Most Recent Trends and Smart Grid Interaction Technologies
No full textAcute necrotizing encephalopathy with organic psychosis: a pediatric case report
No full textBackground. Enteroviruses-associated acute necrotizing encephalopathy
(ANE) of childhood is rarely reported in the literature.
Clinico-radiological features of ANE are well-recognized and bilateral
thalamic nuclei are frequently affected by ANE. Neuropsychiatric
symptoms are rarely seen. Thalamic damage can cause psychosis.
Case. Herein, we present a pediatric case of enterovirus-associated ANE
presenting with psychosis related to thalamus damage in whom a favorable
response to treatment was achieved.
Conclusion. Thalamic damage occurs during the Enteroviruses-associated
acute necrotizing encephalopathy and it can be related psychiatric
sympthoms. Clinicians should be aware of uncommon presentations of ANE,
and patients with thalamic damage should be followed for
neuropsychiatric manifestations. Early recognition and appropriate
treatment of ANE is important to obtain favorable outcomes
İlköğretim Kurumu Yöneticilerinin Kullandıkları Etkileme Taktikleri ile Öğretmenlerin Örgütsel Bağlılığı Arasındaki İlişki *
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