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    EMERGENCY SIMULATION IN A LONG HIGHWAY TUNNEL

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    In regions that are difficult to overcome geographically in road transport, tunnels both shorten the road to be covered and save fuel. It is the worst scenario that a vehicle can burn in a tunnel. There have been major tunnel fires in the world that have resulted in people's lives. In our country, long highway tunnels such as the Ovit, Kop and Zigana tunnels are being built. In this study, emergency modeling was carried out for vehicle fire (30 MW) in a long road tunnel (14.5 km). The critical point for the emergency was determined and the 1000 m long region was examined on a scale of 1/100. Ansys Fluent was used in the study. Turbulent flow conditions are taken into account. Temperature distribution, carbon monoxide (CO) emission distribution and velocity distributions in the region where the fire is located were examined. Results are given in graphs and interpreted. When the temperature values are examined, the average temperature values in the fire zone were obtained above 400 K in the first 30 m. It was obtained that the CO values did not fall below 400 ppm until the firing shaft, especially in the first 50 m, above 1000 ppm on average

    Which out-of-office measurement technique should be used for diagnosing hypertension in prehypertensives?

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    Hypertension (HT) is diagnosed with high office blood pressure (BP), although confirmation with the addition of out-of-office measurements is currently recommended. However, insufficient data are available concerning the use of out-of-office BP measurement techniques for the diagnosis of HT in the prehypertensive population. The aim of the present study was to determine which out-of-office measurements yielded earlier and more frequent detection of development of HT in prehypertensive patients. Two hundred seven prehypertensive patients under monitoring in the Cappadocia cohort were included in the study. Office BP was measured five times at 1-min intervals, followed by 24-h ambulatory BP monitoring (24-h ABPM). Home BP measurement (HBPM) was performed five times, at the same times in the morning and evening, at 1-min intervals for 1 week. The same procedure was carried out at 4-6-month intervals for \~{}2 years. HT was diagnosed in 25.6\% of subjects, masked HT in 11.1\%, and white coat HT in 2.9\%, while 23.7\% remained prehypertensive and 36.7\% became normotensive. Briefly, 56.6\% of the patients with HT were diagnosed with office plus 24-h ABPM, 13.2\% with office plus HBPM, and 30.2\% with office plus HBPM and 24-h ABPM. Office with 24-h ABPM yielded statistically significantly more diagnoses (p < 0.001). In conclusion, our prospective observational study evaluated the usefulness of out-of-office BP measurements in confirming diagnosis of HT in prehypertensive patients. The findings show that 24-h ABPM detected HT earlier and more frequently in this high-risk population

    Micromonospora deserti sp. nov., isolated from the Karakum Desert

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    An isolate, 13K206(T), with typical morphological characteristics of the genus Micromonospora was obtained during a study searching for novel actinobacteria with biosynthetic potential from the Karakum Desert. A polyphasic approach was adopted to determine taxonomic affiliation of the strain. The strain showed chemotaxonomical properties consistent with its classification in the genus Micromonospora such as meso- and 3-OH-A(2)pm in the cell-wall peptidoglycan, xylose in whole-cell hydrolysate and diphosphatidylglycerol, phosphatidylethanolamine and phosphatidylinositol as major polar lipids. The results of phylogenetic analysis based on 16S rRNA gene sequences revealed that the strain was closely related to `Micromonospora spongicola' S3-1(T), Micromonospora nigra DSM 43818(T) and Micromonospora yasonensis DS3186(T) with sequence similarities of 98.6, 98.5 and 98.4 \%, respectively. Digital DNA-DNA hybridization and average nucleotide identity analyses in addition to gyrB gene analysis confirmed the assignment of the strain to a novel species within the genus Micromonospora for which the name Micromonospora deserti sp. nov. is proposed. The type strain is 13K206(T) (=JCM 32583(T)=DSM 107532(T)). The DNA G+C content of the type strain is 72.4 mol\%

    Quality-of-life Evaluation of Healthy Siblings of Children with Chronic Illness

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    Background: Chronic disease of children can cause changes in the health-related quality of life (HrQoL) of the family members. Aims: To evaluate the HrQoL of healthy siblings of children with chronic disease. Study Design: Cross-sectional study. Methods: The study included healthy sibling of children with chronic disease (cerebral palsy, epilepsy; diabetes, celiac disease, hematologic/ oncologic disease, or asthma) and healthy sibling of healthy children to evaluate the quality of life. We used the Pediatric Quality of Life Inventory questionnaire; the physical health and psychosocial health scores were calculated using the responses of the sibling and parent. The primary endpoint was the comparison of HrQoL scores of healthy siblings of children with chronic disease and that of healthy siblings of healthy children. Results: This study included a respective healthy sibling of 191 children with chronic disease and healthy sibling of 100 healthy children. The physical health, psychosocial health, and total health scores of healthy siblings of children with chronic disease were significantly lower than that of healthy siblings of healthy children (p<0.001). Among the healthy siblings of children with chronic disease, the lowest psychosocial health score was found in the siblings of children with cerebral palsy, hematologic/oncologic disease. and asthma (p<0.001). The global impact on the quality of life for healthy siblings of children with chronic disease was significantly higher in the self-report of the children than that of the parents (30.4\% versus 15.1\%, p<0.05). Conclusion: Most healthy siblings of children with chronic disease are physically and psychosocially affected and there is low parental awareness of this condition. This can increase the risk of emotional neglect and abuse of these children. Therefore. special support programs are needed for the families of children with chronic diseases

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