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Seasonal variations in blood parameters among Kyrgyz Elite judo athletes [Variações sazonais de alguns parâmetros sanguíneos em atletas de judô de elite do quirguistão]
No full text
MEASURING PLASMA FERRITIN LEVELS WITH TWO DIFFERENT METHODS: A COMPARISON OF ROCHE COBAS E601 VERSUS ROCHE COBAS C501 (INTEGRATED MODULAR SYSTEM ROCHE COBAS 6000)
No full textBackground: The aim of our study is to compare plasma ferritin levels
found to be high or low in terms of reference range by means of
electrochemiluminescence (ECLIA) and immunoturbidimetric method and to
examine whether they can be used interchangeably.
Methods: 84 patients with high plasma ferritin level and 153 patients
with low ferritin level according to the reference range were included
in the study. Plasma samples measured in Cobas e601 device with ECLIA
were also measured as immunoturbidimetric Cobas c501 device. For method
comparison, CLSI EP-A3 Guideline was used. While the consistency between
the methods were specified with Passing-Bablok regression analysis and
Spearman correlation analysis, bias error between the methods (bias\%)
was determined through Bland-Altman analysis.
Results: Both high and low plasma ferritin levels measured with Cobas
e601 module and determined high in terms of reference range were
compared with the results found with cobas c501 module. The difference
was found to be statistically significant (p<0.001). According to
regression and correlation (for low plasma ferritin levels; r: 0.993,
p<0.001, for high plasma ferritin levels; r: 0.966, p<0.001) results,
the methods were in consistency with each other. Additionally, while the
bias\% value was found to be 10.4\% for low plasma ferritin levels, it
was found to be 12.6\% for high ferritin levels.
Conclusions: Accordingly, we believe that, comparison with more samples
especially in terms of different clinical decision levels is required in
order to examine interchangeable use of immunoturbidimetric method in
integrated devices and ECLIA
Synthesis, Spectroscopic Characterizations of Novel Norcantharimides, Their ADME Properties and Docking Studies Against COVID-19 M-pr degrees
No full textA series of novel Norcantharimide derivatives were synthesized and their
structures were characterized by FTIR, H-1 and C-13 NMR spectroscopy as
well as elemental analyses. The absorption, distribution, metabolism and
excretion (ADME) properties of the synthesized molecules were
investigated. The results obtained in silico demonstrated that these
molecules can be considered as orally active drug candidates due to
their physicochemical properties. Also, docking studies demonstrated
that all derivatives exhibit a good theoretical affinity with MolDock
Score in between 124-138 against the main protease of Coronavirus
Disease 2019 (COVID-19 M-pr degrees) that caused worldwide epidemics. We
believe that newly synthesized norcantharimide derivatives can guide
many future studies in organic synthesis, medicine and pharmaceutical
applications
Exploiting implicit social relationships via dimension reduction to improve recommendation system performance
No full textThe development of Web 2.0 and the rapid growth of available data have
led to the development of systems, such as recommendation systems (RSs),
that can handle the information overload. However, RS performance is
severely limited by sparsity and cold-start problems. Thus, this paper
aims to alleviate these problems. To realize this objective, a new model
is proposed by integrating three sources of information: a user-item
matrix, explicit and implicit relationships. The core strategy of this
study is to use the multi-step resource allocation (MSRA) method to
identify hidden relations in social information. First, explicit social
information is used to compute the similarity between each pair of
users. Second, for each nonfriend pair of users, the MSRA method is
applied to determine the probability of their relation. If the
probability exceeds a threshold, a new relationship will be established.
Then, all sources are incorporated into the Singular Value Decomposition
(SVD) method to compute the missing prediction values. Furthermore, the
stochastic gradient descent technique is applied to optimize the
training process. Additionally, two real datasets, namely, Last.Fm and
Ciao, are utilized to evaluate the proposed method. In terms of
accuracy, the experiment results demonstrate that the proposed method
outperforms eight state-of-the-art approaches: Heats, PMF, SVD, SR,
EISR-JC, EISR-CN, EISR-PA and EISR-RAI
Potential Antioxidant and Enzyme Inhibitory Effects of Nanoliposomal Formulation Prepared from Salvia aramiensis Rech. f. Extract
No full textSalvia aramiensis Rech. f. is a species that grows only in Hatay, Turkey
and is used as a traditional stomachic tea. Neither the chemical
composition nor the potential bioactivity of the plant has been
investigated before. Antioxidant activity (1,1-Diphenyl-2-picrylhydrazyl
Radical (DPPHBLACK CIRCLE) and 2,2'-Azino-bis
(3-ethylbenzothiazoline-6-sulfonic acid (ABTS(+BLACK CIRCLE)) radical
scavenging and beta-carotene/linoleic acid co-oxidation) of 70\%
methanol, 70\% ethanol extracts, and 2\% infusion obtained from S.
aramiensis aerial parts were determined. The effect of 70\% methanol
extract on collagenase and elastase enzyme inhibition and its chemical
composition via chromatographic methods (LC-MS/MS and HPLC) were
analyzed. Nanoliposomes were developed with 70\% methanol extract, were
characterized, and were evaluated. The key parameters for the most
active 70\% methanol extract included the following (DPPHEC50)-E-center
dot: 28.4 mu g/mL, Trolox equivalent antioxidant capacity (TEAC)/ABTS:
1.77 +/- 0.09 mmol/L/Trolox. Furthermore 70\% methanol extract showed
more than 50\% inhibition on collagenase and elastase enzymes at all the
concentrations. The main component of the extract, rich in phenolic
compounds, has been identified as rosmarinic acid; 83.7 mu g/mL extract
was released from the nanoliposomal formulation. The extract and its
formulation are found to be nontoxic on the L929 fibroblast cell line.
This study successfully developed a long-term antioxidant and enzyme
inhibitory formulation containing S. aramiensis, which has been used
safely among the public for years
The impact of [1,2,5]chalcogenazolo[3,4-f]-benzo[1,2,3]triazole structure on the optoelectronic properties of conjugated polymers
No full text
Structural Characteristics in the gamma Chain Variants Associated with Fibrinogen Storage Disease Suggest the Underlying Pathogenic Mechanism
No full textParticular fibrinogen gamma chain mutations occurring in the
gamma-module induce changes that hamper gamma-gamma dimerization and
provoke intracellular aggregation of the mutant fibrinogen, defective
export and plasma deficiency. The hepatic storage predisposes to the
development of liver disease. This condition has been termed hereditary
hypofibrinogenemia with hepatic storage (HHHS). So far, seven of such
mutations in the fibrinogen gamma chain have been detected. We are
reporting on an additional mutation occurring in a 3.5-year-old Turkish
child undergoing a needle liver biopsy because of the concomitance of
transaminase elevation of unknown origin and low plasma fibrinogen
level. The liver biopsy showed an intra-hepatocytic storage of
fibrinogen. The molecular analysis of the three fibrinogen genes
revealed a mutation (Fibrinogen Trabzon Thr371Ile) at exon 9 of the
gamma chain in the child and his father, while the mother and the
brother were normal. Fibrinogen Trabzon represents a new fibrinogen
gamma chain mutation fulfilling the criteria for HHHS. Its occurrence in
a Turkish child confirms that HHHS can present in early childhood and
provides relevant epidemiological information on the worldwide
distribution of the fibrinogen gamma chain mutations causing this
disease. By analyzing fibrinogen crystal structures and calculating the
folding free energy change (Delta Delta G) to infer how the variants can
affect the conformation and function, we propose a mechanism for the
intracellular aggregation of Fibrinogen Trabzon and other gamma-module
mutations causing HHHS