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The Impact of Pre-transplant Cell-free DNA Levels on Leukemia Relapse and Transplant-related Complications in Allogeneic Hematopoietic Stem Cell Transplant Recipients
No full textBackground: Cell-free DNA, which may be considered as ``liquid{''}
biopsy, may serve as a diagnostic and prognostic marker not only in
hematological malignancies but in solid tumors as well.
Aims: To investigate the prognostic role of pre-transplant cell-free DNA
levels in allogeneic hematopoietic stem cell transplant recipients.
Study Design: Retrospective cohort study.
Methods: A total of 177 allogeneic hematopoietic stem cell transplant
recipients {[}median age: 36 (16-66) years; male/female: 111/66] with an
initial diagnosis of acute leukemia were included in the study.
Cell-free DNA was extracted from pre-transplant serum samples by using
the MagNA Pure Compact Nucleic Acid Isolation Kit I with the MagNA Pure
Compact instrument (Roche Diagnostics, Penzberg, Germany).
Results: A positive correlation was demonstrated between cell-free DNA
and age (p=0.018; r=0.177). Pre-transplant cell-free DNA levels were
lower in bcr-abl (+) patients (p=0.001), while an adverse correlation
was indicated between cell-free DNA and bcr-abl levels (p=0.001: r=
0.531). Acute lymphoblastic leukemia patients with bcr-abl positivity
(p=0.001) or abnormal cytogenetics (p=0.038) represented significantly
lower pre-transplant cell-free DNA levels. Cell-free DNA levels were
lower in patients who developed sinusoidal obstruction syndrome
(p=0.035). In terms of long-term complication acute myeloid leukemia
patients who experienced post-transplant relapse had significantly lower
pre-transplant cell-free DNA levels (p=0.024). Overall survival was not
statistically different between high- and low- cell-free DNA groups
(45.2\% vs 22.5; p=0.821).
Conclusion: In general. low serum levels of pre-transplant cellfree DNA
seem to be associated with transplant-related morbiditic, and may be
considered an adverse prognostic factor for allogeneic hematopoietic
stem cell transplant recipients
Parasal Değişkenler ve Çıktı İlişkisinin Türkiye İçin Tarihsel Ayrıştırma Yöntemi İle Analizi
No full textPrediction of shrinkage ratio for 316 l feedstock with artificial neural networks in powder injection molding [Toz enjeksiyon kalıplamada 316 l besleme stokunun çekme yüzdesinin yapay sinir ağları ile tahmin edilmesi]
No full textOxidative Stress and Marine Carotenoids: Application by Using Nanoformulations
No full textCarotenoids are natural fat-soluble pigments synthesized by plants,
algae, fungi and microorganisms. They are responsible for the coloration
of different photosynthetic organisms. Although they play a role in
photosynthesis, they are also present in non-photosynthetic plant
tissues, fungi, and bacteria. These metabolites have mainly been used in
food, cosmetics, and the pharmaceutical industry. In addition to their
utilization as pigmentation, they have significant therapeutically
applications, such as improving immune system and preventing
neurodegenerative diseases. Primarily, they have attracted attention due
to their antioxidant activity. Several statistical investigations
indicated an association between the use of carotenoids in diets and a
decreased incidence of cancer types, suggesting the antioxidant
properties of these compounds as an important factor in the scope of the
studies against oxidative stress. Unusual marine environments are
associated with a great chemical diversity, resulting in novel bioactive
molecules. Thus, marine organisms may represent an important source of
novel biologically active substances for the development of
therapeutics. Marine carotenoids (astaxanthin, fucoxanthin,
beta-carotene, lutein but also the rare siphonaxanthin, sioxanthin, and
myxol) have recently shown antioxidant properties in reducing oxidative
stress markers. Numerous of bioactive compounds such as marine
carotenoids have low stability, are poorly absorbed, and own very
limited bioavailability. The new technique is nanoencapsulation, which
can be used to preserve marine carotenoids and their original properties
during processing, storage, improve their physiochemical properties and
increase their health-promoting effects. This review aims to describe
the role of marine carotenoids, their potential applications and
different types of advanced nanoformulations preventing and treating
oxidative stress related disorders
Materyal Geliştirmede Ses Kayıt ve Düzenleme Programlarının Kullanımına Yönelik Öğrenci Görüşleri
No full textDetermination of body image, self-esteem and depression states among patients with gynecological cancer
No full textEffect of the COVID-19 pandemic on anxiety among children with cystic fibrosis and their mothers
No full textBackground We aimed to evaluate anxiety among children with cystic
fibrosis (CF) and their mothers related to the COVID-19 pandemic.
Methods A total of 45 patients with CF and their mothers were enrolled
in the study together with 90 age-matched healthy children and their
mothers as a control group. The State and Trait Anxiety Inventory (STAI)
was administered by teleconference with children aged 13 to 18 years old
and their mothers. The STAI for children was administered with children
aged 9 to 12 years. Results were compared with age-matched healthy
children and their mothers. The relationship between anxiety scores of
children with CF and their mothers was evaluated by comparing with
clinical data of children with CF. At the conclusion of the
teleconference, mothers were asked whether their anxiety had changed as
a result of the interview. Results It was found that healthy children
aged 13 to 18 years had higher state anxiety scores than age-matched
children with CF. Mothers of children with CF had higher trait anxiety
scores, especially those of children aged 0 to 12 years, than mothers of
healthy children (P < .05). For mothers of children with CF, state
anxiety scores were higher among those whose children had
chronicPseudomonasinfection (P < .05). Most mothers of children with CF
stated that their anxiety decreased following the interview. Conclusion
The COVID-19 pandemic may increase anxiety among mothers of children
with CF as well those with healthy children. However, COVID-19 had no
effect on the anxiety of children with CF. Informing parents of children
with CF about COVID-19 by teleconference may decrease anxiety
Synthesis, Characterization, Absorption and Fastness Properties of Novel Monoazo Dyes Derived from 1-Phenyl-3-amino-4-(2-thiazolilazo)pyrazol-5-one
No full textMonosubstitute thiazolyl amines were diazotized in acetic acid, coupled
to 1-phenyl-3-aminopyrazol-5-one (1a-1c) and acetylated to obtain the
2a-2c dyes. The dyes were characterized by elemental analysis and
spectroscopic (Fourier transform infrared (FTIR), nuclear magnetic
resonance (NMR), ultraviolet (UV)) methods. The effects on the visible
absorption spectra of the substituents present, solvents, pH,
concentration and temperature were investigated in detail. Tautomerism
of the dyes were investigated by spectroscopic methods. Fastness
properties of dyes were studied using the standard method for the
assessment of color fastness of textile