Gazi University Dspace
Not a member yet
26981 research outputs found
Sort by
The attitudes of the students coming from the turkic world towards the texts in turkey turkish language [Türk dünyasından gelen öğrencilerin türkiye türkçesi metinlerine yönelik tutumları]
No full textCombretastatins: An Overview of Structure, Probable Mechanisms of Action and Potential Applications
No full textCombretastatins are a class of closely related stilbenes
(combretastatins A), dihydrostilbenes (combretastatins B), phenanthrenes
(combretastatins C) and macrocyclic lactones (combretastatins D) found
in the bark of Combretum caffrum (Eckl. \& Zeyh.) Kuntze, commonly known
as the South African bush willow. Some of the compounds in this series
have been shown to be among the most potent antitubulin agents known.
Due to their structural simplicity many analogs have also been
synthesized. Combretastatin A4 phosphate is the most frequently tested
compounds in preclinical and clinical trials. It is a water-soluble
prodrug that the body can rapidly metabolize to combretastatin A4, which
exhibits anti-tumor properties. In addition, in vitro and in vivo
studies on combretastatins have determined that these compounds also
have antioxidant, anti-inflammatory and antimicrobial effects.
Nano-based formulations of natural or synthetic active agents such as
combretastatin A4 phosphate exhibit several clear advantages, including
improved low water solubility, prolonged circulation, drug targeting
properties, enhanced efficiency, as well as fewer side effects. In this
review, a synopsis of the recent literature exploring the
combretastatins, their potential effects and nanoformulations as lead
compounds in clinical applications is provided
A comparative study on utilizing hybrid-type nanofluid in plate heat exchangers with different number of plates
No full textDO EFL TEACHING AND MONITORING PRACTICES MATCH THE CURRICULAR PRINCIPLES? INSIGHTS INTO THE IMPLEMENTATION OF ELT CURRICULUM IN THE SECOND GRADES
No full textSome Serum Oxidative Parameters in Normoglycemic Rats: Vascular Endothelial Growth Factor (VEGF) Application
No full textA comparison between a combination of letrozole and clomiphene citrate versus gonadotropins for ovulation induction in infertile patients with clomiphene citrate - A resistant polycystic ovary syndrome-A retrospective study
No full textThe role of laparoscopic experience on the learning curve of holep surgery: A questionnaire-based study
No full text
