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Heinrich Ullrich Müzik Sistemi: Ulwila Renkli Nota Sistemi ve Çalgıları ile Müzik Eğitimi
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Felsefe Etkinliklerinin Okul Öncesi Dönem Çocukların Felsefi Tutum ve Davranışlarına Etkisinin İncelenmesi
No full textDevelopment of Nanocrystal Ziprasidone Orally Disintegrating Tablets: Optimization by Using Design of Experiment and In Vitro Evaluation (vol 21, 115, 2020)
No full textEffects Of Hıstorıcal Trade Roads On Cıty Trade Center, Sılk Road Sample (Bursa And Tabriz Cıtıes)
No full textTarihi ticaret yolları, kültürel ve doğal değerleriyle kültürel -rota- miras niteliğinde olup ulusal ve uluslararasında geçmişten bugüne ulaşım ve iletişim güzergâhlarıdır. Uzun mesafe ticaret yolları ve/veya güzergâhları üzerinde, mola-dinlenme işleviyle kurulan yerlerin kente dönüşümünde ve bu kentlerin ticaret merkezlerinin oluşumundaki bu sarmal etkileşim ve etki çemberi bu tez çalışmasının odağındadır. Bu yaklaşımla, dünyanın en uzun ve uzun süreli kullanılan ve büyük bir kısmı dünya kültür mirası ve kültürel rota olarak tescilli olan İpek Yolu, bu süreci ve kentsel oluşumları açıklayan ulaşım ağı olarak ele alınmıştır. Ancak, ulaşım bağlamıyla birlikte coğrafi koşullar, yerel yaşam ve kültür değerleri ve zamana göre insan ve mal akımının biçimi ve üretilen malın ticari değerleri gibi birçok faktör, ticaret merkezinin mekânsal strüktüründe ve mimarisinde farklılıklara neden olmuştur. Bu nedenle, bu tez çalışmasında İpek Yolu üzerinde, farklı coğrafya ve kültürlere ait Tebriz ve Bursa kentlerinin tarihi ticaret merkezlerinin oluşum ve gelişim süreci, mekânsal ve mimari özellikleri karşılaştırarak değerlendirilmiştir. Böylece, ticaret yollarının kentsel gelişmeye etkilerine ilişkin çıkarımlar elde edilmiş ve bu sürecin kanıtları olan ticaret merkezlerinin miras değerlerinin sürdürülebilirliğine ilişkin genel ilkeler önerilmiştir.In the historical trade routes are cultural -route- heritage with their cultural and natural values and are transportation and communication routes from past to present in national and international aspects. The focus of this thesis is on the helix interaction and its circle of influence in the transformation of the places built by the function of break or rest to urban settlement on long-distance trade roads and / or their destinations and the trade centers of these cities. With this approach, the Silk Road, which has been the longest and longest used road in the world of which world cultural also cultural route heritage has been registered, has been considered as transportation network to explain this process and urban formations. However, various factors like geographical conditions, local life and culture values as well as the form of human and property flow in time and the commercial values of the goods produced have caused differences in the spatial structure and architecture of the trade center. Thus, in this study, the process of formation and development of historical trade centers of Tabriz and Bursa cities from different geographies and cultures on the Silk Road have been compared and evaluated considering their spatial and architectural characteristics. Thus, inferences about the effects of trade routes on urban development were obtained and general principles on the sustainability of heritage values of trade centers, which are evidence of this process, have been recommende
Association of uric acid levels before start of conditioning with mortality after allogeneic hematopoietic stem cell transplantation - a prospective, non-interventional study of the EBMT Transplant Complication Working Party
No full textUric acid is a danger signal contributing to inflammation. Its relevance
to allogeneic stem cell transplantation (alloSCT) derives from
preclinical models where the depletion of uric acid led to improved
survival and reduced graft-versus-host disease (GvHD). In a clinical
pilot trial, peri-transplant uric acid depletion reduced acute GvHD
incidence. This prospective international multicenter study aimed to
investigate the association of uric acid serum levels before start of
conditioning with alloSCT outcome. We included patients with acute
leukemia, lymphoma or myelodysplastic syndrome receiving a first matched
sibling alloSCT from peripheral blood, regardless of conditioning. We
compared outcomes between patients with high and low uric acid levels
with univariate- and multivariate analysis using a cause-specific Cox
model. Twenty centers from 10 countries reported data on 366 alloSCT
recipients. There were no significant differences in terms of baseline
co-morbidity and disease stage between the high- and low uric acid
group. Patients with uric acid levels above median measured before start
of conditioning did not significantly differ from the remaining in terms
of acute GvHD grades II-IV incidence (Hazard ratio {[}HR] 1.5, 95\%
Confidence interval {[}CI]: 1.0-2.4, P=0.08). However, they had
significantly shorter overall survival (HR 2.8, 95\% CI: 1.7-4.7,
P<0.0001) and progression free survival (HR 1.6, 95\% CI: 1.1-2.4,
P=0.025). Non-relapse mortality was significantly increased in alloSCT
recipients with high uric acid levels (HR 2.7, 95\% CI: 1.4-5.0,
P=0.003). Finally, the incidence of relapse after alloSCT was increased
in patients with higher uric acid levels (HR 1.6, 95\% CI: 1.0-2.5,
P=0.04). We conclude that high uric acid levels before the start of
conditioning correlate with increased mortality after alloSCT
EFFECT OF DIETARY FAT ON OBESITY AND METABOLIC SYNDROME IN SMOKERS: A CROSS-SECTIONAL STUDY
No full textOyun Temelli Baba-Bebek Etkileşim Programı’nın Baba ve Bebek Davranışları Üzerindeki Etkisi
No full textSurface enhanced Raman spectroscopy as a novel tool for rapid quantification of heroin and metabolites in saliva
No full textBackground: Heroin can be detected and quantified by certain analytical
methods, however, forensic professionals and criminal laboratories study
for cheaper and faster detection tools. Surface-enhanced Raman
spectroscopy (SERS) rises as a possible alternative tool with its
widening application spectra. There are few studies regarding Raman and
SERS spectra of heroin and its metabolites, which are unfortunately
controversial. In this study, we compared five different surfaces in
order to find out more efficient Raman-active substrate for opiate
detection and rapid quantification of heroin and its metabolites in
saliva.
Materials and methods: Morphine standard material was used to identify
proper surface for SERS analysis of opiates. Heroin and its metabolites
(morphine, morphine-3-beta-glucuronide and 6-monoacetyl morphine) were
calibrated between 50 ppb and 500 ppm and quantified on AuNRs with
signal enhancement of silver colloids in saliva. Raman microscope with a
785-nm laser source was used.
Results and Conclusion: Obtained results showed that heroin and its
metabolites can be detected and quantified in saliva samples using a
SERS-based system. Additionally, the present study revealed that
synergetic effect of a specific gold nano-surface with ability
controlling liquid motion and silver nanoparticles increase band numbers
and intensities. Therefore, we suggest a fast, accurate and
cost-effective method to detect and quantify heroin in biological
fluids
