Gazi University Dspace
Not a member yet
26981 research outputs found
Sort by
Investigation of the Possible Protective Effects of Ketamine and Dantrolene on the Hippocampal Apoptosis and Spatial Learning in Rats Exposed to Repeated Electroconvulsive Seizures as a Model of Status Epilepticus
No full textAIM: To evaluate the possible neuroprotective effects of ketamine and
dantrolene on the hippocampal apoptosis and spatial learning in rats
exposed to repeated electroconvulsive seizures (ECS) as a model of
status epilepticus (SE).
MATERIAL and METHODS: Twenty-four rats were assigned to 4 groups. 1st
Group was Sham. 2nd Group was ECS: ECS was induced by ear electrodes via
electrical stimulation. The same ECS protocol was applied to the 3th and
4th Groups which received ketamine (40 mg/kg s.c.) or dantrolene (5
mg/kg i.p.) 1 h before each ECS, respectively. Following 30 days of
recovery, the cognitive status of the animals was evaluated via Morris
Water Maze (MWM). The same experimental protocol was repeated 14 days
afterward to evaluate the retention of the memory. Hippocampal apoptosis
was examined in corresponding experimental groups.
RESULTS: All the animals in four groups learned the task with no
significant difference between groups in MWM. The ECS+ketamine group
showed memory impairment 14 days afterward. ECS+dantrolene group was not
different from controls. ECS caused long term apoptotic processes in
dentate gyrus (DG) and non-apoptotic neuronal injury in CA1 and CA2.
CONCLUSION: Dantrolene and ketamine inhibited apoptosis and showed
neuroprotective effects. Although ketamine and dantrolene inhibited
ECS-induced apoptosis and non-apoptotic injury, they did not produce
similar effects on memory retention. It will be warranted to evaluate
cognitive dysfunction by taking into consideration the other factors in
addition to apoptosis and neurodegenerative changes
Trimebutine maleate monotherapy for functional dyspepsia: A multicenter, randomized, double-blind placebo controlled prospective trial
No full text
Nasopharyngeal pneumococcal carriage in healthy Turkish children after 13-valent conjugated pneumococcal vaccine implementation in the national immunization program
No full text
Trend Analyses of Meteorological Variables and Lake Levels for Two Shallow Lakes in Central Turkey
No full textTrend analyses of meteorological variables play an important role in
assessing the long-term changes in water levels for sustainable
management of shallow lakes that are extremely vulnerable to climatic
variations. Lake Mogan and Lake Eymir are shallow lakes offering
aesthetic, recreational, and ecological resources. Trend analyses of
monthly water levels and meteorological variables affecting lake levels
were done by the Mann-Kendall (MK), Modified Mann-Kendall (MMK), Sen
Trend (ST), and Linear trend (LT) methods. Trend analyses of monthly
lake levels for both lakes revealed an increasing trend with the
Mann-Kendall, Linear, and Sen Trend tests. The Modified Mann-Kendall
test results were statistically significant with an increasing trend for
Eymir lake levels, but they were insignificant for Mogan lake due to the
presence of autocorrelation. While trend analyses of meteorological
variables by Sen Test were significant at all tested variables and
confidence levels, Mann-Kendall, Modified Mann-Kendall, and Linear trend
provided significant trends for only humidity and wind speed. The trend
analyses of Sen Test gave increasing trends for temperature, wind speed,
cloud cover, and precipitation; and decreasing trends for humidity,
sunshine duration, and pan evaporation. These results show that
increasing precipitation and decreasing pan evaporation resulted in
increasing lake levels. The results further demonstrated an inverse
relationship between the trends of air temperature and pan evaporation,
pointing to an apparent ``Evaporation Paradox{''}, also observed in
other locations. However, the increased cloud cover happens to offset
the effects of increased temperature and decreased humidity on pan
evaporation. Thus, all relevant factors affecting pan evaporation should
be considered to explain seemingly paradoxical observations
Added Value of Contrast Medium in Whole-Body Hybrid Positron Emission Tomography/Magnetic Resonance Imaging: Comparison between Contrast-Enhanced and Non-Contrast-Enhanced Protocols
No full textObjective: To compare the diagnostic ability and time efficiency of
contrast-enhanced (CE) whole body fluorodeoxyglucose (FDG) positron
emission tomography/magnetic resonance imaging (PET/MRI) protocol and
non-CE (NCE) protocol. Subjects and Methods: Ninety-three patients with
known primary tumors underwent whole-body hybrid FDG PET/MRI during the
follow-up of their malignancies with the use of NCE and CE protocols.
The NCE PET/MRI protocol consisted of diffusion-weighted (b = 0 and 800
s/mm(2)) and T1-weighted Turbo Flash in the axial plane and T2-weighted
HASTE sequence in the coronal planes (sigma = 25 min). The CE PET/MRI
protocol was performed by acquiring axial serial CE 3D FS VIBE images in
the upper abdomen, completing the whole body in the late phase in the
axial plane (sigma = 30 min). Results: There was a statistically
significant difference between the total number of lesions detected by
the CE protocol (median 2, interquartile range (IQR) 0-14) and that
detected by the NCE protocol (median 1, IQR 0-5; p < 0.001). More
malignancies were detected in the abdomen (p < 0.001) and brain (p <
0.001) with the CE PET/MRI protocol, whereas no significant difference
was present when comparing the 2 protocols in the detection of
malignancies in the head and neck (p = 0.356), thorax (p = 0.09), lymph
nodes (p = 0.196), and bone (p = 0.414). Conclusion: The CE FDG PET/MRI
protocol enables fast and accurate detection of malignancies compared to
the NCE FDG PET/MRI protocol, particularly in the upper abdomen and
brain. Diagnostic ability and time efficiency can be increased with the
proposed short CE protocol in place of the whole body PET/MRI protocol
including both NCE and CE imaging sequences
