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Development and validation of the English teachers’ attitudes towards recruitment system scale
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Tumour cell PD-L1 expression is prognostic in patients with malignant pleural effusion: the impact of C-reactive protein and immune-checkpoint inhibition
No full textMalignant pleural effusion (MPE) confers dismal prognosis and has
limited treatment options. While immune-checkpoint inhibition (ICI)
proved clinical efficacy in a variety of malignancies, data on the
prognostic role of PD-L1 in MPE is scarce. We retrospectively studied
PD-L1 tumour proportion score and Ki-67 index in pleural biopsies or
cytologies from 123 patients (69 lung cancer, 25 mesothelioma, and 29
extrathoracic primary malignancies). Additionally, the impact of
C-reactive protein (CRP) and platelet count was also analysed. Median
overall survival (OS) after MPE diagnosis was 9 months. Patients with
PD-L1 positive tumours (=1\%) had significantly shorter OS than patients
with negative PD-L1 status (p = 0.031). CRP and Ki-67 index were also
prognostic and remained independent prognosticators after multivariate
analysis. Interestingly, Ki-67 index and CRP influenced the prognostic
power of PD-L1. Finally, patients receiving ICI tended to have a longer
median OS and CRP - but not PD-L1 - was a significant prognosticator in
this subgroup. In summary, histological and circulating biomarkers
should also be taken into account as potential biomarkers in ICI therapy
and they may have an impact on the prognostic power of PD-L1. Our
findings might help personalizing immune-checkpoint inhibition for
patients with MPE and warrant further prospective validation
Impact of apical foreshortening on deformation measurements: a report from the EACVI-ASE Strain Standardization Task Force
No full textAims Foreshortening of apical views is a common problem in
echocardiography. It results in an abnormally thick false apex and a
shortened left ventricular (LV) long axis. We sought to evaluate the
impact of foreshortened (FS) on LV ejection fraction (LVEF) and
layer-specific 2D speckle tracking based segmental (S) and global (G)
longitudinal strain (LS) measurements.
Methods and results We examined 72 participants using a GE Vivid E9
system. FS apical views were collected from an imaging window one
rib-space higher than the optimal images. Ejection fraction as well as
layer-specific GLS and SLS measurements were analysed by GE EchoPAC v201
and TomTec Image Arena 4.6 and compared between optimal and FS images.
On average, LV long axis was 10\% shorter in FS images than in optimal
images. FS induced a relative change in LVEF of 3.3\% and 6.9\% for GE
and TomTec, respectively (both, P < 0.001). Endocardial GLS was 9.0\%
higher with GE and 23.2\% with TomTec (P < 0.001). Midwall GLS
measurements were less affected (7.8\% for GE and 14.1\% for TomTec,
respectively, both P< 0.001). Segmental strain analysis revealed that
the mid-ventricular and apical segments were more affected by
foreshortening, and endocardial measurements were more affected than
midwall.
Conclusion Optimal image geometry is crucial for accurate LV function
assessment. Foreshorhening of apical views has a substantial impact on
longitudinal strain measurements, predominantly in the apex and in the
endocardial layer. Our data suggest that measuring midwall strain might
therefore be the more robust approach for clinical routine use
The Correlation of the SLAP II Lesion Findings Between Physical Examination, Magnetic Resonance Imaging, and Arthroscopic Surgery
No full textObjectives The aim of this study is to demonstrate the importance of
clinical diagnosis by comparing with preoperative physical examination
and magnetic resonance imaging (MRI) images in patients who were
arthroscopically diagnosed as having Superior Labrum Anterior-Posterior
(SLAP) II lesions. Materials and Methods 134 patients, arthroscopically
diagnosed as SLAP II, established the study group, and 200 patients who
underwent shoulder arthroscopy for the other pathologies established the
control group. Preoperative clinical examination of the patients, MRI
findings, and the arthroscopic findings of the patients were recorded.
Results Out of the patients diagnosed with a SLAP II lesion, 107 (79.9)
of those had an MRI finding while only 60 (30\%) of the control group
had it. The O'Brien test results of the patients diagnosed with SLAP
were positive in 111 (82.8\%) while those diagnosed with intact superior
labrum were positive in 132 (66\%). Of the 134 patients with a SLAP II
lesion, 89 (66.4\%) had both O'Brien test positiveness and MRI finding,
and 129 (96\%) had at least one positive result of the O'Brien test or
MRI examination Conclusion The O'Brien test and MRI examination are not
capable enough to indicate a SLAP lesion one by one, because of the low
sensitivity and specificity. But, combining the test with MRI findings
provides more trustable information about the superior labrum
Clinicopathologic features of operated gastric cancer patients, single center nine years experience
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