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Evaluation of Asymptomatic Bacteriuria and Urinary Tract Infection in Patients With Primary Sjogren's Syndrome
No full textObjectives: This study aims to determine the frequency and risk factors
of bacteriuria and urinary tract infection (UTI) in patients with
primary Sjogren's syndrome (SS) and their differences from healthy
individuals and rheumatoid arthritis (RA) patients.
Patients and methods: The study included 107 female primary SS patients
(mean age 50.7 +/- 11.6 years; range, 23 to 76 years), 53 healthy female
control subjects (mean age 46.8 +/- 15.5 years; range 21 to 80 years),
and 40 females with RA (mean age 51.7 +/- 14.2 years; range, 25 to 79
years). Participants were questioned for UTI risk factors and symptoms.
Middle stream urine samples were taken and cultured. All participants
were examined with urinary symptom questioning survey of American
Urological Association (AUA-7).
Results: The urine cultures were positive in 18 primary SS patients
(16.8\%), eight RA patients (20\%), and two healthy controls (3.7\%).
Escherichia coli, enterococci, Klebsiella, streptococci, and candida
were detected in SS patients' cultures. Extended-spectrum beta-lactamase
was positive in three cultures. Asymptomatic bacteriuria was not
detected in any SS patient. The highest AUA-7 score was determined in SS
group (p=0.031). Nineteen SS patients had vaginal dryness symptom and
their AUA-7 scores were higher than the rest of the SS group. The risk
of UTI development was not different between those who had or did not
have vaginal dryness.
Conclusion: Urinary tract infections are seen more often in SS patients
rather than normal population, which may be caused by SS' urinary system
effects. It is difficult to distinguish between asymptomatic bacteriuria
and infection because of the underlying urinary symptoms. Clinicians
must be careful in patients receiving immunosuppressive therapy due to
the high frequency of UTIs
Intervention Protocol: Technology-Based Psychosocial Motivation for Children with Cancer and Their Parents: A Randomized Trial
No full textThe Synthesıs Of Free Amıno Group Contaınıng Styryl Based Organıc Compounds And Theır Schıff Base Derıvatıves As Well As The Investıgatıon Of Theır Nlo, Photophysıcal And Thermal Propertıes
No full textGeleneksel algılayıcıların metaller ve anyonların tespit edilmesinde karşılaşılan yavaş tepki verme ve seçicilik problemlerinden dolayı yeni kolorimetrik kemosensörlerin geliştirilmesi son yıllarda önemli bir ilgi alanı olmuştur. Bu konudaki çalışmalar hedef yapılara karşı seçici ve hızlı yeni floresans kemosensörleri geliştirmeye odaklanmıştır. Hidroksit ve florür anyonları kimyasal özellik olarak birbirlerine çok benzerler ve bu iki anyonun bulunduğu çevre ve biyolojik sistemlerdeki önemlerinden dolayı bu sistemlerde hızlı ve kolay yöntemlerle belirlenmesi önemlidir. Su içerisinde bulunan hidroksit anyonu suyun pH değeri ile ilişkilidir, bu nedenle suda bulunan hidroksit anyonu miktarı suda yaşayan canlı organizmaları etkilemektedir. Florür anyonu ise tıbbi öneme sahip olup osteoporoz gibi kemik hastalıkları insan vücudunda bulunan florür anyonun eksikliğinden kaynaklanmaktadır. Schiff bazları, sentezlenmeleri kolay, sıcaklığa karşı dayanıklı ve geniş bir uygulama alanına sahip olduklarından floresans ve kolorimetrik kemosensörlerin temel yapısı olarak seçilmişlerdir. Bu bilgiler doğrultusunda hidroksit anyonu tayini için yeni bir seri sitiril temelli floresan Schiff bazı sentezi gerçekleştirilmiştir. Sentezlenen Schiff bazları hidroksit anyonu ile deprotonasyon üzerinden etkileşmekte ve trifloroasetik asit (TFA) ile tekrar protonlanabilmektedir. Sentezlenen bileşikler donör-π-akseptör sistemi içerdiği için bileşiklerin NLO (doğrusal olmayan optik) özellikleri de teorik olarak incelenmiş ve potansiyel NLO adayı olup olmadıkları da ortaya koyulmuştur. Kemosensörlerin çeşitli çözücüler içerisindeki fotofiziksel özellikleri, hidroksit anyonuna ve TFA’ya karşı duyarlılığı UV-GB absorpsiyon ve Floresans spektroskopi yöntemleriyle araştırılmıştır. Ayrıca, etkileşim sonucunda meydana gelen kolorimetrik ve florimetrik değişim hem çıplak gözle hem de UV-ışığı altında incelenmiştir. Bileşiklerin ısısal kararlılıkları TGA (Termal Gravimetrik Analiz) yöntemi ile belirlenmiştir. Bileşiklerin 280 oC yüksek sıcaklığa kadar kararlı oldukları ortaya koyulmuşturDevelopment of new colorimetric sensors that will be replacing the current slow and inefficient traditional sensors for detecting both metals and anions in general has been a significant interest in recent years. For this case, many studies have been focused in developing new fluorescence colorimetric sensor that has far better accuracy and speed in determining appropriate substrates. Hydroxide and fluoride are two important anions as they contribute in many environmental, biological and cynical aspects in living ecosystem. For instance, hydroxide concentration in a body of water directly corresponds to pH that affects living organism reside in it. The later has gained medical importance as fluoride concentration in human body is critical in determining diseases such as late osteoporosis. Schiff bases were chosen as the basis structure for fluorescence and colorimetric chemosensors because they are easy to synthesize, temperature-resistant and have a wide range of applications. In these regards, we have designed and synthesized a series of new TFA-reversible fluorescent Schiff bases that can detect hydroxide ion through deprotonation process in a brief and easy manner. Sensors sensitivity against hydroxide anion has been determined using UV-Vis Absorption and Fluorescence spectroscopy. Any physical change of sensors was observed through naked eyes and under illuminating UV-lamp. Because of donor-π-acceptor system found inside molecular structure, there is a good chance to come across non-linear optic nature for each compound, therefore theoretical studies in this regard has been conducted and the result were very promising. Furthermore, all compounds thermal stability was determined by TGA (Thermal Gravimetric Analysis) method and were found to be stable up to 280 oC
Ontolojik Değişimlerin Endüstri Ürünleri Tasarımı Pratiklerine Yansımaları: Yıldız Tasarım ve Katılımcı Tasarım
No full textSimultaneous determination of quercetin and luteolin in mate and white tea samples by voltammetry
No full textOutcomes After Minimally-invasive Versus Open Pancreatoduodenectomy A Pan-European Propensity Score Matched Study
No full textObjective: To assess short-term outcomes after minimally invasive
(laparoscopic, robot-assisted, and hybrid) pancreatoduodenectomy (MIPD)
versus open pancreatoduodenectomy (OPD) among European centers.
Background: Current evidence on MIPD is based on national registries or
single expert centers. International, matched studies comparing outcomes
for MIPD and OPD are lacking. Methods: Retrospective propensity score
matched study comparing MIPD in 14 centers (7 countries) performing >=
10 MIPDs annually (2012-2017) versus OPD in 53 German/Dutch surgical
registry centers performing >= 10 OPDs annually (2014-2017). Primary
outcome was 30-day major morbidity (Clavien-Dindo >= 3). Results: Of
4220 patients, 729/730 MIPDs (412 laparoscopic, 184 robot-assisted, and
130 hybrid) were matched to 729 OPDs. Median annual case-volume was 19
MIPDs (interquartile range, IQR 13-22), including the first MIPDs
performed in 10/14 centers, and 31 OPDs (IQR 21-38). Major morbidity
(28\% vs 30\%,P= 0.526), mortality (4.0\% vs 3.3\%,P= 0.576),
percutaneous drainage (12\% vs 12\%,P= 0.809), reoperation (11\% vs
13\%,P= 0.329), and hospital stay (mean 17 vs 17 days,P> 0.99) were
comparable between MIPD and OPD. Grade-B/C postoperative pancreatic
fistula (POPF) (23\% vs 13\%,P< 0.001) occurred more frequently after
MIPD. Single-row pancreatojejunostomy was associated with POPF in MIPD
(odds ratio, OR 2.95,P< 0.001), but not in OPD. Laparoscopic,
robot-assisted, and hybrid MIPD had comparable major morbidity (27\% vs
27\% vs 35\%), POPF (24\% vs 19\% vs 25\%), and mortality (2.9\% vs
5.2\% vs 5.4\%), with a fewer conversions in robot-assisted- versus
laparoscopic MIPD (5\% vs 26\%,P< 0.001). Conclusions: In the early
experience of 14 European centers performing >= 10 MIPDs annually, no
differences were found in major morbidity, mortality, and hospital stay
between MIPD and OPD. The high rates of POPF and conversion, and the
lack of superior outcomes (ie, hospital stay, morbidity) could indicate
that more experience and higher annual MIPD volumes are needed
Determination of the total antioxidant and oxidant status of some galactagogue and herbal teas
No full text
Correlation between peripheral blood inflammatory indicators and pathologic complete response to neoadjuvant chemotherapy in locally advanced breast cancer patients
No full textThe immune system plays a fundamental role in the response to
neoadjuvant chemotherapy (NAC) of locally advanced breast cancer (LABC)
patients. Patients with pathological complete response (pCR) after NAC
have a higher survival rate. Neutrophil-to-lymphocyte ratio (NLR),
platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio
(LMR) are peripheral blood indicators of inflammatory response. This
investigates the correlation between NLR, PLR, LMR, and other
clinicopathological features of breast cancer patients before receiving
NAC and pCR. Data of LABC patients who underwent NAC between 2009 and
2018 were retrospectively reviewed. Each patient's peripheral complete
blood count was recorded before starting NAC. The cut-off values for
neutrophils, lymphocytes, monocytes, and platelets in the peripheral
blood and NLR, PLR, and LMR were determined by receiver operating
characteristic curve analyses. The records of 131 patients were analyzed
and divided into two groups, pCR (+ve) and pCR (-ve), and their
clinicopathological features and laboratory findings were compared. pCR
was achieved in 23.6\% of patients. The cut-off values of neutrophils,
lymphocytes, monocytes, and platelets at the time of diagnosis and NLR,
PLR, and LMR were, respectively, 4150 mu L, 2000 mu L, 635 mu L, 271 x
10(3) mu L, 1.95, 119, and 3.35. The pCR rate was higher in patients
with low neutrophil count, low NLR, and high lymphocyte count (P = .002,
<.001, and .040, respectively). As per the findings of multivariate
logistic regression analysis, the independent predictive factors of pCR
were clinical tumor size T1 and T2, grade 3, ER negativity, and low NLR
(P = .015, .001, .020, .022, and .001, respectively). While NLR was
found to be an independent predictive factor of pCR in LABC patients
receiving NAC, a similar result was not observed for PLR and LMR. NLR
can be a useful biomarker for predicting the response of patients
receiving NAC
AFFINE ROTATION SURFACES OF ELLIPTIC TYPE IN AFFINE 3-SPACE
No full textIn this paper, we classify affine rotation surfaces of elliptic type in
affine 3-space satisfying some algebraic equations regarding the
co-ordinate functions and the La-placian operators in relation the first
and the second affine fundamental forms of affine rotation surfaces of
elliptic type. We also give explicit forms of these surfaces