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    Ac Module Desıgn And Implementatıon For Solar Panels

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    Sanayileşmeyle birlikte artan enerji talebinden ve fosil yakıtların hem tükeniyor olması hem de çevresel olumsuzluklarından dolayı, alternatif enerji kaynaklarına ihtiyaç duyulmaktadır. Güneş enerjisi temiz, bol ve yenilenebilir olması sebebiyle alternatif kaynaklar arasında öne çıkmaktadır. Teknolojinin gelişmesiyle birlikte güneş enerjisinden düşük maliyetlerle daha yüksek verimde enerji elde edilmesi mümkün hale gelmiştir. Böylece enerjinin ihtiyaç duyulduğu alanlarda yaygın olarak kullanıldığı görülmektedir. Güneş enerjisinden elde edilen enerjinin istenilen güç kalitesinde şebekeye veya yüke aktarılması için güç elektroniği donanımlarına ihtiyaç vardır. Bu çalışmada, fotovoltaik panellerden elde edilen doğru akımı alternatif akıma dönüştüren bir modül tasarımı ve uygulaması üzerine bir çalışma gerçekleştirilmiştir. Normal koşullarda fotovoltaik paneller doğru akım üretmektedir. Ticari nitelikteki güneş enerjisi dönüşüm sistemlerinde doğru akım, ya doğru akım baraları ile ya da panellerin seri bağlanması ile bir DA dizisi oluşturularak eviriciler üzerinden alternatif akıma dönüştürülür. Mevcut sistemler ile elektrik üretmenin bazı dezavantajları bulunmaktadır. Tasarımı yapılan sistem ile güneş enerjisinden maksimum düzeyde güç elde edebilmek ve parçalı gölgeleme sonucu meydana gelen enerji kayıpları gibi olumsuzlukları aza indirerek fotovoltaik sistemlerde bazı iyileştirmeler yapılmak istenmiştir. Bunun için her bir fotovoltaik panele bağlı modül yardımıyla doğrudan alternatif akım elde eden sistem gerçekleştirilmiştir. Güneş panelinden elde edilen doğru gerilimi istenilen seviyeye yükseltmek için yükseltici konvertör tasarlanmıştır. Tasarım için MATLAB programının Simulink aracı ile hem konvertör hem de Maksimum Güç Noktası İzleyicisi (MGNİ) algoritmalarının benzetimleri gerçekleştirilmiştir. Konvertör ile yükseltilen gerilim evirici yardımıyla alternatif gerilime dönüştürülmüştür. Maksimum düzeyde güç elde edebilmek için farklı MGNİ algoritmaları denenmek suretiyle maksimum güç elde edilmeye çalışılmıştır. Böylece hem maksimum güç elde edilmiştir hem de oluşabilecek verim kayıplarını bertaraf edebilecek modül geliştirilmiştir.Alternative energy resources are needed due to the increasing energy demand with industrialization and the depletion of fossil fuels as well as environmental adversities. Solar energy stands out among alternative sources because it is clean, abundant and renewable. With the development of technology, it has become possible to obtain higher efficiency energy from solar energy at lower costs. Thus, it is seen that energy is widely used in areas where it is needed. There is a need for power electronics equipment to transfer the energy obtained from solar energy to the network or load at the desired power quality. In this study, a study has been carried out on the design and application of a module that converts the direct current obtained from photovoltaic panels to alternating current. Under normal conditions, photovoltaic panels produce direct current. In commercial solar power conversion systems, direct current is converted into alternating current via inverters either by direct current busbars or by connecting the panels in series to form a DA array. There are some disadvantages to generating electricity with existing systems. With the designed system, it was aimed to obtain maximum power from the solar energy and to make some improvements in photovoltaic systems by minimizing the negativities such as energy losses due to shading. For this purpose, a system that directly generates alternating current has been realized with the help of the module connected to each photovoltaic panel. Booster converter is designed to increase the correct voltage obtained from the solar panel to the desired level. Simulation of both converter and Maximum Power Point Tracking (MPPT) algorithms were performed with the Simulink tool of MATLAB for design. The voltage raised by the converter is converted to alternative voltage with the help of inverter. In order to obtain maximum power, maximum power was tried by trying different MPPT algorithms. Thus, both maximum power was obtained and a module was developed to eliminate the possible loss of efficienc

    Global Retinoblastoma Presentation and Analysis by National Income Level

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    This cross-sectional analysis reports the retinoblastoma stage at diagnosis across the world during a single year, investigates associations between clinical variables and national income level, and investigates risk factors for advanced disease at diagnosis. Key PointsQuestionIs the income level of a country of residence associated with the clinical stage of presentation of patients with retinoblastoma? FindingsIn this cross-sectional analysis that included 4351 patients with newly diagnosed retinoblastoma, approximately half of all new retinoblastoma cases worldwide in 2017, 49.1\% of patients from low-income countries had extraocular tumor at time of diagnosis compared with 1.5\% of patients from high-income countries. MeaningThe clinical stage of presentation of retinoblastoma, which has a major influence on survival, significantly differs among patients from low-income and high-income countries, which may warrant intervention on national and international levels. ImportanceEarly diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. ObjectivesTo report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis. Design, Setting, and ParticipantsA total of 278 retinoblastoma treatment centers were recruited from June 2017 through December 2018 to participate in a cross-sectional analysis of treatment-naive patients with retinoblastoma who were diagnosed in 2017. Main Outcomes and MeasuresAge at presentation, proportion of familial history of retinoblastoma, and tumor stage and metastasis. ResultsThe cohort included 4351 new patients from 153 countries; the median age at diagnosis was 30.5 (interquartile range, 18.3-45.9) months, and 1976 patients (45.4\%) were female. Most patients (n=3685 {[}84.7\%]) were from low- and middle-income countries (LMICs). Globally, the most common indication for referral was leukocoria (n=2638 {[}62.8\%]), followed by strabismus (n=429 {[}10.2\%]) and proptosis (n=309 {[}7.4\%]). Patients from high-income countries (HICs) were diagnosed at a median age of 14.1 months, with 656 of 666 (98.5\%) patients having intraocular retinoblastoma and 2 (0.3\%) having metastasis. Patients from low-income countries were diagnosed at a median age of 30.5 months, with 256 of 521 (49.1\%) having extraocular retinoblastoma and 94 of 498 (18.9\%) having metastasis. Lower national income level was associated with older presentation age, higher proportion of locally advanced disease and distant metastasis, and smaller proportion of familial history of retinoblastoma. Advanced disease at diagnosis was more common in LMICs even after adjusting for age (odds ratio for low-income countries vs upper-middle-income countries and HICs, 17.92 {[}95\% CI, 12.94-24.80], and for lower-middle-income countries vs upper-middle-income countries and HICs, 5.74 {[}95\% CI, 4.30-7.68]). Conclusions and RelevanceThis study is estimated to have included more than half of all new retinoblastoma cases worldwide in 2017. Children from LMICs, where the main global retinoblastoma burden lies, presented at an older age with more advanced disease and demonstrated a smaller proportion of familial history of retinoblastoma, likely because many do not reach a childbearing age. Given that retinoblastoma is curable, these data are concerning and mandate intervention at national and international levels. Further studies are needed to investigate factors, other than age at presentation, that may be associated with advanced disease in LMICs

    MRI in CLN2 disease patients: Subtle features that support an early diagnosis

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    Neuronal ceroid lipofuscinosis type 2 (CLN2) disease is a rare, paediatric-onset, neurodegenerative disorder characterised in its early stages by language delay, seizures and loss of motor function. It is rapidly progressive and ultimately results in the premature death of patients. We aim to highlight common magnetic resonance imaging (MRI) features seen in early CLN2 disease and increase disease awareness among clinicians in order to facilitate early diagnosis and treatment of patients with disease-modifying enzyme replacement therapy. We obtained MRI scans from 12 Turkish children with CLN2 disease, at symptom onset or time of diagnosis, and at various times during disease progression. Patient details including age at onset of symptoms, age at diagnosis and clinical presentation were collected. MRIs were analysed to identify common features present in patients with CLN2 disease. The median diagnostic delay in this cohort was 2 years, highlighting the need for increased disease awareness among clinicians. Key MRI features suggestive of CLN2 disease that were identified included cerebellar atrophy in 11 patients, linear hyperintensity of central white matter in 10 patients, cerebral atrophy in 8 patients and thinning of the corpus callosum in 6 patients. Thalamic hypointensity was seen in 1 patient and may also indicate CLN2 disease. It is important to consider the presenting symptoms alongside clinical test results in order to support early diagnosis of CLN2 disease. Clinical suspicion of CLN2 disease accompanied by the detection of any of the above-mentioned features on MRI should encourage healthcare professionals to test for CLN2 disease. (c) 2020 The Authors. Published by Elsevier Ltd on behalf of European Paediatric Neurology Society

    Serum C-reactive protein to albumin ratio as a novel inflammation biomarker in psoriasis patients treated with adalimumab, ustekinumab, infliximab, and secukinumab: a retrospective study

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    Aim To assess C-reactive protein to albumin ratio (CAR) be-fore and after treatment with biological agents in patients with psoriasis to determine whether CAR can be used as an inflammation biomarker. Methods Medical records of patients with psoriasis treat-ed with biological agents at the Department of Dermatology, Gazi University Hospital were retrospectively evaluated between June 2018 and August 2019. The patients were divided into four groups based on the type of treatment (adalimumab, ustekinumab, infliximab, secukinumab). CAR was evaluated before and three months after treatment. Results The study enrolled 157 patients with psoriasis vulgaris (91 male) aged between 18 and 85. CAR significantly decreased in all treatment groups (adalimumab group P<0.001; ustekinumab P=0.006; infliximab P=0.007; secukinumab P<0.001). The most prominent decrease in CAR was observed in patients treated with secukinumab (median CAR before treatment 1.52 {[}1.01-3.04] and after treatment 0.84 {[}0.62-0.99]). Conclusion CAR may be a good indicator of systemic inflammation in psoriasis patients treated with biological agents

    On orthomorphism elements in ordered algebra

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