Erciyes University - AVESIS
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Comparison of ceftazidime-avibactam with other appropriate antimicrobial therapy for the treatment of OXA-48-or KPC-producing<i> Enterobacterales</i> infections in Türkiye: A multi-centre retrospective matched-cohort study
No full textObjective: Due to underrepresentation of carbapenemase-producing Enterobacterales infections in randomized controlled trials with ceftazidime-avibactam (CZA) and high cost of CZA therapy, other appropriate antimicrobial therapies (OAAT) are still being used for OXA-48- or KPC-producing Enterobacterales infections in T & uuml;rkiye. Methods: We conducted a multicentre retrospective 1:1 matched cohort study of patients who received >= 48 h of CZA or OAAT for documented OXA-48- or KPC-producing Enterobacterales infections. Patients were matched based on (1) the number of days (+/- 1 d) from the infection onset to the initiation of therapy, (2) INCREMENT-CPE score (+/- 1), (3) source of infection, (4) year of infectious episode, and (5) type of causative microorganism. Results: From 5 Turkish university hospitals, 180 patients were enrolled. Baseline characteristics were all similar between treatment groups. At the time of treatment initiation, 63.9% of patients were in the intensive care unit, 35.6% had septic shock and 41.1% required mechanical ventilation support. Thirty-day mortality occurred in 35.6% (32/90) of patients treated with CZA and in 56.7% (51/90) of those receiving OAAT regimens (P = 0.004). Twenty-one-day clinical response was seen in 50% (45/90) and 26.7% (24/90) of patients receiving CZA and OAAT, respectively (P = 0.002). In multivariable logistic regression analyses, CZA treatment was associated with less likelihood of mortality (aOR = 0.37; 95% CI: 0.19-0.71; P = 0.003) and higher likelihood of 21-d clinical response (aOR = 3.32; 95% CI: 1.68-6.53; P 001). Conclusions: Treatment with CZA is associated with more favourable clinical outcomes in treatment of OXA-48- or KPC-producing Enterobacterales infections. A randomized controlled trial is needed to confirm these results. (c) 2025 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/
Investigation of the structural and acoustic properties of biodegradable nonwovens from chicken feathers that are environmental waste
No full textProducing multi-layer soundproofing materials by combining materials with different properties is a widely used method. The production of these types of structures utilizes the superior properties of each layer contained within the structure. This study addresses the acoustic performance of nonwoven surface structures fabricated in different thicknesses and densities using chicken feather fibres in different constructions. An impedance tube was used to determine the sound absorption and sound transmission loss values of two-layer structures of different densities and thicknesses. The results show that the influence of the layer in front or behind on the values of sound transmission losses is very limited in two-layer structures with varying densities and thicknesses. However, for the degree of sound absorption, it is important which layer is closer to the sound source. These findings are based on an analysis of multifactorial experimental data. Accordingly, the sound absorption coefficients and sound transmission loss values of all two-layer structures decrease slightly with increasing sound frequency in the frequency range of 63–200 Hz and then increase. The low-density layer on the front of the combined structure ensures better sound absorption at low and medium frequencies. As the density of the front layer increases, its ability to absorb sound decreases. It has been found that the sound absorption capacity of structures with a low density on the front and a thick layer on the back is highest
Evaluation of the use of vinpocetine in microsporidia infections
No full textEncephalitozoon intestinalis is a species of microsporidia that causes serious health problems, especially in immunocompromised individuals. The drug of choice for treatment today is albendazole. However, partial effects, resistance, and serious side effects are reported. Recently, vinpocetine has become a safe drug that is being investigated for the treatment of various diseases. In this study, the anti-microsporidial efficacies of vinpocetine, albendazole, and vinpocetine- albendazole combination, and how these combinations affected pathogen-induced tissue damage were assessed. In the study, male BALB/c mice were randomly divided into 6 groups. Except for the control groups, the other groups were infected with E. intestinalis spores after the application of cyclophosphamide. Treatments were started after the spores were detected by the Modified Trichrome method (MTS) in the stool samples. After five doses of treatment, spore load in stool samples was evaluated by MTS. Additionally, the sections obtained from the small intestines were stained with Masson's trichrome, and histopathological damage was evaluated. Although the spore load was higher in the group treated only with vinpocetine compared to the groups treated with albendazole, small intestinal damage was less. In addition, weight gain was observed in the group that was given vinpocetine and albendazole together. As a result, although the effect of vinpocetine on E. intestinalis virulence needs to be supported by larger studies, this study showed that vinpocetine alone has a positive effect on tissue damage. It has also been observed that it does not negatively alter the effectiveness of albendazole when used as a dietary supplement
Efflux Pump Detection and Bacteriocin Intervention in Multidrug-Resistant Pseudomonas aeruginosa from Clinical Specimens
No full textİsimlerden notalara uzanan gizli imza geleneği: Müzikal kriptogramlar
No full textMüzikal kriptogramlar, bestecilerin isimlerini ya da belirli sözcükleri notalara dönüştürerek yapıtlarının dokusuna gizledikleri şifreli imzalardır. Johann Sebastian Bach’ı onurlandıran geleneksel B–A–C–H motifi ile Dmitri Şostakoviç’in kimliğini müziğine kazıyan D–S–C–H monogramı, bu geleneğin en ikonik örnekleri arasında yer alır. Müzikal yapıya ustalıkla işlenen bu küçük motifler, dinleyiciye notaların ardındaki insan hikâyesini sezdirirken, bestecinin iç dünyasına açılan sembolik birer pencere işlevi görür.</p
The Impact of Motivation and Attitudes Toward Health Behavior Change on Self-Management Among Individuals with Chronic Diseases: A Predictive Correlational Study
No full textModeling Egg Yield Values in Alectoris Chukar with Nonlinear models: Modeling of the Egg Yield Values in Alectoris Chukars
No full textMechanical and thermal characteristics of horsehair-woven fabrics reinforced epoxy composites
No full textThis study focuses on the development of epoxy-based composites reinforced with horsehair-woven fabrics. The weft-directional tensile and flexural properties of the composites were investigated. The woven fabric samples were diversified by varying the number of hairs in the weft and warp bundle, weft density, and weave type (plain and twill). All fabric samples except the reference were subjected to NaClO pre-treatment to improve interfacial bonding. The pre-treatment effectively removed surface impurities and improved the smoothness of the hair surface. The tensile strength was positively affected by the alkali treatment, whereas the flexural strength was adversely affected. The tensile and flexural properties were enhanced by doubling the hairs in the weft bundle. Tensile strength decreased in the weft direction as the number of hairs in the warp bundle increased. The twill weave reinforced composite demonstrated superior mechanical properties among all the tested samples, exhibiting the highest tensile strength (57.58 ± 4.4 MPa), tensile strain (7.10 ± 0.8%), and elastic modulus (2.00 ± 0.2 GPa), as well as the highest flexural strength (67.34 ± 1.3 MPa) and flexural modulus (2.8 ± 0.1 GPa)
Enhanced electrochemical performance of Bi3O4Cl supercapacitors under solar radiation: A study on the impact of solar exposure for energy storage applications
No full textPhoto-powered and photo-responsive energy production and storage devices are promising alternatives to meet the growing energy demand in modern society. Solar energy is a clean and sustainable light source for these devices. Bismuth-based materials with oxychloride dopants exhibit superior optoelectronic properties due to their layered structure and rapid electron-hole pair separation ability. The unique crystal structure and inherent electrochemical properties of Bi3O4Cl make it an intriguing candidate for energy storage applications. In this study, we investigated the electrochemical performance of Bi3O4Cl as a supercapacitor material, exposed to both direct solar radiation and solar simulator radiation. Electrochemical measurements were conducted in a three-electrode system using a 2 M KOH electrolyte solution. Cyclic Voltammetry (CV), Galvanostatic Charge-Discharge (GCD), and Electrochemical Impedance Spectroscopy (EIS) were performed. In the GCD measurements, the pure material exhibited an average capacitance of 259.6 F g−1, while specific average capacitance values of 689 F g−1 and 676 F g−1 were observed with direct sunlight exposure and solar simulator exposure, respectively. This represents approximately 165 % and 160 % enhancement in capacitance compared to the pure material