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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia-reperfusion damage in rats
No full textA frequently occurring surgical emergency in gynecology is ovarian torsion, which occurs when the ovary twists on its ligamentous supports, which obstructs blood flow. The aim of the present study was to evaluate the protective effects of hyperbaric oxygen therapy (HBOT) and tadalafil against ischemia-reperfusion (IR) injury in a rat model of ovarian torsion. Female Wistar albino rats were randomly assigned to five groups (n=8/group): Control, IR, IR + tadalafil, IR + HBOT and IR + tadalafil + HBOT. Ovarian torsion was induced under anesthesia for 2 h, followed by daily post-operative treatments with tadalafil (10 mg/kg) and/or HBOT (2.4 atmospheres absolute for 1 h) for 7 days. Blood and ovarian tissue specimens were collected for analysis at the end of the treatment period. IR-induced ovarian tissue injury significantly decreased the counts of primordial, primary and preantral follicles compared with those in the control group. In addition, serum ELISA and immunohistochemical analysis revealed that IR injury reduced anti-M & uuml;llerian hormone (AMH) levels in serum and the granulosa cells of primary, preantral and secondary follicles. HBOT alone resulted in a significant increase in the counts of primordial, primary and preantral cells, as did the combination of HBOT with tadalafil. In addition, AMH immunoreactivity significantly increased in primary, preantral and secondary follicles following treatment with HBOT and tadalafil. Furthermore, all therapeutic interventions elevated serum AMH levels in the IR model rats. These findings suggest that tadalafil treatment combined with HBOT may help protect ovarian reserve and mitigate IR-induced tissue damage in rat ovaries
Melatonin’s phytoremediation potential against salt stress: metabolic and morphological adaptations in onion seedlings
No full textSalt stress is one of the most important environmental factors limiting onion cultivation worldwide. This study investigatedthe effects of different doses of melatonin on some phenological characteristics and biochemistry of three onion genotypeswith different dry skin colors under salinity stress. Onion seedlings treated with 0, 4, and 8 μM exogenous melatonin at certain stages of development were grown under stress conditions irrigated with 0, 150, and 300 mM NaCl. Phenotypic traitswere evaluated, such as the number of leaves, length of the longest leaf, diameter of the white pseudostem, leaf erectness,whole-plant fresh weight, degree of leaf waxiness, and bulb weight. In addition, the total amount of phenolic substances,flavonoids, soluble protein, antioxidant capacity, and carotenoid and chlorophyll contents were also measured. Salt-inducedphytotoxicity markedly affected the development and physiology of all onion cultivars. The degree of salt stress and the levelof melatonin that provided the most effective response differed for each cultivar. For example, 8 µM melatonin supplementation was effective in the Burgaz cultivar to stop the decrease in whole plant weight under 300 mM salt stress conditions. In theGence cultivar samples grown under 300 mM salt stress without melatonin addition, total phenolic matter content increasedwith the addition of 4 µM melatonin and decreased with the addition of 8 µM melatonin. Nevertheless, improvements insome morphological parameters, phenolic, flavonoid, and antioxidant contents, as well as higher chlorophyll contents in planttissues, indicated that exogenous melatonin application may effectively enhance onions’ salt tolerance.</p
Tailoring of Cerium Oxide Nanosheets Having Superior Peroxidase Catalytic Activity for Colorimetric Detection of Hydrogen Peroxide
No full textThe exploitation of an extremely sensitive and reliable nanozyme based colorimetric sensor for highly sensitive detection of hydrogen peroxide (H2O2) in living body system is extensively carping owing to fact that it garnered a prime role in causing toxic diseases. In this work, a highly novel catalyst named as Cerium oxide (CeO2) nanosheets (NSs) was precisely prepared by using a simple one pot hydrothermal method, thereby dowered with a strong intrinsic peroxidase like capability of catalyzing the oxidation-reaction of colorless 3,3′,5,5′-tetramethylbenzidine (TMB) to generate a blue color reaction in the presence of H2O2. Hence, a sensitive visible assessment platform related to CeO2 NSs was engineered, which not only exhibited a wider detection range of 0.01–1000 µM with R2 value of 0.9998, but also perceives exceptional selectivity, tremendous cycling and long term stability. Further, the sensor also evaluates lowest detection limit (LOD) 0.29 ± 0.03 µM and quantification limit (LOQ) of 2.3 ± 0.03 µM. In addition, it also endorses impressive practicality with stronger sensitivity and favorable accuracy in serum samples. Thus, this research-work not only contributed upon CeO2 NSs an outstanding capacity to detect H2O2, but also expands the realm of applications for CeO2 NSs in the domains of environmental preservation, biomedical diagnosis and forensic sciences
The Impact of Motivation and Attitudes Toward Health Behavior Change on Self-Management Among Individuals with Chronic Diseases: A Predictive Correlational Study
No full textModeling Egg Yield Values in Alectoris Chukar with Nonlinear models: Modeling of the Egg Yield Values in Alectoris Chukars
No full textEvaluation of the use of vinpocetine in microsporidia infections
No full textEncephalitozoon intestinalis is a species of microsporidia that causes serious health problems, especially in immunocompromised individuals. The drug of choice for treatment today is albendazole. However, partial effects, resistance, and serious side effects are reported. Recently, vinpocetine has become a safe drug that is being investigated for the treatment of various diseases. In this study, the anti-microsporidial efficacies of vinpocetine, albendazole, and vinpocetine- albendazole combination, and how these combinations affected pathogen-induced tissue damage were assessed. In the study, male BALB/c mice were randomly divided into 6 groups. Except for the control groups, the other groups were infected with E. intestinalis spores after the application of cyclophosphamide. Treatments were started after the spores were detected by the Modified Trichrome method (MTS) in the stool samples. After five doses of treatment, spore load in stool samples was evaluated by MTS. Additionally, the sections obtained from the small intestines were stained with Masson's trichrome, and histopathological damage was evaluated. Although the spore load was higher in the group treated only with vinpocetine compared to the groups treated with albendazole, small intestinal damage was less. In addition, weight gain was observed in the group that was given vinpocetine and albendazole together. As a result, although the effect of vinpocetine on E. intestinalis virulence needs to be supported by larger studies, this study showed that vinpocetine alone has a positive effect on tissue damage. It has also been observed that it does not negatively alter the effectiveness of albendazole when used as a dietary supplement
Efflux Pump Detection and Bacteriocin Intervention in Multidrug-Resistant Pseudomonas aeruginosa from Clinical Specimens
No full textİsimlerden notalara uzanan gizli imza geleneği: Müzikal kriptogramlar
No full textMüzikal kriptogramlar, bestecilerin isimlerini ya da belirli sözcükleri notalara dönüştürerek yapıtlarının dokusuna gizledikleri şifreli imzalardır. Johann Sebastian Bach’ı onurlandıran geleneksel B–A–C–H motifi ile Dmitri Şostakoviç’in kimliğini müziğine kazıyan D–S–C–H monogramı, bu geleneğin en ikonik örnekleri arasında yer alır. Müzikal yapıya ustalıkla işlenen bu küçük motifler, dinleyiciye notaların ardındaki insan hikâyesini sezdirirken, bestecinin iç dünyasına açılan sembolik birer pencere işlevi görür.</p
Mechanical and thermal characteristics of horsehair-woven fabrics reinforced epoxy composites
No full textThis study focuses on the development of epoxy-based composites reinforced with horsehair-woven fabrics. The weft-directional tensile and flexural properties of the composites were investigated. The woven fabric samples were diversified by varying the number of hairs in the weft and warp bundle, weft density, and weave type (plain and twill). All fabric samples except the reference were subjected to NaClO pre-treatment to improve interfacial bonding. The pre-treatment effectively removed surface impurities and improved the smoothness of the hair surface. The tensile strength was positively affected by the alkali treatment, whereas the flexural strength was adversely affected. The tensile and flexural properties were enhanced by doubling the hairs in the weft bundle. Tensile strength decreased in the weft direction as the number of hairs in the warp bundle increased. The twill weave reinforced composite demonstrated superior mechanical properties among all the tested samples, exhibiting the highest tensile strength (57.58 ± 4.4 MPa), tensile strain (7.10 ± 0.8%), and elastic modulus (2.00 ± 0.2 GPa), as well as the highest flexural strength (67.34 ± 1.3 MPa) and flexural modulus (2.8 ± 0.1 GPa)