Erciyes University - AVESIS
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Estimating the total cost of fasciolosis in sheep and goats in Türkiye with a stochastic simulation model
No full textThis study aimed to estimate the total cost of small ruminant fasciolosis in Türkiye. For this purpose, official and previously published prevalence values were considered, and financial losses were calculated with current prices in 2024 year. A stochastic simulation model (Monte Carlo) was used to estimate the total cost due to fasciolosis. The weighted mean prevalence values were calculated for sheep as 3.47% (95% CI, 3.43-3.51%) and goats as 1.25% (95% CI, 1.20-1.30%). In total cost calculations, mortality losses, production losses and control expenditures were considered. As a result, annual total cost of fasciolosis for sheep was estimated to be 86.7-5.7 million (95% CI, 7.9). The annual total cost of the disease in small ruminants was estimated to be 91.8-$110.2) and this amount is equally to 0.8% of total livestock production value in Türkiye. In conclusion, to reduce the impact of the disease for livestock sector and Turkish economy, producers should be informed about the quantity of losses and prevention/treatment procedures and, fasciolosis should be prioritized in national disease control/eradication strategies
An innovative data-driven integrated solution for ridesharing and dynamic vehicle routing
No full textThe increasing demand for flexible and sustainable mobility services has intensified interest in ridesharing and mobility-on-demand systems. However, current solutions remain limited, as they often neglect critical factors such as demand forecasting, vehicle repositioning, workload balance, and real-time adaptability. This study proposes an integrated data-driven framework for ridesharing and dynamic vehicle routing, composed of a periodic and dynamic components. By synchronising these stages, the system captures interdependencies between demand prediction and routing decisions, reducing inefficiencies caused by treating them separetely. The approach was validated on over 300,000 historical trips and tested with 9,016 real-time demands. Results show that the framework achieves a demand cancellation rate below 9%, balances driver workloads, and responds to new requests within 4 s. Sensitivity analyses reveal that omitting clustering or forecasting raises costs, while the full integration yields 6–10% savings. The proposed system provides a holistic, scalable, and sustainable real time optimisation model for future urban mobility
JAPONYA’DA YURTTAŞLIK KAVRAMI: “SHINMIN臣民 - SHIMIN 市民 – KOKUMIN国民 - KŌMIN 公民” KAVRAMLARININ ANALİZİ
No full textMy Daughter Said, “Why Are We Here, Mom?” Experiences of Parents Who Left Their Country for Their Children With Special Needs
No full textThis study investigated the reasons why parents with children with special needs choose to leave their homeland with their children, the difficulties they encounter in their new countries, the services they receive for their children in new countries, and their level of satisfaction with these services. Semistructured interviews were conducted with 15 parents residing in various countries. The findings indicate that parents migrated to developed countries due to negative attitudes toward themselves and their children in Türkiye, discrimination, and dissatisfaction with educational services. These parents emphasized that their children were happy in the countries they migrated to and expressed satisfaction with the special education services they received. Furthermore, most of these parents do not intend to return to Türkiye permanently
Reconstructing The Heart's Rhythm Comparative Evaluation of Mechanical and Bioprosthetic Mitral Valves
No full textThe mitral valve plays a fundamental role in maintaining effective cardiac function by regulating blood flow between the left atrium and left ventricle. Advanced mitral valve diseases, including stenosis and regurgitation, may result in heart failure, arrhythmias, and impaired quality of life. Although valve repair is the preferred surgical option, valve replacement becomes necessary when repair is not feasible. Mechanical and bioprosthetic prostheses represent the primary replacement choices, each offering distinct structural and clinical characteristics. This study examines mechanical and bioprosthetic mitral valves in terms of their design features, durability, clinical outcomes, thromboembolic risk, reoperation rates, mortality, and quality-of-life results. Mechanical valves, typically constructed from pyrolytic carbon, titanium, or stainless steel and designed as bileaflet, tilting-disc, or ball-and-cage systems, demonstrate high durability with a lifespan exceeding 25 years and a structural failure rate of less than 1%. However, their requirement for lifelong anticoagulation due to a 2–4% annual thromboembolic risk constitutes a significant limitation, particularly in older patients. Bioprosthetic valves—derived from porcine, bovine, or human tissue and treated with glutaraldehyde—offer the advantages of reduced thrombogenicity and minimal anticoagulation requirements. Despite these benefits, their durability is limited to 10–20 years, with structural degeneration and reoperation risk increasing substantially after 10–15 years, especially in younger individuals. New-generation bovine pericardial valves show improved performance; nevertheless, mechanical prostheses remain superior in long-term structural integrity. Overall, the findings underscore that mitral valve selection must be individualized, taking into account patient age, life expectancy, comorbidities, bleeding risk, and anticoagulation tolerance. Advances in transcatheter mitral valve replacement, biomaterials, and tissue engineering are expected to enhance the longevity of bioprosthetic valves and may facilitate the development of hybrid valve technologies combining the strengths of both prosthesis types.</p
Proportion of <i>Pit-1</i> Gene Hinfi Polymorphism in Different Cattle Breeds: A Meta-Analysis
No full textThe Pit-1 gene is reported to be one of the strong candidate genes associated with body weight, average daily gain, milk production, and reproductive traits in cattle. This study aimed to determine the pooled frequencies of genotypes and alleles of Pit-1/HinfI gene polymorphism in different cattle breeds by meta-analysis and to compare these frequencies between breeds by subgroup analysis. According to the meta-analysis results, the pooled proportion of the A allele was 0.268 (95 % CI: 0.237-0.299), while the pooled proportion of the B allele was 0.733 (95 % CI: 0.702-0.764). High heterogeneity was found between studies for all genotypes and alleles. According to the subgroup analyses, the lowest frequency of the AA genotype was found in the local group (0.051 (95 % CI: 0.023-0.080)), while the highest frequency was observed in the hybrid group (0.011(95 % CI: 0.021-0.189)). The highest frequency of the AB genotype was found in the local breed group (0.444 (95 % CI: 0.377 - 0.510)). The BB genotype frequency was highest in the Simmental breed (0.592 (95 % CI: 0.558-0.627)). The A and B allele frequencies were highest in local breeds (0.279 (95 % CI: 0.225-0.330)) and Simmental breed (0.768 (95 % CI: 0.680-0.856)) respectively. According to the subgroup analyses, it was thought that the distribution of allelic frequencies of Holstein, Simmental, and Brown Swiss breeds, which were bred in the yield direction, was shaped according to their yield traits, while the highest variation was found in local breeds, suggesting that it may be an important indicator of the sustainability of the desired allele in the gene pool in the future
