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Adaptation of the Turkish Version of the Green Cosmetic Consumption Scale: A Validity and Reliability Study
No full textSynthesis, Cytotoxic Activity, Antiquorum Sensing Effect, Docking and Md Simulation of Novel 1,3-Disubstituted 2-Mercapto-1H-Benzo[D]Imidazolium Chlorides
No full textA series of benzimidazolium chlorides (2a-c) and their corresponding 2-mercapto derivatives (3a-c) were proficiently synthesized and analyzed by NMR and LC-MS spectra. The in vitro cytotoxic assay demonstrated that some synthesized compounds were active on the cancer cell lines. The binding potential of the most active three compounds to topoisomerase II alpha (topo2α) was explored to unveil the possible mode of action for the cytotoxic activity. The binding potential was examined through molecular docking. The stability of compound-enzyme complexes from docking was investigated through molecular dynamics (MD) simulation. The docking study revealed that the three compounds (3a-c) showed the ability to bind to the enzyme. However, the binding strength of compounds was weaker than that of the standard drug, doxorubicin. The MD simulation analysis demonstrated that compounds 3a and 3b gave relatively stable complexes with the enzyme and thus they would remain inside the binding pocket during the simulation period. Furthermore, the pharmacokinetic properties of the relatively active compounds were computed in silico. The computation disclosed that all of compounds exhibited drug-like properties. It is worth mentioning that all of them were found to be nontoxic. In furtherance, the inhibitory effect of compounds (3a-c) on the quorum sensing system was inspected using the biomonitor strains Chromobacterium violaceum 026, Chromobacterium. violaceum VIR07 and Pseudomonas aeruginosa PAO1. In this regard, we focused on the appraisal of the virulence factors, including pyocyanin, elastase, and biofilm formation that are created by P. aeruginosa PAO1 as the source of infectious diseases. As a result, it was determined that all examined compounds displayed statistically significant inhibition effects, and the highest activity was observed on elastase production with an inhibition rate of 84–86%
ARTIFICIAL INTELLIGENCE ASSISTED WEED CONTROL IN THE LAST DECADE: ADVANCES IN CEREAL PRODUCTION AREAS, ADVANTAGES, CHALLENGES AND FUTURE PERSPECTIVES
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Eryngium kotschyi Boiss. Köklerinin RL95-2 Endometriyum Kanser Hücrelerinde Sitotoksik ve Apoptotik Etkilerinin İncelenmesi
No full textA comparative investigation on the freeze–thaw resistance between dry-cured alkali-activated fly ash/slag and portland cement mortars
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Çocuk Odaklı Bütçeleme Yaklaşımı ve Türkiye’de Uygulanabilirliği
No full textSosyal bütçeleme anlayışı genel olarak toplumun dezavantajlı kesimi sayılan kadınlar, çocuklar ve engellilere yönelik harcamaların öne çıkarıldığı, bütçe hazırlama sürecinde bu kesimin aktif katılımının olduğu bir bütçeyi ifade etmektedir. Sosyal bütçelemenin bir türü olan çocuk bütçelemesi, çocukların temel sosyal ihtiyaçlarının karşılanması anlayışının yanı sıra çocukların bu ihtiyaçlarını aktif katılımla belirleyerek uygulanacak politikalar üzerinde karar verici olma durumunu ifade etmektedir. Türkiye’de çocuklara yönelik bir bütçeleme bulunmamakta, çocuklara yönelik harcamalar bakanlık ve yerel yönetim düzeyinde sınırlı kalmakta ve bu harcamaların yeterli olmadığı görülmektedir. Bu çalışmada, çocuk odaklı politikaların uygulama örneklerine ve yapılan çalışmalar üzerinde tespit edilen eksikliklere yer verilmiştir. Yapılan çalışmalardan da görüleceği üzere, temel eksikliklerin çocuklara yönelik ihtiyaçların tam olarak dikkate alınmaması, çocuk katılımlarının yetersizliği ve karar verici olma mekanizmalarının kapalı olması gösterilmektedir. Ayrıca yaşanılan coğrafyanın sorunlarını bilen ve çocukların temel haklarının savunuculuğunu üstlenen sivil toplum kuruluşlarının eksikliğinin, bütçeleme sürecinde çocukların temsil edilmesini olumsuz etkilediği sonucuna varılmaktadır. Çalışmanın amacı, çocuk odaklı sosyal bir bütçelemenin olmadığı Türkiye’de çocuklara yönelik harcamaların yeterliliğini analiz etmek ve çocuk odaklı bütçeleme anlayışının başarıya ulaşması için çocuk katılımının gerekliliğini ortaya koymaktır.</p
Insight into potential anti-diabetic metabolites of Sycamore fig<i> (Ficus</i><i> sycomorus</i> L.) across fruit development using metabolomics and molecular docking
No full textThe metabolic profile, anti-diabetic activity, and bioactive metabolites of Ficus sycomorus L. (Sycamore fig) fruits were investigated across different developmental stages to identify potential candidates for diabetes management. UPLC/MS/MS analysis enabled the annotation of 52 compounds belonging to diverse chemical classes. Notably, unsaturated fatty acids were predominantly present in immature fruits but declined sharply as maturation commenced. Sugars were detected in the second mature stage, showing a substantial increase as fruits reached full ripeness. Alpha-amino acids and alkaloids were initially abundant in immature fruits, but their levels decreased with maturation. Interestingly, triterpenes were exclusively found in immature fruits, suggesting a stage-specific metabolic profile. OPLS-DA coefficient plots highlighted metabolites that distinguished the developmental stages, revealing patterns associated with anti-diabetic potential. Enzymatic assays demonstrated that all tested fruit samples exhibited significant inhibition of alpha-glycosidase and alpha-amylase activities. The immature fruit stage showed the strongest alpha-glycosidase inhibition (IC50 = 0.601 +/- 0.05 mu g/mL), whereas the fully ripe stage demonstrated the highest alpha-amylase inhibition (IC50 = 0.215 +/- 0.007 mu g/mL). Coefficients plots identified ten compounds positively correlated with anti-diabetic effects. Molecular docking was assessed on the ten identified metabolites, revealing rutin as the most potent alpha-amylase inhibitor with a score of -6.1 kcal/mol, while synephrine exhibited the highest stability against alpha-glycosidase (-6.7 kcal/mol). Synephrine, stearic acid, chlorogenic acid, and rutin, with the highest binding affinity to the anti-diabetic enzymes, were selected for further in-vitro assays, confirming their inhibitory activity against alpha-glycosidase or alpha-amylase. These findings position F. sycomorus fruits as promising natural sources of anti-diabetic agents, encouraging further research into their therapeutic potential