Erciyes University - AVESIS
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Enhancing Functional Protein Design Using Heuristic Optimization and Deep Learning for Anti-Inflammatory and Gene Therapy Applications.
No full textIs lingual fracture pattern in sagittal split osteotomy associated with recovery of neurosensory disturbance?
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Novel triazoloquinazoline derivatives as VEGFR inhibitors: synthesis, cytotoxic evaluation and <i>in silico</i> studies
No full textBackgroundNew triazoloquinazoline derivatives were synthesized to explore their cytotoxic activity on various cancer cell lines, prompted by the need for effective anticancer agents.Research design and methodsAll synthesized compounds were confirmed by spectroscopic methods and tested in vitro for their inhibitory activities against hepatocellular carcinoma (HepG-2), breast cancer (MCF-7), and prostate cancer (PC3) cell lines. Ten compounds were tested in vitro to explore their inhibitory activity against the VEGFR-2. Additionally, various studies were investigated for the most active compound 6, including cell cycle analysis, apoptotic activity assessment, effect on gene expression, safety profiling, molecular docking, MD simulation, and ADMET analysis.ResultsCompounds 3a, 3c, and 6 exhibited higher cytotoxic activity against MCF-7 than doxorubicin. Compound 6 was most potent, arresting the cell cycle at G1 phase and showing proapoptotic action. It significantly inhibited VEGFR-2 and altered gene expression, promoting BAX, P21, and P53 while downregulating BCL-2. Docking and MD simulations indicated stable interaction with VEGFR-2, safety, and ADMET profiles suggested favorable drug-likeness and safety.ConclusionsCompound 6 has shown promising anticancer potential, particularly against breast cancer, but further research is needed to confirm these findings and address long-term safety
Hepatoprotective Activity of Prunus laurocerasus Fruit Extract Against 5-FU-Induced Liver Injury and LC-MS/MS Profiling
No full text5-Fluorouracil (5-FU), one of the most widely used chemotherapy drugs, is known to cause widespread toxicity and irreparable tissue damage. The purpose of this work was to analyze the phytochemical components of Prunus laurocerasus (PL) fruit extract using liquid chromatography with tandem mass spectrometry (LC-MS/MS) and to look into the effectiveness of PL pretreatment on 5-FU-induced liver damage. The study consisted of control (C), PL, 5-FU, PL+5-FU groups, and PL groups received 500 mg/kg PL as pretreatment for seven days. On the eighth day, 100 mg/kg 5-FU was administered intraperitoneally as a single dose to the PL+5-FU and 5-FU groups. In the LC-MS/MS results, it was determined that the phenolic compounds found in the foreground in PL were quinic acid and chlorogenic acid. PL pretreatment increased total antioxidant status levels and B-cell lymphoma 2 (Bcl-2) expression and also decreased Keap1, total oxidant status, oxidative stress index levels, and Bcl-2-associated X protein, Caspase-3, and light chain-3B expressions. 8-hydroxy-2'-deoxyguanosine levels were higher in the 5-FU group compared to the C and PL groups. Moreover, in the PL+5-FU group, the levels were similar to the C, PL, and 5-FU groups. In conclusion, PL pretreatment demonstrated hepatoprotective action via regulating the Kelch-like ECH-associated protein 1/nuclear factor-erythroid 2-related factor 2 pathway in 5-FU-induced liver damage, lowering oxidative stress, and decreasing apoptosis and autophagy from programmed cell death
Original Comparison of the effects of two regional anesthetic techniques on pain during high risk hip fracture surgery
No full textObjectives: In this study, we evaluated perioperative pain management using the Analgesia Nociception Index (ANI) monitoring in high-risk ASA III-IV patients scheduled for hip surgery. Specifically, we examined the lumbar plexus (LP), sacral plexus (SP), and supra-inguinal fascia iliaca compartment blocks (SIFIB), as well as combinations of SP blocks. Methods: In this prospective observational study, we included 74 patients who were assigned to one of two groups: Group L, which received LP and SP blocks, and Group F, which received SIFIB and SP blocks. Surgery was performed after confirming the sensory block with the pinprick test and applying the sedation protocol. Sedation levels were evaluated using the BIS monitor whereas analgesic requirements were assessed using the ANI monitor. Demographic data, including age, sex, ASA score, SpO2, heart rate (HR), mean arterial pressure (MAP), duration of sensorimotor block, type and duration of surgery, time to first analgesic use, and total analgesic consumption, were recorded. Visual analog scale (VAS) scores at 0, 6, 12, and 24 h additional analgesic requirements, and satisfaction ratings from patients and surgeons were also evaluated. Results: Compared to Group F, Group L presented significantly greater ANI values at 30, 60, 90 min intraoperatively, as well as at 6 and 12 h postoperatively. The VAS scores were consistently higher in Group F than in Group L at all measurement times. Conclusion: Group L provided better analgesia, required fewer sedatives during surgery, and had greater satisfaction among patients and surgeons. A negative correlation was found between the VAS score and ANI for assessing patient pain
