Erciyes University - AVESIS
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POLY(3-HYDROXYBUTYRATE) (P3HB) / THERMOPLASTIC POLYURETHANE (TPU) NANOCOMPOSITES CONTAINING GRAPHENE
No full textBiodegradable, biocompatible Polyhydroxybutyrate (PHB) is a bacterial piezoactivepolymer from the class of polyhydroxyalkanoates (PHAs) It has been widely used in manyapplication such as biomedical tissue engineering, drug delivery and food packing. PHB islow thermal stability of the melt, high fragility with high crystallinity and hydrophobicity (1)Polyurethanes consist of rigid and soft flexible chains alternately in the polymer back bone.Furthermore thermoplastic polyurethane (TPUs) elastomers have included high strength,highelongation at break and good abrasion resistance and these properties provide them to beprocessed by using extrusion and injection molding techniques [2]. Graphene-based materialsexhibit good biocompatibility, excellent electrical conductivity, supreme thermalconductivity and high mechanical strength properties with high surface area. Furthermorestudies established about the graphene-based materials show that they have excellentantibacterial and angiogenic properties (3) In this study, Poly(3-hydroxybutyrate)/thermoplastic polyurethane (P3HB/TPU) composite materials containinggraphane nanoparticles prepared in a micro-compounder. The nanocomposites characterizedby using Fourier Transform Infrared spectroscopy (FTIR-ATR) for chemical anaysis andthermal gravimetric analysis (TGA) for thermal properties.</p
Sustainable stabilization of clay soils using fly ash and blast furnace slag-based geopolymers: Comprehensive experimental evaluation and artificial neural network modelling
No full textIn this study, clay soils were stabilized using fly ash (FA), ground blast furnace slag (GGBS) and alkaline activators in order to increase their mechanical and durability properties. The effects of different additive ratios on the soil were evaluated by unconfined compressive strength (UCS), and California Bearing Ratio (CBR) tests. The results showed that the combination of alkaline activators and FA significantly increased the strength of clay soils and reached a UCS value of 600 kPa at the end of 28 days. On the other hand, mixtures containing GGBS showed the highest strength and reached a value of 2470 kPa. Field Emission Scanning Electron Microscope (FE-SEM) analyses have confirmed that these mixtures have been geopolymerized successfully and sodium-alumino-silicate-hydrate (N-A-S-H) gel has been formed. Furthermore, the analysis carried out using the Artificial Neural Network (ANN) model showed a high level of predictive accuracy, with an R2 value of 0.86 and a Root Mean Square Error (RMSE) of 198.73, confirming the model's reliability for practical applications in soil stabilization. Overall, this study reveals that environmentally friendly binders offer a viable alternative in clay floor stabilization and have a wide potential in the field of civil engineering. The innovative aspect of the study is the comprehensive experimental investigation of the mechanical performance of clay soils stabilized with sustainable and environmentally friendly geopolymer binders using different proportions of fly ash and blast furnace slag and the use of these experimental data to make highly accurate predictions using artificial neural network (ANN)-based advanced modeling techniques as a practical and reliable forecasting tool in soil stabilization applications. Thus, both the reduction of environmental impacts and the integration of artificial intelligence supported optimization in engineering applications have been achieved
The Effect of Progressive Relaxation Exercise on Pain, Anxiety and Patient Satisfaction Related to Femoral Sheath Removal: A Randomized Controlled Study
No full textBackground: In percutaneous coronary intervention (PCI), the majority of patients experience pain and discomfort during the sheath removal in the femoral region after the intervention. Aims: This study aims to determine the effect of progressive relaxation exercises (PRE) on pain, anxiety, and patient satisfaction associated with femoral sheath removal in patients undergoing PCI. Methods: This is single-center, prospective, randomized controlled trial. This study was completed with a total of 70 patients. Data were collected using the Patient Information Form, Visual Analogue Scale and State-Trait Anxiety Inventory. Patients in the intervention group performed PRE for 20 min before femoral sheath removal. The patients in the control group received the standard care provided by the clinic. Results: The pain and anxiety levels of the intervention group were found to be significantly lower than the control group, while the satisfaction level was found to be significantly higher. After the intervention, the systolic blood pressure of the intervention group was found to be lower. In addition, anxiety before the application and the pain intensity experienced during femoral sheath removal were weakly positively correlated and satisfaction was weakly negatively correlated. Conclusions: According to the study results, PRE applied before the femoral sheath removal reduces pain and anxiety and increases patient satisfaction. PRE may be an effective intervention to prevent complications that may result from intense pain and anxiety experienced during femoral catheter removal
Associations of Salivary Microbiota with Diet Quality, Body Mass Index, and Oral Health Status in Turkish Adolescents
No full textBackground: The oral microbiota is the largest and most diverse microbial community in the human body, shaped by numerous factors such as body composition, dietary habits, and oral health status. However, relationships between these parameters and the salivary microbiota in adolescents are not yet well understood. Objectives: This study aimed to characterize the salivary microbiota of healthy Turkish adolescents and to examine its associations with body mass index (BMI), diet quality, decayed-missing filled teeth (DMFT) index, and community periodontal index of treatment needs (CPITN). Methods: A descriptive, cross-sectional study was conducted among 40 adolescents aged 14–18 years, classified into four BMI z-score categories (underweight, normal weight, overweight, and obese). Anthropometric measurements, nutritional information, and oral health parameters (DMFT, CPITN) were assessed. Unstimulated saliva samples were collected, and the V3–V4 region of the 16S rRNA gene was sequenced using Illumina MiSeq. Alpha and beta diversity, differential abundance (LEfSe), and correlations with HEI components were analyzed. Results: Underweight adolescents exhibited significantly higher alpha diversity than obese participants (p = 0.024), while beta diversity did not differ across BMI, HEI, DMFT, or CPITN categories. LEfSe analysis revealed BMI-specific taxa: Leptotrichia sp., Haemophilus sp., and Treponema socranskii were enriched in the underweight group; Prevotella denticola in the obese group; and Selenomonas sputigena in the normal-weight group. HEI components, including whole fruits, whole grains, and plant-based proteins, showed positive correlations with Desulfobacterota and Proteobacteria. Poor oral hygiene was associated with higher species richness but not with large shifts in community structure. Conclusions: Salivary microbiota diversity and composition in adolescents vary with BMI, diet quality, and oral hygiene. These patterns are consistent with the idea that targeted nutritional and oral health interventions could influence the salivary microbiome during adolescence
Children With Diabetes and At Least One Non-Autoimmune Feature Should Be Considered for Monogenic Diabetes Testing
No full textAims: Monogenic diabetes testing in children currently targets Maturity Onset Diabetes in the Young (MODY) or recognised genetic syndromes. Objective: We aim to determine whether genetic testing for monogenic diabetes should be performed for all children with diabetes and at least one non-autoimmune extra-pancreatic feature (syndromic diabetes). Methods: We recruited 183 children with diabetes and at least one non-autoimmune extra-pancreatic feature (50% (n=91) with self-reported consanguinity). We measured islet-autoantibodies and type 1 diabetes genetic risk score (T1DGRS) and used targeted next generation sequencing to analyse all known causes of monogenic diabetes. Results: 33% (61/183) of children had confirmed monogenic diabetes. Of these, 84% (51/61) had recessive aetiologies with variants in WFS1 (46%), SLC19A2 (12%) and SLC29A3 (12%) being most common. Monogenic cases compared to non-monogenic had similar age of diagnosis (7.4 vs 6, p=0.1) and BMI z-score (-0.08 vs -0.41, p=0.3) but had higher parental consanguinity (62% vs 19%, p=0.01) and features in multiple organ systems (53% vs 28%, p=0.01). Only 59% reported well recognised features of their associated genetic syndrome. Children with low T1DGRS (= 50th centile) (48% vs 3% vs 7%, p<0.0001). Conclusion: Children with diabetes and at least one non-autoimmune extra-pancreatic feature should be considered for monogenic diabetes testing. Measurement of islet-autoantibodies and T1DGRS help prioritise genetic testing
