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Changes in the Quality of Dried Vacuum-Infused Strawberries Enriched with Encapsulated Pomegranate Peel Extract During Storage
No full textThe low stability of phenolic compounds restricts their use in the food industry. Encapsulation can help protect these compounds during food processing. In this study, pomegranate peel extract (PPE) was encapsulated and then used to produce dried vacuum-infused strawberries.The quality changes of strawberry products enriched with encapsulated pomegranate peel extract (EPPE) were investigated during 90 days of storage at 25 degrees C and compared to those infused with non-encapsulated PPE. During storage, the dried strawberries enriched with EPPE exhibited higher contents oftotal phenolics and individual phenolics, such as ellagic acid and punicalagin, than the dried strawberries with PPE.The total phenolic content of the strawberry product with EPPE was preserved at 9.40% better after 90 days of storage compared to the product enriched with PPE. Additionally, after storage, the strawberry product with EPPE showed significantly lower microbial counts (total aerobic mesophilic bacteria, yeast, and mold) and reduced browning index compared to the product with PPE. Moisture content changes during storage were controlled to the greater extent in the product with EPPE, contributing to its structural integrity. These results indicate that encapsulation, combined with vacuum impregnation, can effectively enhance the stability, microbial safety, and shelf-life of dried infused strawberries.Scientific and Technological Research Council of Turkey (TUBITAK) 1002-Short Term R&D Funding Program [119O181]This work was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) 1002-Short Term R&D Funding Program (Project number: 119O181)
Promising Electromagnetic Interference Shielding Materials: Hybrid Fillers Reinforced Bio-Based Composites
No full textElectromagnetic pollution, also known as electromagnetic interference (EMI) issues, is a growing concern as electronic and telecommunication technologies advance. The resulting urgent demand for EMI shielding materials underscores the need for the development of high-performance, environmentally friendly shielding materials. Here, we assess the impact of multiscale carbon-based hybrid filler on the EMI shielding performance of polyamide 11/poly(lactic acid) composites. The effects of the amounts (0.5 to 5 wt%) of graphene nanoplatelets (GNPs) and multiwalled carbon nanotube (MWCNT) nanofillers in carbon fiber (CF)/GNP and CF/MWCNT-reinforced hybrid composites were comparatively investigated. The composites were fabricated through melt blending/compression molding and subsequently characterized in terms of morphological, fiber length, electrical properties, and EMI shielding effectiveness (EMI SE). Morphological imaging revealed a good adhesion between the fillers and the matrix, indicating a favorable interaction. The fiber length analysis demonstrated that fiber lengths were longer in CF/GNP hybrid composites than in CF/MWCNT. The EMI SE measurements showed the synergistic effects of the fillers in the X and Ku bands. The highest EMI SE values at 10 GHz and 16 GHz for the 20CF-5GNP composite were 34 and 40 dB, respectively.Kocaeli University Scientific Research Projects Unit [FDK-2021-2783]; KOUBAPThis work was supported by KOUBAP; Kocaeli University Scientific Research Projects Unit, FDK-2021-278
Baloxavir’in seçilmiş influenza polimeraz bağlanma bölgeleri ile etkileşimlerinin moleküler modelleme yöntemleriyle incelenmesi
No full textDünya Sağlık Örgütü'nün verilerine göre neden olduğu 290000 ile 650000'i ölümle sonuçlanan mevsimsel influenza vakaları nedeniyle, özellikle influenza A virüsleri önemli sağlık sorunlarının başında gelmektedir. Her ne kadar bu sağlık sorununun üstesinden gelebilmek için birçok antiviral kullanımda olsa da influenza genomunda meydana gelen antiviral dirençlilik ilişkili mutasyonlar nedeniyle bu ilaçlar etkisiz kalabilmektedir. Bu tez kapsamında ilk kez Yoğunluk Fonksiyoneli Teorisi (DFT) hesaplamaları ile günümüze en yakın zamanda kullanım onayı alan Baloxavir ile seçilmiş amino asitler arasındaki kovalent olmayan etkileşimlerin (NCI) incelenmesi hedeflenmiştir. Bu hedefe ulaşabilmek için Baloxavir ve seçilmiş amino asitlerin konformer analizleri MMFF (Merck Molecular Force Field) algoritması kullanılarak gerçekleştirilmiştir. Geometri optimizasyonu ve frekans analizleri ise Gaussian 16 kullanılarak, ωB97XD/6-31+G(d,p) seviyesinde DFT ile yapılmıştır. Bu çalışma sonucunda izolösin, treonin, lizin, glutamik asit, alanin ve tirozin ile Baloxavir arasında literatürde farklı yöntemlerle tespit edilen NCI türlerinin yanı sıra birçok farklı NCI türü tanımlanmıştır. Ayrıca bu çalışmaya konu olan amino asitler ile Baloxavir arasındaki bağlanma enerjileri de hesaplanmış ve glutamik asitin en yüksek, alaninin ise en düşük bağlanma enerjisine sahip olduğu tespit edilmiştir.According to World Health Organization, seasonal influenza cases, which result in 290,000 to 650,000 deaths, place influenza A viruses among the leading causes of major health issues. Although many antivirals are used to overcome this health problem, these drugs may be ineffective due to antiviral resistance-related mutations in the influenza genome. The aim of this thesis is to investigate the noncovalent interactions (NCI) between baloxavir, which is one of the most recently approved drugs for use, and selected amino acids through Density Functional Theory (DFT) calculations for the first time. To achieve this goal, conformer analyses of Baloxavir and selected amino acids were performed using the MMFF (Merck Molecular Force Field) algorithm. Geometry optimization and frequency analyses were performed using density functional theory (DFT) at the ωB97XD/6-31+G(d,p) level using Gaussian 16. As a result of this study, numerous types of NCIs were identified between baloxavir and isoleucine, threonine, lysine, glutamic acid, alanine, and tyrosine, in addition to the NCI types previously reported in the literature using different methods. Furthermore, the binding energies between the amino acids and baloxavir were calculated, revealing that glutamic acid exhibits the highest binding energy, while alanine has the lowest
Industries Integrating Türkiye to the World: An Empirical Analysis Using Intercountry Forward and Backward Linkage Coefficients
No full textGlobal value chain (GVC) is defined as a production process involving value-added from at least two countries with increasing global integration. This study aims to identify the industries triggered by the exports/imports of intermediate inputs in the rest of the world / Türkiye for the industries that Türkiye has identified as targets in the 2023 Industry and Technology Strategy Document. In this way, it is determined in which industries Türkiye is articulated to GVCs through its target industries. The analysis is carried out by calculating the forward and backward linkage coefficients between countries in the multi-country input-output matrix. As an analysis tool, the input-output matrix with 45 industries and 64 countries produced by the OECD for 2018 is used. In the analysis, the matrix is used by aggregating it as two countries in the form of Türkiye and the rest of the world. Analysis indicates that inter-country calculated forward and backward linkage coefficients for both intermediate input exports and imports of the target industries “electrical equipment”, “chemicals”, “machinery” and “motor vehicles” are greater than 1. This finding can be interpreted as a mutual interdependence between the production of the world and Türkiye through these industries. Additionally, it can be said that Türkiye is unidirectionally dependent on imports from abroad in the “computers and electronic and optical products” industry. Another finding is that there is a relative compatibility between the industries that Türkiye has been exporting the most for many years and the industries with high value-added and high technology content that are targeted to be exported in the recent period
An In-Depth Analysis of the Finfish Aquaculture in Türkiye: Current Status, Challenges, and Future Prospects
No full textAquaculture emerges as a crucial solution for addressing the global food shortage of an estimated 10 billion people by 2050. In Türkiye, aquaculture plays a significant role in supporting the economy and ensuring food security. Over the past two decades, finfish production in Türkiye surged from 61,163 to 547,505 t, generating $1.7 billion in export revenue across over 100 countries. This growth has been driven by technological advancements, robust governmental support, and increasing global demand for aquaculture products. However, the sector also faces persistent challenges, including the need to enhance sustainability, mitigate ecological impacts, and manage finite resources. As Europe's leading fish producer, the Turkish aquaculture sector must continue to innovate and expand to meet the demands of a growing population. Despite the expanding research on Turkish finfish aquaculture, there is no comprehensive review that consolidates both scientific progress and sectoral developments. This study fills that void by combining a bibliometric analysis of 1958 scientific publications from 1983 to 2023 with an in-depth sectoral evaluation, providing a holistic understanding of the Turkish aquaculture sector. The bibliometric analysis highlights key research areas, trends, and knowledge gaps, while the sectoral overview examines production trends, dynamics of the feed industry, technological innovations, and economic factors. It also addresses challenges such as climate change impacts, reliance on imported feed ingredients, and disease issues, discussing potential avenues for sustainable growth through innovation, policy reforms, and technological integration. This review serves as a valuable resource for researchers, policymakers, and industry stakeholders, offering insights into the current state and future directions of finfish aquaculture in Türkiye. © 2025 Elsevier B.V., All rights reserved
Karbon emisyonlarının temel ekonomik belirleyicileri: Gelişmiş ve gelişmekte olan ülkeler üzerine panel veri analizi
No full textKüresel ısınma ve iklim değişikliği, günümüz dünyasında sürdürülebilir kalkınmayı tehdit eden en önemli çevresel sorunların başında gelmektedir. Karbon emisyonları (CO2), bu sürecin temel itici gücü olarak görülmekte ve ülkelerin çevre, enerji ve ekonomi politikaları üzerindeki baskısını her geçen gün artırmaktadır. Bu bağlamda, karbon emisyonlarının ekonomik, enerji temelli ve kurumsal belirleyicilerinin ortaya konulması etkili politika üretimi açısından kritik öneme sahiptir. Bu çalışma, 2000-2021 döneminde 22'si gelişmiş ve 19'u gelişmekte olan toplam 41 ülkeyi kapsayan panel veri seti kullanarak karbon emisyonlarını etkileyen temel faktörleri analiz etmeyi amaçlamaktadır. Bağımsız değişkenler olarak kişi başına düşen GSYİH, enerji etkinliği, yenilenebilir enerji kullanımı, fosil yakıt tüketimi ve mülkiyet hakları ele alınmıştır. Çalışmada panel birim kök ve eş bütünleşme testlerinin ardından Augmented Mean Group (AMG) tahmincisi ile uzun dönemli etkiler incelenmiş, Dumitrescu-Hurlin panel nedensellik testi ile değişkenler arasındaki nedensel ilişkiler ortaya konulmuştur. Analiz bulgularına göre, karbon emisyonları üzerindeki etkiler ülke gruplarına göre farklılık göstermektedir. Enerji etkinliği her iki grup için de emisyonları azaltmak yerine artırıcı etki göstermiş; ekonomik büyüme ise emisyonları artırıcı yönde anlamlı bulunmuştur. Yenilenebilir enerji kullanımı yalnızca gelişmiş ülkelerde emisyonları azaltırken, fosil yakıt tüketimi tüm ülkelerde emisyonları yükseltmiştir. Mülkiyet hakları değişkeni ise doğrudan anlamlı çıkmasa da bazı ülkelerde dolaylı etkiler göstermiştir. Bu sonuçlar, sürdürülebilir kalkınma hedeflerine ulaşmada politika tasarımlarının ülke gruplarına göre farklılaştırılması gerektiğini ortaya koymaktadır.Global warming and climate change stand as the foremost environmental challenges threatening sustainable development in the contemporary world. Carbon emissions (CO2), regarded as the primary driver of this process, exert increasing pressure on nations' environmental, energy, and economic policies with each passing year. In this context, elucidating the economic, energy-related, and institutional determinants of carbon emissions is of critical importance for the formulation of effective policy measures. This study aims to analyze the key factors influencing carbon emissions by employing a panel dataset encompassing 41 countries422 developed and 19 developing-over the period 2000-2021. The independent variables under consideration include GDP per capita, energy efficiency, renewable energy consumption, fossil fuel consumption, and property rights. Following panel unit root and cointegration tests, the long-term effects are examined using the Augmented Mean Group (AMG) estimator, while the Dumitrescu-Hurlin panel causality test is applied to uncover causal relationships among the variables. The findings reveal that the impacts on carbon emissions vary across country groups. Energy efficiency, contrary to expectations, exhibits an emission-increasing effect in both groups, whereas economic growth is found to have a significant positive impact on emissions. Renewable energy consumption reduces emissions solely in developed nations, while fossil fuel consumption elevates emissions across all countries. Although the property rights variable does not yield a direct significant effect, it demonstrates indirect influences in certain nations. These results underscore the necessity of tailoring policy designs according to country-specific characteristics to achieve sustainable development objectives
How Perceived Parental Stress Levels and Family-Centered Care Change During The First Week of Admission to The Neonatal Intensive Care Unit: A Descriptive Follow-Up Study
No full textYYBÜ'ye kabulün ilk haftasında algılanan ebeveyn stres düzeyleri ve aile merkezli bakım nasıl değişir: Tanımlayıcı bir takip çalışması Öz Amaç: Bu araştırma, yenidoğan yoğun bakım ünitesine (YYBÜ) bebeği yatan ebeveynlerin stres düzeyleri ve aile merkezli bakım algılarını değerlendirmeyi amaçlamıştır. Yöntem: Bu tanımlayıcı takip çalışması, bebekleri doğumdan hemen sonra üniteye kabul edilen ve en az yedi gün kalması beklenen 62 ebeveynin katılımı ile III. Düzey YYBÜ’de Kasım 2017-Mayıs 2018 tarihlerinde yürütülmüştür. Verilerin toplanmasında; T1 (yatışın 2. günü) ve T2'de (yatışın 7. günü) YYBÜ Ebeveyn Stres Ölçeği (PSS: NICU), Aile Merkezli Bakım Ölçeği-Tutarlılık (FCCS-Consistency) ve Ebeveyn-Bebek Bilgi Formundan yararlanılmıştır. Analiz için tanımlayıcı istatistikler ve tekrarlanan ölçümler t-testleri kullanılmıştır. Bulgular: Ebeveynlerin T1 ve T2'deki PSS: NICU ve FCCS-Consistency puan ortalamalarında istatistiksel olarak anlamlı farklılıklar bulunmuştur (pHow perceived parental stress levels and family-centered care change during the first week of admission to the NICU: A descriptive follow-up study Abstract Objective: This study aimed to evaluate the evolving dynamics of perceived parental stress levels and family-centered care (FCC) during the initial week of infant admission to the Neonatal Intensive Care Unit (NICU). Methods: Conducted in a Level III NICU from November 2017 to May 2018, this descriptive follow-up study involved 62 parents whose infants were admitted to the unit immediately after birth and were expected to remain for at least seven days. Data collection at T1 (2nd day of admission) and T2 (7th day of admission) utilized the Parental Stress Scale: NICU (PSS: NICU), Family-Centered Care Scale-Consistency (FCCS-Consistency), and Parent-Infant Information Form. Descriptive statistics and repeated measures t-tests were employed for analysis. Results: Statistically significant differences were found in the mean scores of parents’ PSS: NICU and FCCS-Consistency at T1 and T2 (
Myofunctional therapy: a bibliometric study of the most cited 50 articles
No full textAim The objective of this bibliometric analysis was to provide an overview of the current literature status of myofunctional therapy and to assist practitioners and researchers to make clinically relevant decisions and to foster collaborations by mapping out bibliographic information.Methods A literature search was conducted using the Web of Science Core Collection through the electronic library of Ege University by applying the query (TS = (myofunctional therapy OR dental myofunctional therapy OR myofunctional treatment OR myofunctional appliance)). The 50 most-cited articles were analysed in September 2024 using VOSviewer software to assess parameters associated with authorship, the country of origin, academic institutions, and keywords, so that the interrelationships could be mapped.Results The 50 most-cited articles, authored by a total of 227 researchers, were published between 1998 and 2022, and attracted a cumulative total of 2483 citations. According to the Web of Science (WoS) categories, most of the publications were classified under Dentistry, Oral Surgery & Medicine, followed by Clinical Neurology. The United States was the country with the highest number of citations, while Stanford University emerged as the institution with the greatest number of frequently cited works.Conclusion This bibliometric analysis highlights the increasing research interest in myofunctional therapy and its role in addressing a malocclusion, obstructive sleep apnoea, and other orofacial conditions. While international collaboration is growing, limited cross-specialty integration remains, emphasising the need for more interdisciplinary studies and randomised controlled trials to strengthen evidence-based practices
Genel cerrahi servisinde yatan hastaların hemşirelik bakım kalitesi algılamaları ile memnuniyet durumları arasındaki ilişkinin incelenmesi
Get PDFAmaç: Bu araştırma genel cerrahi servisinde yatmakta olan hastaların hemşirelik bakım kalitesini algılamaları ile memnuniyet durumları arasındaki ilişkinin incelenmesi amacıyla yapıldı. Gereç ve Yöntemler: Bu araştırma, 1 Aralık 2023 - 1 Mart 2024 tarihleri arasında Ege Üniversitesi Hastanesi Genel Cerrahi servisinde yürütüldü. Tanımlayıcı ve kesitsel tipte olan bu araştırmanın örneklemini; genel cerrahi servisinde yatmakta olan araştırmaya katılmaya gönüllü 132 hasta oluşturdu. Verilerin toplanmasında, "Hasta Tanıtım Formu", "Bakım Davranışları Ölçeği - BDÖ24" ve "Newcastle Hemşirelik Bakımı Memnuniyet Ölçeği - NHBMÖ" kullanıldı. Araştırma verilerinin analizinde "Statistical Package For Social Science (SPSS) 25.0" paket programı kullanıldı. Verilerin dağılımı "tanımlayıcı analiz parametreleri" [ortalama, standart sapma, minimum, maksimum, frekans ve yüzde] ile gösterildi. Verilerin normal dağılıma uyup uymadığı "Shapiro Wilk testi" ile analiz edildi. Verilerin normal dağılıma uymaması nedeniyle analizlerde "Kruskal Wallis ve Mann Whitney U testi" kullanıldı. Farklılığın bulunduğu karşılaştırmalarda, farklılığın kaynak aldığı grubun tespit edilmesinde "Tamhane's T2 Post Hoc testi" kullanıldı. Verilerin analizinde "%95 güven aralığı" tercih edildi. Bulgular: Araştırmaya dahil olan hastaların yaş ortalaması 50,67±15,95'tir. Hastaların en küçüğü 21, en büyüğü ise 89 yaşındadır ve büyük çoğunluğu (%35,6) 35-49 yaş grubundadır. Hastaların %32,6'sı ortaokul mezunu, %22,8'i emekli, %50,8'i çalışmamakta, %91,7'si ilde yaşamakta, %100'ü sosyal güvence sahibi, %65,2'sinin kronik hastalığı yoktur. Hastaların %53,0'ının daha önce hastaneye yattığı; %59,8'inin daha önce cerrahi girişim geçirdiği ve %47,7'sinin şu ana kadar 1 defa hastanede kaldığı ve %25,0'ının 3 gece hastanede kaldığı belirlendi. "Newcastle Hemşirelik Bakımı Memnuniyet Ölçeği puan ortalaması" 79,00±16,47'dir. Hastaların "Newcastle Hemşirelik Bakımı Memnuniyet Ölçeği toplam puanı"yla yaş, medeni durum ve bu yatışlarında hastanede kaç gece kaldıkları arasında "istatiksel olarak anlamlı fark" bulundu [p<0.05]. 65 yaş ve üzeri hastaların, diğer yaş gruplarındaki hastalara göre daha yüksek "NHBMÖ puan ortalaması"na sahip olduğu belirlendi. Hastanedeki gece kalış süresi 5 gece olan hastaların" NHBMÖ puanları" daha yüksek bulundu. "Bakım Davranışları Ölçeği genel puan ortalaması" 5,19 ±0,86 olarak saptandı. Dört alt boyutlu ölçeğin "bağlılık alt boyutu toplam puanı" 5,13 ±0,92, "saygılı olma alt boyutu toplam puanı" 5,18 ±0,92, "bilgi beceri alt boyutu toplam puanı" 5,23 ±0,84 ve "güvence alt boyutu toplam puanı" 5,22 ±0,87 olarak bulundu. Yaşlarına göre, 65 ve üzeri yaş hastaların "BDÖ" "bağlılık", "bilgi-beceri", "güvence" ve "BDÖ toplam puan ortalaması" diğer yaş gruplarından yüksek bulundu. Bekar hastalar, "BDÖ" "bağlılık" ve "saygılı olma alt boyutu"nda evli hastalara göre hemşirelik bakımından daha çok memnunlardı. Hastaların bu yatışlarındaki hastanede gece kalış süreleri yönünden, "BDÖ toplam puanı", "bağlılık alt boyutu"nda, "bilgi-beceri alt boyutu"nda ve "güvence alt boyutu"nda, 4 gece kalan hastaların diğer hastalardan hemşirelik bakımı algılamaları daha yüksek oltuğu tespit edildi. Hastanede gece kalış süresi ile bakım davranışları arasında "istatistiksel olarak anlamlı bir fark" bulundu [p<0.05]. Hemşirelik bakımı algılamaları puanı en düşük olan hastalar; "bağlılık alt boyutu"nda 3 gece kalan hastalar, "saygılı olma alt boyutu"nda 2 gece kalan hastalar, "bilgi-beceri alt boyutu"nda 3 gece kalan hastalar ve "güvence alt boyutu"ndaysa 2 gece kalan hastalar olduğu tespit edildi. Sonuç: Araştırmaya katılan hastaların "NHBMÖ"den aldıkları "puan ortalaması"nın orta değerin üzerinde yüksek olduğu, "BDÖ toplam puan" ve "alt boyut puan ortalamaları"nınsa çok yüksek olduğu; yaş, medeni durum ve hastanede gece kalış süresinin "NHBMÖ" ve "BDÖ toplam" ve "alt boyutlarının puan ortalamaları" arasında "istatistiksel olarak anlamlı bir ilişki" olduğu saptandı.Aim: This study was conducted to examine the relationship between the perception of nursing care quality and the satisfaction levels of patients hospitalized in the general surgery unit. Material and Methods: This study was conducted between December 1, 2023, and March 1, 2024, in the "General Surgery Unit of Ege University Hospital". The study, which was descriptive and cross-sectional in design, included a sample of 132 patients hospitalized in the general surgery unit who voluntarily agreed to participate. Data were collected using the "Patient Demographic Form", "Caring Behaviors Inventory - CBI24" and "Newcastle Satisfaction with Nursing Care Scale - NSNCS". For data analysis, the "Statistical Package for Social Sciences (SPSS) version 25.0" was utilized. The distribution of the data was presented using "descriptive analysis parameters" [mean, standard deviation, minimum, maximum, frequency, and percentage]. The normality of the data distribution was assessed using the "Shapiro-Wilk test". As the data did not follow a normal distribution, "Kruskal-Wallis and Mann-Whitney U tests" were employed in the analysis. For comparisons showing significant differences, the source of the difference was identified using the "Tamhane's T2 Post Hoc test". A "95% confidence interval" was used for the analysis. Results: The average age of the patients participating in the study was 50.67±15.95 years. The youngest patient was 21 years old, while the oldest was 89 years old, with the majority (35.6%) falling into the 35-49 age group. Among the participants, 32.6% were middle school graduates, 22.8% were retirees, 50.8% were unemployed, 91.7% resided in the city, and 100% had social security coverage. Additionally, 65.2% of the patients reported having no chronic illness. It was also determined that 53.0% of the patients had been hospitalized before, 59.8% had undergone a surgical procedure in the past, 47.7% had been hospitalized only once until now, and 25.0% had stayed in the hospital for three nights during their most recent hospitalization. The mean score of the "Newcastle Satisfaction with Nursing Care Scale (NSNCS)" was 79.00±16.47. A statistically significant difference was found between the total "NSNCS score" and the patients' age, marital status, and the number of nights they stayed in the hospital during this admission [p<0.05]. It was observed that patients aged 65 and older had higher "NSNCS" mean scores compared to those in other age groups. Additionally, patients who stayed in the hospital for five nights had higher "NSNCS" scores. The overall mean score of the "Caring Behaviors Inventory (CBI)" was found to be 5.19 ± 0.86. The subscale scores were as follows: the "Commitment" subscale scored 5.13 ± 0.92, the "Respectfulness" subscale scored 5.18 ± 0.92, the "Knowledge and Skill" subscale scored 5.23 ± 0.84, and the "Assurance" subscale scored 5.22 ± 0.87. Patients aged 65 and older had higher mean scores in the "Commitment," "Knowledge and Skill," and "Assurance" subscales, as well as in the overall "CBI score", compared to other age groups. It was observed that single patients reported greater satisfaction with nursing care in the "Commitment" and "Respectfulness" subscales compared to married patients. Regarding the number of nights spent in the hospital during this admission, patients who stayed for four nights had higher overall "CBI scores" and higher scores in the "Commitment," "Knowledge and Skill," and "Assurance" subscales than those who stayed for fewer or more nights. "A statistically significant difference" was found between the length of hospital stay and the perception of caring behaviors [p<0.05]. The lowest scores in the perception of nursing care were observed among patients who stayed for three nights in the "Commitment" subscale, those who stayed for two nights in the "Respectfulness" subscale, those who stayed for three nights in the "Knowledge and Skill" subscale, and those who stayed for two nights in the "Assurance" subscale. Conclusion: It was determined that the mean score of the "Newcastle Satisfaction with Nursing Care Scale (NSNCS)" among the patients participating in the study was above the median level, indicating a high level of satisfaction. Additionally, the overall and subscale mean scores of the "Caring Behaviors Inventory (CBI)" were found to be very high. "A statistically significant relationship" was identified between age, marital status, and the length of hospital stay, and the mean scores of both the "NSNCS" and the overall and "subscale scores of the CBI"
Overweight, obesity, and cardiovascular disease in heterozygous familial hypercholesterolaemia: the EAS FH Studies Collaboration registry
No full textBackground and Aims Overweight and obesity are modifiable risk factors for atherosclerotic cardiovascular disease (ASCVD) in the general population, but their prevalence in individuals with heterozygous familial hypercholesterolaemia (HeFH) and whether they confer additional risk of ASCVD independent of LDL cholesterol (LDL-C) remains unclear. Methods Cross-sectional analysis was conducted in 35 540 patients with HeFH across 50 countries, in the EAS FH Studies Collaboration registry. Prevalence of World Health Organization-defined body mass index categories was investigated in adults (n = 29 265) and children/adolescents (n = 6275); and their association with prevalent ASCVD. Results Globally, 52% of adults and 27% of children with HeFH were overweight or obese, with the highest prevalence noted in Northern Africa/Western Asia. A higher overweight/obesity prevalence was found in non-high-income vs. high-income countries. Median age at familial hypercholesterolaemia diagnosis in adults with obesity was 9 years older than in normal weight adults. Obesity was associated with a more atherogenic lipid profile independent of lipid-lowering medication. Prevalence of coronary artery disease increased progressively across body mass index categories in both children and adults. Compared with normal weight, obesity was associated with higher odds of coronary artery disease in children (odds ratio 9.28, 95% confidence interval 1.77-48.77, adjusted for age, sex, lipids, and lipid-lowering medication) and coronary artery disease and stroke in adults (odds ratio 2.35, 95% confidence interval 2.10-2.63 and odds ratio 1.65, 95% confidence interval 1.27-2.14, respectively), but less consistently with peripheral artery disease. Adjusting for diabetes, hypertension and smoking modestly attenuated the associations. Conclusions Overweight and obesity are common in patients with HeFH and contribute to ASCVD risk from childhood, independent of LDL-C and lipid-lowering medication. Sustained body weight management is needed to reduce the risk of ASCVD in HeFH.Pfizer Independent Grant for Learning Change [16157823]; Merck Sharp Dohme; Regeneron; National Institute for Health and Care Research (NIHR) Applied Research Collaboration Northwest London; NIHR Applied Research Collaboration Northwest London and Imperial NIHR Biomedical Research Centre; Ministry of Universities, Spain; University of Seville, Spain; Ricerca Corrente from the Ministry of Health to IRCCS MultiMedica; Ministry of Higher Education (MOHE); National Professorial Council (MPN); Universiti Teknologi MARA (UiTM), Malaysia; Austrian Heart Foundation; Tyrolean Regional GovernmentThe EAS FHSC is an academic initiative that has received funding from a Pfizer Independent Grant for Learning & Change 2014 (16157823) and from investigator-initiated research grants to Imperial College London from Amgen, Merck Sharp & Dohme, Sanofi-Aventis, Daiichi Sankyo, and Regeneron. K.I.D. acknowledges support for a PhD Studentship from the National Institute for Health and Care Research (NIHR) Applied Research Collaboration Northwest London. K.K.R. acknowledges support from the NIHR Applied Research Collaboration Northwest London and Imperial NIHR Biomedical Research Centre. The views expressed in this Article are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. A.J.V.-V. acknowledges support from the Programme Beatriz Galindo from the Ministry of Universities, Spain, and University of Seville, Spain. A.L.C. is supported in part by the grant Ricerca Corrente from the Ministry of Health to IRCCS MultiMedica. H.N. acknowledges support from the Ministry of Higher Education (MOHE), National Professorial Council (MPN) and Universiti Teknologi MARA (UiTM), Malaysia. The Austrian Familiar Hypercholesterolemia Registry, which contributed to the FHSC registry, has been supported by funds form the Austrian Heart Foundation and the Tyrolean Regional Government