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Biyoaktif materyal içerikli deneysel diş macununun başlangıç çürükleri üzerindeki remineralizasyon etkisinin incelenmesi
No full textAmaç: Bu çalışmanın amacı biyoaktif materyal içerikli yeni bir diş macunu üretmek ve bu diş macunuyla birlikte piyasada bulunan farklı aktif içeriklere sahip diş macunlarının yapay başlangıç mine çürüğü oluşturulmuş dişlerin remineralizasyonu üzerine olan etkilerini in vitro ortamda karşılaştırmalı olarak incelemektir. Yöntem: Çalışmamızda 60 adet üst kesici diş kullanılmış ve örnekler rastgele 6 gruba ayrılmıştır; G1. Deneysel macun, G2. Sensodyn Onarım ve Koruma, G3. Zubio Aktif Karbonlu Beyazlatıcı, G4. GC Tooth Mouse, G5. Colgate Hassasiyete Pro-Çözüm, G6. Kontrol (Yapay tükürük solüsyonu). Çalışmamızda kullanılacak olan dişler, yapay çürük oluşturmak amacıyla 3 gün demineralizasyon solüsyonunda bekletilmiştir. Daha sonra 7 gün boyunca demineralizasyon-remineralizasyon döngüsüne tabii tutulan örneklere diş macunları günde 2 kere bir aplikatör yardımıyla uygulanmış ve yüzeyde 2 dakika bekletilmiştir. Mine dokusunun yüzey sertliğinde meydana gelen değişimler Vickers mikrosertlik cihazıyla, yüzey yapısındaki morfolojik değişimler Taramalı Elektron Mikroskobu (SEM) ve iyon miktarındaki değişimler Enerji dağılımlı X-ışını Spektroskopisi (EDS) ile, kimyasal yapıda meydana gelen değişiklikler Zayıflatılmış Toplam Yansıma-Fourier Dönüşümlü Kızılötesi Spektroskopisi (ATR-FTIR) ile incelenmiştir. Elde edilen verilerin istatistiksel analizi, SPSS (vers. 27.0, IBM Corp., Chicago, IL, ABD) programı kullanılarak yapılmıştır. Bulgular: Mikrosertlik (MS) değerleri incelendiğinde demineralizasyon sonrası tüm gruplarda MS’de azalma tespit edilmiştir. Kontrol grubu hariç tüm gruplarda remineralizasyon sonrası anlamlı bir MS artışı olmuştur (p0.05). ATR-FTIR analizi sonucu başlangıç-remineralizasyon aşamalarındaki pik alanları farkı (Δ AUC B-R) ve demineralizasyon-remineralizasyon aşamalarındaki pik alanları farkı (Δ AUC D-R) tüm bağ türleri için gruplar arasında anlamlı fark göstermemektedir (p>0.05). Başlangıç-remineralizasyon aşamalarındaki mineral/matriks oranları farkı (Δ M/M B-R) ve demineralizasyon-remineralizasyon aşamalarındaki mineral/matriks oranları farkı (Δ M/M D-R) incelendiğinde gruplar arasında anlamlı fark bulunmuştur (p0.05). ATR-FTIR analysis showed that the differences in peak area values (ΔAUC B–R and ΔAUC D–R) between baseline–remineralization and demineralization–remineralization phases did not reveal statistically significant differences between groups for any functional bond type (p>0.05). However, significant differences were observed among the groups in terms of changes in mineral-to-matrix ratios (ΔM/M B–R and ΔM/M D–R) between both baseline–remineralization and demineralization–remineralization stages (p<0.05)
Toxicity of the two insect growth regulators, pyriproxyfen and Lufox® against cotton bollworm
No full textThis study investigated the field effects of two insect growth regulators, pyriproxyfen and lufenuron+fenoxycarb (A commercial combination), on some biological and physiological characteristics of third instar larvae of the cotton bollworm, Helicoverpa armigera Hubner. The insecticides significantly affected the weight and duration of larval and pupal development, the longevity of males and females, the egg laying and hatching rates. The larvae treated with sublethal concentrations showed an increase in the total number of hemocytes, plasmatocytes and granulocytes. A significant increase in aminotransferase activity was also observed in the hemolymph of treated larvae. The increased activity of acid phosphatase and alkaline phosphatase was also observed in the treated H. armigera larvae. The total activity of esterase and glutathione S-transferase as detoxifying enzymes also increased significantly after pyriproxyfen and lufenuron+fenoxycarb treatments compared to control. In contrast, the amount of storage macromolecules, protein, triglycerides and glycogen, which are related to the energy cost of pesticide treatment, decreased in the treated larvae compared to the control. According to the results of the present research, the pesticides pyriproxyfen and lufox can be used to control the population of H. armigera by interfering with the intermediate metabolism and cellular immunity of the larvae, but their efficiency and compatibility should be considered with other control methods, especially biological factors
Corrosive Substance Ingestion: When to Perform Endoscopy?
No full textAim: Ingestion of corrosive substances is a difficult and important medical problem to manage. The aim of this study is to present an algorithm that will regulate the treatment and follow-up of paediatric patients with corrosive ingestion. Methods: Children who were admitted to the paediatric emergency department with corrosive substance ingestions between July 2015 and December 2021 were included. Between July 2015 and January 2020, endoscopy was performed on all patients. After January 2020, endoscopy was performed only for patients presenting with hypersalivation and dysphagia. Results: 172 patients were followed up and treated in our clinic due to corrosive substance ingestion. Endoscopic evaluation of 19 patients with hypersalivation revealed oesophageal corrosion stages as follows: grade I in 5 patients, grade II-A in 1 patient, grade II-B in 3 patients, and normal findings in the remaining patients. Of the 14 patients with dysphagia, 1 had grade I, 2 had grade II-A, and 4 had grade II-B corrosion, and the remaining patients had normal endoscopic findings. In the long-term follow-up of the patients without hypersalivation and dysphagia, no complications developed and no additional treatment was required. Conclusions: In patients presenting with suspicion of ingestion of high risk corrosive substances, there is no need for endoscopy unless hypersalivation and dysphagia are present simultaneously. © 2025 Elsevier B.V., All rights reserved
Fatigue in Inflammatory Bowel Diseases: A Bibliometric and Content Analysis
No full text[Abstract Not Acaileble
Silver nanoparticles produced from Agropyron repens: A green synthesis approach and antimicrobial analysis
No full textThe plant Agropyron repens is invasively distributed both in natural grassland areas and in agricultural areas. It contains valuable metabolites such as carbohydrates, phenolic compounds, flavonoids, saponins, essential oils, and minerals. A. repens plant extract has the potential as an alternative source for nanoparticle synthesis. The total phenolic and carbohydrate contents of the aqueous extract were analyzed using spectrophotometric methods. Silver nanoparticles (AgNPs) were synthesized at room temperature using the aqueous extract of A. repens without any chemical stabilizer or reducing agent. The formation of AgNPs was confirmed by the observed color change. UV-Vis spectroscopy, dynamic light scattering (DLS), Fourier transform infrared spectroscopy, and X-ray diffraction were used for characterization. An absorption was obtained in the UV-Vis spectrum. In DLS measurements, the size of AgNPs was determined to be approximately 75 nm. The obtained AgNPs and fabrics treated with these nanoparticles showed antibacterial activity against both gram positive (Staphylococcus aureus) and gram negative (Escherichia coli) bacteria. AgNPs and fabric samples exhibited antifungal activity against Candida albicans. In addition, the antioxidant activities of aqueous extracts and AgNPs were evaluated. This study highlights that A. repens can be used in the production of AgNPs by green synthesis methods. © 2025 Elsevier B.V., All rights reserved
A new perspective on forefoot biomechanics: the dual arch structure of the metatarsal transverse arch and the trimaran effect
No full textObjective: The structure and function of the Metatarsal Transverse Arch (MTA) remain underexplored. It was hypothesized that, during the push-off phase of gait, the MTA does not form a single arch between the first and fifth metatarsals; rather, it consists of 2 separate arches—one spanning the first to the third metatarsals and the other spanning the third to the fifth metatarsals—that function like the hulls of a trimaran boat. This study aims to investigate the biomechanical role of the MTA during this critical phase. Methods: Dynamic pedobarographic measurements were utilized from 1250 adults (847 females, 403 males). Maximum pressures on all metatarsal heads during the push-off phase were recorded, and MTA arches were calculated using the SAP2000 program. Statistical significance was set at P < .05. Results: The mean pressure on the third metatarsal was 160.0 (minimum: 9.0, maximum: 1799.0) for the left foot and 142.0 (minimum: 0.0, maximum: 1753.0) for the right foot. The maximum pressure in both feet occurred at the third metatarsal head (left: 67.0%, right: 54.6%). There was no statistically significant difference between genders regarding the maximum load on the metatarsal heads. Conclusion: This study reinterprets the biomechanical behavior of the forefoot and MTA during the push-off phase, potentially aiding in the understanding of forefoot pathologies. Future research on children and adolescents could further illuminate forefoot biomechanics. Level of Evidence: Level III. © 2025 Elsevier B.V., All rights reserved
Axiomatic analysis of state operators in Sheffer stroke BCK-algebras associated with algorithmic approaches
No full textIn this paper, we have presented a novel exploration of the construction of Riecan, Bosbach, internal, and general states within the framework of Sheffer stroke BCK-algebra B. We highlighted the originality of our work by examining key characteristics and the independence of the axiomatic systems associated with these states. Notably, we demonstrated that a Riecan state can correspond to a Bosbach state and vice versa, revealing significant interconnections between these concepts. Additionally, we introduced the innovative concepts of faithful and fixed sets generated by internal states on B, proving that each Sheffer stroke BCK-algebra retains its structure under an internal state. Our investigation also included internal state-(filters, compatible filters, and prime filters) on B and their related results, as well as the relationship between internal state congruence and filters. Furthermore, we explore whether general states imply Riecan and Bosbach states, enhancing our understanding of these relationships. Finally, we introduced the concept of general state-morphism and discuss its implications for B. To support our findings, we provided compelling examples and fundamental algorithms, underscoring the practical significance of our study across various fields including artificial intelligence, computer science, and quantum logic
Anorektal malformasyonlu çocukların ve annelerinin yaşam deneyimleri, yaşam kaliteleri ve bakım yükünün annelerin yaşam kalitesine etkisi
No full textAmaç: Anorektal malformasyonlu (ARM) çocukların ve annelerinin yaşam deneyimleri, yaşam kaliteleri ve bakım yükünün annelerin yaşam kalitesine etkisini belirlemek amacıyla yapıldı. Yöntem: Nitel ve nicel yöntemin birlikte kullanıldığı karma tipteki bu araştırmanın evrenini; Türkiye Anorektal Malformasyon Aile Derneğinde kayıtlı olan çocuklar ve anneleri, örneklemini; Anorektal Malformasyon Aile Derneğine üye ve 8-18 yaş grubundaki çalışmaya katılmaya gönüllü çocuklar (n=43) ve anneleri (n=43) oluşturdu. Nicel veriler (n=86); ARM'li çocuklar ve annelerine çocuk ve aile tanılama formu, (8- 12 yaş) çocuklar için yaşam kalitesi ölçeği çocuk ve ebeveyn, (13-18 yaş) çocuklar için yaşam kalitesi ölçeği ergen ve ebeveyn, SF-12 (yaşam kalitesi ölçeği) ve Bakım verme yükü ölçeği formları doldurtularak toplandı. Nitel veriler (n=80) yarı yapılandırılmış derinlemesine görüşme soru formlarıyla, çevrim içi iletişim araçları ile ses kaydı alınarak toplandı. Görüşme öncesi katılımcıların yazılı ve sözlü onamları ve ses kaydı yapılacağına dair izin alındı. Verilerin değerlendirilmesi; Nicel veriler; SPSS for Windows 25.0 programı kullanılarak analiz edildi. Verilerin değerlendirilmesi tanımlayıcı istatistikler, Mann Whitney U Testi, Kruskal Wallis Testi, değişkenler arasındaki ilişkiyi bulmak için korelasyon analizi, ölçeklerin güvenilirliğini test etmek amacıyla "Güvenilirlik Analizi" ile yapıldı. Nitel veriler; MAXQDA 2024 programı kullanılarak, araştırmadan elde edilen veriler tematik analiz ve içerik analizi yöntemleri çerçevesinde incelendi. Bulgular: Çocukların yaş ortalamasının 11,60 ± 3,42, %74'ü erkek, geçirdikleri ameliyat sayısı ortalamasının 5,60±3,30 olduğu görüldü. Annelerin yaş ortalamasının 38,09±6,36 olduğu görüldü. Erkek çocukların yaşam kalitesinin kızlardan daha iyi olduğu, çocukların okul ve duygusal yaşamlarının olumsuz etkilendiği, sürekli kullandığı ilacı olmayan, gelir düzeyi iyi olan, ARM dışında geçirilmiş ameliyatı, ek hastalığı olmayan çocukların yaşam kalitelerinin anlamlı derecede daha yüksek olduğu (p<0.005), çocukların yaşam kalitesinde okul ve duygusal işlevsellik puanlarının fiziksel sağlık ve sosyal sağlık puanlarına göre daha düşük olduğu, annelerin yaşam kalitesinde fiziksel sağlık puanının (FBÖ-12=52,33) orta düzeyde, mental sağlık puanının (MBÖ-12=46.83) düşük seviyede olduğu, annelerin BVYÖ puanlarının 34,95±11,85 olup, bakım yüklerinin hafif / orta derecede olduğu ve çocuğu ARM dışında ek ameliyatlar geçiren annelerin bakım veren yükü'nün geçirilen başka ameliyatı olmayan çocuk annelerinin BVYÖ puanlarından anlamlı derecede (p<0.05) daha yüksek olduğu, geçirilen ameliyat sayısı ile; Ebeveyn formu fiziksel sağlık (EFSTP), psikolojik sağlık (EPSTP), çocuklar için yaşam kalitesi toplam (EÖTP) toplam puanları ve okul işlevselliği (EOİP), arasında anlamlı ve negatif yönlü bir ilişki olduğu görüldü. Katılımcıların yaşam deneyimlerine yönelik, 0-1 yaş. 1-6 yaş, 6-18 yaş, bağırsak eğitim programı, ihtiyaçlar, güçlükler, gelecekle ilgili sorunlar, destek sistemler ve tavsiye olmak üzere, 9 ana tema elde edildi. Sonuç: ARM'li çocukların okul ve duygusal yaşamlarının daha çok etkilendiği, annelerin bakım veren yükü'nün hafif ve orta derecede olduğu ve bakım yükü arttıkça yaşam kalitelerinin düştüğü, çocuklar ve annelerin yaşam deneyimlerinde yaşam kalitesini düşürecek çok ciddi zorluklar ve kısıtlamalar yaşadıkları görüldü.Aim: This study was conducted to determine the life experiences and quality of life of children with anorectal malformation (ARM) and their mothers and the effect of care burden on the quality of life of mothers. Method: The population of this mixed-type study, in which qualitative and quantitative methods were used together, consisted of children and their mothers who were registered in the Anorectal Malformation Family Association of Turkey, and the sample consisted of children and their mothers who were members of the Anorectal Malformation Family Association and volunteered to participate in the study in the 8-18 age group. The population of this mixed design study consisted of children registered in the Anorectal Malformation Family Association of Turkey and their mothers, and the sample consisted of children aged 8-18 years who were members of the Anorectal Malformation Family Association and volunteered to participate in the study and their mothers. Quantitative data (n=86) were collected by having children with ARM and their mothers fill out the child and family identification form, the quality of life scale for children (8-12 years) child and parent, the quality of life scale for children (13-18 years) adolescent and parent, the SF-12 (quality of life scale), and the caregiving burden scale (Burden Interview). Qualitative data (n=80) were collected with semi- structured in-depth interview questionnaires and audio-recorded with online communication tools. Written and verbal consent of the participants and permission for audio recording were obtained before the interview. Data evaluation; Quantitative data were analyzed using SPSS for Windows 25.0 program. Data were analyzed using descriptive statistics, Mann Whitney U Test, Kruskal Wallis Test, correlation analysis to find the relationship between variables, and "Reliability Analysis" to test the reliability of the scales. Qualitative; Using MAXQDA 2024 program, the data obtained from the research were analyzed within the framework of thematic analysis and content analysis methods. Results: Quantitative; The mean age of the children was 11.60±3.42 years, 74% were male, and the mean number of operations was 5.60±3.30. The mean age of the mothers was 38.09±6.36 years. It was found that the quality of life of boys was better than that of girls, school and emotional lives of children were negatively affected, the quality of life of children without continuous medication, good income level, previous surgery other than ARM, and no additional disease was significantly higher (p<0.005), school and emotional functionality scores in the quality of life of children were lower than physical health and social health scores, physical health score (FIM-12=52.33) in the quality of life of mothers was at a moderate level, mental health score (MHQ-12=46. 83) were at a low level, the mothers' Burden Interview were 34.95±11.85, their caregiver burden score was mild/moderate, and the caregiver burden of mothers whose children had additional surgeries other than ARM was significantly (p<0. 05), there was a significant and negative correlation between the number of previous surgeries and the parent form physical health (EFSTP), school functioning (SFRS), psychological health (EPSTP), and child quality of life total scores (QoLTS). Qualitative; for the life experiences of the participants; 0-1 years. 1-6 years, 6-18 years, bowel training program, needs, difficulties, future problems, support systems and advice, 9 main themes were obtained. Conclusion: It was observed that the school and emotional lives of children with ARM were more severely affected, the caregiver burden of mothers was mild to moderate and as the caregiving burden increased, their quality of life decreased, children and mothers experience very serious difficulties and limitations in their life experiences that reduce the quality of life
I sbirlik i Insan-Robot Y k Ta sima G revlerinde Insan Operat r n n Katkisinin l lmesi
No full textIsik University33rd IEEE Conference on Signal Processing and Communications Applications, SIU 2025-- -- Istanbul; Isik University Sile Campus -- 211450In this study, collaborative human-robot interaction is aimed and realized using an inherently unstable mobile robot called ballbot. Three different experiments are considered for scenarios of guidance of the ballbot by the human operator and collaborative/cooperative human-robot load carrying activities. The force applied by the human operator is measured with a force gauge sensor and considered as a measure of the effort provided by the human. Based on this measure, the contribution of the human operator in collaborative/cooperative human-robot load carrying scenarios is investigated. © 2025 Elsevier B.V., All rights reserved
Izef interaktif herbaryumunun güncel sayısal görüntüleme teknikleri kullanarak geliştirilmesi
No full textBu çalışmada Türkiye'nin ilk interaktif herbaryumu olan Ege Üniversitesi Eczacılık Fakültesi bünyesindeki IZEF Herbaryumunda bulunan örneklerin profesyonel ekipman, yeni çekim teknikleri, gelişmiş fotoğraf işleme programları kullanılarak yaşadığımız çağın gereklerine uygun olarak iyiliştirmesi, detayları arttırılmış görsellerin "IZEF Herbaryum 1.0" veri tabanına aktarılması ve böylece hem geleceğe aktarımı hem de zaman ve mekan sınırlaması olmaksızın tüm araştırmacıların hizmetine sunumunun sağlanması amaçlanmıştır. IZEF Herbaryumuna kayıtlı 6230 herbaryum örneği onarım ve bakım işlemleri yapılarak çekime hazırlanmış, makro standında DSLR fotoğraf makinesi ile fotoğrafları çekilmiş ve veriler sunucunun izin verdiği en büyük boyutta veri tabanına girilmiştir.In this study, it is aimed to improve the samples in IZEF Herbarium of Ege University Faculty of Pharmacy, which is the first interactive herbarium in Turkey, by using professional equipment, new shooting techniques, advanced photo processing programs in accordance with the requirements of our age, to transfer the detailed images to the "IZEF Herbarium 1.0" database and thus to transfer them to the future and to provide them to the service of all researchers without any time and space limitations. 6230 herbarium specimens registered in the IZEF Herbarium were prepared for shooting by performing repair and maintenance procedures, their photographs were taken with a DSLR camera on a macro stand, and the data was entered into the database in the largest size allowed by the server