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Structure-Function Relationship of Novel Tetrakis (Mercapto-Terphenyl)Benzene Cobalt (II) Phthalocyanines: Synthesis and Computational Evaluation
No full textThis study introduces a newly synthesized Co(II) phthalocyanine complex (Co-Pc, 4) incorporating two (mercapto-terphenyl)thio-dione substituents, along with a detailed exploration of its structural, spectroscopic, and binding characteristics. The key precursor, 4-[(4 ''-mercapto-[1,1 ':4 ',1 ''-terphenyl]-4-yl)thio]phthalonitrile (compound 3), was first obtained and subsequently used to construct the phthalocyanine macrocycle through cyclotetramerization in the presence of cobalt and zinc salts under heat and vacuum in dimethylformamide. The resulting compounds (3 and 4) were characterized using a comprehensive array of analytical techniques, including elemental analysis, UV-Vis spectroscopy, FT-IR, 1H-NMR, and Q-TOF mass spectrometry. Additionally, density functional theory (DFT) and time-dependent DFT (TD-DFT) calculations were employed to elucidate the electronic structure and geometrical features of Co-Pc 4, providing theoretical support for the experimental findings. The integration of theoretical and experimental findings provides in-depth insight into the electronic behavior and reactivity of compound 4, highlighting its promise as a candidate for photovoltaic applications. Further studies may investigate how structural modifications influence these properties, potentially leading to improved device performance
Pnömoni Hastalarında BioFire® FilmArray® Pnömoni Plus Hızlı Sendromik Multipleks PCR Testinin Kullanımı – Bir Uzman Görüşü Raporu
No full textThis consensus report presents current expert opinions on the clinical use of the BioFire® FilmArray® Pneumonia Plus (PNplus) rapid molecular test in patients with pneumonia. A group of eight physicians with clinical experience in pneumonia identified common questions encountered in clinical practice regarding the use of PNplus for lower respiratory tract infections and developed consensus-based answers. Based on this process, a list of recommendations was compiled for the use of the PNplus rapid syndromic molecular test, which detects the most common bacteria, viruses, and resistance genes. These recommendations were supported by case examples based on fictional clinical scenarios, along with a proposed diagnostic algorithm for the management of pneumonia. © 2025 Elsevier B.V., All rights reserved
Rivastigmin yüklü lipozom ve transferozom formülasyonlarının mikroakışkan cihaz kullanılarak geliştirilmesi
No full textAlzheimer, bilişsel işlevlerin kaybına yol açan nöronal bozulma ile karakterize, geri dönüşsüz bir nörodejeneratif hastalıktır. Alzheimer tedavisinde asetilkolinesteraz ve bütirilkolinesteraz enzim inhibitörleri kullanılmaktadır. Donepezil ve galantamin maddeleri kolinesteraz inhibitörleri olarak sınıflandırılır, ancak sadece Rivastigmin hem asetilkolinestaraz hem de bütirilkolinesterazı inhibe etme yeteneğine sahiptir. Rivastigmin, Alzheimer tedavisinde kullanılan hidrofilik ve hidrofobik özelliklere sahip bir etkin madde olmakla birlikte beyne Rivastigmin iletimi, kan beyin bariyeri (KBB) ile sınırlıdır. Bu molekülün kısa bir yarı ömre ve hidrofilik özelliklere sahip olması da KBB'yi ve beyin omurilik sıvısını (BOS) geçmesini zorlaştırmaktadır. Literatürde de Rivastigmin etkin maddesinin transdermal, oral ve paranteral uygulama için tasarlandığı ve hazırlandığı formülasyon çalışmalar bulunmaktadır. Buna rağmen Rivastigminin tedavide kullanımı hala optimize edilebilmiş değildir. Rivastigmin etkin maddesinin oral ilaç formları, optimal terapötik dozda ilaç alımını engelleyen gastrointestinal yan etkiler ve maksimum plazma konsantrasyonuna hızlı ulaşma gibi istenmeyen etkilerle ilişkilidir. Ayrıca Rivastigminin oral yoldan verilmesi, özellikle yaşlı popülasyonda diğer ilaçlarla etkileşime sebep olmakta ve tedaviye uyum eksikliği görülmektedir. Transdermal yol, gastrointestinal yan etkiler ve oral uygulamada karşılaşılan diğer problemleri aşmak için uygun bir uygulama yoludur. Rivastigmin içeren transdermal yama şeklindeki piyasa preparatı 2007 yılında pek çok ülkede kullanıma sunulmuştur. Öte yandan transdermal uygulama yoluyla verilen preparatlarda da KBB engel oluşturmaya devam etmektedir. Bu sorunların üstesinden gelmek için kimyasal manyetik ilaç hedeflemenin veya antikorlar, veziküler sistemler veya nanopartiküller gibi ilaç taşıyıcı sistemlerin geliştirilmesini içeren birçok strateji geliştirilmiştir. Lipozomal sistemler lipozom, etazom, transferozom, niozom gibi farklı lipidik sistemleri barındıran bir formülasyon grubudur. Bu gruptaki her bir sistem klasik lipozomların farklı dezavantajlarını ortadan kaldırmak üzere tasarlanmıştır. Bu sistemler içerisinde özellikle transferozomların lipozomlara göre deriden daha etkin geçiş sağladığı yapılan çalışmalarda gösterilmiştir. Transferozomlar fosfolipitler ve kenar aktivatörlerinden oluşan lipozomal veziküllerdir. Kenar aktivatörleri yapıya elastikiyet sağlamanın yanı sıra transferozomların vezikül boyutunu da etkiler. Transferozomların deri yoluyla daha fazla nüfuz etmesinin ardındaki mekanizma, bu sistemlerin uygulama alanı boyunca deforme olabilme yeteneği ve transdermal osmotik gradyandır. Transferozomların bu yapısal özellikleri sayesinde kan beyin bariyerinden geçiş üzerinde önemli avantajları bulunmaktadır. Lipozomal sistemlerin geleneksel hazırlama yöntemleri, ince film hidrasyonu, çözücü liyofilizasyonu, püskürterek kurutma, ikincil emülsifikasyon, ters fazlı buharlaştırma ve etanol enjeksiyonudur. Bu makro ölçekli tekniklerin lipozomal sistemlerin boyutu ve polidispersitesi üzerinde kesin kontrol sağlayamaması formülasyon geliştirmede çeşitli sorunlar ortaya çıkarmaktadır. Bu nedenle lipozomal sistemlerin farklı yenilikçi yöntemler ile üretim prosesi geliştirme çalışmaları son yıllarda hız kazanmıştır ve birçok farklı üretim prosesinde kullanılan mikroakışkan teknolojisi lipozomal sistemlerin geliştirilmesinde de kullanılmaya başlanmıştır. Mikroakışkan sistemler; emülsiyonlar, mikrokapsüller, mikropartiküller ve veziküler sistemlerin geliştirilmesi için yüksek tekrarlanabilirlik ve boyut kontrol edilebilirliği sağlamaktadır. Mikroakışkan sistemler ile üretim koşulları hızlı bir şekilde optimize edilebilmekte ve bu sayede ölçek büyütme aşamasına daha kolay geçilebilmektedir. Lipidik sistemlerin mikroakışkan cihazlar yardımıyla geliştirilmesine yönelik çalışmalar yapılmış olmasına rağmen mikroakışkan sistemler özellikle lipozomlar üzerine yoğunlaşmıştır ve farklı lipidik veziküller hakkında sınırlı sayıda çalışma bulunmaktadır. Transferozomların hazırlanması amacıyla mikroakışkan teknolojilerin kullanıldığı bir çalışmaya literatür incelenmesinde rastlanmamıştır. Bu anlamda mikroakışkan sistemlerde, sistem optimizasyonun ele alınması, farklı lipidik veziküllerin geliştirilmesi ve farklı proses şartlarında optimum parametrelerin belirlenmesi gerekmektedir. Tez çalışması kapsamında Rivastigmin etkin maddesi yüklü lipozom ve transferozom sistemler mikroakışkan teknolojisi kullanılarak hazırlanmıştır. Hazırlanan lipozom ve transferozomlar partikül boyutu, PDI değeri, zeta potansiyel ve morfolojik özellikleri gibi parametreler açısından karakterize edilmiştir. Merkezi kompozit tasarım ile sistem parametrelerinin ve formülasyon bileşenlerinin ürün spesifikasyonları üzerine etkisi değerlendirilmiş ve hem proses optimizasyonu hem de formülasyon optimizasyonu gerçekleştirilmiştir. Hazırlanan formülasyonların in-vitro salım, ex-vivo permeasyon özellikleri incelenmiş ve kan beyin bariyerinden geçiş yetenekleri değerlendirilmiştir. Son olarak geliştirilen sistemlerin Alzheimer üzerindeki etkinlikleri ferrototik hücre ölümü aracılığıyla in-vitro olarak test edilmiştir. Sonuç olarak; mikroakışkan teknolojileri ile lipozom ve transferozom üretim prosesi optimize edilerek Rivastigmin yüklü veziküller başarı ile hazırlanmıştır. Etkinlikleri gösterilmiş formülasyonların Alzheimer tedavisinde kullanılabilecek potansiyel sistemler olduğu düşünülmektedir.Alzheimer's disease is an irreversible neurodegenerative disease characterised by neuronal deterioration leading to loss of cognitive functions. Acetylcholinesterase and butyrylcholinesterase enzyme inhibitors are used in Alzheimer's treatment. Donepezil and galantamine are classified as cholinesterase inhibitors, but only Rivastigmine has the ability to inhibit both acetylcholinesterase and butyrylcholinesterase. Rivastigmine is a molecule with both hydrophilic and hydrophobic properties used in the treatment of Alzheimer's disease, but Rivastigmine delivery to the brain is limited by the blood-brain barrier (BBB). This molecule has a short half-life and a hydrophilic structure, making it difficult to cross the BBB and cerebrospinal fluid (CSF). In the literature, there are many formulation studies in which Rivastigmine active substance has been designed and produced for transdermal, oral and parenteral administration. Despite this, the use of Rivastigmine in treatment is still not optimised. Oral drug forms of the active substance rivastigmine are associated with undesirable effects such as gastrointestinal side effects and rapid attainment of maximum plasma concentrations, which interfere with drug intake at the optimal therapeutic dose. In addition, oral administration of Rivastigmine causes interactions with other drugs, especially in the elderly population, and there is a lack of compliance with treatment. Transdermal administration is a convenient way to overcome gastrointestinal side effects and other problems encountered in oral administration. A market preparation in the form of a transdermal patch containing rivastigmine was introduced in many countries in 2007. On the other hand, ENT continues to be an obstacle in preparations given via transdermal administration. Many strategies have been developed to overcome these problems, including the development of chemical magnetic drug targeting or drug delivery systems such as antibodies, vesicular systems or nanoparticles. Liposomal systems are a group of formulations containing different lipidic systems such as liposomes, etazomes, transferosomes and niozomes. Each system in this group is designed to eliminate different disadvantages of classical liposomes. Among these systems, it has been shown in previous studies that transferosomes provide more effective passage through the skin than liposomes. Transferosomes are liposomal vesicles composed of phospholipids and edge activators. In addition to providing elasticity to the structure, edge activators also affect the vesicle size of transferosomes. The mechanism behind the increased penetration of transferosomes through the skin is the ability of these systems to deform along the application area and the transdermal osmotic gradient. These structural features of transferosomes have important advantages on the passage through the blood-brain barrier. Traditional preparation methods of liposomal systems include thin film hydration, solvent lyophilisation, spray drying, secondary emulsification, reverse phase evaporation and ethanol injection. The inability of these macroscale techniques to provide precise control over the size and polydispersity of liposomal systems poses various problems in formulation development. For this reason, studies on the development of the production process of liposomal systems with different innovative methods have accelerated in recent years and microfluidic technology used in many processes has started to be used in the production of liposomal systems. Microfluidic systems provide high reproducibility and size controllability for the production of emulsions, microcapsules, microparticles and vesicular systems. With microfluidic systems, production conditions can be quickly optimised and the scale-up phase can be achieved more easily. Although there have been studies on the production of lipidic systems with the help of microfluidic devices, microfluidic systems have been focused especially on liposomes and there are limited scientific studies on different lipidic vesicles. In the literature, no study using microfluidic technologies for the preparation of transferosomes was found. In this sense, it is necessary to address system optimisation in microfluidic systems, to produce different lipidic vesicles and to determine the optimum parameters under different process conditions. Within the scope of the thesis study, liposome and transferosome systems loaded with Rivastigmine active substance were produced using microfluidic technology. Prepared liposomes and transferosomes were characterized in terms of parameters such as particle size, PDI value, zeta potential and morphological properties. The effects of system parameters and formulation components on product specifications were evaluated with central composite design and both process optimization and formulation optimization were performed. In-vitro release, ex-vivo permeation properties of prepared formulations were examined and their ability to pass through the blood-brain barrier was evaluated. Finally, the activities of the developed systems on Alzheimer's disease were tested in-vitro via ferrototic cell death
Tasarımın yakın tarihi ve modern tasarım için alternatif olma potansiyeli: Afiş tasarımı örneği
No full textTasarım disiplinleri tarih boyunca yaşadığımız dünyayı şekillendirmiş ve değiştirmiş insanlığın karşılaştığı birçok probleme çözüm oluşturmuştur. Sanayi devriminden sonra ortaya çıkan ana akım tarihsel tasarım hareketlerine odaklanan bu tez çalışması geleceğin tasarım dilini oluştururken aynı şekilde günümüz tasarım problemlerine çözüm ararken tasarımda tarihsellikten yararlanılabilir mi sorusunun peşine düşmüştür. Bu noktada1850–2000 yılları arasında ortaya çıkan on yedi tarihsel tasarım hareketinin tasarım prensipleri, bu hareketleri meydana getiren faktörler, toplumsal, politik kültürel iklim incelemiş çağdaş tasarım trendleriyle karşılaştırılmış ve elde edilen veriler uygulamalı bir değerlendirmeden geçmiştir. Çalışmada üç aşamalı bir yöntem izlenmiştir: (1) tarihsel hareketlerin ortaya çıkış nedenleri, tasarım prensipleri, karakteristik özellikleri, form–işlev dengesi, malzeme ve teknoloji kullanımı incelenmiştir, (2) 2025 iletişim tasarımı trendleri incelenmiş tarihsel tasarım hareketlerine özgün tasarım prensipleri bu trendler üzerindeki varlığı analiz edilmiş, karşılaştırmalı bir değerlendirme yapılmıştır, (3) elde edilen veriler uygulamalı değerlendirme kısmında, "Afiş Tasarımı Uygulamaları ve Değerlendirme" dört tasarım projesi üzerinde test edilerek, tasarımda tarihsellikten ilham alan alternatif tasarım dilleri oluşturulmuştur. Araştırma sonuçları, tarihsel tasarım prensiplerinin salt aktarımının nostaljik bir etki yarattığını ancak modern kullanıcı gereksinimlerini tam karşılamadığını; bunun aksine tarihsel prensiplerin esnek ve yenilikçi biçimde yeniden yorumlanmasının hem estetik hem işlevsellik açısından daha başarılı alternatif tasarım dilleri oluşturduğunu göstermiştir. Bu bulgular, geçmişin temel değerlerinin, modern üretim teknikleri ve bugünün ruhunu yansıtan yaklaşımlarla bütünleştirildiğinde geleceğe yönelik yaratıcı çözümler sunma potansiyeline sahip olduğunu ortaya koymaktadır.Design disciplines have shaped and changed the world we live in throughout history and have created solutions to many problems faced by humanity. This thesis, which focuses on the mainstream historical design movements that emerged after the industrial revolution, pursues the question of whether historicity can be utilized in design while creating the design language of the future and seeking solutions to today's design problems. At this point, the design principles of seventeen historical design movements that emerged between 1850-2000, the factors that brought these movements into being, the social, political and cultural climate were analyzed and compared with contemporary design trends and the data obtained were subjected to an applied evaluation. A three-stage method was followed in the study: (1) the reasons for the emergence of historical movements, design principles, characteristic features, form-function balance, use of materials and technology were examined, (2) communication design trends for 2025 were examined, the presence of design principles unique to historical design movements on these trends were analyzed, and a comparative evaluation was made, (3) the data obtained were tested on four design projects in the applied evaluation section, "Poster Design Applications and Evaluation", and alternative design languages inspired by historicity in design were created. The results of the research have shown that the mere transmission of historical design principles creates a nostalgic effect but does not fully meet modern user needs; on the contrary, flexible and innovative reinterpretation of historical principles creates alternative design languages that are more successful in terms of both aesthetics and functionality. These findings reveal that the core values of the past have the potential to offer creative solutions for the future when integrated with modern production techniques and approaches that reflect the spirit of today
From bees to wings: Ecofeminist perspectives in Sue Monk Kidd's The Secret Life of Bees and The Invention of Wings
No full textThis thesis focuses on the relationship between feminism and environmentalism through the lens of ecofeminist theory, using two novels by Sue Monk Kidd: The Secret Life of Bees and The Invention of Wings. Ecofeminism suggests that the oppression of women and the destruction of nature come from the same patriarchal mindset. Based on this idea, this thesis explores how literature can reflect, question, and resist these interconnected systems of power and emphasizes the power of storytelling. The theoretical part of the study starts with a brief overview of feminism and the historical “waves” that shaped it. After the summary of feminism, it continues with the development of ecofeminist thinking by looking at the works of key figures like Karen J. Warren, Vandana Shiva, Carol J. Adams, and Greta Gaard. Moreover, various ecofeminist approaches are discussed along with criticisms of the movement. Using a qualitative and interpretive method, the thesis analyzes how Kidd’s novels reflect ecofeminist values like connection, care, healing, and resistance. The characters undergo transformations and nature supports their growth instead of being a mere background. In addition, the analysis explores themes such as women’s empowerment, sisterhood, spirituality, and racial injustice through symbolic elements and metaphors in Sue Monk Kidd’s novels. These novels are chosen because Kidd uses symbols like bees, wings, or natural elements to emphasize how change and healing happen not through force, but through empathy and solidarity. This closely aligns with ecofeminism which offers a holistic approach to creating a just and harmonious world. This study also contributes to the ongoing discussions within both literary criticism and feminist theory by illustrating how fiction can serve as a space for reimagining ecological justice. By combining literary analysis with philosophical inquiry, it suggests that stories are not only reflections of reality but also tools for reshaping it. Ultimately, it is argued in this work that Kidd’s works offer a meaningful contribution to ecofeminist literary criticism. This study does not aim to offer a final word, instead it tries to explore how Sue Monk Kidd’s novels speak to ecofeminist concerns in subtle and meaningful ways. They do more than tell stories; they offer insights on how women find strength in each other and in nature. Kidd uses storytelling to invite us to reflect on our own roles within society, as well as our relationship with the environment, and even ourselves. In the end, literature becomes a space where transformation begins not with violence, but with understanding, empathy, and care.This thesis focuses on the relationship between feminism and environmentalism through the lens of ecofeminist theory, using two novels by Sue Monk Kidd: The Secret Life of Bees and The Invention of Wings. Ecofeminism suggests that the oppression of women and the destruction of nature come from the same patriarchal mindset. Based on this idea, this thesis explores how literature can reflect, question, and resist these interconnected systems of power and emphasizes the power of storytelling. The theoretical part of the study starts with a brief overview of feminism and the historical “waves” that shaped it. After the summary of feminism, it continues with the development of ecofeminist thinking by looking at the works of key figures like Karen J. Warren, Vandana Shiva, Carol J. Adams, and Greta Gaard. Moreover, various ecofeminist approaches are discussed along with criticisms of the movement. Using a qualitative and interpretive method, the thesis analyzes how Kidd’s novels reflect ecofeminist values like connection, care, healing, and resistance. The characters undergo transformations and nature supports their growth instead of being a mere background. In addition, the analysis explores themes such as women’s empowerment, sisterhood, spirituality, and racial injustice through symbolic elements and metaphors in Sue Monk Kidd’s novels. These novels are chosen because Kidd uses symbols like bees, wings, or natural elements to emphasize how change and healing happen not through force, but through empathy and solidarity. This closely aligns with ecofeminism which offers a holistic approach to creating a just and harmonious world. This study also contributes to the ongoing discussions within both literary criticism and feminist theory by illustrating how fiction can serve as a space for reimagining ecological justice. By combining literary analysis with philosophical inquiry, it suggests that stories are not only reflections of reality but also tools for reshaping it. Ultimately, it is argued in this work that Kidd’s works offer a meaningful contribution to ecofeminist literary criticism. This study does not aim to offer a final word, instead it tries to explore how Sue Monk Kidd’s novels speak to ecofeminist concerns in subtle and meaningful ways. They do more than tell stories; they offer insights on how women find strength in each other and in nature. Kidd uses storytelling to invite us to reflect on our own roles within society, as well as our relationship with the environment, and even ourselves. In the end, literature becomes a space where transformation begins not with violence, but with understanding, empathy, and care
Cilt kanseri teşhisi için yeni bir derin öğrenme algoritması
No full textCilt hastalıkları teşhisi, yapay zekâ ve derin öğrenme alanlarında önemli bir konudur. Deri lezyonlarının doğru teşhisi, erken tedaviye ve etkin sağlık hizmetlerine katkı sağlar. Bu süreç, görüntü analizi, öznitelik çıkarımı ve sınıflandırıcı algoritmalarla gerçekleştirilir. Ancak, deri lezyonlarının boyut, şekil, renk ve cilt tonlarındaki farklılıklar, ışık koşulları ve arka plan karmaşıklığı gibi faktörler, teşhisi zorlaştırabilir. Bu zorluklara rağmen, derin öğrenme algoritmaları, cilt hastalıkları teşhisinde önemli ilerlemeler kaydetmiştir. Bu çalışmada, yedi farklı deri hastalığı sınıfı içeren HAM10000 veri seti kullanılmıştır. Yeni bir derin öğrenme modeli geliştirilmiş ve altı farklı CNN algoritması ile deneysel çalışmalar yapılarak sonuçları karşılaştırılmıştır. Yapılan iyileştirmelerle, daha düşük maliyetli ve yüksek doğruluk oranına sahip yeni bir model geliştirilmiş; bu sayede deri hastalıklarının tespitinde yüksek başarı sağlanmıştır.The diagnosis of skin diseases is a significant topic in the fields of artificial intelligence and deep learning. Accurate diagnosis of skin lesions contributes to early treatment and effective healthcare services. This process involves image analysis, feature extraction, and classification algorithms. However, factors such as variations in the size, shape, color, and skin tones of lesions, lighting conditions, and background complexity can complicate the diagnosis. Despite these challenges, deep learning algorithms have achieved significant advancements in the diagnosis of skin diseases. In this study, the HAM10000 dataset, containing seven different classes of skin diseases, was utilized. A new deep learning model was developed, and experimental studies were conducted by comparing the results with six different CNN algorithms. With the improvements made, a new model that is both cost-efficient and highly accurate was developed, achieving high success in the detection of skin diseases
Üniversite Öğrencilerinin Umutsuzluğunu Etkileyen Faktörlerin İncelenmesi: İzmir Demokrasi Üniversitesi Örneği
No full textBu çalışma, üniversite öğrencilerinin umutsuzluk algısını etkileyen sosyodemografik faktörleri kapsamlı bir şekilde incelemeyi amaçlamaktadır. Umutsuzluk, özellikle genç yetişkinlerde yaygın bir sorun olarak ele alınmış olup, sosyoekonomik, psikolojik ve çevresel faktörlerle ilişkili olarak değerlendirilmiştir. COVID-19 pandemisi ve 23 Şubat Depremleri gibi olağanüstü durumlar, üniversite öğrencilerinin umutsuzluk düzeylerinde artışa yol açmıştır. Bunun yanında, şehir değiştirme, barınma ve uyum sorunları gibi bireysel zorlukların da umutsuzluk üzerinde önemli bir etkisinin olduğu tespit edilmiştir. Araştırma, nicel bir araştırma olup, betimsel ve ilişkisel tarama modeli ile gerçekleştirilmiştir. Araştırma kapsamında bir devlet üniversitesinde lisans öğrenimi gören 410 katılımcıdan anket yöntemiyle veriler toplanmıştır. Katılımcılardan elde edilen veriler sosyodemografik özellikleri, akademik baskılar, sınav stresi, iş bulma kaygıları ve bölüm seçimi gibi faktörler üzerinden analiz edilmiştir. Veri analizleri SPSS ve JASP programları aracılığıyla gerçekleştirilmiştir. Elde edilen bulgular, gelir durumunun umutsuzluk algısı üzerinde belirgin bir etkisi olduğunu ortaya koymuş; düşük gelir seviyesine sahip öğrencilerin daha yüksek umutsuzluk yaşadıkları saptanmıştır. Ayrıca, üniversite diplomasının işlevselliğine inanan öğrencilerin, diplomanın iş bulmada etkili olmadığına inananlara kıyasla daha umutlu olduğu belirlenmiştir. Akademik baskılar ve sınav stresinin, öğrencilerin umutsuzluk düzeylerini anlamlı şekilde artırdığı bu çalışmanın önemli bulgularındandır. Sonuç olarak, üniversite öğrencilerinin umutsuzluk algısını etkileyen sosyoekonomik, akademik ve toplumsal faktörlerin belirlenmesinde önemli katkılar sunmakta ve bu doğrultuda çeşitli çözüm önerileri geliştirilmesi gerektiğini vurgulamaktadır
Maladaptive perfectionism can explain the inverse relationship between dispositional mindfulness and procrastination
No full textGiven the widespread occurrence of procrastination and its adverse association with well-being, investigating the individual variables that influence procrastination is a crucial matter. Previous research has identified dispositional mindfulness to be negatively associated with procrastination, but the underlying mechanisms driving this relationship remain unclear. In this study, the aim was to investigate whether the inverse relationship between dispositional mindfulness and procrastination could be explained by the mediating roles of trait anxiety and maladaptive perfectionism. In a cross-sectional survey, 126 participants (aged 18-33) completed the 15-Item Five-Facet Mindfulness Questionnaire, the State-Trait Anxiety Inventory-Trait Form, the Almost Perfect Scale-Revised, and the Pure Procrastination Scale. A parallel mediation model was tested to investigate the mediating role of self-reported maladaptive perfectionism and trait anxiety to explain the relationship between dispositional mindfulness and procrastination with a bootstrapped multivariate technique. The results revealed that maladaptive perfectionism significantly mediated the relationship between mindfulness and procrastination -indicating that dispositional mindfulness has a significant indirect effect on procrastination via decreased levels of maladaptive perfectionism. It was determined that 15% of the variance in procrastination was significantly explained by this model (R-2 = .15, beta = -.39, B = -.83, 95% CI = [-1.18, -.48], p < .001]. As the study highlights the importance of maladaptive perfectionism to explain the link between mindfulness and procrastination, we suggest that future research could investigate the influence of mindfulness on procrastination via mindfulness-based interventions, and include measurements of both trait anxiety and maladaptive perfectionism across longitudinal or experimental designs to unpack causality with respect to our pattern of observed findings
ANALYSIS OF ORAL AND MAXILLOFACIAL PATHOLOGIES AMONG A SAMPLE OF THE ELDERLY PATIENTS FROM A SINGLE INSTITUTE IN TURKEY: A RETROSPECTIVE STUDY
No full textIntroduction: The global elderly population is increasing and becoming more susceptible to oral and systemic diseases. Therefore, comprehensive clinical and histopathological examinations of the oral and maxillofacial area to assess the oral health of this population are crucial. This study aimed to increase the knowledge base regarding the prevalence of biopsied oral and maxillofacial lesions among a sample of the elderly Turkish population (>= 65 years of age). Materials and Method: The clinical records of geriatric patients >= 65 years of age, who underwent biopsy for a pathological formation(s) in the oral region between January 2017 and January 2020 at Ege University School of Dentistry, Department of Oral and Maxillofacial Surgery (& Idot;zmir, T & uuml;rkiye), were reviewed. Clinical follow-up data including demographic information, anatomical localization of the pathological mass, preliminary diagnosis, and biopsy results were evaluated. In order to ascertain the relationship between lesion formation and the independent variables, univariate analysis was employed. Results: Data were collected from 353 of 400 patients over a threeyear period. There was a high prevalence of odontogenic lesions (42.5%), and pathological diagnosis revealed an increased number of cases (43.1%). Pathological lesions were reported mostly in the posterior mandible (33.4%), followed by the anterior maxilla (21%), anterior mandible (13.3%), and posterior maxilla (7.1%). Conclusion: These findings are in accordance with those of previous studies based on histopathological data, emphasizing their importance in guiding public health policies for this patient population
ANALYZING THE AGEING POPULATION AND HEALTHCARE EXPENDITURES FROM AN ENVIRONMENTAL SUSTAINABILITY PERSPECTIVE FOR THE EU COUNTRIES: A SPATIAL APPROACH
No full textThe aim of this study is to analyze the impact of population aging (AG), healthcare expenditures (HE), per capita GDP, and renewable energy budgets (REB) on environmental quality (EQ). To achieve this, data from 22 European Union (EU) countries covering the period from 2005 to 2020 were examined using spatial panel data analysis. The findings indicate the presence of spatial interactions among EU countries. Model specification tests supported the spatial panel lag model with fixed effects. The spatial effect coefficient was found to be 0.53 and statistically significant. While AG and REB positively influenced EQ, HE and per capita GDP exhibited negative effects. The results highlight the complex interactions among economic, social, and environmental factors. The study concludes with policy recommendations aimed at supporting EU countries in achieving their climate goals