Aksaray University Institutional Repository
Not a member yet
8503 research outputs found
Sort by
Effects of 2,3-dihydrophthalazine-1,4-dion unit on therapeutic properties of organic fluorescent dyes
No full textKanser, vücudun diğer kısımlarına yayılabilen ve hemen hemen tüm organlarını etkileyebilen bir hastalık grubudur. O nedenle kanser çok ciddi bir sağlık problemi olup tüm dünyada toplumlara sosyal ve ekonomik olarak ağır yükler getirmektedir. Üstelik hali hazırda kullanılan ameliyat, kemoterapi, radyoterapi, immün terapi gibi klinik yöntemlerin birçoğunun etkinliği bu yöntemlere özgü dezavantajlar nedeniyle arzu edilen düzeyde değildir. O nedenle kanser tedavisinde kullanılabilecek etkili yöntem ve ilaçların geliştirilmesi için dünya çapında araştırmalar yapılmaktadır. Araştırmalar özellikle teranostik olarak işlev görebilecek ve kombine tedaviler için elverişli yeni nesil malzemelerin geliştirilmesi üzerine odaklanmıştır. Bu tez çalışmasında kanser tedavisine imkân verecek organik bileşiklerin rasyonel tasarımı sentezi ve karakterizasyonu üzerinde durulmuştur. Tasarımda bir yanda reaktif oksijen türlerine karşı duyarlılık gösterecek bir ünite; diğer yanda ise üstün özellikleri ile biyogörüntüleme, fotodinamik terapi, ve/veya fototermal terapi için elverişli floresans boyaları aynı anda bünyesinde bulunduran yeni bileşikler elde edilmiştir. Sentezlenen floresans malzemelerin yapıları spektroskopik yöntemler ile aydınlatılmış ve fotoduyarlaştırıcı ajanlar olarak potansiyelleri belirlenmiştir. Elde edilen veriler, burada tasarlanan yapıların teranostik ajan olarak işlev görebileceğini ve kombine tedaviler için elverişli yeni nesil malzemeler olarak kullanılabileceğini göstermektedir.Cancer is a group of diseases that can spread to other parts of the body and affect almost all organs. Therefore, it is a very serious health problem and brings heavy social and economic burdens to societies all over the world. Moreover, the effectiveness of many of the current clinical methods, such as surgery, chemotherapy, radiotherapy, and immune therapy, are not at the desired level due to the specific disadvantages of each method. Consequently, enormous effort has been devoted to develop effective methods and drugs that can be used in cancer treatment worldwide. In particular, research has focused on the development of next-generation materials that can function as theranostics and are suitable for combinatorial therapies. In this thesis, rational design, synthesis and characterization of organic compounds that will enable cancer treatment are described. The design was rationalized by combination of two distinct units. The first unit is sensitive to reactive oxygen species whereas the second one consists of fluorescent organic dyes which are suitable for bioimaging, photodynamic therapy, and/or photothermal therapy with their superior properties. The structures of the synthesized fluorescent materials were elucidated by spectroscopic methods and their potential as photosensitizers was determined. The obtained data show that the designed structures can function as theranostic agents and can be used as new generation materials suitable for combinatorial therapies
Development of an instructional module on formation of seasons through a stem approach and examination of its applicability in flipped classrooms
No full textBu çalışma, 8. sınıf fen bilimleri dersi öğretim programında yer alan mevsimlerin oluşumu konusunun öğretimine yönelik olarak ters yüz edilmiş STEM sınıf stratejisine dayanan titiz ve uyarlanabilir bir metodoloji sunmaktadır. Çalışma, karma yöntem araştırma desenlerinden gömülü desene uygun olarak yürütülmüştür. Araştırmanın nicel boyutunda ön test, son test kontrol gruplu yarı deneysel desen, nitel boyutunda ise olgubilim deseni kullanılmıştır. Araştırmanın örneklemini, 2021-2022 eğitim öğretim yılı güz döneminde, Orta Anadolu şehirlerinden birinin ilçe merkezindeki bir okulda öğrenim gören 40 sekizinci sınıf öğrencisi oluşturmaktadır. Mevsimlerin oluşumu konusunun öğretiminde, deney grubunda ters yüz edilmiş STEM sınıf stratejisi uygulanırken, kontrol grubunda ise öğretim programında yer alan yöntemler kullanılmıştır. Araştırmanın nicel verileri, ters yüz öğrenme ölçeği, akademik başarı testi, STEM'e ve fen dersine yönelik tutum ölçeği ile toplanmıştır. Araştırmanın nitel verileri ise doküman analizi ve yarı yapılandırılmış görüşmeler ile toplanmıştır. Araştırmanın nicel verileri SPSS 26.0 ve AMOS programına aktarılarak analiz edilirken, nitel verileri betimsel analiz ve içerik analizine tabi tutulmuştur. Araştırma sonucunda deney grubu ile kontrol grubu arasında akademik başarı, STEM ve fene yönelik tutumlar açısından deney grubu lehine düşük düzeyde anlamlı bir fark olduğu belirlenmiştir.Ters yüz öğrenme ölçeği ile elde edilen verilerde ise yüksek düzeyde anlamlı fark bulunmuştur. Nitel verilerin içerik analizi sonucu ulaşılan 5 tema ve 29 kod, deney grubu öğrencilerinin başarı ve tutum düzeylerinde yaşanan artışın sebeplerini ortaya koymaktadır. Araştırma ile elde edilen sonuçlar, ters yüz sınıflarda STEM temelli öğretim modülünün uygulanabilir olduğunu ve öğrencilerin ters yüz öğrenmeye yönelik düşünceleri, akademik başarıları, STEM'e ve fene ilişkin tutumları ile TYESSS'e ilişkin görüşleri üzerinde olumlu bir etkiye sahip olduğunu göstermektedir.This study, provides a rigorous and adaptable methodology based on the inverted STEM classroom strategy in teaching the formation of seasons in the 8th grade science course curriculum. This study was carried out in accordance with the embedded design, one of the mixed method research designs. The preliminary test in the quantitative dimension of the study, semi-experimental pattern with a final test control group, and phenomenology pattern in qualitative dimension were used. The sample of the research consists of 40 eighth-grade students studying in a school in the district center of one of the Central Anatolian cities in the fall semester of the 2021-2022 academic year. In the teaching of the formation of the seasons, the flipped STEM classroom strategy was used in the experimental group, while the methods included in the curriculum were used in the control group. Quantitative data of the study were collected by the scale of inverted learning, academic achievement test, attitude towards STEM, and science course. Qualitative data of the research were collected through document analysis and semi-structured interviews. While the quantitative data of the research were analyzed by transferring them to SPSS 26.0 and AMOS program, the qualitative data were subjected to descriptive and content analysis. As a result of the research, it was determined that there was a low-level significant difference in favor of the experimental group in terms of academic achievement, attitudes towards STEM and science between the experimental group and the control group. A high-level significant difference was found in the data obtained with the flipped learning scale. The 5 themes and 29 codes obtained as a result of the content analysis of the qualitative data reveal the reasons for the increase in the achievement and attitude levels of the experimental group students. The results obtained with the research show that the STEM based teaching module is applicable in flipped classrooms and has a positive effect on students' thoughts towards flipped learning, their academic achievement, their attitudes towards STEM and science, and their views on TYESSS
Cryptocurrency investor attitudes examination through socio demographic variables
No full textKripto paralar, blok zinciri sistemi ile birlikte 2009 yılından itibaren kullanılmaya başlanmıştır. Blok zinciri sistemi dağıtık bir defter olarak tanımlanmakta ve kripto paralara ilişkin veriler bu dağıtık defterde kayıt altına alınmaktadır. Kripto paralar blok zinciri sistemi sayesinde güvenli olarak alım satıma konu olmakta ve transfer maliyetleri bu sistem sayesinde herhangi bir üçüncü tarafa ihtiyaç duyulmadan yapıldığı için daha düşük işlem maliyeti bulunmaktadır. Kripto paralar değişim aracı olarak kullanıldığı gibi aynı zamanda yatırım amacıyla da kullanılmaktadır. Bu çalışmanın amacı kipto para piyasalarında yatırım davranışında bulunan yatırımcıların kripto paralara ilişkin yatırımlarıyla ilgili tutum ve algılarını incelemeye yönelik yapılmıştır. Çalışmada kripto para yatırım davranışında bulunan 541 adet kripto para yatırımcısına anket uygulanmıştır. Analiz sonucunda elde edilen bulgulara göre kripto para yatırım davranışında bulunan yatırımcıların sosyo-demografik özelliklere göre tutumların farklılaştığı sonucuna ulaşılmıştır. Kripto paralara yönelik yatırımcı davranışlarıyla ilgili literatürde yapılan çalışmaların azlığı nedeniyle literatüre katkı sağlayacağı düşünülmektedir.Crypto currency with blockchain system are introduce gradually after year 2009. Blockchain system described as complicated notebook, and data about crypto currencies are recorded by this complicated notebook. Thanks to blockchain system, crypto currencies are subject to safe trade and because of there is no need for 3rd party for transfer, transfer fees are cheaper. As used as a medium of Exchange, crypto currencies also used as a investing instrument. Purpose of this study is analysis of investors who have investment behaviour to crypto currency, by attitude and perception to crypto currency. In this study 541 crypto currency investors are surveyed. According to findings of the study, attitude of the investors varies by social-demographic status of investor. Social-demographic traits effect the attitude of investors. As a results shows social-demographic features of investors also effect perception of attitude. Because of there isn't many studies about behaviours of investors, it's believed that this study will contribute to literature
Investigation of stability of two- and three-dimensional crystal structures of GeSe compound by ab-initio method
No full textBu tez çalışmasında, GeSe bileşiğinin α, β ve γ fazlarının iki ve üç boyutlu kristal yapılarının yapısal, elektronik, mekanik, termodinamik ve termoelektrik özellikleri yoğunluk fonksiyoneli teorisine dayanan ab initio metoduyla incelendi. Değiş-tokuş korelasyon enerjisinin hesabında genelleştirilmiş grandyent yaklaşımı ve Grimme methodu kullanıldı. GeSe bileşiğinin elektronik bant yapıları, elastik sabitleri, polikristal özellikleri hesaplandı ve yorumlandı. Ayrıca, fonon dağınımı ve fonon durum yoğunlukları, termodinamik ve termoelektrik özellikler detaylı incelendi. Hesaplanan örgü parametreleri kuramsal ve deneysel çalışmalar ile uyum içindedir. GeSe bileşiğinin α, β ve γ fazları mekaniksel ve dinamik yönden kararlılık göstermektedir.In this thesis, the structural, electronic, mechanical, thermodynamic, and thermoelectric properties of the two- and three-dimensional crystal structures of the α, β and γ phases of GeSe compound were investigated by the ab initio method based on the density functional theory. The generalized grandyen approach and the Grimme method were used to calculate the exchange correlation energy. Electronic band structures, elastic constants, polycrystalline properties of GeSe compound were calculated and interpreted. In addition, phonon dispersion and phonon density of states, thermodynamic and thermoelectric properties were studied in detail. The calculated lattice parameters are in agreement with the theoretical and experimental studies. The α, β and γ phases of the GeSe compound show mechanical and dynamic stability
A case of presumed bonsai-induced severe toxic optic neuropathy
Get PDFApart from the known factors that cause toxic optic neuropathy, there may be factors that have not yet been identified. We report a 32-year-old man who presented with a complaint of decreased vision. His optic discs were diffusely covered with a black pigment, and below were atrophic. The vessels appeared to have disappeared below the pigmentation. He reported smoking tobacco, drinking alcohol, and using cannabis. His vision in both eyes began decreasing gradually after he started using bonsai, a synthetic cannabinoid, 2 years previously. No case of toxic optic neuropathy with bilateral severe vision loss and intense pigmentation with the use of bonsai has been reported before, and our case will be reinforced if other such cases are reported in the future
Preservice elementary mathematics teachers' use of patterns and pattern problems when planning and implementing lessons
No full textThis study examines how preservice elementary mathematics teachers create patterns, write pattern problems, and prepare and apply lesson plans on this topic. In this context, five preservice elementary mathematics teachers who were in the final semester of their undergraduate education volunteered to participate in this research. The study was carried out within the scope of an elective course which lasted eleven weeks and in which patterns were discussed. Data were collected through interview, observation and document analysis. The results show that besides the complexity and originality criteria of written problems, preservice teachers have difficulty in writing quadratic growing pattern problems. In addition, some preservice teachers adopt a teacher-centered approach in planning and implementing their lesson plans. Most of the preservice teachers did not make connections between patterns and daily life and most of them did not use concrete materials in their lesson plans or lessons
The effect of self-regulated programming learning on undergraduate students' academic performance and motivation
No full textPurpose The purpose of this study was to investigate the effect of self-regulated programming learning on undergraduate students' academic performance and motivation compared to traditional methods. Design/methodology/approach This study was conducted with an explanatory sequential mixed method. Participants consist of 31 undergraduate students studying in the department of computer and instructional technologies education. The students were separated into two groups as experimental (n = 15) and control (n = 16) in the robotic programming course. Academic performance tests, programming motivation scale and interview form were used as data collection tools. After collecting quantitative data, interviews were conducted with the students regarding their academic performance and motivation. Findings The results indicated that the self-regulated programming learning process can contribute positively to students' academic performance and motivation compared to traditional methods. Students stated that self-regulated learning strategies can positively affect their academic performance and motivation. Originality/value In this study, a self-regulated learning support system was designed to encourage students to use self-regulated learning strategies. This study has the potential to contribute to the gap in the literature, especially as a study of adapting the phased model of self-regulated learning to programming teaching. Instructors can use the self-regulating programming learning framework by adapting it to different disciplines
Foetal cardiac function in third trimester pregnancies with reduced fetal movements
Get PDF*Gül, Murat ( Aksaray, Yazar )The objective of our study was to investigate the possible relationship between poor perinatal outcome and foetal cardiac functions in pregnant women with reduced foetal movements (RFM). This cross-sectional study included 126 pregnant women with normal foetal movements (Group 1, Controls) and 42 pregnant women over 32 weeks gestation with RFM (Group 2). Group 2 was further divided into two subgroups according to their perinatal outcome: normal perinatal outcome (Group 2a) and poor perinatal outcome (Group 2b). Cardiotocography, the E/A ratio in both atrioventricular valves, myocardial performance index (MPI) and foetal tricuspid annular plane systolic excursion (f-TAPSE) were evaluated. Foetuses with poor perinatal outcome had a higher MPI (p =.003), higher tricuspid and mitral E/A (p <.001), and lower f-TAPSE values (p <.001). In regression analysis, f-TAPSE was the only parameter (p =.04) independently associated with poor perinatal outcome. İn conclusion, examining f-TAPSE may predict adverse perinatal outcome in pregnancies with RFM.IMPACT STATEMENTWhat is already known on this subject? Reduced foetal movement (RFM) is associated with adverse pregnancy outcome. Cardiotocography, amniotic fluid assessment, estimated birthweight, foetal Doppler and formal foetal movement count (kick chart) are generally used in the clinical assessment of pregnancies with reduced foetal movements. These tests, we currently use to assess foetal wellbeing in women with reduced foetal movements, have limited sensitivity in predicting foetal compromise. What do the results of this study add? Foetal cardiac Doppler may potentially be used as an important adjunct to the conventional management of women with a perception of reduced foetal movements. What are the implications of these findings for clinical practice and/or further research? Foetal echocardiographic evaluation, such as f-TAPSE, may influence clinical practice by enabling improved risk stratification for poor perinatal outcome, thus allowing more timely definitive intervention. This could help to decrease the rate of stillbirth related to reduced foetal movements. The few established echocardiographically derived parameters, which can asses global right ventricle function, are not always easy to obtain, however, f-TAPSE is easily obtainable using ultrasound and it appears to be a clinically useful echocardiographic measurement of right ventricular function
Anxiety, social support and satisfaction of patients’ families in intensive care units: A descriptive-correlational study
No full textThis study was conducted with family members of patients’ in the intensive care unit (ICU) to identify their anxiety level, social support and satisfaction with the ICU. Background: Admission of critical patients to the ICU usually involves the participation of family members. Design: A descriptive-correlational design was used and reported according to the STROBE checklist. Methods: The sample consisted of 250 family members in ICUs in a city of Turkey. Data were collected by the Multidimensional Perceived Social Support Scale, the State-Trait Anxiety Inventory and the Family Satisfaction in the Intensive Care Unit scale. Results: A negative correlation was found between family satisfaction of the ICU and state anxiety (r = −0.349, p < 0.001), and a negative relationship between the satisfaction of the ICU and trait anxiety of the participants (r = −0.151, p < 0.05). There was a significant relationship between the state anxiety level (Adjusted R² = 0.080, F = 8.247, p < 0.001), trait anxiety level (Adjusted R² = 0.185, F = 19.821, p < 0.001), the perceived social support (Adjusted R² = 0.094, F = 9.640, p < 0.001) and satisfaction (Adjusted R² = 0.013, F = 4.161, p < 0.001) of family members and their sociodemographic characteristics. Conclusions: The study concluded that anxiety levels of relatives of the families were high, their social support and satisfaction with the intensive care unit were at a moderate level. There was a correlation between anxiety levels, satisfaction with the intensive care unit, and the perceived social support of families. Relevance to clinical practice: Holistic care for the psychosocial needs of families who have a member in the ICU should be planned to increase satisfaction. Nurses should observe families closely for anxiety, allow them to ask questions and include them in the care of their family member
Experiences of children (ages 6-12) during COVID-19 pandemic from mothers' perspectives
Get PDFPurpose: This study evaluated the experiences of children between ages 6 and 12 based on their mothers' perspectives during the COVID-19 pandemic.
Methods: Ten mothers living in Ankara, Turkey with children in the aforementioned age range, participated in this study. Data were collected through focus group interview with a qualitative phenomenological approach followed by thematic data analysis.
indings: Three categories were obtained relating to the pandemic, including negative effects, positive effects, and the resultant needs and expectations of parents.
Conclusion: The findings show that the pandemic has significantly affected children in psychological, social, developmental, and academic realms. Therefore, it is necessary to plan interventions with a multidisciplinary approach to increase children's physical and psychosocial health, minimizing children's level of negative influences