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ANTECEDENTS OF GASTRONOMY DESTINATION BRAND EQUITY: AN EXAMINATION OF GASTRONOMY EXPERIENCE, MOTIVATION, AND DESTINATION SATISFACTION
Full text linkThis paper aims to test the relationships among gastronomic experience, motivation, destination satisfaction, and gastronomy destination brand equity. Data (n:600) was gathered from domestic visitors visiting Gaziantep in March, April to May 2018. Scale development to measure gastronomy experiences and scale adaptation process of destination brand equity were carried out. The relationships among the variables were examined with structural equation modeling. According to the findings, except H5 and H8, all hypotheses are significant in the research model. At the end of the study, significant theoretical and managerial implications were provided for the tourism providers and destination marketers, and managers
MOLECULAR DIAGNOSIS IN PATIENTS WITH MONOGENIC DIABETES MELLITUS, AND DETECTION OF A NOVEL CANDIDATE GENE
No full textAim: We aimed to investigate molecular genetic basis of monogenic diabetes (DM) and novel responsible candidate genes with targeted Next Generation Sequencing (NGS) and Whole Exome Sequencing (WES).
Methods: A hundred cases presenting with clinical findings and a family history of monogenic DM were included in the study. Molecular analysis was performed using an NGS panel including 14 genes. Following targeted NGS, WES was planned in cases in whom no variant was detected.
Results: Thirty different disease-causing variants in seven different genes were detected in thirty-five (35%) cases with targeted NGS approach. Most common pathogenic variant was found in GCK gene in 25 (25%) cases. Four different variants were detected in 4 (4%) patients in ABCC8 gene. In 45 of 65 cases; WES analyses were done. A heterozygous c.2635C>T(p.Gln879Ter) variant was detected in IFIH1 gene in a patient with incidental hyperglycemia. In the segregation analysis affected mother was shown to be heterozygous for the same variant.
Conclusion: Molecular etiology was determined in 35% cases with the NGS targeted panel. Seventeen novel variants in monogenic DM genes have been identified. A candidate gene determined by WES analysis in a case that could not be diagnosed with NGS panel in this study
Determination of Multi-Elemental Analysis and Antioxidant Activities of Helichrysum arenarium (L.) Moench Species
Full text linkIn this study, multi-elemental analysis and antioxidant activity of samples belonging to two different populations of Helichrysum arenarium (L.) Moench known as the immortal flower was determined. The results obtained were compared among themselves. Ca, Mg, Al, Fe, Na, Li, Be, B, Ti, Cr, Ni, Zn, Mo, and Pb element contents of the sample belonging to the B population were determined that be higher than that of the other population. The K, V, Mn, Co, Cu, As, Se, Sn, and Ba element contents of the sample belonging to the G population were determined that be higher than that of the other population. When the antioxidant activity results of the species were evaluated; according to the CUPRAC (Cupric Reducing Antioxidant Capacity) method, the sample extracts of the B and G populations were determined that showed lower activity than the standard BHA, BHT, and Trolox values at 20 and 40 µg/mL concentrations, and showed close activity compared to the standards at 80 µg/mL concentrations. The species was determined that be antioxidant activity even at low concentrations. According to DPPH (2,2-diphenyl-1-picrylhydrazyl) method, the antioxidant activity of the extract of the B and G populations was determined as 22.95 and 23.76 mg TE/mL, respectively
Dung use in Southeastern Anatolia from the Late Neolithic to the Iron Age: An ethnoarchaeological assessment
No full textTez çalışması, Geç Neolitik Dönem'den Demir Çağı'na kadar Güneydoğu Anadolu'da yaşamış arkeolojik topluluklarda hayvan gübresi kullanımına ilişkin etnoarkeolojik bir araştırmayı kapsamaktadır. Tamamen doğal kaynaklarla yaşayan bu arkeolojik topluluklarda, özellikle kerpiç inşaatlarda yapıştırıcı madde olarak, yemek pişirmek için yakıt ve şiddetli soğuk mevsimlerde ısınma kaynağı olarak hayvan gübresinin kullanımı doğal bir olasılıktır. Belirtilen bu ihtiyaçlara ek olarak, bölgedeki günümüz yerel topluluklar hayvan gübresini hastalıkların tedavisinde, ek gelir elde etme, tarım arazilerinde verimliliği sağlama, avcılık faaliyetlerinde tuzak kurma gibi çeşitli amaçlarla kullanmaktadır. Çalışmada öncelikle mevcut arkeolojik kaynaklar kullanılarak bölgedeki arkeolojik topluluklarda hayvan gübresinin kullanımına ilişkin ipuçları araştırılmıştır. Etnografik saha araştırması yöntemi kullanılarak, günümüzde Güneydoğu Anadolu Bölgesi'nde yaşayan geleneksel topluluklarda hayvan gübresi kullanımı esas alınarak, Geç Neolitik'ten Demir Çağı'na kadar yaşamış arkeolojik toplulukların gübre kullanım tercihlerine de ışık tutmuştur.This study presents an ethnoarchaeological assessment about the use of animal dung in archaeological societies of Southeastern Anatolia from the Late Neolithic to the Iron Age. People in these respected periods lived a life entirely dependent on natural resources, and therefore, likely used animal dung for the construction of mud-brick houses, for cooking, and heating during harsh winters. Such common usages of animal dung can also be observed among the traditional societies in Southeastern Anatolia today. People in the region also use animal dung for a variety of other purposes, including as a first aid and useful element for treatment of various human ailments, partial source of income by selling the dried dung-cakes, as natural fertilizer for higher production in agricultural fields, and often as bait for hunting and trapping wild birds. With the help of published archaeological sources, this study first explores the clues about the use of animal dung in the archaeological settlements in Southeast Anatolia. With the help of ethnographic field study on animal dung use among the present traditional societies in the region, it further sheds some new light on the use of animal dung in archaeological societies in Southeast Anatolia from the Late Neolithic to the Iron Age
Strong Women Characters of Netflix's algorithm: Sample of foreign detective series
No full textCinsiyete dayalı toplumsal iş bölümünün yeniden üretilmesinde dijital platformlar "yeni" alternatifler sunmaktadır. Dijital platformlar kullanıcı deneyimlerini algoritmik işleyişle şekillendirirken, içeriklerini de söylemsel sınıflandırmalarla sunmaktadır. Söz konusu sınıflandırmalar, ataerkil toplum içerisinde cinsiyet rollerinin nasıl kavrandığını ortaya koymaya yarayacak özellikler taşıyabilmektedir. Bu tez çalışmasında uluslararası ölçekte faaliyet gösteren bir dijital içerik platformu olan Netflix'te yer alan sınıflandırmalardan biri olarak "Güçlü Kadın Karakterlerin Oynadığı Diziler" kategorisindeki yabancı polisiye dizilere odaklanılmaktadır. Amaca yönelik örnekleme tekniği aracılığıyla farklı tarihlerde izleyiciyle buluşan dört yapım örneklem olarak belirlenmiştir. Örneklem belirlenirken dizilerin türsel özelliklerinin temelde polisiye olmakla birlikte farklı türsel kesişimler taşımasına da dikkat edilmiştir. Bunun yanı sıra dizilerin farklı tarihlerde izleyiciyle buluşmasına dikkat edilmiş, böylece bulgular arasındaki ilişkisel niteliklerin hem türsel kesişimler hem de süreklilik ve kesintiler bağlamında değerlendirilmesine imkan yaratılmak istenmiştir. Küresel ölçekli bir konu olan toplumsal cinsiyete dair kalıpların işlendiği anlatı yapıları sorgulanmıştır. Böylece söz konusu dizilerde yer alan kadın karakterlerin mesleki ve gündelik deneyimler ile bu deneyimlerde yer bulan cinsiyetçi temsillere ulaşılmıştır. Sonuç olarak güç söyleminin; kadınların ataerkil toplum düzeni içerisinde deneyimledikleri zorluklarla ve bu zorluklara dayanma pratikleriyle ilişkilendirildiği kaydedilmiştir.Digital platforms offer "new" alternatives for reproducing the social division of labour based on gender. While digital platforms shape user experiences with algorithmic processes, they also present their content with discursive classifications. The classifications in question may have features that will help to reveal how gender roles are comprehended in the patriarchal society. This thesis focuses on foreign detective series in the category of "Series Played by Strong Female Characters" as one of the classifications in Netflix, an internationally operating digital content platform. Four productions that met with the audience on different dates through the purposeful sampling technique were determined as samples. While determining the sample, attention was paid to the fact that the generic features of the series are basically detective, but also have different generic intersections. In addition, attention was paid to the series of meetings with the audience on different dates, so that the relational qualities between the findings were evaluated in terms of both generic intersections and continuity and interruptions. The narrative structures in which stereotypes about gender, which is a global-scale issue, are discussed were questioned. Thus, the professional and daily experiences of the female characters in the said series and the sexist representations found in these experiences have been reached. As a result, the power discourse; It has been noted that women are associated with the difficulties they experience in the patriarchal social order and the practices of enduring these difficulties
Suriyeli göçmen romancılar nezdinde kadının imajı (2011-2021)
No full textÇalışmada son on yılda Suriyeli göçmen kadın romancıların çalışmalarına yansıyan Suriyeli kadın portresi, Suriye devrimi sebebiyle Suriye toplum yapısında oluşan büyük dönüşümler neticesinde Suriyeli kadınların davranışlarında ve bakış açısında görülen değişiklikler incelenmiştir. Suriyeli kadın romancıların kendi çalışmalarında Suriyeli kadın portresini araştırmaya sevk eden amıller bırbırınden farklıdır. Devrımın ılk yıllarında yapılan çalışmalar ıle daha sonradan yapılan çalışmalar birbirinden farklı içeriğe sahiptir. Suriyeli göçmen kadın romancılar, yeni teknikler kullanarak kadın meselesini irdelemişlerdir. Bütün bu hususlar savaş etkisinde olgunlaşan, yeni bir bilinç ve farklı bır bakış açısı kazanan Suriyeli kadınların yazdığı Suriye savaş romanlarının çerçevesini belirlemiştir.The study tackled the image of the Syrian woman which was reflected in the works of Syrian immigrant women novelists in the past ten years. It also considered the changes in the behaviour and perspective of Syrian women because of the major transformations that occurred in the Syrian society due to the Syrian revolution. The factors that prompted Syrian women novelists to search for the image of the Syrian woman in their own works differ from one another. The studies conducted in the early years of the revolution are different from those conducted in the years that followed. Syrian immigrant women novelists studied the case of women using new techniques. All of these issues framed the Syrian war narratives written by Syrian women who have matured under the influence of war and gained a new awareness and perspective
Green synthesis and characterization of selenium nanoparticles (Se NPs) from the skin (testa) of Pistacia vera L. (Siirt pistachio) and investigation of antimicrobial and anticancer potentials
No full textMetallic nanoparticles created by ecologically friendly synthesis processes are becoming increasingly useful in a variety of
applications. Because of their strong bioactive component qualities, biocompatible architectures, high stability, and low toxicity, green-produced selenium nanoparticles are particularly signifcant materials for various medicinal applications. Plants
include a wealth of essential phytochemicals with therapeutic and medical capabilities. Pistachio vera L. (Siirt pistachio) is
a seasonal fruit that is frequently consumed for its nutritional worth and health advantages. However, the outer colored skin
of the P. vera (Siirt pistachio) fruit, which is not consumed, contains many biologically active compounds. In this study,
plant-mediated synthesis of selenium nanoparticles (SeNPs) was successfully accomplished after adding the sodium selenite
solution to the aqueous extract of P. vera colored skin waste. The synthesized Se NPs were characterized with UV–Vis,
transmission electron microscopy (TEM), dynamic light scattering (DLS), zeta distribution, atomic force microscope (AFM),
Fourier transform infrared spectrum (FTIR), thermogravimetric (TGA) and diferential thermal analysis, X-ray difraction
(XRD), and energy-dispersive X-ray spectrum (EDX). Biogenic Pistacia vera (PV) PV-SeNPs were also tested for their ability to suppress the development of various pathogenic bacteria and cancerous cell lines. The UV-visible (UV–Vis) spectra
revealed an absorption peak at 325 nm, which refected the surface plasmon band. The signifcant selenium signal on the EDX
spectrum at 1.5 keV confrmed the creation of Se NPs. The presence of several peaks on the FTIR spectrum of the aqueous
extract of Pv and the nanoparticles indicated the presence of some important functional groups such as amines, carbonyl
compounds, and phenols, which are important in facilitating the process of capping and bioreduction, as well as conferring
stability to nanoparticles. The TEM microphotographs revealed that the nanoparticles were highly distributed, had a spherical
morphological form, and were monodisperse below 10 nm. Biogenic Pv-SeNPs exhibited similar antimicrobial activity as
standard antibiotics. However, it was determined that the cytotoxic activity of Se-NPs against cancer cell lines was quite high
depending on the dose and time. As a result, the Pv-SeNPs are likely to be extremely benefcial in the pharmaceutical and
cosmetic sectors, as well as in the food and cosmetic industries, in producing antimicrobial and/or anticancer medications
Assessment of Correlative Digital Drawing Features in the Design Processes of Unstructured Creativity
Full text linkThis research critically challenges the conventional perception of drawings as mere technical blueprints and delves into the intricate integration of design ideation, abstraction, and speculation with geometrical manipulations and semantic labelling. By focusing on unconventional architectural design studio experiments at the undergraduate level, the study aims to explore the role of creativity in speculative drawing. It adopts a 3-dimensional design thinking process that transcends the rigid constraints of traditional drawings and embraces the fluidity of representational norms. Furthermore, the paper elucidates on the pedagogical aspects of the design studio, including the unstructured creativity inherent in the design process. The methodology employed in this study is exemplified through different stages of the design studio, incorporating a variety of representations such as 2D, 2.5D, and 3D, encompassing scalar, geometric, and material transfigurations. To assess the outcomes of the studio, the research utilises correlation diagrams that establish connections between digital drawing features at different stages and the unstructured creativity manifested in the final design. These scatter and correlation diagrams capture the syntactic relationships between the objects within digital drawings. The findings of this study reveal insight on the nuanced interplay between intuitive, reflective, and retrospective aspects of unstructured creativity during the design ideation process. By unravelling the intricate role of digital design tools and methods this research contributes to a deeper understanding of how design ideation is generated and manifested through the dynamic interplay of the modulating compounds of drawing objects. It highlights the significance of meaningful, conceptual, and speculative representations that directly relate to the creation of buildable forms and architectural spaces. Through its critical insights, this study paves the way for advancements in the field of CAAD and offers valuable perspective for architectural education and practice.Mardin Artuklu University -- 2021/2
The relationship of international service trade and economic growth: An application on Turkey
No full textKüreselleşme süreci ile birlikte dış ticaretin önündeki engellerin giderek azalması ve ülkelerin uluslararası ticari ilişkilerinin artış göstermesi, sektörlerin dış ticarette aktif bir rol kazanmasına neden olmaktadır. Mal ticareti açısından, tarım ve sanayi sektörü tarihsel olarak dünyanın önde gelen sektörleri olmuştur. Hizmet sektörü ise özellikle bilgi ve iletişim teknolojisinin gelişmesi, yaşam standartlarının artması, insanların tercih ve alışkanlıklarının değişmesi ile birlikte dış ticarette önemli bir sektör haline gelmiştir. Hizmet sektörü dış ticarete katkısının yanı sıra GSMH'ye ve istihdama olan katkısı bakımından da önemli bir sektördür. Tüm bunlarla beraber, diğer sektörlere belirli alanlarda alt yapı hizmeti sunması da hizmet sektörünün önemini ortaya koymaktadır. Birçok ülkenin ekonomisine katkısı itibariyle gelir kaynağı haline gelen hizmet sektörü, Türkiye ekonomisi üzerinde de pozitif bir etkiye sahip olmaktadır. Nitekim özellikle cari açıkların giderilmesinde hizmet sektöründen sağlanan gelir ekonomide önemli bir yer tutmaktadır. Bu nedenle Türkiye, uluslararası alanda yüksek potansiyele sahip hizmet sektörlerine yönelik teşvik politikaları uygulamalı ve hizmet ticaretini artırmaya yönelik çalışmaları hızlandırmalıdır. Yapılan çalışmada Türkiye'de hizmet sektörünün ekonomik büyümeye olan katkısı incelemiştir. Bu bağlamda, 1990-2021 yılları arasındaki veriler kullanılarak zaman serisi analizi yapılmıştır. Seriler eş bütünleşme ve nedensellik analizleri ile test edilmiş olup, hizmet dış ticaretinin hem GSMH'ye hem de istihdama katkıda bulunduğu sonucuna varılmıştır.With the globalization process, the gradual decrease in the barriers to foreign trade and the increase in the international trade relations of countries cause sectors to gain an active role in foreign trade. In terms of trade in goods, agriculture and industry sectors have historically been the leading sectors in the world. The service sector has become an important sector in foreign trade, especially with the development of information and communication technology, increasing in living standards, and changes in people's preferences and habits. In addition to its contribution to foreign trade, the service sector is also an important sector in terms of its contribution to GNP and employment. In addition to all these, the fact that it provides infrastructure services to other sectors in certain areas also reveals the importance of the service sector. The service sector, which has become a source of income for many countries, also has a positive impact on the Turkish economy. As a matter of fact, the income obtained from the service sector has an important place in the economy, especially in the elimination of current account deficits. Therefore, Turkiye should implement incentive policies for services sectors that have high potential in the international arena and accelerate efforts to increase trade in services. In this study, the contribution of the service sector to economic growth in Turkiye has been examined. In this context, time series analysis has been conducted using data from 1990-2021. The series have been tested with cointegration and causality analyses and it has been concluded that foreign trade in services contributes to both GDP and employment
The relationship between tax revenues and economic growth: An analysis on developing countries
No full textİnsanlık tarihi kadar eski bir geçmişi bulunan vergilerin fonksiyonları sürekli tartışılagelmiştir. Tartışmalar tarafsız vergileme ve müdahaleci vergileme arasında yoğunlaşmaktadır. Maliye politikası araçları arasında gösterilen vergiler aracılığıyla devletin ekonomik fonksiyonları gerçekleştirilmeye çalışılır. Bu bağlamda büyümenin sağlanması devletin ekonomik fonksiyonları arasında kabul edilmektedir. Büyümenin sağlanmasında vergiler önemli bir işleve sahiptir. Büyümenin sağlanması için vergilerin önemli olduğunu belirten çalışmaların yanı sıra tersi düşünceyi savunan çalışmalar da bulunmaktadır. İkisi arasında herhangi bir ilişkinin olmadığını ortaya koyan çalışmalara rastlamak da mümkündür. Bu çalışmada vergiler ile büyüme arasında nasıl bir ilişki olduğu ekonometrik yöntemler ile ortaya konulmuştur. Çalışma ile devletin ekonomik fonksiyonlarını gerçekleştirmede vergilerin rolü ortaya konulacağından bu bakımdan politika yapıcılara yol gösterici öneriler sunulması amaçlanmaktadır. Seçilmiş 20 OECD ülkesinin 1980-2020 yılları arasındaki dönem için toplam vergi, dolaysız vergi ve dolaylı vergilerin ekonomik büyüme üzerindeki etkisi panel veri analizi ile incelenmiştir. İki modelin kurulduğu çalışmada öncelikle toplam verginin ekonomik büyüme üzerindeki etkisi, ikinci modelde ise doğrudan ve dolaylı vergilerin ekonomik büyüme üzerindeki etkisi Westerlund (2007) eş-bütünleşme analizi ile incelenmiştir. Her iki modelde de değişkenler arasında eş- bütünleşme ilişkisi tespit edilmiştir. Son olarak, hem panel hem birimler düzeyinde eş- bütünleşme katsayıları CCE (Common Correlated Effects Mean Group estimator) modeliyle tahmin edilmiştir. Hem panel hem de tüm birimler için toplam verginin ekonomik büyüme üzerinde pozitif ve istatistiki olarak anlamlı etkisi olduğu tespit edilmiştir. Doğrudan ve dolaylı vergilerin de ekonomik büyüme üzerinde pozitif ve istatistiki olarak anlamlı olduğu panel düzeyinde tespit edilmiştir. Ancak dolaylı vergi serisinin katsayısı doğrudan vergi serisinin katsayısından daha büyük çıktığından dolaylı vergilerinin ekonomik büyüme üzerindeki etkisinin nispi olarak daha fazla olduğu söylenebilir. Çalışma ile literatüre katkı sunulacağı düşünülmektedir.Taxes, which have a history as old as human history, have been constantly discussed. Discussions are centered between suspension and interpretation arrangements. Taxes, which are among the fiscal policy instruments, are tried to be run economically. In this context, the guarantee of growth is accepted among economic employment. Taxes play an important role in ensuring growth. In addition to the employees that taxes are important for growth, there is also an operation that advocates the opposite opinion. It is also possible to come across to reveal that there is no relationship between the two. The relationship between taxes and growth, which is affected by this situation, has been revealed by econometric guidance. With this study, it is aimed to provide guiding suggestions to these aimless policy advocates, since taxes will arise in realizing the economic functions of the system. The effect of total taxes, direct taxes and consumer taxes on economic growth of 20 selected OECD countries for the period 1980-2020 results in a panel data analysis. The amounts brought by the two models are consistent with the Westerlund (2007) cointegration analysis, primarily the effect of total taxes on economic growth, and in the second model, the effect of direct and restrictive taxes on economic growth. In both models, a cointegration relationship was found between the variables. Finally, the cointegration coefficients with both the panel and its units were estimated with the CCE (Common Corulated Effects Mean Group estimator) model. It has been determined that the total tax for both the panel and all parts has a positive and statistically consequential effect on economic growth. It has been determined throughout the panel that direct and collected taxes are also positive and statistically correct on economic growth. However, the lower tax office business has a relatively higher unit on economic growth of the taxes carried by larger transports than the direct tax businesses. Sevens in which the literature contribution will be presented with the study