Mardin Artuklu University Institutional Repository
Not a member yet
5052 research outputs found
Sort by
Diagnostic Performance of Erythropoietin and Erythropoietin Receptors Levels in Children with Attention Deficit Hyperactivity Disorder
Get PDFObjective: Attention deficit hyperactivity disorder (ADHD) is a heterogeneous, highly heritable, a common childhood neurobehavioural disorder resulting from complex gene-gene and gene-environment interactions. The erythropoietin (Epo)/erythropoietin receptors (EpoR) system turned out to have additional important functions in nonhematopoietic tissue. In this study, we aimed to investigate the levels of Epo and and EpoR, and also their diagnostic values in children with ADHD.
Methods: A total of 70 children were included in the study, 35 drug-naive patients with ADHD (age: 6−12 years; male/female: 20/15) and 35 healthy controls (age: 6−12 years; male/female: 22/13). Serum Epo and EpoR levels was determined using a commercial sandwich enzyme-linked immunosorbent assay kit.
Results: The results indicated that the levels of Epo decreased in patients with ADHD compared to control (p < 0.05). On the other hand, EpoR levels increased in these patients (p < 0.05). Furthermore, the ratio of Epo/EpoR was significantly lower in ADHD patients than controls (p < 0.05). Receiver operator characteristic curve analysis showed high diagnostic performance for Epo and EpoR, areas under curve were 0.980 and 1.000, respectively.
Conclusion: This is the first report to investigate the association between serum Epo and EpoR levels in ADHD patients. Our results indicated that Epo may play a role in the etiology of ADHD, and Epo therapy may be beneficial in these disorders if given in addition to the routine treatment of children with ADHD. Furthermore, our results reveal possible diagnostic value of Epo and EpoR
Biochemical components, enzyme inhibitory, antioxidant and antimicrobial activities in endemic plant Scilla mesopotamica speta
Get PDFIn this study, in vitro antioxidant, antimicrobial, anticholinesterase and phenolic profile of different solvent extracts of Scilla mesopotamica speta were determined in detail. In vitro antioxidant activities and total phenolic and flavonoid contents of plant extracts obtained with different solvents were tested in terms of 2.2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activities. The highest total phenolic and total flavonoid contents were determined in the ethyl acetate extract (62.24 mu g GAE/mg) and chloroform extract (87.72 mu g QE/mg) respectively. The highest DPPH radical scavenging activity was detected in ethyl acetate extracts. Antimicrobial and antifungal activities were investigated by MIC method. The inhibitory activities of the extracts on the acetyl cholinesterase enzyme were investigated. Liquid chromatography (LC) tandem mass spectrometry LC-MS/MS was used to determine the phenolic component content of extracts. Thirty-one different components were identified in the analyses and their amounts were measured. Practical applications Scilla mesopotamica speta is an endemic and medicinal plant. It was determined that the extracts of this plant had a very rich content in terms of phenolic compounds, especially caffeic and ferulic acids. However, this plant was remarkable for its antioxidant, anticholinesterase, and antimicrobial activities. Considering the strong antioxidant, antimicrobial, and enzyme inhibition activities of the Scilla mesopotamica speta it can be suggested as a source of anticancer, antimicrobial, and antiviral drugs
Synthesis and Characterization of Bionanomaterials and Evaluation of Their Antioxidant, Antibacterial, and DNA Cleavage Activities
No full textIn this study, the hexagonal boron nitride (hBN) (1), poly-levodopa (P-L(DP) (2), P-L(DP) coated hBN (hBN@P(L-DP)) (3), and silver nanoparticles (AgNPs) decorated hBN@P(L-DP) (hBN@P(L-DP)-AgNPs) (4) were synthesized and characterized by multiple spectroscopic techniques. Additionally, their biological properties such as antioxidant, antibacterial, and DNA cleavage activities were determined. It is worth noting that, products 3 and 4 were newly synthesized structures. The antioxidant activities of all the nanomaterials 1, 2, 3, and 4 nanomaterials were investigated using some tests such as DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging and reducing power ability. Among the synthesized nanomaterials, product 2 exhibited the highest radical scavenging (64.8±1.94 %) and reducing power activity (0.61±0.017) at a concentration of 200 mg L−1. Product 4 was determined to have antibacterial activity against all three Gram-positive and three Gram-negative test bacteria. In addition, all the nanomaterials were tested for cleavage activity using pBR 322 plasmid DNA, as a result of which it was determined that only product 4 showed the ability of cleavage from both chains of DNA
Instructional Design Studies Between 1975 and 2019: A Bibliometric Analysis
Get PDFThis study aimed to examine the bibliometric results (co-authorship, citation, co-occurrence, bibliographic coupling, and co-citation) of publications in the field of instructional design. The study includes the publications in the database of the Web of Science in the period between 1975 and 2019. It was found through co-authorship analysis that 9,344 authors who had written in the field of instructional design functioned as co-authors and had links. There were studies on an instructional design from 103 different countries. It was also found that keywords such as e-learning and online learning were frequently used and that the studies published in recent years prioritized the keywords of the massive open online courses, mobile learning, flipped classroom, gamification, and augmented reality. While the most published authors were F. Paas and J. van Merrienboer in the field, the author who was the most cited was J. Sweller
Thevenin Equivalent of Solar PV Cell Model and Maximum Power Transfer
No full textPhotovoltaic (PV) is the conversion of solar energy into DC electrical energy using PV cells. In addition, solar energy is an important renewable energy source. In this study, it is proposed that Thevenin's equivalent PV cell model produces a voltage-current characteristic that is quite representative of the operation of the PV source. Thevenin's elements depend on ambient temperature conditions, so charging is derived and simplified to construct a model that closely predicts and demonstrates adequate PV cell characteristic for different ambient temperature conditions. This method is very useful for estimating the desired performance and also for examining different Maximum Power Point Tracking (MPPT) algorithms. Theoretically, the simulation was supplemented with test data, then used to develop an equivalent Thevenin model in which the resistance is non-linear and voltage dependent. Thevenin's method and variable pitch is to improve the maximum power transfer to the load by increasing the performance of the PV cell. These methods were modeled and studied in a simulation program
First report of fruit rot of eggplant caused by Pythium viniferum in Turkey
No full textIn August 2019, symptoms including dark brown and irregular sunken lesions or blights on the fruit pedicel and calyx of eggplants (Solanum melongena L.) occurred with a 3% incidence in two felds in Şanlıurfa province of Turkey
Removal of carbol fuchsin from aqueous solution by using three-dimensional porous, economic, and eco-friendly polymer
No full textIn this study, a three-dimensional (3D) porous polydimethylsiloxane (PDMS) was prepared using a cheap material with a highly simple and different method. PDMS was firstly applied for the removal of carbol fuchsin (CF) cationic organic dye pollution in this study. Besides, the adsorption capacity of 3D PDMS for removal of the CF was found quite high compared to other materials in already published results. The synthesized PDMS was characterized using several spectroscopic and imaging techniques such as FTIR, Raman, SEM, stereomicroscope, EDX, UV/Vis, and TGA. The optimal conditions were found as 10 mg L−1 initial concentration, 20 mg of adsorbent dose, 2 h contact time, pH 10, and 25°C temperature. The removal % of CF and the maximum adsorption capacity were calculated at approximately 89% and 88.8 mg g−1, respectively. Furthermore, the equilibrium studies showed that the Langmuir isotherm model fitted well with the removal of CF. Moreover, according to the kinetic results, the second-order kinetic model was found suitable (qe,cal 89.3 mg g−1 and qe,exp 88.8 mg g−1 close to each other) for the adsorption of CF. Also, the thermodynamic studies indicated that adsorption occurs spontaneously, and the adsorption process was physical adsorption. Besides, the reusability of the adsorbent was studied. Practitioner points: Water treatment technology should be low cost, economically viable and in the meantime, eco-friendly. The 3D porous PDMS was prepared by using cheap material with a highly simple method and eco-friendly This unique material was firstly applied for the removal of organic dye in water in this study
Fast and Low-Cost Biosynthesis of AgNPs with Almond Leaves: Medical Applications with Biocompatible Structures
Get PDFIn this study, silver nanoparticles (AgNPs) were obtained in a low cost, easy and simple way by using the leaf extract of Prunus dulcis L. (almond tree) growing in the Mardin region. Characterization of AgNPs obtained by biosynthesis: Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Diffractometer (XRD), UV-visible spectrophotometer (UV-Vis.), Scanning Electron Microscope (SEM), Transmission Electron Microscope(TEM), Zeta potential and Zeta size analysis was done through data. It was determined that AgNPs have maximum absorbance at 443 nm wavelength, they exhibit 14.67 crystal nano size, -19.9 mV zeta potential in spherical appearance. The Minimum Inhibition Concentration (MIC) of the obtained AgNPs was determined by using microdilution method on the growth of pathogen strains
Intangible cultural heritage: Local food and tourism
No full textIntangible cultural heritage: Local food and touris
Local trend of symbolism at the dawn of the Neolithic: The painted bone plaquettes from PPNA Kortiktepe, Southeast Turkey
No full textThe PPNA site of Körtiktepe in the Upper Tigris Basin yielded one of the richest Pre-Pottery Neolithic assemblages in Western Asia. The site also stands among a few key Epipalaeolithic–Neolithic transitional centers that played vital roles in the origin and evolution of Neolithic symbolism in Upper Mesopotamia. The site was occupied from the second half of the 11th millennium BCE, and throughout much of the 10th millennium BCE the sedentary hunter-gatherers at Körtiktepe engaged in a socio-symbolic organization with elaborate funerary practice and extensive manufacture of symbolic artifacts, including figurative plaquettes, engraved stone vessels, incised shaft straighteners with elaborate designs, scepters, and large assemblages of beads, mostly unearthed from c2000 intra-site burials. No other PPN site has yielded such an extensive number of burial remains and grave goods. Here, we present a group of painted bone plaquettes displaying morphological features and some imagery so far not seen at any other Pre-Pottery Neolithic site in Western Asia. Assessing the specimens in light of the wider symbolic practices among the first Neolithic societies, we argue that Körtiktepe was an important center of symbolic trend at the dawn of the Neolithic in the Upper Tigris Basin