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Kinik Asitin Antioksidan ve Antimikrobiyal Kapasitesi
No full textRecently, agents with natural antioxidant and antimicrobial properties have been popularly studied. For this purpose, phenolic compounds, terpenes, and organic acids are examined for their antioxidant and antimicrobial properties. Of these, organic acids are increasingly being used in pharmacology, medicine, food, and industry. Quinic acid is a natural organic compound found in many edible fruits and plants. In this study, the antioxidant effect of quinic acid, which has the structure of cyclohexane carboxylic acid, was determined in vitro using seven different methods (DPPH, ABTS, CUPRAC, DMPD, FRAP, Fe3+ reduction, and Total antioxidant method). In addition, its antimicrobial effect on fungi (C. albicans), gram-positive bacteria (S. aureus, S. pyogenes), and gram-negative bacteria (E. coli, K. pneumoniae, and P. aeruginosa) were determined by the disk diffusion method. As a result, it was found that quinic acid has broad-spectrum antimicrobial properties, but its antioxidant properties are too low to be highlighted. While its antimicrobial activity was quite good, especially on K. pneumoniae E. coli, S. aureus, S. Pyogenes, and P. aeruginosa, it did not show any effect on C. albicans. Although the antioxidant property of quinic acid is low, it showed more antioxidant properties in the DMPD method, which is one of these methods, because it dissolves very well in water
THE RELATIONSHIP OF EXPORT, ENERGY AND ECONOMIC GROWTH: CAUSALITY ANALYSIS FOR ADVANCED AND DEVELOPING NUTS 2 REGIONS
Get PDFBu çalışmanın amacı, Düzey 2 bölgelerinde ekonomik büyüme, ihracat ve enerji arasındaki nedensellik ilişkilerini tespit etmektir. 26 alt bölgenin farklı gelişme düzeyine sahip olmalarından dolayı analizler gelişmiş ve gelişmekte olan bölgeler olarak ikiye ayrılarak yapılmıştır. Gelişmiş Düzey 2 bölgelerinde ekonomik büyümeden ihracata ve ekonomik büyümeden elektrik tüketimine doğru tek yönlü ve ihracat ile elektrik tüketimi arasında ise çift yönlü nedensellik ilişkisine rastlanmıştır. Böylece, gelişmiş bölgelerde koruma hipotezi desteklenmiştir. Gelişmekte olan Düzey 2 bölgelerinde ise ihracattan ekonomik büyümeye doğru tek yönlü nedensellik ilişkisi bulunmuş ve ihracata dayalı büyüme hipotezinin geçerliliği ispatlanmıştır
A Forgotten School Administrator: How Does the Administration Style of Deputy Principals Affect the School Climate?
Get PDFBu araştırmanın amacı, okul müdür yardımcılarının benimsediği yönetim tarzlarının okul iklimine olan etkilerini
incelemektir. Araştırma, nitel araştırma yöntemlerinden durum çalışması deseniyle yürütülmüştür. Araştırmanın verileri,
2021-2022 eğitim öğretim yılında Mardin’deki ilkokul ve ortaokullarda görev yapan öğretmen ve okul müdürlerinden yarı
yapılandırılmış görüşme formu aracılığıyla toplanmıştır. Veriler, içerik analizi yöntemiyle analiz edilmiştir. Araştırma
sonucunda, sağlıklı bir okul ikliminin oluşturulmasında okul müdür yardımcılarının önemli bir rolü olduğu görülmüştür.
Ayrıca araştırma, müdür yardımcılarının benimsedikleri yönetim tarzlarının okul iklimini etkilediğine dair kanıtlar
sunmaktadır. Demokratik, işbirlikçi ve destekleyici yönetim tarzlarını benimseyen müdür yardımcılarının okul iklimini
olumlu etkilediği, buna karşın otoriter, ilgisiz ve karşı koyucu yönetim tarzını benimseyen müdür yardımcılarının ise okul
iklimini olumsuz etkilediği sonucuna ulaşılmıştır. Bu bağlamda okul müdüründen sonraki en kilit rolü üstlenen müdür
yardımcılarının okulda sağlıklı bir iklimin oluşması için öğretmenleri destekleyici ve motive edici bir anlayışla hareket
etmeleri önemlidir.This research aims to examine the effects of the administration styles adopted by the deputy principals on the
school climate. The research was conducted using a case study design, one of the qualitative research methods. The study
data were collected through a semi-structured interview form from teachers and school principals working in primary and
secondary schools in Mardin during the school year 2021-2022. The content analysis technique was used to analyze the data.
As a result of the research, it has been seen that deputy principals have an important role in forming a healthy school climate.
The research provides evidence that the administration styles adopted by deputy principals affect the school climate. It has
been concluded that deputy principals who adopt democratic, collaborative and supportive administration styles positively
impact the school climate, whereas deputy principals who adopt an authoritarian, disinterested, and oppositional
administration style negatively affect the school climate. In this context, it is essential that deputy principals, who assume the
most critical role after the school principal, act with a supportive and motivating understanding to create a healthy climate at
school
Increased visinin-like protein-1, YKL-40, lipocalin-2, and IL-23 levels in patients with migraine
No full textBackground: Migraine is a type of primary headache caused by changes in the trigeminal system and has been reported to be associated with neurovascular inflammation of cerebral and extracerebral vessels. Objective: It is known that inflammation is an important process in the pathogenesis of migraine. It has been shown that the molecules of visinin-like protein 1 (Vilip-1), YKL-40, lipocalin-2 and interleukin (IL)-23 play a role in the inflammatory process. Our aim is to investigate the role of this molecule in the metabolic pathway of migraine disease. Methods: Fifty migraine patients with and without aura in the interictal period were included in the study. Vilip-1, YKL-40, lipocalin-2, and IL-23 levels were measured by ELISA method. Results: Serum vilip-1, YKL-40, lipocalin-2, and IL-23 levels were found to be significantly higher in migraine patients compared to the control group. We found that this molecule increased significantly in migraine subgroups compared to the control group (p < 0.001). A positive significant correlation was found between vilip-1 level and YKL-40 and lipocalin-2 levels in migraine patients. In addition, a positive correlation was observed between visual analogue scale score, number of days with pain and vilip-1 level (p < 0.01). The results of our study showed that activation of inflammatory mediators may play a role in the pathogenesis of migraine disease. In addition, our study is valuable in that inflammatory molecules are high in the interictal period and these biomarkers have never been analyzed in migraine patients. However, we still believe that larger studies are needed to explain the role of vilip-1, YKL-40, lipocalin-2, and IL-23 in the molecular mechanism of migraine disease
A comprehensive review on detection of cyber-attacks: Data sets, methods, challenges, and future research directions
No full textRapid developments in network technologies and the amount and scope of data transferred on networks are increasing day by day. Depending on this situation, the density and complexity of cyber threats and attacks are also expanding. The ever-increasing network density makes it difficult for cyber-security professionals to monitor every movement on the network. More frequent and complex cyber-attacks make the detection and identification of anomalies in network events more complex. Machine learning offers various tools and techniques for automating the detection of cyber attacks and for rapid prediction and analysis of attack types. This study discusses the approaches to machine learning methods used to detect attacks. We examined the detection, classification, clustering, and analysis of anomalies in network traffic. We gave the cyber-security focus, machine learning methods, and data sets used in each study we examined. We investigated which feature selection or dimension reduction method was applied to the data sets used in the studies. We presented in detail the types of classification carried out in these studies, which methods were compared with other methods, the performance metrics used, and the results obtained in tables. We examined the data sets of network attacks presented as open access. We suggested a basic taxonomy for cyber attacks. Finally, we discussed the difficulties encountered in machine learning applications used in network attacks and their solutions
“Voiced at Lale Film Studios”: An Interview with Necip Sarıcı on Dubbing in Turkish Cinema
Get PDFNecip Sarıcı, Türk Sinemasının en önemli isimlerinden biridir. 1949 yılında, henüz on beş yaşındayken, makinist çırağı olarak girdiği sinemaya yetmiş yılı aşkın süredir hizmet etmeye devam etmektedir. Üç yüz elliden fazla filmi seslendirmiş, bu filmlerin seslerini kaydetmiş ya da ses mühendisi olarak altyapısını düzenlemiştir. Bunun yanı sıra yapımcılık ve yönetmenlik koltuklarına da oturmuştur. 1979 yılında Lale Film’i satın alarak değerli arşivinin korunmasını sağlamıştır. Bu görüşme hem Sarıcı’nın zengin geçmişine hem de onun anlatımıyla Türk Sinemasında seslendirmenin yolculuğuna odaklanmaktadır.Necip Sarıcı is one of the most important names of Turkish Cinema. He
entered the cinema as a machinist’s apprentice in 1949, when he was
only fifteen years old, and has been serving for more than seventy years.
He has voiced more than three hundred and fifty films, recorded the
sounds of these films or arranged the infrastructure of films as a sound
engineer. In addition, he has also sat in the production and directing
chairs. By purchasing Lale Film in 1979, he has ensured the preservation
of its valuable archive. This interview focuses on both Sarıcı’s rich past
and the journey of voice acting in Turkish Cinema with his narration
GLASS USE IN RE-USED HISTORICAL BUILDINGS: THE CASE STUDY OF TRABZON KIZLAR MONASTERY
Get PDFRapidly developing technological data in the current age affects the field of building materials. Glass is a transparent and fragile building material that is often preferred with traditional materials in restorations. In this study, it is aimed to determine the architectural compatibility of the glass used in the restoration of historical buildings and to reveal the advantages and disadvantages. In this context, Kızlar Monastery, which is located Trabzon in Turkey, has been discussed. The study consists of three stages. In the first stage, the theoretical infrastructure for the subject was created through literature research. The data related to the study area were obtained in the second stage, and the current situation features were examined. In the third stage, glass usage areas were analyzed in the re-using process in Kızlar Monastery. In the findings of the study, it was seen that the interventions made for Kızlar Monastery to connect the past and the future of the building greatly contributed to the original value of the building. As a result, it has been determined that the interventions made by paying attention to the preservation of the original space flow of historical buildings contribute to the sustainability of the values of the buildin
Green Synthesis of Silver Nanoparticles and Their Antimicrobial Effects on Some Food Pathogens
Get PDFBu çalışmada, gümüş nanopartiküller (AgNP’ler) biyolojik yöntemle kolay, düşük maliyetli ve çevre dostu bir şekilde elde edilmiştir. Sentezi yapılan AgNP’lerin karakterizasyonu UV-visible Spektrofotometre (UV-Vis.), Alan Emisyon Taramalı Elektron Mikroskobu (FE-SEM), Transmisyon Elektron Mikroskobu (TEM), Enerji Dağılımlı X-Işını Spektroskopisi (EDX), X- Işını Kırınımı Difraktrometresi (XRD), Fourier Dönüşümü Kızılötesi Spektroskopisi (FT-IR) ve Zeta boyut ve potansiyel cihazı kullanılarak yapılmıştır. AgNP’lerin 440-450 nm absorbansta maksimum pik vermiştir. TEM ve FE-SEM sonuçlarına göre nanopartiküllerin morfolojik yapılarının küresel ve ortalama 38 nm; XRD sonuçlarına göre nanopartiküllerin toz kristal yapılarının kübik ve 21.94 nm boyutunda; zeta boyutunun ise ortalama 158.2 nm, zeta potansiyelinin -23.4 mV olduğu görülmüştür. Sentezlenen AgNP'lerin Staphylococcus aureus ATCC 29213, Bacillus subtilis ATCC 11774 Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853 ve Candida albicans üzerinde Minimum İnhibisyon Konsantrasyonları (MİK) (mg/mL) sırasıyla 1.25, 0.625, 2.50, 1.25 ve 0.312 olarak tespit edilmiştir. Söz konusu mikroorganizmaların AgNO3 ve antibiyotik MİK değerleri (mg/mL) sırasıyla 2.65;2, 1.32;1, 0.66;2, 1.32;4, 0.66;2 olarak tespit edilmiştir.In this study, silver nanoparticles (AgNPs) were obtained by biological method in a simple, low-cost and environmentally friendly way. The characterization of the synthesized AgNPs was fulfilled using UV-visible Spectrophotometer, Field Emission Scanning Electron Microscope (FE-SEM), Transmission Electron Microscopy (TEM), Energy-Dispersive X-Ray Spectroscopy, X-Ray Diffraction Diffractrometer (XRD), Fourier Transform Infrared Spectroscopy and Zeta sizer and potantial devices. It was determined that AgNPs gave a maximum peak at 440-450 nm absorbance. According to the TEM and FE-SEM results, the morphological structures of the nanoparticles were spherical and their average size was 38 nm. According to the XRD pattern, it was observed that the powder crystal structures of the nanoparticles were cubic and 21.94 nm in size. The zeta size of the nanoparticles was 158.2 nm on average and zeta potential of nanoparticles was -23.4 mV. Minimum Inhibition Concentrations (MIC) (mg/mL) of the synthesized AgNPs on Staphylococcus aureus ATCC 29213, Bacillus subtilis ATCC 11774, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853 and Candida albicans were determined as 1.25, 0.625, 2.5, 1.25 and 0.312, respectively. AgNO3 and antibiotic MIC values (mg/mL) of the mentioned microorganisms were determined as 2.65;2, 1.32;1, 0.66;2, 1.32;4, 0.66;2, respectively
Investigation of Secondary School Students' Attitudes Towards Physical Activity
Get PDFThis research was conducted to reveal secondary school students' attitudes towards physical activity according to the opinions of the students
based on dependent and independent variables. The physical activity attitude scale for secondary school students developed by Yildizer et
al., (2019) was used (PAAS). PAAS consists of 5 sub-dimensions and 25 items. The necessary permissions were obtained for the scale
method used in this study, with the decision of the Scientific Research and Publication Ethics Committee of Mardin Artuklu University,
dated 08.06.2022 and numbered 2022/6-4. The sample group of the research consisted of 305 students, and the data obtained were analyzed
with the SPSS 25.0 software. Independent sample T Test and One-Way ANOVA tests were used in the analysis of the data obtained from
the participants. In the study, it was determined that the physical activity levels of female students were higher than male students. In the
analyses performed in the research, a difference was found in the grade level of the secondary school students, and there was a decrease in
the level of physical activity as the grade level increased. Also, "Pearson correlation analysis" was conducted in order to determine the level
and direction of the relationship between dependent variables. In the correlation analysis, it was seen that the strongest relationship was
between "PAAS" and the love sub-dimension (r= 0.807; p<0.05). As a result of the research, it was seen that the jobs of the mothers and
fathers of the students, the number of siblings of the students, and the place of residence of the students did not lead to a difference in their
attitudes towards physical activity
Nikah Akdi: İslam Hukukunda Evlilik ile Akit Arasındaki İlişkinin Açıklanması
Get PDFThe combination of marriage and contract (ʿaqd al-nikāḥ) has been one of the interesting subjects for the scholars to be discuss and elaborate. The focus of this attention has been on analysis and understanding of the contractual component of the marriage reflecting a similarity with economic contracts. Recent studies endeavored to explain this nexus; however, they have also neglected to include how contract as a concept operates in Islamic law and beyond, and the discussions between the schools on the metaphoric aspect of the marriage contract. Classical legal scholars elaborated how marriage is represented by contract model, its relation to other economic contracts, and how the contractual aspect of the marriage is articulated. In particular, the argument that the contractual aspect of nikāḥ is partly related to metaphor offers another dimension in exploring the nature of the marriage contract. This study aims to analyse the nexus by including both the discussions on the metaphoric aspect of the marriage contract and the shortcomings in explanations of the contractual component of the marriage contract