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Bright Circularly Polarized Electrochemiluminescence from Heterobinuclear Ir III –Au I Enantiomers
No full textInternational audienceThe development of efficient circularly polarized electrochemiluminescence (CP‐ECL) probes is still at its infancy and examples are still very limited. Yet, their achievement would enable gathering a readout that carries privileged information on the probe's chiral environment by monitoring luminescence polarization bias with high signal‐to‐noise ratio. Notwithstanding, this is a highly challenging task and requires judicious chemical engineering of chiral ECL‐active emitters. Herein, we aim at expanding the palette of CP‐ECL luminophores by presenting a novel class of enantiopure heterobinuclear Ir(III)–Au(I) complexes, which are investigated thoroughly by means of chemical, structural, and (chiro‐)optical techniques. The ground and excited state properties are also elucidated by using density functional theory (DFT) approaches including spin‐orbital coupling (SOC) perturbation. The chiral‐at‐metal complexes display luminescence with a polarization bias of the emitted light that is function of the helical arrangement of the coordination sphere around the Ir(III) center. Overall, the photo‐ and electro‐active complexes unraveled in this work combine unparallelly high photoluminescence quantum yield in the orange region, excellent circularly polarized luminescence (CPL) brightness up to 4.5 M −1 cm −1 with a notable ECL activity. Finally, these features provide emitters with CP‐ECL efficiency that encompass remarkably by a factor 3.5 that of the well‐known benchmark tris ‐(2,2′‐bipyridyl)ruthenium(II)
Small persistent humid forest clearings drive tropical forest biomass losses
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Copeptin is a reliable biomarker of vasopressin and is associated with urine osmolality in patients on peritoneal dialysis
No full textInternational audienceAbstract Background Vasopressin, a hormone regulating water metabolism, has been poorly studied in patients on peritoneal dialysis (PD). Vasopressin measurement is challenging and not routinely available in clinical practice. This study aimed to evaluate whether copeptin, a stable surrogate marker of vasopressin, could be used to assess vasopressin levels in patients on PD and to determine if vasopressin maintains its antidiuretic effect in this population. Methods We included 34 PD patients from three French nephrology centers. Plasma vasopressin was measured using radioimmunoassay, while copeptin was quantified with a non-competitive immunofluorescence assay. Urine osmolality and 24-hour urine output were assessed, and peritoneal adequacy tests were performed. Associations between copeptin, vasopressin, and clinical parameters were analyzed using Spearman correlations and mixed-effect models. Healthy controls were included for comparison. Results Copeptin levels were strongly correlated with vasopressin levels (Spearman's rho = 0.62, P < 0.001), confirming its reliability as a biomarker of vasopreassin. Higher copeptin levels were associated with increased urine osmolality (β = 3.63, P = 0.008) and decreased 24-hour urine output (β = −0.53, P = 0.008), indicating that vasopressin retains its antidiuretic activity in PD patients. Compared to healthy controls, PD patients had lower urine osmolality and required higher copeptin levels to achieve similar urine concentration, suggesting vasopressin resistance. Copeptin levels were also associated with lower residual kidney function and higher brain natriuretic peptide levels but were not influenced by blood pressure, plasma sodium, or PD characteristics. Conclusions This study provides evidence that vasopressin maintains an antidiuretic effect in PD patients, and supports the use of copeptin as a robust biomarker for vasopressin in this population
Wind Power Subseasonal-to-Seasonal (S2S) Forecast over France
No full textInternational audienceWind Power Subseasonal-to-Seasonal (S2S) Forecast over France The file contains S2S forecasts of Wind Power over France. The ECMWF S2S ensemble weather forecasts with daily initialization, 51 members, and lead times ranging from 1 day to 46 days are converted to the French wind power supply. The data covers all forecasts initialized during 2023-2024 at a daily resolution. It provides the corresponding supply, the raw converted S2S forecasts, as well as 8 post-processed S2S forecasts using different post-processing methods. 2 baselines are also given: a climatological and a bootstrap climatological proxy
Oral mucosal wound healing: A photograph‐based prospective study
No full textInternational audienceAbstract Background Oral mucosa heals with minimal scar formation compared with other tissues. The aim of this study was to explore the differential healing properties between keratinized gingiva and non‐keratinized alveolar mucosa, and to analyze the healing dynamic of these tissues through a clinical photograph‐based prospective study. Methods Fourteen patients received 26 interdental piezocisions as part of orthodontic therapy. Piezocisions penetrated through the oral mucosa, the periosteum, and the cortical bone. They overlapped both keratinized gingiva and non‐keratinized alveolar mucosa. Wounds were evaluated at four time points (1, 3, 8, and 20 weeks) by measuring the Mucosal Scarring Index (MSI) on standardized photographs. Results The analysis included 364 incisions evaluated at four time‐points. The scar length showed a significant reduction up to 3 weeks in the alveolar mucosa ( p < 0.001) and up to 8 weeks in the gingiva ( p = 0.048). At 1 week, the posterior regions had higher MSI scoring than the anterior regions, particularly in the mandibular alveolar mucosa. No significant changes in the scar length or MSI scores were observed after 8 weeks, indicating stabilization of the healing processes. By 20 weeks, 64.05% and 52.22% of the incisions were devoid of scars in the gingiva and alveolar mucosa, respectively. Conclusion The study confirmed that both oral mucosa and gingiva heal with no scar or minimal scarring, following full‐thickness incisions. Neither keloid nor hypertrophic scars were observed. No significant differences were found between gingiva and alveolar mucosa in terms of final scar visibility. However, healing outcomes were notably less favorable in the posterior regions, highlighting the influence of anatomical location. Plain language summary Oral mucosa exhibits minimal scar formation compared with other tissues. Studies evaluating the healing dynamics of the various intraoral tissue types remain limited. This prospective study investigates the healing characteristics of keratinized gingiva and non‐keratinized alveolar mucosa, by focusing on scar formation following piezocision. Complete wound closure was observed at all sites 1 week after surgery. More than half of the piezocisions produced no visible scarring. Notably, even though the incisions penetrated the full thickness of the tissue and involved perforation of the vestibular cortical bone, no significant scarring was observed. However, increased scar visibility was noted in patients with pigmented gingiva. The healing results appear to vary according to anatomical regions
Identification and functional validation of intracellular protein partners of phosphorothioate splice-switching oligonucleotides using AP-MS
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Botulinum toxin A for post-stroke spasticity: Insights from the French National Hospital Discharge Database (2015–2023)
No full textInternational audienceAbstract Background Botulinum neurotoxin type A (BoNT-A) is a well-established treatment for post-stroke spasticity. However, its real-world use remains underexplored. This study evaluated BoNT-A use trends among stroke survivors in France from 2015 to 2023. Methods A retrospective cohort study was conducted using data from the French National Hospital Discharge Database. We analyzed stroke hospitalizations and BoNT-A treatment rates by age and care pathway. Among patients presenting with stroke between 2017 and 2019 who survived beyond 6 months post-stroke, we estimated the prevalence of patients with coded post-stroke spasticity, BoNT-A use, and time from stroke onset to spasticity coding and the first BoNT-A injection. Results Between 2015 and 2023, 1,170,436 hospitalizations for stroke were recorded in France. BoNT-A treatment rates remained low, ranging from 1.4% in 2015 to 1.9% in 2022. BoNT-A treatment rates increased from 3.3% to 3.8% in stroke survivors aged 20–29 and from 1.0% to 1.6% in those aged 70–79 between 2015 and 2022. Patients who, during their care pathway, stayed in a neurovascular or neurorehabilitation unit were more likely to receive BoNT-A treatment—rising from 2.0% in 2015 to 2.6% in 2022 and 7.3% to 9.6%, respectively—than those managed in non-specialized units, where rates increased from 0.9% in 2015 to 1.1% in 2022. Among 287,370 patients presenting with stroke between 2017 and 2019, 37,692 (13.1%) were coded with post-stroke spasticity, 8056 (2.8%) received ⩾1 BoNT-A injection between 2017 and 2023, 4360 (1.5%) received ⩾3 injections, and 1003 (0.35%) received ⩾3 injections spaced ⩽6 months apart. The median time from stroke onset to spasticity coding was 96 days, and to the first BoNT-A injection 258 days. Conclusion BoNT-A remains underutilized in the treatment of post-stroke spasticity in France. These results emphasize the need to enhance access to and adherence to BoNT-A therapy to optimize post-stroke spasticity management
Idealized modeling of stratospheric aerosol injection deployment scenarios with two non-cooperative actors
No full textInternational audienceThis code is the version of https://github.com/OB-IPSL/two-actor-SRM used in the article by Määttänen et al. (2025) in Environmental Science: Atmospheres of the Royal Society of Chemistry (A. Määttänen, F. Ravetta, J. Bureau, T. Lurton and O. Boucher, Environ. Sci.: Atmos., 2026, DOI: 10.1039/D5EA00022J. The article investigates solar radiation management scenarios of two non-cooperative actors deploying stratospheric aerosol injection (SAI) through idealized experiments. The repository includes the codes for a four-box Energy Balance Model capable of predicting hemispheric temperatures and monsoon precipitation and the coupled PI-controller. A short README is included
From Written Tests to OSCE: A Study on the Perceptions of Assessment Reform by Students and Faculty in the French Dental Curriculum
No full textInternational audienceTraditional assessment methods in dental education, such as written tests and multiple-choice questions, primarily measure theoretical knowledge but inadequately evaluate clinical and interpersonal competencies. The Objective Structured Clinical Examination (OSCE), recognized globally for its validity and reliability, addresses these limitations and is widely adopted in medical curricula; however, its implementation in dental education remains poorly undocumented. This study explored perceptions of OSCE compared to traditional formats within the Clinical and Therapeutic Synthesis Certificate (CTSC) at Toulouse Faculty of Health during its first OSCE-based session in January 2019. Eighty-four fifth-year students and eight faculty assessors completed a validated questionnaire assessing fairness, educational value, and stress levels. Results indicated that OSCE was perceived as covering diverse clinical skills (86%) and offering authentic scenarios (83%). Despite being stressful (76%), OSCE was considered the fairest (60% vs. MCQ 31%, WT 41%; p < 0.001) and most educational (77% vs. MCQ 17%, WT 31%). Eighty-three percent of students recommended its broader use, while assessors unanimously endorsed its fairness and utility. Both groups highlighted its formative potential. These findings support OSCE's integration into French dental curricula to strengthen competency-based assessment and enhance clinical skill evaluation