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Juvenile-onset mixed connective tissue disease: A multicenter retrospective cohort study
No full textInternational audienceObjectives: Juvenile-onset mixed connective tissue disease (jMCTD) accounts for 7-23 % of MCTD cases but remains poorly described. We aimed to characterize clinical features, treatments, and outcomes of patients with jMCTD, and compare them to adult-onset MCTD (aMCTD) patients. Methods: We conducted a multicenter, retrospective, case-control study within the French MCTD cohort. Each jMCTD patient was compared to 3 matched aMCTD patients. Results: Forty-seven jMCTD patients (93.6 % girls; median age at onset 14 [11-16] years) were included. Forty-four (93.6 %) jMCTD patients fulfilled either Sharp or Kasukawa diagnostic criteria. None of them met other diagnostic criteria without fulfilling Sharp or Kasukawa criteria. At diagnosis, jMCTD patients' main manifestations were Raynaud's phenomenon, arthralgia, and myalgia. jMCTD patients had less frequently puffy fingers than aMCTD (p < 0.0001). Cumulatively, jMCTD patients mainly received glucocorticoids (80.9 %), hydroxychloroquine (95.7 %) and immunosuppressants (93.6 %). They received a higher initial dose of glucocorticoids (30 [20-60] mg/day vs. 15 [10-35] mg/day, p = 0.02), and significantly more frequently methotrexate (Methotrexate) and rituximab (p = 0.01) over time compared to aMCTD. After a median follow-up of 9.8 [6.6-16.2] years, 29 (61.7 %) jMCTD patients were in remission (vs. 62 (44.0 %) aMCTD; p < 0.05), 36 % had progressed to another CTD (vs. 30.5 % aMCTD; p = 0.5), mainly systemic lupus erythematosus, 11 (23.4 %) had developed interstitial lung disease, 2 (4.3 %) pulmonary arterial hypertension, and 1 (2.1 %) died. Conclusions: jMCTD share the same clinical characteristics as aMCTD patients, but less frequently have puffy fingers. Outcomes appear more favorable in jMCTD than aMCTD, with higher remission rates, albeit at the cost of more intensive treatment
Panorama rapide de l’actualité « Numérique » de la semaine 15 janvier au 22 janvier 2026
No full textInternational audienceSommaireIntelligence artificielle1) Neutralité du réseau Internet face à l’IA générative : L’Arcep se prononce : Rapport Arcep IA générative : des défis pour l’avenir de l’Internet ouvert », janvier 2026 2) Wikimédia face aux modèles d’IA : du libre accès à la rémunération : Wikipédia annonce du 15 janvier 20263) Les Cnil européennes désapprouvent le report des obligations IA Dans leur avis conjoint publié le 21 janvierCommerce en ligne1) Contrats numériques et code de la consommation : la consécration du “petit professionnel” 2) Une décision qui dit plus que ce qu’elle tranche : la complexité du contentieux numérique (Responsabilité des plateformes, propriété intellectuelle et marché en ligne) : CA Versailles 7 janvier 2026, n°24/03975Contenus en ligne (DSA)Le masculinisme en ligne : le HCE pointe les limites de la régulation des plateformes son rapport annuel, publié le 21 janvier
Discrete series representations of quaternionic GLn(D) with symplectic periods
No full textFor a non-Archimedean locally compact field F of odd residue characteristic and characteristic 0, we prove a conjecture of D. Prasad predicting that, for an integer n ě 1 and a non-split quaternionic F -algebra D, a discrete series representation of GLnpDq has a symplectic period if and only if it is cuspidal and its Jacquet–Langlands transfer to GL2npF q is non-cuspida
Inundation flow velocities generated by tropical cyclones across atoll islands, derived from two centuries of megaclast deposits in French Polynesia
No full textInternational audienceUnderstanding potential flow velocities during high-energy marine inundation events is crucial for coastal risk assessment. However, modelling struggles to simulate wave energy dissipation across atoll island coastlines. Here, we examined coral reefblocks transported by past tropical cyclones to calculate the minimum flow velocities (MFVs) responsible. Fieldwork on 6 atolls in the Tuamotu archipelago (South Pacific) examined 196 reefblocks, some megaclasts exceeding 300 cubic metres in size. These blocks are scattered between the oceanside reef edge and the atoll lagoon over several hundred metres and suggest flow velocities much higher than those modelled in an assumed ‘extreme reference scenario’ (HS = 12 m). Through U/Th dating and by studying archives and historical aerial photos, the cyclones that moved these reefblocks were identified. Inundation flows generated by two recent cyclones (March and April 1983), two historical cyclones (1903 AD and 1906 AD) and one prehistorical cyclone (54–80 AD) were calculated (storms with swells 10–18.5 m in height). Calculations reveal that previous modelling underestimates flow velocities across atoll islands (inhabited areas) for two reasons: the underestimation of extreme swell heights and the unaccounted-for degradation of shoreline rubble ramparts. During a supercyclone (HS > 15 m), flows can exceed 3 m/s at 350 m from the reef edge and are capable of transporting 20-ton coral blocks. Findings have a wider significance to tropical coral reef coastlines beyond these atolls studied, where the presence of reefblocks can allow hindcasting of the characteristics of prehistorical cyclone inundations
Highstand, drop and stillstand: reconstructing MIS 5.5 sea-level changes in the central Mediterranean
No full textInternational audienc
Long-term air pollution exposure and mental health in French adults of the CONSTANCES cohort: Role of black carbon independently of PM2.5
No full textInternational audienceAmbient air pollution could be associated with poor mental health. Black carbon (BC) has been highlighted as a crucial component of particulate matter; however, its isolated role independent from the total particulate matter mass has been poorly studied. Our study aimed to examine the associations between long-term exposure to particulate matter with a diameter <2.5 μm (PM2.5), BC and nitrogen dioxide (NO2) and psychological distress in the French CONSTANCES cohort and to assess the role of BC independently of PM2.5. This cross-sectional study included 104,146 adults. Psychological distress was assessed in 2019 using the General Health Questionnaire-12 (GHQ-12). Annual concentrations of PM2.5, BC, and NO2 estimated from land-use regression models at each participant's residential address. Negative binomial models with different covariate adjustments were used. A residuals method was used to assess the independent role of BC. Incident rate ratios (IRR) per an interquartile range (IQR) increase in exposure to each pollutant were calculated. Stratified analyses by age, sex, education and season were also conducted. Mean exposures were 9.38 μg/m3 for PM2.5 (IQR = 2.6), 1.15 × 10−5/m for BC (IQR = 0.5) and 19.1 μg/m3 for NO2 (IQR = 11.5). Exposure to each pollutant was significantly associated with higher psychological distress (IRR (95 % CI): 1.052 (1.014–1.092) for PM2.5, 1.078 (1.055–1.101) for BC, and 1.082(1.057–1.109) for NO2). Stronger associations were found for men, elderly, lower-educated, and during warm season. BC residuals were significantly associated with higher psychological distress when regressed on PM2.5 (1.055 (1.039–1.071)) and when regressed on NO2 (1.067(1.041–1.093)). Exposure to ambient air pollution was associated with psychological distress, with BC showing a deleterious role independently of PM2.5 and NO2
Combining LIDAR, all-sky camera, and ECMWF-ERA5 reanalysis to investigate contrail formation and evolution over Clermont-Ferrand, France on June 2, 2023
No full textInternational audienceContrails formed by aircraft in the upper troposphere contribute to anthropogenic climate forcing. However, the conditions driving their formation and persistence remain incompletely understood. This study combines a ACTRIS/EARLINET ground-based LIDAR, all-sky camera imagery, ADS-B aircraft tracking, and ECMWF-ERA5 reanalysis to analyse contrails formation and evolution over Clermont-Ferrand, France, on June 2, 2023. Twelve contrails are documented throughout the day, including five persistent and seven non-persistent contrails. Persistent contrails formed at 10.36 km altitude or lower are observed under ice-supersaturated conditions (relative humidity with respect to ice, RHi > 105 %) and at temperatures between 217 and 223 K. Non-persistent contrails produced by higher altitudes aircrafts, are associated with lower RHi mostly below 100 % and colder temperatures (214-217 K). The horizontal persistent contrail widths range from 0.53 ± 0.10 to 1.60 ± 0.44 km (all-sky camera estimation) and 0.35 ± 0.14 to 1.90 ± 0.32 km (LIDAR estimation), and vertical extents varied from 340 ± 10 to 440 ± 20 m. The optical properties of these contrails have also been estimated by LIDAR. Aerosol backscatter coefficient vary from 0.02 to 0.05 km-1 sr-1, scattering ratios from 8 to 20, volume linear depolarization from 0.13 to 0.24 and particle linear depolarization from 0.17 to 0.45. The maximum contrail observation duration by camera is 180 min. The study highlights the potential of ground-based remote sensing for contrail monitoring
The COVID-19 pandemic influence on French-speaking occupational therapists' occupational identity and competence
No full textInternational audienceBackground The restrictive measures implemented during the COVID-19 pandemic affected the mental health and daily activities of occupational therapists (OT). Objectives To understand how the global environment, during the COVID-19 pandemic, influenced OTs' occupational identity and competence. Methodology Five French-speaking OTs per country (France, Belgium, Switzerland and Canada) were randomly recruited from the initial eCO3 (study on Occupational Competence during Confinement in the context of the COVID-19 pandemic) study. They took part in semi-structured interviews using the Occupational Performance History Interview-II (OPHI-II) between September and December 2021. Interviews were analysed using categorical content analysis, supported by a similarity analysis using IRAMUTEQ software. Results Few differences were established depending on the country. Maintaining stability while transforming one's occupations and developing social interactions was essential. At least one participant per country criticised their global environment. Conclusion During the pandemic, OTs took time to reflect on their occupational identity while remaining active to maintain a satisfying occupational competence. OTs, for whom adaptability has become essential, have strengthened their resilience during the crisis
A Case of Mediastinal Adenopathy and Clinically Suspected Myocarditis
No full textInternational audienc
Uncertainty in projected changes of Indian Summer Monsoon Rainfall by CMIP6 models
No full textInternational audienceA robust and trustworthy rainfall projection over the Indian landmass is vital for devising climate adaptation strategies. However, past studies show large inter-model spread in Indian Summer monsoon (ISM) rainfall projections thus calling for more detailed investigations on the underlying process. In the present study, we investigate this aspect using Coupled Model Intercomparison Project Phase 6 (CMIP6) model projections (Shared Socioeconomic Pathways, SSP5–8.5) and historical simulations. The Multi-Model Ensemble mean (MME) results show intensification of ISM rainfall at the end of the 21st century with ISM rainfall increasing by 1.6 ± 0.8 mm/day under SSP5–8.5 scenario. A moisture budget analysis for the MME further infers that the thermodynamic effect (TH) due to global warming plays a dominant role in enhancing ISM rainfall in the projections, with its dynamic counterpart (DY) assuming an additional contribution. It is also revealed that both DY and TH terms contribute to the inter-model uncertainty in ISM rainfall, but with DY dominating over the other this time. The inter-model uncertainty in DY and ISM rainfall changes is linked to inter-model spread in interhemispheric thermal contrast which in-turn depends on the diversity in Equilibrium Climate Sensitivity (ECS) and Global Mean Temperature (GMT) among the models. Intriguingly, when we remove the inter-model diversity in ECS through a GMT scaling, an Atlantic meridional surface temperature gradient, involving both land and ocean, emerges as a crucial driver in controlling the uncertainty in both DY and ISM rainfall changes, and drives large-scale monsoon circulation changes over African and the Indian subcontinents