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Operando Photoemission Imaging of the Energy Landscape from a 2D Material-Based Field-Effect Transistor
No full textWhole‐exome sequencing in families from Lifou Island (New Caledonia) reveals candidate variants involved in gout pathogenesis
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Highly Efficient UV-Activated TiO 2 /SnO 2 Surface Nano-matrix Gas Sensor: Enhancing Stability for ppb-Level NO x Detection at Room Temperature
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"Crocus Morus", "Bim-Bam" and other carnival funerals in Strasbourg
No full textStrasbourg, nowadays self-proclaimed “Capital of Christmas”, will never become an epicentre of carnival in Europe as intended by local executives concerned with decent city marketing, popular animation and global outreach. Indeed, the history of carnival in Strasbourg is one of latency between futile research of tradition, short revivals and sarcastic burials during the twentieth century. Suspended in after-war times, carnival was rarely glorying on the streets of this quiet city on the Southern Rhine. Bearing in mind the historical, religious and intercultural specificities of Alsace, torn between Germany and France, this contribution will focus on efforts to reinvent street carnival in the French city of Strasbourg between 1956 and 1963. On the one hand, we will examine the Crocus Morus convoy, staged in 1956 by Germain Muller and his satirical cabaret troupe “De Barabli”. This carnival march criticized the lethargy of the municipality that ruled the city. On the other hand, the following parades named Bim-Bam, sponsored by merchants from 1957 onwards, or Cavalcade de l’Est in 1961, were calm carnivals that legitimized the established order and bored finally “even its managers”, as French ethnologist Ève Cerf concluded. In order to explore composite dimensions of cultural transfers, it will be interesting to reflect how the organisers of street carnival in Strasbourg reconsidered visual elements of spring rituals and copied protest parades using funeral procession as a performative model
L’identita’ nazionale, oggetto educativo mitico, impossibile o invisibile ? Il caso dell’educazione civica in Svezia
No full textGraphene Nanodots as Substrates for SEIRAS and SERS Studies on Membrane Proteins
No full textGraphene nanostructures are capable of supporting plasmonic resonances in the visible and infrared parts of the spectrum. Thus, they can be exploited as platforms for Surface-Enhanced Infrared Absorption Spectroscopy (SEIRAS) and Surface-Enhanced Raman Spectroscopy (SERS) studies. One application of SEIRAS and SERS is the study of proteins at very low concentrations, down to the picomolar range. Among the different forms of graphene, graphene nanodots are ideal nanostructures that can be produced on a large scale using established protocols relying on sonication-assisted exfoliation under specific experimental conditions. Their rich surface chemistry facilitates stable and nondenaturing adsorption of membrane proteins, ensuring preservation of their native secondary structure upon immobilization. In this study, we exploited graphene nanodots deposited by drop casting or spray coating onto a silicon wafer as a substrate to study the cytochrome bd-I oxidase fromE. coli, a membrane protein that is present in the respiratory chains of bacteria. The amide I signal was examined to confirm the structural integrity of the protein once immobilized onto the graphene nanodots. SEIRAS and SERS experiments revealed reproducible enhancement of the protein signal, approximately by a factor of 2 and 6-10 compared to other substrates, respectively, enabling analyte detection with a sensitivity down to the nanomolar range. Furthermore, our tailored substrate exhibited high stability of the protein exceeding 6 days, thus underscoring its high potential for biosensing
Prevention of liver cancer in the era of next-generation antivirals and obesity epidemic.
No full textPreventive interventions are expected to substantially improve the prognosis of patients with primary liver cancer, predominantly HCC and cholangiocarcinoma. HCC prevention is challenging in the face of the evolving etiological landscape, particularly the sharp increase in obesity-associated metabolic disorders, including metabolic dysfunction-associated steatotic liver disease. Next-generation anti-HCV and HBV drugs have substantially reduced, but not eliminated, the risk of HCC and have given way to new challenges in identifying at-risk patients. The recent development of new therapeutic agents and modalities has opened unprecedented opportunities to refine primary, secondary, and tertiary HCC prevention strategies. For primary prevention (before exposure to risk factors), public health policies, such as universal HBV vaccination, have had a substantial prognostic impact. Secondary prevention (after or during active exposure to risk factors) includes regular HCC screening and chemoprevention. Emerging biomarkers and imaging modalities for HCC risk stratification and detection may enable individual risk-based personalized and cost-effective HCC screening. Clinical studies have suggested the potential utility of lipid-lowering, antidiabetic/obesity, and anti-inflammatory agents for secondary prevention, and some of them are being evaluated in prospective clinical trials. Computational and experimental studies have identified potential chemopreventive strategies directed at diverse molecular, cellular, and systemic targets for etiology-specific and/or agnostic interventions. Tertiary prevention (in conjunction with curative-intent therapies for HCC) is an area of active research with the development of new immune-based neoadjuvant/adjuvant therapies. Cholangiocarcinoma prevention may advance with recent efforts to elucidate risk factors. These advances will collectively lead to substantial improvements in liver cancer mortality rates.journal article2025 Jan 142025 01 14importe
